Over-prescription of acid-suppressing medications in infants: How it came about, why it's wrong, and what to do about it

Journal of Pediatrics

Volumn 160, Issue 2, 2012, Pages 193-198

  Hassall, Eric ^a  

^a Sutter Pacific Medical Foundation   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HISTAMINE H2 RECEPTOR ANTAGONIST; PLACEBO; PROTON PUMP INHIBITOR;

ACHLORHYDRIA; ACUTE GASTROENTERITIS; ANXIETY; BACTERIAL OVERGROWTH; BODY POSITION; CANDIDEMIA; CHILD CARE; COLIC; COMMUNITY ACQUIRED PNEUMONIA; CONSTIPATION; COUGHING; CRYING; CYANOCOBALAMIN DEFICIENCY; DISEASE EXACERBATION; DRUG EFFICACY; DRUG MARKETING; DRUG MEGADOSE; DRUG METABOLISM; EOSINOPHILIC ESOPHAGITIS; ESOPHAGUS; FOOD ALLERGY; FOOD REGURGITATION; GASTROESOPHAGEAL REFLUX; HEADACHE; HEARTBURN; HUMAN; HYPERTRANSAMINASEMIA; INAPPROPRIATE PRESCRIBING; INFANT COLIC; INFANT DISEASE; INFANT FEEDING; MEDICAL INFORMATION; NECROTIZING ENTEROCOLITIS; NOTE; PARENTAL ATTITUDE; PEPTIC ULCER; PHARMACIST; PRIORITY JOURNAL; REFLUX ESOPHAGITIS; SATIETY; SIDE EFFECT; STOMACH ACID; STOMACH FUNCTION;

ANTACIDS; GASTROESOPHAGEAL REFLUX; HISTAMINE H2 ANTAGONISTS; HUMANS; INAPPROPRIATE PRESCRIBING; INFANT; PHYSICIAN'S PRACTICE PATTERNS; PROGNOSIS; PROTON PUMP INHIBITORS;

EID: 84855705395     PISSN: 00223476     EISSN: 10976833     Source Type: Journal    
DOI: 10.1016/j.jpeds.2011.08.067     Document Type: Note

References (50)

1. T.S. Gunasekaran, and E.G. Hassall Efficacy and safety of omeprazole for severe gastroesophageal reflux in children J Pediatr 123 1993 148 154 (Pubitemid 23185219)
2. P. Sherman, E. Hassall, U. Fagundes-Neto, B.D. Gold, S. Kato, and S. Koletzko A global evidence-based consensus on the definition of gastroesophageal reflux disease in children Am J Gastroenterol 104 2009 1278 1295
3. E. Hassall, D. Israel, R. Shepherd, M. Radke, A. Dalvag, and B. Skold Omeprazole for treatment of chronic erosive esophagitis in children: a multicenter study of efficacy, safety, tolerability and dose requirements. International Pediatric Omeprazole Study Group J Pediatr 137 2000 800 807
4. S. Fiedorek, V. Tolia, B.D. Gold, B. Huang, J. Stolle, and C. Lee Efficacy and safety of lansoprazole in adolescents with symptomatic erosive and non-erosive gastroesophageal reflux disease J Pediatr Gastroenterol Nutr 40 2005 319 327 (Pubitemid 40344098)
5. V. Tolia, G. Ferry, T. Gunasekaran, B. Huang, R. Keith, and L. Book Efficacy of lansoprazole in the treatment of gastroesophageal reflux disease in children J Pediatr Gastroenterol Nutr 35 Suppl. 4 2002 S308 S318
6. B.D. Gold, T. Gunasekaran, V. Tolia, G. Wetzler, H. Conter, and B. Traxler Safety and symptom improvement with esomeprazole in adolescents with gastroesophageal reflux disease J Pediatr Gastroenterol Nutr 45 2007 520 529 (Pubitemid 350307136)
7. V. Tolia, N.N. Youssef, M.A. Gilger, B. Traxler, and M. Illueca Esomeprazole for the treatment of erosive esophagitis in children: an international, multicenter, randomized, parallel-group, double-blind (for dose) study BMC Pediatr 10 2010 41
8. R. Baker, V.M. Tsou, J. Tung, S.S. Baker, H. Li, and W. Wang Clinical results from a randomized, double-blind, dose-ranging study of pantoprazole in children aged 1 through 5 years with symptomatic histologic or erosive esophagitis Clin Pediatr (Phila) 49 2010 852 865
9. Hassall E, Shepherd R, Koletzko S, Radke M, Henderson C, Lundborg P. Prospective long-term maintenance treatment with proton pump inhibitors in children with erosive esophagitis. Aliment Pharmacol Ther 2011. In press.
10. E. Hassall, W. Kerr, and H.B. El-Serag Characteristics of children receiving proton pump inhibitors continuously for up to 11 years duration J Pediatr 150 2007 262 267
11. Y. Vandenplas, C.D. Rudolph, C. Di Lorenzo, E. Hassall, G. Liptak, and L. Mazur Pediatric gastroesophageal reflux clinical practice guidelines: joint recommendations of the North American Society of Pediatric Gastroenterology, Hepatology, and Nutrition and the European Society of Pediatric Gastroenterology, Hepatology, and Nutrition J Pediatr Gastroenterol Nutr 49 2009 498 547
12. G. Boccia, F. Manguso, E. Miele, R. Buonavolont'a, and A. Staiano Maintenance therapy for erosive esophagitis in children after healing by omeprazole: is it advisable? Am J Gastroenterol 192 2007 1291 1297 (Pubitemid 46802013)
13. E. Hassall Outcomes of fundoplication: causes for concern, newer options Arch Dis Child 90 2005 1047 1052 (Pubitemid 41406613)
14. J.J. Barron, H. Tan, J. Spalding, A.W. Bakst, and J. Singer Proton pump inhibitor utilization patterns in infants J Pediatr Gastroenterol Nutr 45 2007 421 427 (Pubitemid 350307159)
15. S.R. Orenstein, and E. Hassall Infants and proton pump inhibitors: tribulations, no trials J Pediatr Gastroenterol Nutr 45 2007 395 398 (Pubitemid 350307154)
16. A.J. Martin, N. Pratt, J.D. Kennedy, P. Ryan, R.E. Ruffin, and E. Miles Natural history and familial relationships of infant spilling to 9 years of age Pediatrics 109 2002 1061 1067 (Pubitemid 34587431)
17. S.P. Nelson, E.H. Chen, G.M. Syniar, and K.K. Christoffel Prevalence of symptoms of gastroesophageal reflux during infancy. A pediatric practice-based survey. Pediatric Practice Research Group Arch Pediatr Adolesc Med 151 1997 569 572 (Pubitemid 27262280)
18. R.G. Barr Changing our understanding of infant colic Arch Pediatr Adolesc Med 156 2002 1172 1174 (Pubitemid 36343429)
19. S.R. Orenstein Crying in infant GERD: acid or volume? Heartburn or dyspepsia? Curr Gastroenterol Rep 10 2008 433 436
20. A.A. Condino, J. Sondheimer, Z. Pan, J. Gralla, D. Perry, and J.A. O'Connor Evaluation of infantile acid and nonacid gastroesophageal reflux using combined pH monitoring and impedance measurement J Pediatr Gastroenterol Nutr 42 2006 16 21 (Pubitemid 43061004)
21. S.R. Orenstein, E. Hassall, W. Furmaga-Jablonska, S. Atkinson, and M. Raanan Multicenter, double-blind, randomized, placebo-controlled trial assessing efficacy & safety of proton pump inhibitor lansoprazole in infants with symptoms of gastroesophageal reflux disease J Pediatr 154 2009 514-520 e4
22. D.J. Moore, B.S. Tao, D.R. Lines, C. Hirte, M.L. Heddle, and G.P. Davidson Double-blind placebo-controlled trial of omeprazole in irritable infants with gastroesophageal reflux J Pediatr 143 2003 219 223 (Pubitemid 37082956)
23. J.M. Donohue, M. Cevasco, and M.B. Rosenthal A decade of direct-to-consumer advertising of prescription drugs N Engl J Med 357 2007 673 681 (Pubitemid 47267237)
24. B. Mintzes, M.L. Barer, R.L. Kravitz, K. Bassett, J. Lexchin, and A. Kazanjian How does direct-to-consumer advertising (DTCA) affect prescribing? A survey in primary care environments with and without legal DTCA CMAJ 169 2003 405 412 (Pubitemid 37076252)
25. P.E. Hyman, P.J. Milla, M.A. Benninga, G.P. Davidson, D.F. Fleisher, and J. Taminiau Childhood functional gastrointestinal disorders: neonate/toddler Gastroenterology 130 2006 1519 1526
26. Barr RG. Crying behaviour and its importance for psychosocial development in children. In: Tremblay RE, Barr RG, Peters RDeV, editors. Encyclopedia on early childhood development [online]. Montreal, Quebec: Centre of Excellence for Early Childhood Development. Available at: http://www.child-encyclopedia.com/ pages/PDF/BarrANGxp.pdf. Accessed October 4, 2011.
27. R.G. Barr, J.A. Paterson, L.M. MacMartin, L. Lehtonen, and S.N. Young Prolonged and unsoothable crying bouts in infants with and without colic J Dev Behav Pediatr 26 2005 14 23 (Pubitemid 40439701)
28. R.G. Barr, J. Hanley, D.K. Patterson, and J. Wooldridge Breath hydrogen excretion in normal newborn infants in response to usual feeding patterns: evidence for "functional lactase insufficiency" beyond the first month of life J Pediatr 104 1984 527 533 (Pubitemid 14125675)
29. E. Hassall, J.E. Dimmick, and D.M. Israel Parietal cell hyperplasia in children receiving omeprazole Gastroenterology 108 1995 A110
30. Y.X. Yang, and D.C. Metz Safety of proton pump inhibitor exposure Gastroenterology 139 2010 1115 1127
31. E.C. Klinkenberg-Knol, F. Nelis, J. Dent, P. Snel, B. Mitchell, and P. Prichard Long-term omeprazole treatment in resistant gastroesophageal reflux disease: efficacy, safety, and influence on gastric mucosa Gastroenterology 118 2000 661 669 (Pubitemid 30171615)
32. E. Hassall, D. Owen, W. Kerr, T. Sturby, P. Richardson, and H. El-Serag Gastric histology in children treated with proton pump inhibitors (PPIs) long-term, with emphasis on ECL hyperplasia Aliment Pharmacol Ther 33 2011 829 836
33. R. Fossmark, G. Johnsen, E. Johanessen, and H.L. Waldum Rebound acid hypersecretion after long-term inhibition of gastric acid secretion Aliment Pharmacol Ther 21 2005 149 154 (Pubitemid 40222967)
34. C. Reimer, B. Sondergaard, L. Hilsted, and P. Bytzer Proton-pump inhibitor therapy induces acid-related symptoms in healthy volunteers after withdrawal of therapy Gastroenterology 137 2009 80 87
35. R.B. Canani, P. Cirillo, P. Roggero, C. Romano, B. Malamisura, and G. Terrin Therapy with gastric acidity inhibitors increases the risk of acute gastroenteritis and community-acquired pneumonia in children Pediatrics 117 2006 e817 e820
36. 2-blocker therapy and higher incidence of necrotizing enterocolitis in very low birth weight infants Pediatrics 117 2006 e137 e142
37. L. Saiman, E. Ludington, M. Pfaller, S. Rangel-Frausto, R.T. Wiblin, and J. Dawson Risk factors for candidemia in neonatal intensive care unit patients. The National Epidemiology of Mycosis Survey study group Pediatr Infect Dis J 19 2000 319 324 (Pubitemid 30213071)
38. C. Williams, and K.E. McColl Review article: proton pump inhibitors and bacterial overgrowth Aliment Pharmacol Ther 23 2006 3 10 (Pubitemid 43381161)
39. M.S. Dial Proton pump inhibitor use and enteric infections Am J Gastroenterol 104 Suppl. 2 2009 S10 S16
40. L.A. Garcia Rodriguez, A. Ruigomez, and J. Panes Use of acid-suppressing drugs and the risk of bacterial gastroenteritis Clin Gastroenterol Hepatol 5 2007 1418 1423 (Pubitemid 350181606)
41. R.J. Laheij, M.C. Sturkenboom, R.J. Hassing, J. Dieleman, B.H. Stricker, and J.B. Jansen Risk of community-acquired pneumonia and use of gastric acid-suppressive drugs JAMA 292 2004 1955 1960 (Pubitemid 39411203)
42. R.J. Valuck, and J.M. Ruscin A case-control study on adverse effects: H2 blocker or proton pump inhibitor use and risk of vitamin B12 deficiency in older adults J Clin Epidemiol 57 2004 422 428 (Pubitemid 38609284)
43. Y.X. Yang, J.D. Lewis, S. Epstein, and D.C. Metz Long-term proton pump inhibitor therapy and risk of hip fracture JAMA 296 2006 2947 2953 (Pubitemid 46021498)
44. FDA Communication. Low magnesium levels can be associated with long-term use of proton pump inhibitor drugs (PPIs). Available at http://www.fda.gov/ Drugs/DrugSafety/ucm245011.htm2011. Accessed October 2, 2011.
45. E. Untersmayr, and E. Jensen-Jarolim The role of protein digestibility and antacids on food allergy outcomes J Allergy Clin Immunol 121 2008 1301 1308 (Pubitemid 351795582)
46. S. Orenstein, and J. McGowan Efficacy of conservative therapy as taught in the primary care setting for symptoms suggesting infant gastroesophageal reflux J Pediatr 152 2008 310 314
47. D.J. Hill, N. Roy, R.G. Heine, C.S. Hosking, D.E. Francis, and J. Brown Effect of a low-allergen maternal diet on colic among breastfed infants: a randomized, controlled trial Pediatrics 116 2005 e709 e715
48. D.J. Hill, R.G. Heine, D.J. Cameron, A.G. Catto-Smith, C.W. Chow, and D.E. Francis Role of food protein intolerance in infants with persistent distress attributed to reflux esophagitis J Pediatr 136 2000 641 647 (Pubitemid 30318395)
49. E. Hassall Step-up and step-down approaches to treatment of gastroesophageal reflux disease in children Curr Gastroenterol Rep 10 2008 324 331
50. E. Hassall Treatment interruptus: the need for withdrawal Am J Gastroenterol 102 2007 2108 2109