Identification of a Coordinated CD8 and CD4 T Cell Response Directed Against Mismatched HLA Class I Causing Severe Acute Graft-versus-Host Disease

Biology of Blood and Marrow Transplantation

Volumn 18, Issue 2, 2012, Pages 210-219

  Amir, Avital L ^a   Hagedoorn, Renate S ^a   van Luxemburg Heijs, Simone A P ^a   Marijt, Erik W A ^a   Kruisselbrink, Alwine B ^a   Frederik Falkenburg, J H ^a   Heemskerk, Mirjam H M ^a  

^a LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

Allo HLA directed immune response; AML blast; Coordinated immune response; GVHD; HLA derived peptides; HLA mismatched stem cell transplantation

Indexed keywords

BUSULFAN; FLUDARABINE; HLA A2 ANTIGEN; THYMOCYTE ANTIBODY;

ACUTE GRAFT VERSUS HOST DISEASE; ACUTE GRANULOCYTIC LEUKEMIA; ADULT; ALLOIMMUNITY; ARTICLE; BLAST CELL; CASE REPORT; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL CLONING; CELL COMPARTMENTALIZATION; CHRONIC GRAFT VERSUS HOST DISEASE; CROSS REACTION; DONOR LYMPHOCYTE INFUSION; HUMAN; HUMAN CELL; MALE; MEMORY T LYMPHOCYTE; MYELODYSPLASTIC SYNDROME; NONMYELOABLATIVE CONDITIONING; T CELL DEPLETION; T LYMPHOCYTE ACTIVATION;

ACUTE DISEASE; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; GRAFT VS HOST DISEASE; HISTOCOMPATIBILITY ANTIGENS CLASS II; HISTOCOMPATIBILITY TESTING; HLA-A2 ANTIGEN; HUMANS; IMMUNOLOGIC MEMORY; LEUKEMIA, MYELOID, ACUTE; LYMPHOCYTE ACTIVATION; MALE; MIDDLE AGED; STEM CELL TRANSPLANTATION;

EID: 84855599410     PISSN: 10838791     EISSN: 15236536     Source Type: Journal    
DOI: 10.1016/j.bbmt.2011.10.018     Document Type: Article

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