Diagnostic features of mild cellulitis phlegmon in patients with rheumatoid arthritis treated with tocilizumab: A report of two cases

Modern Rheumatology

Volumn 21, Issue 6, 2011, Pages 673-677

  Hirao, Makoto ^a   Nampei, Akihide ^a   Shi, Kenrin ^a   Yoshikawa, Hideki ^a   Nishimoto, Norihiro ^b   Hashimoto, Jun ^a  

^a OSAKA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b WAKAYAMA MEDICAL UNIVERSITY   (Japan)

Author keywords

Cellulitis phlegmon; CRP; Neutrophil; Tocilizumab; WBC

Indexed keywords

C REACTIVE PROTEIN; METHOTREXATE; PREDNISOLONE; TACROLIMUS; TOCILIZUMAB;

ADULT; ARTICLE; CASE REPORT; CELLULITIS; CHRONIC DRUG ADMINISTRATION; COMBINATION CHEMOTHERAPY; DOG BITE; DRUG WITHDRAWAL; FEMALE; HUMAN; LEUKOCYTE COUNT; PHLEGMON; PRIORITY JOURNAL; RASH; RHEUMATOID ARTHRITIS; SOFT TISSUE INFECTION; TREATMENT DURATION; TREATMENT OUTCOME;

ANTIBODIES, MONOCLONAL, HUMANIZED; ANTIRHEUMATIC AGENTS; ARTHRITIS, RHEUMATOID; C-REACTIVE PROTEIN; CELLULITIS; FEMALE; HUMANS; MIDDLE AGED;

EID: 84855658567     PISSN: 14397595     EISSN: 14397609     Source Type: Journal    
DOI: 10.1007/s10165-011-0459-y     Document Type: Article

References (17)

1. Ellerin T, Rubin RH, Weinblatt ME. Infections and anti-tumor necrosis factor alpha therapy. Arthritis Rheum. 2003;48:3013-22. (Pubitemid 37409310)
2. Strangfeld A, Listing J. Infection and musculoskeletal conditions: Bacterial and opportunistic infections during anti-TNF therapy. Best Pract Res Clin Rheumatol. 2006;20:1181-95. (Pubitemid 44774817)
3. Arnett EC, Edworthy SM, Bloch DA, McShane DJ, Fries JF, Cooper NS, et al. The American Rheumatology Association 1987 revised criteria for the classification of rheumatoid arthritis. Arthritis Rheum. 1988;31:315-24. (Pubitemid 18091653)
4. Ohzato H, Yoshizaki K, Nishimoto N, Ogata A, Tagoh H, Monden M, et al. Interleukin-6 as a new indicator of inflammatory status: Detection of serum levels of interleukin-6 and C-reactive protein after surgery. Surgery. 1992;111:201-9.
5. Mackiewicz A, Speroff T, Ganapathi MK, Kushner I. Effects of cytokine combinations on acute phase protein production in two human hepatoma cell lines. J Immunol. 1991;146:3032-7.
6. Nishimoto N, Terao K, Mima T, Nakahara H, Takagi N, Kakehi T. Mechanisms and pathologic significances in increase in serum interleukin-6 (IL-6) and soluble IL-6 receptor after administration of an anti-IL-6 receptor antibody, tocilizumab, in patients with rheumatoid arthritis and Castleman disease. Blood. 2008;112: 3959-64.
7. Hirao M, Hashimoto J, Tsuboi H, Nampei A, Nakahara H, Yoshio N, et al. Laboratory and febrile features after joint surgery in patients with tocilizumab. Ann Rheum Dis. 2009;68:654-7.
8. Niimi M, Wada Y, Sato M, Takahara J, Kawanishi K. Effect of continuous intravenous injection of interleukin-6 and pretreatment with cyclooxygenase inhibitor on brain c-fos expression in the rat. Neuroendocrinology. 1997;66:47-53. (Pubitemid 27271991)
9. Wang JP, Dunn AJ. Mouse interleukin-6 stimulates the HPA axis and increases brain tryptophan and serotonin metabolism. Neurochem Int. 1998;33:143-54. (Pubitemid 28410138)
10. Besedovsky HO, Del Ray A, Futukawa H, Arditi GM, Kabiersch A. Cytokines as modulators of the hypothalamus-pituitary- adrenal axis. J Steroid Biochem Mol Biol. 1991;40:613-8.
11. Van der Meer MJM, Sweep CGJ, Rijnkels CEM, Pesman GJ, Tilders FJH, Kloppenborg PWC, Hermus ARMM. Acute stimulation of the hypothalamic-pituitary- adrenal axis by IL-1b, TNFa and IL-6: A dose response study. J Endocrinol Invest. 1996;19:175-82. (Pubitemid 26162611)
12. Nouri AME, Panayi GS, Goodman SM. Cytokines and the chronic inflammation of rheumatic disease: I. The presence of interleukin-1 in synovial fluids. Clin Exp Immunol. 1984;55:295.
13. Di Giovine FS, Nuki G, Duff GW. Tumour necrosis factor in synovial exudates. Ann Rheum Dis. 1988;47:768-72.
14. Newcombe DS, Fahey JV, Ishikawa Y. Hydrocortisone inhibition of the bradykinin activation of human synovial fibroblasts. Prostaglandins. 1977;13:235.
15. Oguogho A, Alomaka CP, Ereigbre AB. Depressed endotheliumdependent relaxation responses to acetylcholine and histamine in isolated human epigastric arteries from pre-eclamptic women. Clin Auton Res. 1996;6:153-5.
16. Suzuki Y, Yamamoto T, Suzumori K, Kajikuri J, Itoh T. Modified histamine-induced NO-mediated relaxation in resistance arteries in pre-eclampsia. Eur J Pharmacol. 2000;410:7-13. (Pubitemid 32008125)
17. Cockell AP, Poston L. Flow-mediated vasodilatation is enhanced in normal pregnancy but reduced in preeclampsia. Hypertension. 1997;30:247-51. (Pubitemid 27329005)