Identification of novel, potent and selective inhibitors of Polo-like kinase 1

Bioorganic and Medicinal Chemistry Letters

Volumn 22, Issue 2, 2012, Pages 1247-1250

  Chen, Shaoqing ^a   Bartkovitz, David ^a   Cai, Jianping ^a   Chen, Yi ^a   Chen, Zhi ^a   Chu, Xin Jie ^a   Le, Kang ^a   Le, Nam T ^a   Luk, Kin Chun ^a   Mischke, Steve ^a   Naderi Oboodi, Goli ^a   Boylan, John F ^a,b   Nevins, Tom ^a   Qing, Weiguo ^a,c   Chen, Yingsi ^a   Wovkulich, Peter M ^a  

^a HOFFMANN LA ROCHE INC   (United States)

^b CELGENE CORPORATION   (United States)

^c Zhangjiang Hi Tech Park   (China)

Author keywords

Antitumor agent; Kinase inhibitor; Polo like kinase 1 (PLK1); Pyrimidodiazepines

Indexed keywords

ANTINEOPLASTIC AGENT; POLO LIKE KINASE 1; PROTEIN SERINE THREONINE KINASE INHIBITOR; PYRIMIDODIAZEPINONE DERIVATIVE; RO 3280; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; CANCER INHIBITION; NONHUMAN; STRUCTURE ACTIVITY RELATION; TUMOR REGRESSION; XENOGRAFT;

ANIMALS; ANTINEOPLASTIC AGENTS; AZEPINES; CELL CYCLE PROTEINS; CELL LINE, TUMOR; CELL PROLIFERATION; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; MICE; MOLECULAR STRUCTURE; NEOPLASMS, EXPERIMENTAL; PROTEIN KINASE INHIBITORS; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; PYRIMIDINES; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84855699388     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2011.11.052     Document Type: Article

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