Reduced-Intensity Conditioning before Allogeneic Hematopoietic Stem Cell Transplantation in Patients Over 60 Years: A Report from the SFGM-TC

Biology of Blood and Marrow Transplantation

Volumn 18, Issue 2, 2012, Pages 289-294

  Chevallier, Patrice ^a   Szydlo, Richard M ^b   Blaise, Didier ^c   Tabrizi, Reza ^d   Michallet, Mauricette ^e   Uzunov, Madalina ^f   Fegueux, Nathalie ^g   Guilhot, François ^h   Lapusan, Simona ⁱ   Gratecos, Nicole ^j   Cahn, Jean Yves ^k   Socié, Gerard ^l   Yakoub Agha, Ibrahim ^m   Huynh, Anne ⁿ   Francois, Sylvie ^o   Bay, Jacques Olivier ^p   Maury, Sébastien ^q   Buzyn, Agnes ^r   Contentin, Nathalie ^s   Mohty, Mohamad ^a  

^a NANTES UNIVERSITY HOSPITAL   (France)

^b HAMMERSMITH HOSPITAL   (United Kingdom)

^c INSTITUT PAOLI CALMETTES   (France)

^d UNIVERSITÉ DE BORDEAUX   (France)

^e EDOUARD HERRIOT HOSPITAL   (France)

^f PITIÉ SALPÊTRIÈRE HOSPITAL   (France)

^g LAPEYRONIE HOSPITAL   (France)

^h POITIERS UNIVERSITY HOSPITAL   (France)

ⁱ HÔTEL DIEU   (France)

^j CENTRE HOSPITALIER UNIVERSITAIRE DE NICE   (France)

^k HÔPITAL MICHALLON   (France)

^l SAINT LOUIS HOSPITAL   (France)

^m LILLE UNIVERSITY HOSPITAL   (France)

ⁿ CHU PURPAN   (France)

^o ANGERS UNIVERSITY HOSPITAL   (France)

^p UNIVERSITY HOSPITAL OF CLERMONT FERRAND   (France)

^q FACULTÉ DE MÉDECINE   (France)

^r HÔPITAL NECKER ENFANTS MALADES   (France)

^s CENTRE HENRI BECQUEREL   (France)

more..

Author keywords

Age; Allo HSCT; Elderly patients; RIC; SFGM TC

Indexed keywords

ADULT; AGE DISTRIBUTION; AGED; ALLOGENEIC HEMATOPOIETIC STEM CELL TRANSPLANTATION; ARTICLE; COMPARATIVE STUDY; CONTROLLED STUDY; DISEASE FREE SURVIVAL; FEMALE; FOLLOW UP; GERIATRIC CARE; GERIATRIC DISORDER; HEMATOLOGIC DISEASE; HUMAN; MAJOR CLINICAL STUDY; MALE; MORTALITY; OUTCOME ASSESSMENT; OVERALL SURVIVAL; PROGNOSIS; REDUCED INTENSITY CONDITIONING; RELAPSE; REMISSION; RETROSPECTIVE STUDY;

AGE FACTORS; AGED; DISEASE-FREE SURVIVAL; FEMALE; FOLLOW-UP STUDIES; HEMATOLOGIC NEOPLASMS; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HUMANS; MALE; MIDDLE AGED; RETROSPECTIVE STUDIES; RISK FACTORS; SURVIVAL RATE; TISSUE DONORS; TRANSPLANTATION CONDITIONING; TRANSPLANTATION, HOMOLOGOUS;

EID: 84855581029     PISSN: 10838791     EISSN: 15236536     Source Type: Journal    
DOI: 10.1016/j.bbmt.2011.07.013     Document Type: Article

References (26)

1. Mohty M., Rocha V., Chevallier P., et al. Reduced-intensity conditioning for allogeneic stem cell transplantation: 10 years later. Curr Opin Oncol 2009, 21(Supp 1):S1.
2. Diaconescu R., Flowers C.R., Storer B., et al. Morbidity and mortality with nonmyeloablative compared with myeloablative conditioning before hematopoietic cell transplantation from HLA-matched related donors. Blood 2004, 104:1550-1558.
3. Aoudjhane M., Labopin M., Gorin N.C., et al. Comparative outcome of reduced intensity and myeloablative conditioning regimen in HLA identical sibling allogeneic haematopoietic stem cell transplantation for patients older than 50 years of age with acute myeloblastic leukaemia: a retrospective survey from the Acute Leukaemia Working Party (ALWP) of the European group for Blood and Marrow Transplantation (EBMT). Leukemia 2005, 19:2304-2312.
4. Massenkeil G., Nagy M., Neuburger S., et al. Survival after reduced-intensity conditioning is not inferior to standard high-dose conditioning before allogeneic haematopoietic cell transplantation in acute leukaemias. Bone Marrow Transplant 2005, 36:683-689.
5. Martino R., Iacobelli S., Brand R., et al. Retrospective comparison of reduced-intensity conditioning and conventional high-dose conditioning for allogeneic hematopoietic stem cell transplantation using HLA-identical sibling donors in myelodysplastic syndromes. Blood 2006, 108:836-846.
6. Scott B.L., Sandmaier B.M., Storer B., et al. Myeloablative vs nonmyeloablative allogeneic transplantation for patients with myelodysplastic syndrome or acute myelogenous leukemia with multilineage dysplasia: a retrospective analysis. Leukemia 2006, 20:128-135.
7. Mohty M., Labopin M., Volin L., et al. Reduced-intensity versus conventional myeloablative conditioning allogeneic stem cell transplantation for patients with acute lymphoblastic leukemia: a retrospective study from the European Group for Blood and Marrow Transplantation. Blood 2010, 116:4439-4443.
8. Sorror M.L., Maris M.B., Storb R., et al. Hematopoietic cell transplantation (HCT-specific comorbidity index: a new tool for risk assessment before allogeneic HSCT. Blood 2005, 106:2912-2919.
9. Sorror M., Storer B., Sandmaier B.M., et al. Hematopoietic cell transplantation-comorbidity index and Karnofsky performance status are independent predictors of morbidity and mortality after allogeneic nonmyeloablative hematopoietic cell transplantation. Cancer 2008, 112:1992-2001.
10. Bertz H., Potthoff K., Finke J. Allogeneic stem-cell transplantation from related and unrelated donors in older patients with myeloid leukemia. J Clin Oncol 2003, 21:1480-1484.
11. Shapira M.Y., Resnick I.B., Bitan M., et al. Low transplant-related mortality with allogeneic stem cell transplantation in elderly patients. Bone Marrow Transplant 2004, 34:155-159.
12. Gupta V., Daly A., Lipton J.H., et al. Nonmyeloablative stem cell transplantation for myelodysplastic syndrome or acute myeloid leukemia in patients 60 years or older. Biol Blood Marrow Transplant 2005, 11:764-772.
13. Shimoni A., Kröger N., Zabelina T., et al. Hematopoietic stem-cell transplantation from unrelated donors in elderly patients (age>55 years) with hematologic malignancies: older age is no longer a contraindication when using reduced intensity conditioning. Leukemia 2005, 19:7-12.
14. Corradini P., Zallio F., Mariotti J., et al. Effect of age and previous autologous transplantation on nonrelapse mortality and survival in patients treated with reduced-intensity conditioning and allografting for advanced hematologic malignancies. J Clin Oncol 2005, 23:6690-6698.
15. Falda M., Busca A., Baldi I., et al. Non-myeloablative allogeneic stem cell transplantation in elderly patients with hematological malignancies: results from the GITMO multicenter prospective clinical trial. Am J Hematol 2007, 82:863-966.
16. Majhail N.S., Brunstein C.G., Tomblyn M., et al. Reduced intensity allogeneic transplant in patients older than 55 years: unrelated umbilical cord blood is safe and effective for patients without a matched related donor. Biol Blood Marrow Transplant 2008, 14:282-289.
17. Schetelig J., Bornhauser M., Schmid C., et al. Matched unrelated or matched sibling donors results in comparable survival after allogeneic stem-cell transplantation in elderly patients with acute myeloid leukemia: a report from the cooperative German transplant study group. J Clin Oncol 2010, 26:5183-5191.
18. Gyurkocza B., Storb R., Storer B.E., et al. Nonmyeloablative allogeneic hematopoietic cell transplantation in patients with acute myeloid leukaemia. J Clin Oncol 2010, 28:2859-2867.
19. McClune B., Weisdorf D.J., Pedersen T.L., et al. Effect of age on outcome of reduced-intensity hematopoietic cell transplantation for older patients with Acute Myeloid Leukemia in first complete remission or with myelodysplastic syndrome. J Clin Oncol 2010, 28:1878-1887.
20. Koreth J., Aldridge J., Kim H.T., et al. Reduced-intensity conditioning hematopoietic stem cell transplantation in patients over 60 years: hematologic malignancy outcomes are not impaired in advanced age. Biol Blood Marrow Transplant 2010, 16:792-800.
21. Krauter J., Wagner K., Stadler M., et al. Prognostic factors in allo-SCT of elderly patients with AML. Bone Marrow Transplant 2011, 46:545-551.
22. Sorror M.L., Storer B., Storb R.F. Validation of the hematopoietic cell transplantation-specific comorbidity index (HCT-CI) in single and multiple institutions: limitations and inferences. Biol Blood Marrow Transplant 2009, 15:757-758.
23. Sorror M.L., Storer B., Storb R. Assignment of scores for the hematopoietic cell transplantation comorbidity index: integer vs exact weights. Bone Marrow Transplant 2011, 46:464-466.
24. Castagna L., Furst S., Marchetti N., et al. Retrospective analysis of common scoring systems and outcome in patients older than 60years treated with reduced-intensity conditioning regimen and alloSCT. Bone Marrow Transplant 2011, 46:1000-1005.
25. Richa E., Papari M., Allen J., et al. Older age but not donor health impairs allogeneic granulocyte colony-stimulating factor (G-CSF) peripheral blood stem cell mobilizatio. Biol Blood Marrow Transplant 2009, 15:1394-1399.
26. Brissot E., Chevallier P., Guillaume T., et al. Factors predicting allogeneic PBSCs yield after G-CSF treatment in healthy donors. Bone Marrow Transplant 2009, 44:613-615.