-
1
-
-
0025779484
-
Atrial fibrillation as an independent risk factor for stroke: The Framingham Study
-
Wolf PA, Abbott RD, Kannel WB. Atrial fibrillation as an independent risk factor for stroke: the Framingham Study. Stroke 1991; 22:983-988.
-
(1991)
Stroke
, vol.22
, pp. 983-988
-
-
Wolf, P.A.1
Abbott, R.D.2
Kannel, W.B.3
-
2
-
-
20444395760
-
Contribution of atrial fibrillation to incidence and outcome of ischemic stroke: Results from a population-based study
-
DOI 10.1161/01.STR.0000166053.83476.4a
-
Marini C, De Santis F, Sacco S, et al. Contribution of atrial fibrillation to incidence and outcome of ischemic stroke: results from a population-based study. Stroke 2005; 36:1115-1119. (Pubitemid 40803473)
-
(2005)
Stroke
, vol.36
, Issue.6
, pp. 1115-1119
-
-
Marini, C.1
De Santis, F.2
Sacco, S.3
Russo, T.4
Olivieri, L.5
Totaro, R.6
Carolei, A.7
-
3
-
-
45949095568
-
Antithrombotic therapy in atrial fibrillation: American College of Chest Physicians evidence-based clinical practice guidelines (8th edition)
-
DOI 10.1378/chest.08-0678
-
Singer DE, Albers GW, Dalen JE, et al. Antithrombotic therapy in atrial fibrillation: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th edition). Chest 2008; 133 (6 Suppl):546S-592S. (Pubitemid 351892972)
-
(2008)
Chest
, vol.133
, Issue.6 SUPPL. 6
-
-
Singer, D.E.1
Albers, G.W.2
Dalen, J.E.3
Fang, M.C.4
Go, A.S.5
Halperin, J.L.6
Lip, G.Y.H.7
Manning, W.J.8
-
4
-
-
0035832261
-
Prevalence of diagnosed atrial fibrillation in adults: National implications for rhythm management and stroke prevention: The anticoagulation and risk factors in atrial fibrillation (ATRIA) study
-
Go AS, Hylek EM, Phillips KA, et al. Prevalence of diagnosed atrial fibrillation in adults: national implications for rhythm management and stroke prevention: the anticoagulation and risk factors in atrial fibrillation (ATRIA) study. JAMA 2001; 285:2370-2375. (Pubitemid 32424106)
-
(2001)
Journal of the American Medical Association
, vol.285
, Issue.18
, pp. 2370-2375
-
-
Go, A.S.1
Hylek, E.M.2
Phillips, K.A.3
Chang, Y.C.4
Henault, L.E.5
Selby, J.V.6
Singer, D.E.7
-
5
-
-
34548455445
-
Independent predictors of stroke in patients with atrial fibrillation: A systematic review
-
Stroke Risk in Atrial Fibrillation Working Group
-
Stroke Risk in Atrial Fibrillation Working Group. Independent predictors of stroke in patients with atrial fibrillation: a systematic review. Neurology 2007; 69:546-554.
-
(2007)
Neurology
, vol.69
, pp. 546-554
-
-
-
6
-
-
34347394385
-
Meta-analysis: Antithrombotic therapy to prevent stroke in patients who have nonvalvular atrial fibrillation
-
Hart RG, Pearce LA, Aguilar MI. Meta-analysis: antithrombotic therapy to prevent stroke in patients who have nonvalvular atrial fibrillation. Ann Intern Med 2007; 146:857-867. (Pubitemid 351650486)
-
(2007)
Annals of Internal Medicine
, vol.146
, Issue.12
, pp. 857-867
-
-
Hart, R.G.1
Pearce, L.A.2
Aguilar, M.I.3
-
7
-
-
0030953564
-
Stroke recurrence: Predictors, severity, and prognosis
-
The Copenhagen Stroke Study
-
Jorgensen HS, Nakayama H, Reith J, et al. Stroke recurrence: predictors, severity, and prognosis. The Copenhagen Stroke Study. Neurology 1997; 48:891-895.
-
(1997)
Neurology
, vol.48
, pp. 891-895
-
-
Jorgensen, H.S.1
Nakayama, H.2
Reith, J.3
-
8
-
-
0027505093
-
Secondary prevention in nonrheumatic atrial fibrillation after transient ischaemic attack or minor stroke
-
European Atrial Fibrillation Trial (EAFT) Study Group
-
European Atrial Fibrillation Trial (EAFT) Study Group. Secondary prevention in nonrheumatic atrial fibrillation after transient ischaemic attack or minor stroke. Lancet 1993; 342:1255-1262.
-
(1993)
Lancet
, vol.342
, pp. 1255-1262
-
-
-
9
-
-
69849100157
-
The net clinical benefit of warfarin anticoagulation in atrial fibrillation
-
Singer DE, Chang Y, Fang MC, et al. The net clinical benefit of warfarin anticoagulation in atrial fibrillation. Ann Intern Med 2009; 151:297-305.
-
(2009)
Ann Intern Med
, vol.151
, pp. 297-305
-
-
Singer, D.E.1
Chang, Y.2
Fang, M.C.3
-
10
-
-
45949103309
-
Pharmacology and management of the vitamin K antagonists: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th Edition)
-
DOI 10.1378/chest.08-0670
-
Ansell J, Hirsh J, Hylek E, et al. Pharmacology and management of the vitamin K antagonists: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th edition). Chest 2008; 133 (6 Suppl): 160S-198S. (Pubitemid 351892967)
-
(2008)
Chest
, vol.133
, Issue.6 SUPPL. 6
-
-
Ansell, J.1
Hirsh, J.2
Hylek, E.3
Jacobson, A.4
Crowther, M.5
Palareti, G.6
-
11
-
-
38349147756
-
New oral anticoagulants in atrial fibrillation
-
Turpie AG. New oral anticoagulants in atrial fibrillation. Eur Heart J 2008; 29:155-165.
-
(2008)
Eur Heart J
, vol.29
, pp. 155-165
-
-
Turpie, A.G.1
-
12
-
-
0028343127
-
Risk factors for intracranial hemorrhage in outpatients taking warfarin
-
Hylek E, Singer D. Risk factors for intracranial hemorrhage in outpatients taking warfarin. Ann Intern Med 1994; 120:897-902. (Pubitemid 24179151)
-
(1994)
Annals of Internal Medicine
, vol.120
, Issue.11
, pp. 897-902
-
-
Hylek, E.M.1
Singer, D.E.2
-
13
-
-
33644650849
-
Optimal INR for prevention of stroke and death in atrial fibrillation: A critical appraisal
-
DOI 10.1016/j.thromres.2004.11.025, PII S0049384804006292
-
Oden A, Fahlen M, Hart RG. Optimal INR for prevention of stroke and death in atrial fibrillation: a critical appraisal. Thromb Res 2006; 117:493-499. (Pubitemid 43326133)
-
(2006)
Thrombosis Research
, vol.117
, Issue.5
, pp. 493-499
-
-
Oden, A.1
Fahlen, M.2
Hart, R.G.3
-
14
-
-
77449130241
-
Persistent use of secondary preventive drugs declines rapidly during the first 2 years after stroke
-
Glader EL, Sjolander M, Eriksson M, Lundberg M. Persistent use of secondary preventive drugs declines rapidly during the first 2 years after stroke. Stroke 2010; 41:397-401.
-
(2010)
Stroke
, vol.41
, pp. 397-401
-
-
Glader, E.L.1
Sjolander, M.2
Eriksson, M.3
Lundberg, M.4
-
15
-
-
33747162193
-
Atrial fibrillation and stroke in the general medicare population: A 10-year perspective (1992 to 2002)
-
DOI 10.1161/01.STR.0000230607.07928.17, PII 0000767020060800000010
-
Lakshminarayan K, Solid CA, Collins AJ, et al. Atrial fibrillation and stroke in the general medicare population: a 10-year perspective (1992-2002). Stroke 2006; 37:1969-1974. (Pubitemid 44309888)
-
(2006)
Stroke
, vol.37
, Issue.8
, pp. 1969-1974
-
-
Lakshminarayan, K.1
Solid, C.A.2
Collins, A.J.3
Anderson, D.C.4
Herzog, C.A.5
-
16
-
-
0037817710
-
Anticoagulant-related bleeding in older persons with atrial fibrillation: Physicians' fears often unfounded
-
DOI 10.1001/archinte.163.13.1580
-
Man-Son-Hing M, Laupacis A. Anticoagulant-related bleeding in older persons with atrial fibrillation: physicians' fears often unfounded. Arch Intern Med 2003; 163:1580-1586. (Pubitemid 36835103)
-
(2003)
Archives of Internal Medicine
, vol.163
, Issue.13
, pp. 1580-1586
-
-
Man-Son-Hing, M.1
Laupacis, A.2
-
17
-
-
0034627893
-
Why do patients with atrial fibrillation not receive warfarin?
-
Bungard TJ, Ghali WA, Teo KK, et al. Why do patients with atrial fibrillation not receive warfarin? Arch Intern Med 2000; 160:41-46. (Pubitemid 30040971)
-
(2000)
Archives of Internal Medicine
, vol.160
, Issue.1
, pp. 41-46
-
-
Bungard, T.J.1
Ghali, W.A.2
Teo, K.K.3
McAlister, F.A.4
Tsuyuki, R.T.5
-
18
-
-
77953851760
-
Underuse of oral anticoagulants in atrial fibrillation: A systematic review
-
e4
-
Ogilvie IM, Newton N, Welner SA, et al. Underuse of oral anticoagulants in atrial fibrillation: a systematic review. Am J Med 2010; 123:638-645; e4.
-
(2010)
Am J Med
, vol.123
, pp. 638-645
-
-
Ogilvie, I.M.1
Newton, N.2
Welner, S.A.3
-
19
-
-
33744945247
-
Clopidogrel plus aspirin versus oral anticoagulation for atrial fibrillation in the Atrial fibrillation Clopidogrel Trial with Irbesartan for prevention of Vascular Events (ACTIVE W): A randomised controlled trial
-
ACTIVE Writing Group on behalf of the ACTIVE Investigators
-
ACTIVE Writing Group on behalf of the ACTIVE Investigators, Connolly S, Pogue J, Hart R, Pfeffer M, Hohnloser S, et al. Clopidogrel plus aspirin versus oral anticoagulation for atrial fibrillation in the Atrial fibrillation Clopidogrel Trial with Irbesartan for prevention of Vascular Events (ACTIVE W): a randomised controlled trial. Lancet 2006; 367:1903-1912.
-
(2006)
Lancet
, vol.367
, pp. 1903-1912
-
-
Connolly, S.1
Pogue, J.2
Hart, R.3
Pfeffer, M.4
Hohnloser, S.5
-
20
-
-
33746206423
-
Rationale and design of ACTIVE: The atrial fibrillation clopidogrel trial with irbesartan for prevention of vascular events
-
Connolly S, Yusuf S, Budaj A, et al. Rationale and design of ACTIVE: the atrial fibrillation clopidogrel trial with irbesartan for prevention of vascular events. Am Heart J 2006; 151:1187-1193.
-
(2006)
Am Heart J
, vol.151
, pp. 1187-1193
-
-
Connolly, S.1
Yusuf, S.2
Budaj, A.3
-
21
-
-
65649145705
-
Effect of clopidogrel added to aspirin in patients with atrial fibrillation
-
Connolly SJ, Pogue J, Hart RG, et al. Effect of clopidogrel added to aspirin in patients with atrial fibrillation. N Engl J Med 2009; 360:2066-2078.
-
(2009)
N Engl J Med
, vol.360
, pp. 2066-2078
-
-
Connolly, S.J.1
Pogue, J.2
Hart, R.G.3
-
22
-
-
34548031359
-
The pharmacokinetics, pharmacodynamics and tolerability of dabigatran etexilate, a new oral direct thrombin inhibitor, in healthy male subjects
-
DOI 10.1111/j.1365-2125.2007.02899.x
-
Stangier J, Rathgen K, Stahle H, et al. The pharmacokinetics, pharmacodynamics and tolerability of dabigatran etexilate, a new oral direct thrombin inhibitor, in healthy male subjects. Br J Clin Pharmacol 2007; 64:292-303. (Pubitemid 47283865)
-
(2007)
British Journal of Clinical Pharmacology
, vol.64
, Issue.3
, pp. 292-303
-
-
Stangier, J.1
Rathgen, K.2
Stahle, H.3
Gansser, D.4
Roth, W.5
-
23
-
-
34447522035
-
In-vitro profile and ex-vivo anticoagulant activity of the direct thrombin inhibitor dabigatran and its orally active prodrug, dabigatran etexilate
-
DOI 10.1160/TH07-03-0183
-
Wienen W, Stassen JM, Priepke H, et al. In-vitro profile and ex-vivo anticoagulant activity of the direct thrombin inhibitor dabigatran and its orally active prodrug, dabigatran etexilate. Thromb Haemost 2007; 98:155-162. (Pubitemid 47078782)
-
(2007)
Thrombosis and Haemostasis
, vol.98
, Issue.1
, pp. 155-162
-
-
Wienen, W.1
Stassen, J.-M.2
Priepke, H.3
Ries, U.J.4
Hauel, N.5
-
24
-
-
17644400166
-
Pharmacokinetic profile of the oral direct thrombin inhibitor dabigatran etexilate in healthy volunteers and patients undergoing total hip replacement
-
DOI 10.1177/0091270005274550
-
Stangier J, Eriksson BI, Dahl OE, et al. Pharmacokinetic profile of the oral direct thrombin inhibitor dabigatran etexilate in healthy volunteers and patients undergoing total hip replacement. J Clin Pharmacol 2005; 45:555-563. (Pubitemid 40562946)
-
(2005)
Journal of Clinical Pharmacology
, vol.45
, Issue.5
, pp. 555-563
-
-
Stangier, J.1
Eriksson, B.I.2
Dahl, O.E.3
Ahnfelt, L.4
Nehmiz, G.5
Stahle, H.6
Rathgen, K.7
Svard, R.8
-
25
-
-
77952167209
-
Pharmacology, pharmacokinetics, and pharmacodynamics of dabigatran etexilate, an oral direct thrombin inhibitor
-
Stangier J, Clemens A. Pharmacology, pharmacokinetics, and pharmacodynamics of dabigatran etexilate, an oral direct thrombin inhibitor. Clin Appl Thromb Hemost 2009; 15 (1 Suppl):9S-16S.
-
(2009)
Clin Appl Thromb Hemost
, vol.15
, Issue.1 SUPPL.
-
-
Stangier, J.1
Clemens, A.2
-
26
-
-
38749131205
-
The metabolism and disposition of the oral direct thrombin inhibitor, dabigatran, in humans
-
DOI 10.1124/dmd.107.019083
-
Blech S, Ebner T, Ludwig-Schwellinger E, et al. The metabolism and disposition of the oral direct thrombin inhibitor, dabigatran, in humans. Drug Metab Dispos 2008; 36:386-399. (Pubitemid 351185753)
-
(2008)
Drug Metabolism and Disposition
, vol.36
, Issue.2
, pp. 386-399
-
-
Blech, S.1
Ebner, T.2
Ludwig-Schwellinger, E.3
Stangier, J.4
Roth, W.5
-
27
-
-
59349098538
-
Coadministration of dabigatran etexilate and atorvastatin: Assessment of potential impact on pharmacokinetics and pharmacodynamics
-
Stangier J, Rathgen K, Stahle H, et al. Coadministration of dabigatran etexilate and atorvastatin: assessment of potential impact on pharmacokinetics and pharmacodynamics. Am J Cardiovasc Drugs 2009; 9:59-68.
-
(2009)
Am J Cardiovasc Drugs
, vol.9
, pp. 59-68
-
-
Stangier, J.1
Rathgen, K.2
Stahle, H.3
-
28
-
-
35348879239
-
Dabigatran With or Without Concomitant Aspirin Compared With Warfarin Alone in Patients With Nonvalvular Atrial Fibrillation (PETRO Study)
-
DOI 10.1016/j.amjcard.2007.06.034, PII S0002914907014610
-
Ezekowitz MD, Reilly PA, Nehmiz G, et al. Dabigatran with or without concomitant aspirin compared with warfarin alone in patients with nonvalvular atrial fibrillation (PETRO study). Am J Cardiol 2007; 100:1419-1426. (Pubitemid 47576022)
-
(2007)
American Journal of Cardiology
, vol.100
, Issue.9
, pp. 1419-1426
-
-
Ezekowitz, M.D.1
Reilly, P.A.2
Nehmiz, G.3
Simmers, T.A.4
Nagarakanti, R.5
Parcham-Azad, K.6
Pedersen, K.E.7
Lionetti, D.A.8
Stangier, J.9
Wallentin, L.10
-
29
-
-
64349107688
-
Rationale and design of RE-LY: Randomized evaluation of long-term anticoagulant therapy, warfarin, compared with dabigatran
-
10 e1-10 e2
-
Ezekowitz MD, Connolly S, Parekh A, et al. Rationale and design of RE-LY: randomized evaluation of long-term anticoagulant therapy, warfarin, compared with dabigatran. Am Heart J 2009; 157:805-810; 10 e1-10 e2.
-
(2009)
Am Heart J
, vol.157
, pp. 805-810
-
-
Ezekowitz, M.D.1
Connolly, S.2
Parekh, A.3
-
30
-
-
70349306707
-
Dabigatran versus warfarin in patients with atrial fibrillation
-
Connolly SJ, Ezekowitz MD, Yusuf S, et al. Dabigatran versus warfarin in patients with atrial fibrillation. N Engl J Med 2009; 361:1139-1151.
-
(2009)
N Engl J Med
, vol.361
, pp. 1139-1151
-
-
Connolly, S.J.1
Ezekowitz, M.D.2
Yusuf, S.3
-
31
-
-
78049490509
-
Newly identified events in the RE-LY trial
-
Connolly SJ, Ezekowitz MD, Yusuf S, et al. Newly identified events in the RE-LY trial. N Engl J Med 2010; 363:1875-1876.
-
(2010)
N Engl J Med
, vol.363
, pp. 1875-1876
-
-
Connolly, S.J.1
Ezekowitz, M.D.2
Yusuf, S.3
-
32
-
-
78349313002
-
Dabigatran compared with warfarin in patients with atrial fibrillation and previous transient ischaemic attack or stroke: A subgroup analysis of the RE-LY trial
-
Diener HC, Connolly SJ, Ezekowitz MD, et al. Dabigatran compared with warfarin in patients with atrial fibrillation and previous transient ischaemic attack or stroke: a subgroup analysis of the RE-LY trial. Lancet Neurol 2010; 9:1157-1163.
-
(2010)
Lancet Neurol
, vol.9
, pp. 1157-1163
-
-
Diener, H.C.1
Connolly, S.J.2
Ezekowitz, M.D.3
-
33
-
-
78549249603
-
Dabigatran compared to warfarin in patients with atrial fibrillation and prior TIA or stroke: Results of RE-LY [abstract]
-
26 February 2010; San Antonio TX. Abst. 195
-
Diener H, Connolly S, Ezekowitz M, et al. Dabigatran compared to warfarin in patients with atrial fibrillation and prior TIA or stroke: results of RE-LY [abstract]. American Stroke Association International Stroke Conference 2010; 26 February 2010; San Antonio, TX. Abst. 195.
-
(2010)
American Stroke Association International Stroke Conference
-
-
Diener, H.1
Connolly, S.2
Ezekowitz, M.3
-
34
-
-
79958126202
-
Risk of bleeding with 2 doses of dabigatran compared with warfarin in older and younger patients with atrial fibrillation: An analysis of the randomized evaluation of long-termanticoagulant therapy (RE-LY) trial
-
Eikelboom JW, Wallentin L, Connolly SJ, et al. Risk of bleeding with 2 doses of dabigatran compared with warfarin in older and younger patients with atrial fibrillation: an analysis of the randomized evaluation of long-termanticoagulant therapy (RE-LY) trial. Circulation 2011; 123:2363-2372.
-
(2011)
Circulation
, vol.123
, pp. 2363-2372
-
-
Eikelboom, J.W.1
Wallentin, L.2
Connolly, S.J.3
-
35
-
-
79957715797
-
Anticoagulant options: Why the FDA approved a higher but not a lower dose of dabigatran
-
Beasley BN, Unger EF, Temple R. Anticoagulant options: why the FDA approved a higher but not a lower dose of dabigatran. N Engl J Med 2011; 364:1788-1790.
-
(2011)
N Engl J Med
, vol.364
, pp. 1788-1790
-
-
Beasley, B.N.1
Unger, E.F.2
Temple, R.3
-
36
-
-
79953332012
-
Canadian Cardiovascular Society atrial fibrillation guidelines 2010: Prevention of stroke and systemic thromboembolism in atrial fibrillation and flutter
-
Cairns JA, Connolly S, McMurtry S, et al. Canadian Cardiovascular Society atrial fibrillation guidelines 2010: prevention of stroke and systemic thromboembolism in atrial fibrillation and flutter. Can J Cardiol 2011; 27:74-90.
-
(2011)
Can J Cardiol
, vol.27
, pp. 74-90
-
-
Cairns, J.A.1
Connolly, S.2
McMurtry, S.3
-
37
-
-
77957699729
-
Guidelines for the management of atrial fibrillation: The Task Force for the management of atrial fibrillation of the European Society of Cardiology (ESC)
-
Camm AJ, Kirchhof P, Lip GY, et al. Guidelines for the management of atrial fibrillation: the Task Force for the Management of Atrial Fibrillation of the European Society of Cardiology (ESC). Eur Heart J 2010; 31:2369-2429.
-
(2010)
Eur Heart J
, vol.31
, pp. 2369-2429
-
-
Camm, A.J.1
Kirchhof, P.2
Lip, G.Y.3
-
38
-
-
78751623197
-
ACCF/AHA/HRS focused update on the management of patients with atrial fibrillation (updating the 2006 guideline): A report of the American college of cardiology foundation/American heart association task force on practice guidelines
-
Wann LS, Curtis AB, January CT, et al. 2011 ACCF/AHA/HRS focused update on the management of patients with atrial fibrillation (updating the 2006 guideline): a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines. Circulation 2011; 123:104-123.
-
(2011)
Circulation
, vol.123
, pp. 104-123
-
-
Wann, L.S.1
Curtis, A.B.2
January, C.T.3
-
39
-
-
71649109346
-
Oral direct thrombin inhibitor AZD0837 for the prevention of stroke and systemic embolism in patients with nonvalvular atrial fibrillation: A randomized dose-guiding, safety, and tolerability study of four doses of AZD0837 vs. vitamin K antagonists
-
Lip GY, Rasmussen LH, Olsson SB, et al. Oral direct thrombin inhibitor AZD0837 for the prevention of stroke and systemic embolism in patients with nonvalvular atrial fibrillation: a randomized dose-guiding, safety, and tolerability study of four doses of AZD0837 vs. vitamin K antagonists. Eur Heart J 2009; 30:2897-2907.
-
(2009)
Eur Heart J
, vol.30
, pp. 2897-2907
-
-
Lip, G.Y.1
Rasmussen, L.H.2
Olsson, S.B.3
-
40
-
-
77749298350
-
Safety and tolerability of an immediate-release formulation of the oral direct thrombin inhibitor AZD0837 in the prevention of stroke and systemic embolism in patients with atrial fibrillation
-
Olsson SB, Rasmussen LH, Tveit A, et al. Safety and tolerability of an immediate-release formulation of the oral direct thrombin inhibitor AZD0837 in the prevention of stroke and systemic embolism in patients with atrial fibrillation. Thromb Haemost 2010; 103:604-612.
-
(2010)
Thromb Haemost
, vol.103
, pp. 604-612
-
-
Olsson, S.B.1
Rasmussen, L.H.2
Tveit, A.3
-
41
-
-
25844525489
-
Safety, pharmacodynamics, and pharmacokinetics of single doses of BAY 59-7939, an oral, direct factor Xa inhibitor
-
DOI 10.1016/j.clpt.2005.06.011, PII S000992360500281X
-
Kubitza D, Becka M, Voith B, et al. Safety, pharmacodynamics, and pharmacokinetics of single doses of BAY 59-7939, an oral, direct factor Xa inhibitor. Clin Pharmacol Ther 2005; 78:412-421. (Pubitemid 41393676)
-
(2005)
Clinical Pharmacology and Therapeutics
, vol.78
, Issue.4
, pp. 412-421
-
-
Kubitza, D.1
Becka, M.2
Voith, B.3
Zuehlsdorf, M.4
Wensing, G.5
-
42
-
-
66449099711
-
Metabolism and excretion of rivaroxaban, an oral, direct factor Xa inhibitor, in rats, dogs, and humans
-
Weinz C, Schwarz T, Kubitza D, et al. Metabolism and excretion of rivaroxaban, an oral, direct factor Xa inhibitor, in rats, dogs, and humans. Drug Metab Dispos 2009; 37:1056-1064.
-
(2009)
Drug Metab Dispos
, vol.37
, pp. 1056-1064
-
-
Weinz, C.1
Schwarz, T.2
Kubitza, D.3
-
43
-
-
33846448135
-
Body weight has limited influence on the safety, tolerability, pharmacokinetics, or pharmacodynamics of rivaroxaban (BAY 59-7939) in healthy subjects
-
DOI 10.1177/0091270006296058
-
Kubitza D, Becka M, Zuehlsdorf M, Mueck W. Body weight has limited influence on the safety, tolerability, pharmacokinetics, or pharmacodynamics of rivaroxaban (BAY 59-7939) in healthy subjects. J Clin Pharmacol 2007; 47:218-226. (Pubitemid 46146488)
-
(2007)
Journal of Clinical Pharmacology
, vol.47
, Issue.2
, pp. 218-226
-
-
Kubitza, D.1
Becka, M.2
Zuehlsdorf, M.3
Mueck, W.4
-
44
-
-
58949098587
-
Rivaroxaban: Clinical pharmacology
-
Mismetti P, Laporte S. Rivaroxaban: clinical pharmacology. Ann Fr Anesth Reanim 2008; 27 (3 Suppl):S16-S21.
-
(2008)
Ann Fr Anesth Reanim
, vol.27
, Issue.3 SUPPL.
-
-
Mismetti, P.1
Laporte, S.2
-
46
-
-
42949123582
-
Population pharmacokinetics and pharmacodynamics of rivaroxaban: An oral, direct factor Xa inhibitor: In patients undergoing major orthopaedic surgery
-
Mueck W, Eriksson BI, Bauer KA, et al. Population pharmacokinetics and pharmacodynamics of rivaroxaban: an oral, direct factor Xa inhibitor: in patients undergoing major orthopaedic surgery. Clin Pharmacokinet 2008; 47:203-216.
-
(2008)
Clin Pharmacokinet
, vol.47
, pp. 203-216
-
-
Mueck, W.1
Eriksson, B.I.2
Bauer, K.A.3
-
47
-
-
78649289929
-
Effects of renal impairment on the pharmacokinetics, pharmacodynamics and safety of rivaroxaban, an oral, direct factor Xa inhibitor
-
Kubitza D, Becka M, Mueck W, et al. Effects of renal impairment on the pharmacokinetics, pharmacodynamics and safety of rivaroxaban, an oral, direct factor Xa inhibitor. Br J Clin Pharmacol 2010; 70:703-712.
-
(2010)
Br J Clin Pharmacol
, vol.70
, pp. 703-712
-
-
Kubitza, D.1
Becka, M.2
Mueck, W.3
-
48
-
-
80052592404
-
Rivaroxaban versus warfarin in nonvalvular atrial fibrillation
-
Patel MR, Mahaffey KW, Garg J, et al. Rivaroxaban versus warfarin in nonvalvular atrial fibrillation. N Engl J Med 2011; 365:883-891.
-
(2011)
N Engl J Med
, vol.365
, pp. 883-891
-
-
Patel, M.R.1
Mahaffey, K.W.2
Garg, J.3
-
49
-
-
80052825103
-
Apixaban versus warfarin in patients with atrial fibrillation
-
Granger CB, Alexander JH, McMurray JJ, et al. Apixaban versus warfarin in patients with atrial fibrillation. N Engl J Med 2011; 365:981-992.
-
(2011)
N Engl J Med
, vol.365
, pp. 981-992
-
-
Granger, C.B.1
Alexander, J.H.2
McMurray, J.J.3
-
50
-
-
80054071757
-
Prevention of stroke and systemic embolism with rivaroxaban compared with warfarin in patients with nonvalvular atrial fibrillation and moderate renal impairment
-
Fox KA, Piccini JP, Wojdyla D, et al. Prevention of stroke and systemic embolism with rivaroxaban compared with warfarin in patients with nonvalvular atrial fibrillation and moderate renal impairment. Eur Heart J 2011; 32:2387-2394.
-
(2011)
Eur Heart J
, vol.32
, pp. 2387-2394
-
-
Fox, K.A.1
Piccini, J.P.2
Wojdyla, D.3
-
51
-
-
58149458160
-
Apixaban metabolism and pharmacokinetics after oral administration to humans
-
Raghavan N, Frost CE, Yu Z, et al. Apixaban metabolism and pharmacokinetics after oral administration to humans. Drug Metab Dispos 2009; 37:74-81.
-
(2009)
Drug Metab Dispos
, vol.37
, pp. 74-81
-
-
Raghavan, N.1
Frost, C.E.2
Yu, Z.3
-
52
-
-
50249129715
-
Apixaban, an oral, direct inhibitor of activated factor Xa
-
Shantsila E, Lip GY. Apixaban, an oral, direct inhibitor of activated factor Xa. Curr Opin Investig Drugs 2008; 9:1020-1033.
-
(2008)
Curr Opin Investig Drugs
, vol.9
, pp. 1020-1033
-
-
Shantsila, E.1
Lip, G.Y.2
-
53
-
-
76749166335
-
In vitro assessment of metabolic drug-drug interaction potential of apixaban through cytochrome P450 phenotyping, inhibition, and induction studies
-
Wang L, Zhang D, Raghavan N, et al. In vitro assessment of metabolic drug-drug interaction potential of apixaban through cytochrome P450 phenotyping, inhibition, and induction studies. Drug Metab Dispos 2010; 38:448-458.
-
(2010)
Drug Metab Dispos
, vol.38
, pp. 448-458
-
-
Wang, L.1
Zhang, D.2
Raghavan, N.3
-
54
-
-
77649249878
-
Apixaban for reduction in stroke and other thromboembolic events in atrial fibrillation (ARISTOTLE) trial: Design and rationale
-
Lopes RD, Alexander JH, Al-Khatib SM, et al. Apixaban for reduction in stroke and other thromboembolic events in atrial fibrillation (ARISTOTLE) trial: design and rationale. Am Heart J 2010; 159:331-339.
-
(2010)
Am Heart J
, vol.159
, pp. 331-339
-
-
Lopes, R.D.1
Alexander, J.H.2
Al-Khatib, S.M.3
-
55
-
-
79952301326
-
Apixaban in patients with atrial fibrillation
-
Connolly SJ, Eikelboom J, Joyner C, et al. Apixaban in patients with atrial fibrillation. N Engl J Med 2011; 364:806-817.
-
(2011)
N Engl J Med
, vol.364
, pp. 806-817
-
-
Connolly, S.J.1
Eikelboom, J.2
Joyner, C.3
-
56
-
-
34548314559
-
Drug evaluation: DU-176b, an oral, direct Factor Xa antagonist
-
Hylek E. DU-176b, an oral, direct factor Xa antagonist. Curr Opin Investig Drugs 2007; 8:778-783. (Pubitemid 47345534)
-
(2007)
Current Opinion in Investigational Drugs
, vol.8
, Issue.9
, pp. 778-783
-
-
Hylek, E.1
-
57
-
-
35048854973
-
Antithrombotic effects of factor Xa inhibition with DU-176b: Phase-I study of an oral, direct factor Xa inhibitor using an ex-vivo flow chamber
-
DOI 10.1160/TH07-04-0312
-
Zafar MU, Vorchheimer DA,Gaztanaga J, et al. Antithrombotic effects of factor Xa inhibition with DU-176b: phase-I study of an oral, direct factor Xa inhibitor using an ex-vivo flow chamber. Thromb Haemost 2007; 98:883-888. (Pubitemid 47555083)
-
(2007)
Thrombosis and Haemostasis
, vol.98
, Issue.4
, pp. 883-888
-
-
Zafar, M.U.1
Vorchheimer, D.A.2
Gaztanaga, J.3
Velez, M.4
Yadegar, D.5
Moreno, P.R.6
Kunitada, S.7
Pagan, J.8
Fuster, V.9
Badimon, J.J.10
-
58
-
-
77954361232
-
Randomised, parallel-group, multicentre, multinational phase 2 study comparing edoxaban, an oral factor Xa inhibitor, with warfarin for stroke prevention in patients with atrial fibrillation
-
Weitz JI, Connolly SJ, Patel I, et al. Randomised, parallel-group, multicentre, multinational phase 2 study comparing edoxaban, an oral factor Xa inhibitor, with warfarin for stroke prevention in patients with atrial fibrillation. Thromb Haemost 2010; 104:633-641.
-
(2010)
Thromb Haemost
, vol.104
, pp. 633-641
-
-
Weitz, J.I.1
Connolly, S.J.2
Patel, I.3
-
59
-
-
77957932391
-
Evaluation of the novel factor Xa inhibitor edoxaban compared with warfarin in patients with atrial fibrillation: Design and rationale for the effective anticoagulation with factor Xa next generation in atrial fibrillation-thrombolysis in myocardial infarction study 48 (ENGAGE AF-TIMI 48)
-
Ruff CT, Giugliano RP, Antman EM, et al. Evaluation of the novel factor Xa inhibitor edoxaban compared with warfarin in patients with atrial fibrillation: design and rationale for the effective anticoagulation with factor Xa next generation in atrial fibrillation-thrombolysis in myocardial infarction study 48 (ENGAGE AF-TIMI 48). Am Heart J 2010; 160:635-641.
-
(2010)
Am Heart J
, vol.160
, pp. 635-641
-
-
Ruff, C.T.1
Giugliano, R.P.2
Antman, E.M.3
|