Ethosuximide reduces allodynia and hyperalgesia and potentiates morphine effects in the chronic constriction injury model of neuropathic pain

European Journal of Pharmacology

Volumn 674, Issue 2-3, 2012, Pages 260-264

  Hamidi, Gholam Ali ^a   Ramezani, Mehdi Honarkar ^a   Arani, Meysam Noorani ^a   Talaei, Sayyed Alireza ^a   Mesdaghinia, Azam ^a   Banafshe, Hamid Reza ^a  

^a KASHAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

Allodynia; Chronic constriction injury; Ethosuximide; Hyperalgesia; Morphine; Neuropathic pain

Indexed keywords

ETHOSUXIMIDE; MORPHINE;

ALLODYNIA; ANALGESIC ACTIVITY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BEHAVIOR; COLD SENSITIVITY; CONTROLLED STUDY; DISEASE MODEL; DOSE RESPONSE; DRUG EFFECT; DRUG EFFICACY; DRUG POTENTIATION; HYPERALGESIA; MALE; MECHANICAL STIMULATION; NERVE COMPRESSION; NEUROPATHIC PAIN; NONHUMAN; PRIORITY JOURNAL; RAT; SCIATIC NERVE; THERMAL STIMULATION;

ANALGESICS, OPIOID; ANIMALS; CALCIUM CHANNEL BLOCKERS; COLD TEMPERATURE; CONSTRICTION; DISEASE MODELS, ANIMAL; DRUG SYNERGISM; ETHOSUXIMIDE; HOT TEMPERATURE; HYPERALGESIA; MALE; MORPHINE; NEURALGIA; PERIPHERAL NERVE INJURIES; RATS; RATS, SPRAGUE-DAWLEY; TIME FACTORS;

EID: 84855553718     PISSN: 00142999     EISSN: 18790712     Source Type: Journal    
DOI: 10.1016/j.ejphar.2011.11.026     Document Type: Article

References (46)

1. 2+ channel current in rat sensory neurons by a G-protein-independent mechanism. J. Neurosci. 17, 8721-8728.
2. Arner, S., Meyerson, B.A., 1988. Lack of analgesic effect of opioids on neuropathic and idiopathic forms of pain. Pain 33, 11-23.
3. Banafshe, H.R., Mesdaghinia, A., Arani, M.N., Ramezani, M.H., Heydari, A., Hamidi, G.A., 2012. Lithium attenuates pain-related behavior in a rat model of neuropathic pain: possible involvement of opioid system. Pharmacol. Biochem. Behav. 100, 425-430.
4. Bennett, G.J., Xie, Y.K., 1988. A peripheral mononeuropathy in rat that produces disorders of pain sensation like those seen in man. Pain 33, 87-107.
5. Bian, D., Nichols, M.L., Ossipov, M.H., Lai, J., Porreca, F., 1995. Characterization of the antiallodynic efficacy of morphine in a model of neuropathic pain in rats. Neuroreport 6, 1981-1984.
6. Choi, Y., Yoon, Y.W., Na, H.S., Kim, S.H., Chung, J.M., 1994. Behavioral signs of ongoing pain and cold allodynia in a rat model of neuropathic pain. Pain 59, 369-376.
7. Christoph, T., Kögel, B., Strassburger, W., Schug, S.A., 2007. Tramadol has a better potency ratio relative to morphine in neuropathic than in nociceptive pain models. Drugs R. D. 8, 51-57. (Pubitemid 46191807)
8. Coulter, D.A., Huguenard, J.R., Prince, D.A., 1990. Differential effects of petit mal anticonvulsants and convulsants on thalamic neurons. Br. J. Pharmacol. 100, 807-813. (Pubitemid 20233323)
9. Decocted, I., Woolf, C.J., 2000. Spared nerve injury: an animal model of persistent peripheral neuropathic pain. Pain 87, 149-158. (Pubitemid 30621447)
10. DeLeo, J.A., Coombs, D.W., Willenbring, S., Colburn, R.W., Fromm, C., Wagner, R., et al., 1994. Characterization of a neuropathic pain model: sciatic cryoneurolysis in the rat. Pain 56, 9-16. (Pubitemid 24037255)
11. Dellemijn, P.L., Vanneste, J.A., 1997. Randomised double-blind active-placebo-controlled crossover trial of intravenous fentanyl in neuropathic pain. Lancet 349, 753-758. (Pubitemid 27122457)
12. Devor, M., Janig, W., Michaelis, M., 1994. Modulation of activity in dorsal root ganglion neurons by sympathetic activation in nerve-injured rats. J. Neurophysiol. 71, 38-47. (Pubitemid 24058839)
13. Dickenson, A.H., 1994. Neurophysiology of opioid poorly responsive pain. Cancer Surv. 21, 5-16. (Pubitemid 24355810)
14. Dogrul, A., Gardell, L.R., Ossipov, M.H., Tulunay, F.C., Lai, J., Porreca, F., 2003. Reversal of experimental neuropathic pain by T-type calcium channel blockers. Pain 105, 159-168. (Pubitemid 37162485)
15. Dworkin, R.H., Backonja, M., Rowbotham, M.C., Allen, R.R., Argoff, C.R., Bennett, G.J., et al., 2003. Advances in neuropathic pain: diagnosis, mechanisms, and treatment recommendations. Arch. Neurol. 60, 1524-1534. (Pubitemid 37443116)
16. Fox, A., Gentry, C., Patel, S., Kesingland, A., Bevan, S., 2003. Comparative activity of the anti-convulsants oxcarbazepine, carbamazepine, lamotrigine and gabapentin in a model of neuropathic pain in the rat and guinea-pig. Pain 105, 355-362. (Pubitemid 37162506)
17. Galer, B.S., 1995. Neuropathic pain of peripheral origin: advances in pharmacologic treatment. Neurology 45, 517-525.
18. Gold, M.S., White, D.M., Ahlgren, S.C., Guo, M., Levine, J.D., 1994. Catecholamine-induced mechanical sensitization of cutaneous nociceptors in the rat. Neurosci. Lett. 175, 166-170. (Pubitemid 24215512)
19. Gracely, R.H., Lynch, S.A., Bennett, G.J., 1993. Painful neuropathy: altered central processing maintained dynamically by peripheral input. Pain 51, 175-194.
20. Hama, A.T., Borsook, D., 2005. Behavioral and pharmacological characterization of a distal peripheral nerve injury in the rat. Pharmacol. Biochem. Behav. 81, 170-181. (Pubitemid 40718966)
21. Hamidi, G.A., Manaheji, H., Janahmadi, M., Noorbakhsh, S.M., Salami, M., 2006. Coadministration of MK-801 and morphine attenuates neuropathic pain in rat. Physiol. Behav. 88, 628-635. (Pubitemid 44093630)
22. Hansson, P.T., Dickenson, A.H., 2005. Pharmacological treatment of peripheral neuropathic pain conditions based on shared commonalities despite multiple etiologies. Pain 113, 251-254. (Pubitemid 40127504)
23. Hansson, P., Lindblom, U., 1992. Hyperalgesia assessed with quantitative sensory testing in patients with neurogenic pain. Hyperalgesia and allodynia, pp. 335-343. New York.
24. Hao, J.X., Blakeman, K.H., Yu, W., Hultenby, K., Xu, X.J., Wiesenfeld-Hallin, Z., 2000. Development of a mouse model of neuropathic pain following photochemically induced ischemia in the sciatic nerve. Exp. Neurol. 163, 231-238. (Pubitemid 30314378)
25. Hargreaves, K., Dubner, R., Brown, F., Flores, C., Joris, J., 1988. A new and sensitive method for measuring thermal nociception in cutaneous hyperalgesia. Pain 32, 77-88.
26. Jensen, T.S., Madsen, C.S., Finnerup, N.B., 2009. Pharmacology and treatment of neuropathic pains. Curr. Opin. Neurol. 22, 467-474.
27. Kim, S.H., Chung, J.M., 1992. An experimental model for peripheral neuropathy produced by segmental spinal nerve ligation in the rat. Pain 50, 355-363.
28. Kingery, W.S., Guo, T.Z., Davies, M.F., Limbird, L., Maze, M., 2000. The alpha (2A) adrenoceptor and the sympathetic postganglionic neuron contribute to the development of neuropathic heat hyperalgesia in mice. Pain 85, 345-358. (Pubitemid 30214162)
29. Kostyuk, P.G., Molokanova, E.A., Pronchuk, N.F., Savchenko, A.N., Verkhratsky, A.N., 1992. Different action of ethosuximide on low- and high-threshold calcium currents in rat sensory neurons. Neuroscience 51, 755-758.
30. Lee, Y.W., Chaplin, S.R., Yaks, T.L., 1995. Systemic and supraspinal, but not spinal, opiates suppress allodynia in a rat neuropathic pain model. Neurosci. Lett. 199, 111-114.
31. Liu, X., Chung, K., Chung, J.M., 1999. Ectopic discharges and adrenergic sensitivity of sensory neurons after spinal nerve injury. Brain Res. 849, 244-247.
32. Matthews, E.A., Dickenson, A.H., 2001. Effects of spinally delivered N- and P-type voltage-dependent calcium channel antagonists on dorsal horn neuronal responses in a rat model of neuropathy. Pain 92, 235-246. (Pubitemid 32367955)
33. Ossipov, M.H., Lopez, Y., Nichols, M.L., Bian, D., Porreca, F., 1995. The loss of antinociceptive efficacy of spinal morphine in ratswith nerve ligation injury is prevented by reducing spinal afferent drive. Neurosci. Lett. 199, 87-90.
34. Perez-Reyes, E., 2003. Molecular physiology of low-voltage-activated t-type calcium channels. Physiol. Rev. 83, 117-161. (Pubitemid 36459879)
35. Pogatzki, E.M., Gebhart, G.F., Brennan, T.J., 2002. Characterization of Adelta- and C-fibers innervating the plantar rat hindpaw one day after an incision. J. Neurophysiol. 87, 721-731. (Pubitemid 34670839)
36. Przewlocki, R., Przewlocka, B., 2001. Opioids in chronic pain. Eur. J. Pharmacol. 429, 79-91. (Pubitemid 33043984)
37. Roberts, W.J., 1986. A hypothesis on the physiological basis for causalgia and related pains. Pain 24, 297-311. (Pubitemid 16162632)
38. Seltzer, Z., Dubner, R., Shir, Y., 1990. A novel behavioural model of neuropathic pain disorders produced in rats by partial sciatic nerve injury. Pain 43, 205-218. (Pubitemid 20385185)
39. 2+ current in adult rat sensory neurons: effects of anticonvulsant and anesthetic agents. J. Neurophysiol. 79, 240-252.
40. Todorovic, S.M., Meyenburg, A., Jevtovic-Todorovic, V., 2002. Mechanical and thermal antinociception in rats following systemic administration of mibefradil, a T-type calcium channel blocker. Brain Res. 951, 336-340. (Pubitemid 35248032)
41. Todorovic, S.M., Rastogi, A.J., Jevtovic-Todorovic, V., 2003. Potent analgesic effects of anticonvulsants on peripheral thermal nociception in rats. Br. J. Pharmacol. 140, 255-260. (Pubitemid 37249184)
42. 2+channel currents to a mu opioid in isolectin B4-positive and -negative dorsal root ganglion neurons. J. Pharmacol. Exp. Ther. 311, 939-947.
43. Wu, Z.Z., Cai, Y.Q., Pan, H.L., 2009. A functional link between T-type calcium channels and mu-opioid receptor expression in adult primary sensory neurons. J. Neurochem. 109, 867-878.
44. Yoon, Y.W., Na, H.S., Chung, J.M., 1996. Contributions of injured and intact afferents to neuropathic pain in an experimental rat model. Pain 64, 27-36. (Pubitemid 26062244)
45. Youn, W.L., Kyung, A.P., Won, T.L., 2002. Effects of MK-801 and morphine on spinal C-fos expression during the development of neuropathic pain. Yonsei Med. J. 43, 370-376.
46. Zimmermann, M., 1983. Ethical guidelines for investigations of experimental pain in conscious animals. Pain 16, 109-110. (Pubitemid 13058546)