Thromboembolic safety and efficacy of prothrombin complex concentrates in the emergency reversal of warfarin coagulopathy

Thrombosis Research

Volumn 129, Issue 2, 2012, Pages 146-151

  Majeed, Ammar ^a,b   Eelde, Anna ^a   Ågren, Anna ^a   Schulman, Sam ^a,c   Holmström, Margareta ^a  

^a KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^b Malar Hospital   (Sweden)

^c MCMASTER UNIVERSITY   (Canada)

Author keywords

Bleeding; Oral anticoagulant reversal; Prothrombin complex concentrates; Thromboembolism

Indexed keywords

BLOOD CLOTTING FACTOR 9 CONCENTRATE; PROTHROMBIN COMPLEX; VITAMIN K GROUP; WARFARIN;

ADULT; AGED; ARTICLE; BLEEDING; BLOOD CLOTTING; BLOOD CLOTTING DISORDER; DEEP VEIN THROMBOSIS; DRUG EFFICACY; DRUG SAFETY; EMERGENCY SURGERY; FEMALE; HEART INFARCTION; HUMAN; INTERNATIONAL NORMALIZED RATIO; LUNG EMBOLISM; MAJOR CLINICAL STUDY; MALE; PERIOPERATIVE PERIOD; PRIORITY JOURNAL; PROSPECTIVE STUDY; RISK ASSESSMENT; SPLEEN INFARCTION; STROKE; THROMBOEMBOLISM;

AGED; AGED, 80 AND OVER; ANTICOAGULANTS; COAGULANTS; COMORBIDITY; DRUG INTERACTIONS; EMERGENCY MEDICAL SERVICES; FEMALE; HEMORRHAGE; HUMANS; MALE; PREVALENCE; PROTHROMBIN; RISK ASSESSMENT; RISK FACTORS; SWEDEN; THROMBOEMBOLISM; TREATMENT OUTCOME; WARFARIN;

EID: 84855651166     PISSN: 00493848     EISSN: 18792472     Source Type: Journal    
DOI: 10.1016/j.thromres.2011.07.024     Document Type: Article

References (24)

1. S. Schulman, R.J. Beyth, C. Kearon, and M.N. Levine Hemorrhagic complications of anticoagulant and thrombolytic treatment: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th Edition) Chest 133 2008 257S 298S (Pubitemid 351892969)
2. T.G. Phan, M. Koh, and E.F. Wijdicks Safety of discontinuation of anticoagulation in patients with intracranial hemorrhage at high thromboembolic risk Arch Neurol 57 2000 1710 1713
3. M. Yasaka, K. Minematsu, H. Naritomi, T. Sakata, and T. Yamaguchi Predisposing factors for enlargement of intracerebral hemorrhage in patients treated with warfarin Thromb Haemost 89 2003 278 283 (Pubitemid 36227279)
4. H.B. Huttner, P.D. Schellinger, M. Hartmann, M. Kohrmann, E. Juettler, and J. Wikner Hematoma growth and outcome in treated neurocritical care patients with intracerebral hemorrhage related to oral anticoagulant therapy: comparison of acute treatment strategies using vitamin K, fresh frozen plasma, and prothrombin complex concentrates Stroke 37 2006 1465 1470 (Pubitemid 44305727)
5. J.J. Flibotte, N. Hagan, J. ODonnell, S.M. Greenberg, and J. Rosand Warfarin, hematoma expansion, and outcome of intracerebral hemorrhage Neurology 63 2004 1059 1064 (Pubitemid 39287915)
6. M. Makris, M. Greaves, W.S. Phillips, S. Kitchen, F.R. Rosendaal, and E.F. Preston Emergency oral anticoagulant reversal: the relative efficacy of infusions of fresh frozen plasma and clotting factor concentrate on correction of the coagulopathy Thromb Haemost 77 1997 477 480 (Pubitemid 27121012)
7. S.B. Lee, E.M. Manno, K.F. Layton, and E.F. Wijdicks Progression of warfarin-associated intracerebral hemorrhage after INR normalization with FFP Neurology 67 2006 1272 1274 (Pubitemid 44566354)
8. J. Bux Transfusion-related acute lung injury (TRALI): a serious adverse event of blood transfusion Vox Sang 89 2005 1 10 (Pubitemid 40839544)
9. J.M. Lusher Thrombogenicity associated with factor IX complex concentrates Semin Hematol 28 1991 3 5
10. Rosovsky RP, Crowther MA. What is the evidence for the off-label use of recombinant factor VIIa (rFVIIa) in the acute reversal of warfarin? ASH evidence-based review 2008. Hematology / the Education Program of the American Society of Hematology. American Society of Hematology. Education Program. 2008:36-8.
11. M. Levi, J.H. Levy, H.F. Andersen, and D. Truloff Safety of recombinant activated factor VII in randomized clinical trials N Engl J Med 363 2010 1791 1800
12. S. Schulman Clinical practice. Care of patients receiving long-term anticoagulant therapy N Engl J Med 349 2003 675 683 (Pubitemid 36980605)
13. A. Majeed, Y.K. Kim, R.S. Roberts, M. Holmstrom, and S. Schulman Optimal timing of resumption of warfarin after intracranial hemorrhage Stroke 41 2010 2860 2866
14. J.H. Crawford, and B.M. Augustson Prothrombinex use for the reversal of warfarin: is fresh frozen plasma needed? Med J Aust 184 2006 365 366
15. I. DA Use and efficacy of prothrombin complex concentrate in the west of Scotland 2007-2008 bjh 145 suppl. S1 2009 1 88
16. T. Franken, W. Rees, N. Hubner, J. Albers, B. Gansera, and M. Uhl Octaplex in routine clinical use for prophylaxis and therapy of bleeding in patients with prothrombin complex factor deficiency Crit Care 11 2007 376
17. B. Vigue, C. Ract, B. Tremey, N. Engrand, P.E. Leblanc, and A. Decaux Ultra-rapid management of oral anticoagulant therapy-related surgical intracranial hemorrhage Intensive Care Med 33 2007 721 725 (Pubitemid 46474890)
18. L. van Aart, H.W. Eijkhout, J.S. Kamphuis, M. Dam, M.E. Schattenkerk, and T.J. Schouten Individualized dosing regimen for prothrombin complex concentrate more effective than standard treatment in the reversal of oral anticoagulant therapy: an open, prospective randomized controlled trial Thromb Res 118 2006 313 320 (Pubitemid 44173049)
19. A.S. Dunn, and A.G. Turpie Perioperative management of patients receiving oral anticoagulants: a systematic review Arch Intern Med 163 2003 901 908 (Pubitemid 36522737)
20. A.C. Spyropoulos, and A.G. Turpie Perioperative bridging interruption with heparin for the patient receiving long-term anticoagulation Curr Opin Pulm Med 11 2005 373 379 (Pubitemid 41291078)
21. I. Pabinger, B. Brenner, U. Kalina, S. Knaub, A. Nagy, and H. Ostermann Prothrombin complex concentrate (Beriplex P/N) for emergency anticoagulation reversal: a prospective multinational clinical trial J Thromb Haemost 6 2008 622 631 (Pubitemid 351404929)
22. M.W. Lankiewicz, J. Hays, K.D. Friedman, G. Tinkoff, and P.M. Blatt Urgent reversal of warfarin with prothrombin complex concentrate J Thromb Haemost 4 2006 967 970
23. J. Hill, and T. Treasure Reducing the risk of venous thromboembolism (deep vein thrombosis and pulmonary embolism) in patients admitted to hospital: summary of the NICE guideline Heart 96 2010 879 882
24. P.J. Devereaux, H. Yang, S. Yusuf, G. Guyatt, K. Leslie, and J.C. Villar Effects of extended-release metoprolol succinate in patients undergoing non-cardiac surgery (POISE trial): a randomised controlled trial Lancet 371 2008 1839 1847