메뉴 건너뛰기




Volumn 32, Issue 3, 2011, Pages 173-180

Dabigatran in atrial fibrillation: Pharmacology and clinical trials

Author keywords

Anticoagulation; Atrial fibrillation; Dabigatran; Randomized clinical trials

Indexed keywords

ACETYLSALICYLIC ACID; CREATININE; DABIGATRAN; DIGOXIN; RIFAMPICIN; WARFARIN;

EID: 84855611604     PISSN: 1383875X     EISSN: 15728595     Source Type: Journal    
DOI: 10.1007/s10840-011-9593-x     Document Type: Conference Paper
Times cited : (9)

References (40)
  • 1
    • 33747052359 scopus 로고    scopus 로고
    • Secular trends in incidence of atrial fibrillation in Olmsted County, Minnesota, 1980 to 2000, and implications on the projections for future prevalence
    • DOI 10.1161/CIRCULATIONAHA.105.595140, PII 0000301720060711000007
    • Miyasaka, Y., Barnes, M. E., Gersh, B. J., Cha, S. S., Bailey, K. R., Abhayaratna, W. P., et al. (2006). Secular trends in incidence of atrial fibrillation in Olmsted County, Minnesota, 1980 to 2000, and implications on the projections for future prevalence. Circulation, 114, 119-125. (Pubitemid 44420743)
    • (2006) Circulation , vol.114 , Issue.2 , pp. 119-125
    • Miyasaka, Y.1    Barnes, M.E.2    Gersh, B.J.3    Cha, S.S.4    Bailey, K.R.5    Abhayaratna, W.P.6    Seward, J.B.7    Tsang, T.S.M.8
  • 2
    • 0033593072 scopus 로고    scopus 로고
    • Warfarin use among ambulatory patients with nonvalvular atrial fibrillation: The anticoagulation and risk factors in atrial fibrillation (ATRIA) study
    • Go, A. S., Hylek, E. M., Borowsky, L. H., Phillips, K. A., Selby, J. V., & Singer, D. E. (1999). Warfarin use among ambulatory patients with nonvalvular atrial fibrillation: the anticoagulation and risk factors in atrial fibrillation (ATRIA) study. Annals of Internal Medicine, 131, 927-934. (Pubitemid 30005032)
    • (1999) Annals of Internal Medicine , vol.131 , Issue.12 , pp. 927-934
    • Go, A.S.1    Hylek, E.M.2    Borowsky, L.H.3    Phillips, K.A.4    Selby, J.V.5    Singer, D.E.6
  • 3
    • 33644770242 scopus 로고    scopus 로고
    • Patterns of use of antithrombotic therapy and quality of anticoagulation among patients with non-valvular atrial fibrillation in clinical practice
    • DOI 10.1111/j.1368-5031.2006.00790.x
    • Boulanger, L., Kim, J., Friedman, M., Hauch, O., Foster, T., & Menjin, J. (2006). Patterns of use of antithrombotic therapy and quality of anticoagulation among patients with non-valvular atrial fibrillation in clinical practice. International Journal of Clinical Practice, 60(3), 258-264. (Pubitemid 43337604)
    • (2006) International Journal of Clinical Practice , vol.60 , Issue.3 , pp. 258-264
    • Boulanger, L.1    Kim, J.2    Friedman, M.3    Hauch, O.4    Foster, T.5    Menzin, J.6
  • 4
    • 9544248668 scopus 로고    scopus 로고
    • Adjusted-dose warfarin versus low-intensity, fixed-dose warfarin plus aspirin for high-risk patients with atrial fibrillation: Stroke prevention in atrial fibrillation III randomised clinical trial
    • Stroke Prevention in Atrial Fibrillation Investigators
    • Stroke Prevention in Atrial Fibrillation Investigators. (1996). Adjusted-dose warfarin versus low-intensity, fixed-dose warfarin plus aspirin for high-risk patients with atrial fibrillation: Stroke Prevention in Atrial Fibrillation III randomised clinical trial. Lancet, 348, 633-638.
    • (1996) Lancet , vol.348 , pp. 633-638
  • 5
    • 0024543543 scopus 로고
    • Placebo-controlled, randomised trial of warfarin and aspirin for prevention of thromboembolic complications in chronic atrial fibrillation. The Copenhagen AFASAK study
    • Petersen, P., Boysen, G., Godtfredsen, J., Anderson, E. D., & Anderson, B. (1989). Placebo-controlled, randomised trial of warfarin and ASA for prevention of thromboembolic complications in chronic atrial fibrillation: the Copenhagen AFASAK study. Lancet, 1(8631), 175-179. (Pubitemid 19038801)
    • (1989) Lancet , vol.1 , Issue.8631 , pp. 175-179
    • Petersen, P.1    Godtfredsen, J.2    Andersen, B.3    Boysen, G.4    Andersen, E.D.5
  • 6
    • 0025241137 scopus 로고
    • The effect of low-dose warfarin on the risk of stroke in nonrheumatic atrial fibrillation
    • Boston Area Anticoagulation Trial for Atrial Fibrillation Investigators
    • Boston Area Anticoagulation Trial for Atrial Fibrillation Investigators. (1990). The effect of low-dose warfarin on the risk of stroke in nonrheumatic atrial fibrillation. The New England Journal of Medicine, 323(22), 1505-1511.
    • (1990) The New England Journal of Medicine , vol.323 , Issue.22 , pp. 1505-1511
  • 7
    • 0025914693 scopus 로고
    • Stroke prevention in atrial fibrillation study. Final results
    • Stroke Prevention in Atrial Fibrillation Investigators
    • Stroke Prevention in Atrial Fibrillation Investigators. (1991). Stroke prevention in atrial fibrillation study. Final results. Circulation, 84(2), 527-539.
    • (1991) Circulation , vol.84 , Issue.2 , pp. 527-539
  • 8
    • 0026478818 scopus 로고
    • Warfarin in the prevention of stroke associated with nonrheumatic atrial fibrillation: Veterans affairs stroke prevention in nonrheumatic atrial fibrillation investigators
    • Ezekowitz, M. D., Bridgers, S. L., James, K. E., Carliner, N. H., Colling, C. L., & Gornick, C. C. (1992). Warfarin in the prevention of stroke associated with nonrheumatic atrial fibrillation: Veterans Affairs Stroke Prevention in Nonrheumatic Atrial Fibrillation Investigators. The New England Journal of Medicine, 327(14), 1406-1412.
    • (1992) The New England Journal of Medicine , vol.327 , Issue.14 , pp. 1406-1412
    • Ezekowitz, M.D.1    Bridgers, S.L.2    James, K.E.3    Carliner, N.H.4    Colling, C.L.5    Gornick, C.C.6
  • 10
    • 34547693119 scopus 로고    scopus 로고
    • Warfarin versus aspirin for stroke prevention in an elderly community population with atrial fibrillation (the Birmingham Atrial Fibrillation Treatment of the Aged Study, BAFTA): A randomised controlled trial
    • DOI 10.1016/S0140-6736(07)61233-1, PII S0140673607612331
    • Mant, J., Hobbs, F. D., Fletcher, K., Roalfe, A., Fitzmaurice, D., Lip, G. Y., et al. (2007). Warfarin versus aspirin for stroke prevention in an elderly community population with atrial fibrillation (the Birmingham atrial fibrillation treatment of the aged study, BAFTA) : a randomised controlled trial. Lancet, 370, 493-503. (Pubitemid 47212371)
    • (2007) Lancet , vol.370 , Issue.9586 , pp. 493-503
    • Mant, J.1    Hobbs, F.R.2    Fletcher, K.3    Roalfe, A.4    Fitzmaurice, D.5    Lip, G.Y.6    Murray, E.7
  • 11
    • 33744945247 scopus 로고    scopus 로고
    • Clopidogrel plus aspirin versus oral anticoagulation for atrial fibrillation in the Atrial fibrillation clopidogrel trial with irbesartan for prevention of vascular events (ACTIVE W) : A randomised controlled trial
    • Connolly, S., Pogue, J., Hart, R., Pfeffer, M., Hohnloser, S., Chrolavicius, S., et al. (2006). Clopidogrel plus aspirin versus oral anticoagulation for atrial fibrillation in the Atrial fibrillation Clopidogrel Trial with Irbesartan for prevention of Vascular Events (ACTIVE W) : a randomised controlled trial. Lancet, 367, 1903-1912.
    • (2006) Lancet , vol.367 , pp. 1903-1912
    • Connolly, S.1    Pogue, J.2    Hart, R.3    Pfeffer, M.4    Hohnloser, S.5    Chrolavicius, S.6
  • 12
    • 0038693328 scopus 로고    scopus 로고
    • Factors influencing physicians' reported use of anticoagulation therapy in nonvalvular atrial fibrillation: A cross-sectional survey
    • DOI 10.1016/S0149-2918(03)80167-4
    • Gross, C. P., Vogel, E. W., Dhond, A. J., Marple, C. B., Edwards, R. A., Hauch, O., et al. (2003). Factors influencing physicians' reported use of anticoagulation therapy in non-valvular atrial fibrillation: a cross-sectional survey. Clinical Therapeutics, 25(6), 1750-1764. (Pubitemid 36801946)
    • (2003) Clinical Therapeutics , vol.25 , Issue.6 , pp. 1750-1764
    • Gross, C.P.1    Vogel, E.W.2    Dhond, A.J.3    Marple, C.B.4    Edwards, R.A.5    Hauch, O.6    Demers, E.A.7    Ezekowitz, M.8
  • 13
    • 0030763778 scopus 로고    scopus 로고
    • Physician attitudes concerning warfarin for stroke prevention in atrial fibrillation: Results of a survey of long-term care practitioners
    • Monette, J., Gurwitz, J. H., Rochon, P. A., & Avorn, J. (1997). Physician attitudes concerning warfarin for stroke prevention in atrial fibrillation: results of a survey of long-term care practitioners. Journal of the American Geriatrics Society, 45, 1060-1065. (Pubitemid 27377551)
    • (1997) Journal of the American Geriatrics Society , vol.45 , Issue.9 , pp. 1060-1065
    • Monette, J.1    Gurwitz, J.H.2    Rochon, P.A.3    Avorn, J.4
  • 16
    • 41949116970 scopus 로고    scopus 로고
    • Clinical pharmacokinetics and pharmacodynamics of the oral direct thrombin inhibitor dabigatran etexilate
    • DOI 10.2165/00003088-200847050-00001
    • Stangier, J. (2008). Clinical pharmacokinetics and pharmacodynamics of the oral direct thrombin inhibitor dabigatran etexilate. Clinical Pharmacokinetics, 47(5), 285-295. (Pubitemid 351508116)
    • (2008) Clinical Pharmacokinetics , vol.47 , Issue.5 , pp. 285-295
    • Stangier, J.1
  • 18
    • 77952792359 scopus 로고    scopus 로고
    • Long-term open label extension of the prevention of embolic and thrombotic events on dabigatran in atrial fibrillation (PETRO-Ex study)
    • Abstract no. 4629
    • Nagarakanti, R., Ezekowitz, M. D., Parcham-Azad, K., Reilly, P. A., Nehmiz, G., Lionetti, D. A., et al. (2008). Long-term open label extension of the prevention of embolic and thrombotic events on dabigatran in atrial fibrillation (PETRO-Ex study). Circulation, 118, S 922. Abstract no. 4629.
    • (2008) Circulation , vol.118 , pp. 922
    • Nagarakanti, R.1    Ezekowitz, M.D.2    Parcham-Azad, K.3    Reilly, P.A.4    Nehmiz, G.5    Lionetti, D.A.6
  • 19
    • 78049490509 scopus 로고    scopus 로고
    • Newly identified events in the RE-LY trial
    • Randomized Evaluation of Long-Term Anticoagulation Therapy Investigators
    • Connolly, S. J., Ezekowitz, M. D., Yusuf, S., Reilly P. A., Wallentin, L., Randomized Evaluation of Long-Term Anticoagulation Therapy Investigators. (2010). Newly identified events in the RE-LY trial. The New England Journal of Medicine, 363(19), 1875-1876.
    • (2010) The New England Journal of Medicine , vol.363 , Issue.19 , pp. 1875-1876
    • Connolly, S.J.1    Ezekowitz, M.D.2    Yusuf, S.3    Reilly, P.A.4    Wallentin, L.5
  • 20
    • 55749115770 scopus 로고    scopus 로고
    • Disparate stroke rates on warfarin among contemporaneous cohorts with atrial fibrillation: Potential insights into risk from a comparative analysis of SPORTIF III versus SPORTIF V
    • Hylek, E. M., Frison, L., Henault, L. E., & Cupples, A. (2008). Disparate stroke rates on warfarin among contemporaneous cohorts with atrial fibrillation: potential insights into risk from a comparative analysis of SPORTIF III versus SPORTIF V. Stroke, 39, 3009-3014.
    • (2008) Stroke , vol.39 , pp. 3009-3014
    • Hylek, E.M.1    Frison, L.2    Henault, L.E.3    Cupples, A.4
  • 21
    • 34249715284 scopus 로고    scopus 로고
    • Major hemorrhage and tolerability of warfarin in the first year of therapy among elderly patients with atrial fibrillation
    • DOI 10.1161/CIRCULATIONAHA.106.653048, PII 0000301720070529000005
    • Hylek, E. M., Evans-Molina, C, Shea, C, Henault, L. E., & Regan, S. (2007). Major hemorrhage and tolerability of warfarin in the first year of therapy among elderly patients with atrial fibrillation. Circulation, 115, 2689-2696. (Pubitemid 46842784)
    • (2007) Circulation , vol.115 , Issue.21 , pp. 2689-2696
    • Hylek, E.M.1    Evans-Molina, C.2    Shea, C.3    Henault, L.E.4    Regan, S.5
  • 22
    • 64349107688 scopus 로고    scopus 로고
    • Rationale and design of RE-LY: Randomized evaluation of long-term anticoagulant therapy, warfarin, compared with dabigatran
    • Ezekowitz, M. D., Connolly, S., Parekh, A., Reilly, P. A., Varrone, J., Wang, S., et al. (2009). Rationale and design of RE-LY: randomized evaluation of long-term anticoagulant therapy, warfarin, compared with dabigatran. American Heart Journal, 157(5), 805-810.e1-2
    • (2009) American Heart Journal , vol.157 , Issue.5
    • Ezekowitz, M.D.1    Connolly, S.2    Parekh, A.3    Reilly, P.A.4    Varrone, J.5    Wang, S.6
  • 23
    • 15844410955 scopus 로고    scopus 로고
    • Evaluation of the pattern of treatment, level of anticoagulation control, and outcome of treatment with warfarin in patients with non-valvar atrial fibrillation: A record linkage study in a large British population
    • DOI 10.1136/hrt.2004.042465
    • Jones, M., McEwan, P., Morgan, C. L., Peters, J. R., Goodfellow, J., & Currie, C. J. (2005). Evaluation of the pattern of treatment, level of anticoagulation control, and outcome of treatment with warfarin in patients with non-valvar atrial fibrillation: a record linkage study in a large British population. Heart, 91, 472-477. (Pubitemid 40432773)
    • (2005) Heart , vol.91 , Issue.4 , pp. 472-477
    • Jones, M.1    McEwan, P.2    Morgan, C.Ll.3    Peters, J.R.4    Goodfellow, J.5    Currie, C.J.6
  • 24
    • 0042387879 scopus 로고    scopus 로고
    • Effect of intensity of oral anticoagulation on stroke severity and mortality in atrial fibrillation
    • DOI 10.1056/NEJMoa022913
    • Hylek, E. M., Go, A. S., Chang, Y., Jensvold, N. G., Henault, L. E., Selby, J. V., et al. (2003). Effect of intensity of oral anticoagulation on stroke severity and mortality in atrial fibrillation. The New England Journal of Medicine, 349, 1019-1026. (Pubitemid 37087616)
    • (2003) New England Journal of Medicine , vol.349 , Issue.11 , pp. 1019-1026
    • Hylek, E.M.1    Go, A.S.2    Chang, Y.3    Jensvold, N.G.4    Henault, L.E.5    Selby, J.V.6    Singer, D.E.7
  • 25
    • 34249863576 scopus 로고    scopus 로고
    • Frequency of adverse events in patients with poor anticoagulation: A meta-analysis
    • DOI 10.1503/cmaj.061523
    • Oake, N., Fergusson, D. A., Forster, A. J., & Van Walraven, C. (2007). Frequency of adverse events in patients with poor anticoagulation: a meta-analysis. Canadian Medical Association Journal, 176, 1589-1594. (Pubitemid 46868607)
    • (2007) Canadian Medical Association Journal , vol.176 , Issue.11 , pp. 1589-1594
    • Oake, N.1    Fergusson, D.A.2    Forster, A.J.3    Van Walraven, C.4
  • 26
    • 77956977472 scopus 로고    scopus 로고
    • Efficacy and safety of dabigatran compared with warfarin at different levels of international normalised ratio control for stroke prevention in atrial fibrillation: An analysis of the RE-LY trial
    • Wallentin, L., Yusuf, S., Ezekowitz, M., Alings, M., Flather, M., Franzosi, M. G, et al. (2010). Efficacy and safety of dabigatran compared with warfarin at different levels of international normalised ratio control for stroke prevention in atrial fibrillation: an analysis of the RE-LY trial. Lancet, 376(9745), 975-983.
    • (2010) Lancet , vol.376 , Issue.9745 , pp. 975-983
    • Wallentin, L.1    Yusuf, S.2    Ezekowitz, M.3    Alings, M.4    Flather, M.5    Franzosi, M.G.6
  • 27
    • 0014145890 scopus 로고
    • Complications in 220 patients with cardiac dysrhythmias treated by phased direct current shock, and indications for electroconversion
    • Resnekov, L., & McDonald, L. (1967). Complications in 220 patients with cardiac dysrhythmias treated by phased direct current shock, and indications for electroconversion. British Heart Journal, 29, 926-936.
    • (1967) British Heart Journal , vol.29 , pp. 926-936
    • Resnekov, L.1    McDonald, L.2
  • 28
    • 73649169745 scopus 로고
    • "Cardioversion" of atrial fibrillation: A report on the treatment of 65 episodes in 50 patients
    • Lown, B., Perlroth, M. G, Kaidbey, S., Abe, T., & Harken, D. E. (1963). "Cardioversion" of atrial fibrillation: a report on the treatment of 65 episodes in 50 patients. The New England Journal of Medicine, 269, 325-331.
    • (1963) The New England Journal of Medicine , vol.269 , pp. 325-331
    • Lown, B.1    Perlroth, M.G.2    Kaidbey, S.3    Abe, T.4    Harken, D.E.5
  • 30
    • 0014470842 scopus 로고
    • The efficacy of anticoagulant therapy in preventing embolism related to DC electrical conversion of atrial fibrillation
    • Bjerkelund, C. J., & Orning, O. M. (1969). The efficacy of anticoagulant therapy in preventing embolism related to DC electrical conversion of atrial fibrillation. The American Journal of Cardiology, 23, 208-216.
    • (1969) The American Journal of Cardiology , vol.23 , pp. 208-216
    • Bjerkelund, C.J.1    Orning, O.M.2
  • 31
  • 32
    • 45949095568 scopus 로고    scopus 로고
    • Antithrombotic therapy in atrial fibrillation: American College of Chest Physicians evidence-based clinical practice guidelines (8th edition)
    • DOI 10.1378/chest.08-0678
    • Singer, D. E., Albers, G. W., Dalen, J. E., Fang, M. C., Go, A. S., Halperin, J. S., et al. (2008). Antithrombotic therapy in atrial fibrillation: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th Edition). Chest, 133, 546S-592S. (Pubitemid 351892972)
    • (2008) Chest , vol.133 , Issue.6 SUPPL. 6
    • Singer, D.E.1    Albers, G.W.2    Dalen, J.E.3    Fang, M.C.4    Go, A.S.5    Halperin, J.L.6    Lip, G.Y.H.7    Manning, W.J.8
  • 34
    • 0028244264 scopus 로고
    • Risk factors for stroke and efficacy of antithrombotic therapy in atrial fibrillation: Analysis of pooled data from 5 randomized controlled trials
    • Atrial Fibrillation Investigators
    • Atrial Fibrillation Investigators. (1994). Risk factors for stroke and efficacy of antithrombotic therapy in atrial fibrillation: analysis of pooled data from 5 randomized controlled trials. Archives of Internal Medicine, 154, 1449-1457.
    • (1994) Archives of Internal Medicine , vol.154 , pp. 1449-1457
  • 35
    • 0035854054 scopus 로고    scopus 로고
    • Validation of clinical classification schemes for predicting stroke: Results from the National Registry of Atrial Fibrillation
    • Gage, B. F., Waterman, A. D., Shannon, W., Boechler, M., Rich, M. W., & Radford, M. J. (2001). Validation of clinical classification schemes for predicting stroke: results from the National Registry of Atrial Fibrillation. Journal of the American Medical Association, 285, 2864-2870. (Pubitemid 32537350)
    • (2001) Journal of the American Medical Association , vol.285 , Issue.22 , pp. 2864-2870
    • Gage, B.F.1    Waterman, A.D.2    Shannon, W.3    Boechler, M.4    Rich, M.W.5    Radford, M.J.6
  • 36
    • 77957699729 scopus 로고    scopus 로고
    • Guidelines for the management of atrial fibrillation
    • Task Force for the Management of Atrial Fibrillation of the European Society of Cardiology ESC
    • The Task Force for the Management of Atrial Fibrillation of the European Society of Cardiology (ESC). (2010). Guidelines for the management of atrial fibrillation. European Heart Journal, 31, 2369-2429.
    • (2010) European Heart Journal , vol.31 , pp. 2369-2429
  • 37
    • 78649998684 scopus 로고    scopus 로고
    • Dabigatran versus warfarin in atrial fibrillation with low, moderate and high CHADS2 score: A RELY subgroup analysis
    • Abstract
    • Oldgren, J., Alings, M., Darius, H., Eikelboom, J., Ezekowitz, M. D., Parekh, A., et al. (2010). Dabigatran versus warfarin in atrial fibrillation with low, moderate and high CHADS2 score: A RELY subgroup analysis. Journal of the American College of Cardiology, 55 (10 A), E2. Abstract.
    • (2010) Journal of the American College of Cardiology , vol.55 , Issue.10 A
    • Oldgren, J.1    Alings, M.2    Darius, H.3    Eikelboom, J.4    Ezekowitz, M.D.5    Parekh, A.6
  • 38
    • 84855607134 scopus 로고    scopus 로고
    • Dabigatran versus warfarin and impact of CHADS2VASc score on outcome in atrial fibrillation patients: A RELY subgroup analysis
    • Abstract
    • Oldgren, J., Ezekowitz, M. D., Alings, M., Diener, H.-C., Reilly, P. A., Yusuf, S., et al. (2011). Dabigatran versus warfarin and impact of CHADS2VASc score on outcome in atrial fibrillation patients: a RELY subgroup analysis. Journal of the American College of Cardiology, 15(14), E7. Abstract.
    • (2011) Journal of the American College of Cardiology , vol.15 , Issue.14
    • Oldgren, J.1    Ezekowitz, M.D.2    Alings, M.3    Diener, H.-C.4    Reilly, P.A.5    Yusuf, S.6
  • 39
    • 17444396697 scopus 로고    scopus 로고
    • Hepatic findings in long-term clinical trials of ximelagatran
    • DOI 10.2165/00002018-200528040-00006
    • Lee, W. M., Larrey, D., Olsson, R., Lewis, J. H., Keisu, M., Auclert, L., et al. (2005). Hepatic findings in long-term clinical trials of ximelagatran. Drug Safety, 28, 351-370. (Pubitemid 40545769)
    • (2005) Drug Safety , vol.28 , Issue.4 , pp. 351-370
    • Lee, W.M.1    Larrey, D.2    Olsson, R.3    Lewis, J.H.4    Keisu, M.5    Auclert, L.6    Sheth, S.7
  • 40
    • 79551589662 scopus 로고    scopus 로고
    • Cost-effectiveness of dabigatran compared with warfarin for stroke prevention in atrial fibrillation
    • Freeman, J. V., Zhu, R. P., Owens, D. K., Garber, A. M., Hutton, D. W., Go, A. S., et al. (2011). Cost-effectiveness of dabigatran compared with warfarin for stroke prevention in atrial fibrillation. Annals of Internal Medicine, 154(1), 1-11.
    • (2011) Annals of Internal Medicine , vol.154 , Issue.1 , pp. 1-11
    • Freeman, J.V.1    Zhu, R.P.2    Owens, D.K.3    Garber, A.M.4    Hutton, D.W.5    Go, A.S.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.