Formaldehyde and tobacco smoke as alkylating agents: The formation of N-methylenvaline in pathologists and in plastic laminate workers

Science of the Total Environment

Volumn 414, Issue , 2012, Pages 701-707

  Bono, Roberto ^a   Romanazzi, Valeria ^a   Pirro, Valentina ^a   Degan, Raffaella ^a   Pignata, Cristina ^a   Suppo, Elisa ^a   Pazzi, Marco ^a   Vincenti, Marco ^a  

^a UNIVERSITY OF TURIN   (Italy)

Author keywords

Alkylating agents; Formaldehyde; N Methylenvaline; Occupational exposition; Tobacco smoke

Indexed keywords

ALKYLATING AGENTS; BIOLOGICAL RESPONSE; CONTROL GROUPS; COTININE; ISOTHIOCYANATES; MEAN VALUES; N-METHYLENVALINE; OCCUPATIONAL EXPOSITION; PASSIVE AIR SAMPLER; PENTAFLUOROPHENYL; POSITIVE CORRELATIONS; REDUCING CONDITIONS; TOBACCO SMOKE; UV DETECTION;

ALKYLATION; EXHIBITIONS; FORMALDEHYDE; HEMOGLOBIN; LAMINATES; MUTAGENS; PLASTIC LAMINATES; SMOKE ABATEMENT; TOBACCO;

SMOKE;

ALKYLATING AGENT; BIOLOGICAL MARKER; FORMALDEHYDE; GLOBIN; HEMOGLOBIN; HEMOGLOBIN DERIVATIVE; ISOTHIOCYANIC ACID DERIVATIVE; N METHYLENVALINE; PENTAFLUOROPHENYL ISOTHIOCYANATE; TOBACCO SMOKE; UNCLASSIFIED DRUG;

CONCENTRATION (COMPOSITION); FORMALDEHYDE; FORMATION MECHANISM; OCCUPATIONAL EXPOSURE; QUANTITATIVE ANALYSIS; SMOKE; TOBACCO;

ADSORPTION; AIR SAMPLER; ALKYLATION; ANALYSIS OF VARIANCE; ARTICLE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; FEMALE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HOSPITAL DEPARTMENT; HUMAN; INDUSTRIAL WORKER; MALE; MASS FRAGMENTOGRAPHY; OCCUPATIONAL EXPOSURE; PARAMEDICAL PERSONNEL; PATHOLOGIST; PLASTIC INDUSTRY; PRIORITY JOURNAL; SMOKING HABIT;

AIR POLLUTANTS; ALKYLATION; ANALYSIS OF VARIANCE; CHEMICAL INDUSTRY; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; FORMALDEHYDE; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; HEMOGLOBINS; HUMANS; MEDICAL LABORATORY PERSONNEL; OCCUPATIONAL EXPOSURE; PATHOLOGY; PLASTICS; SMOKING;

NICOTIANA TABACUM;

EID: 84855552103     PISSN: 00489697     EISSN: 18791026     Source Type: Journal    
DOI: 10.1016/j.scitotenv.2011.10.047     Document Type: Article

References (38)

1. Bono R., Arossa W., Scursatone E., Meineri V., Gilli G. Tobacco smoke habits in a group of adolescents: responsibility of the cohabitants in the active and passive exposure. Environ Res; 1997, 75:95-99.
2. Bono R., Vincenti M., Meineri V., Pignata C., Saglia U., Giachino O., Scursatone E. Formation of N-(2-hydroxyethyl)valine due to exposure to ethylene oxide via tobacco smoke: A risk factor for onset of, cancer. Environ Res; 1999, 81:62-71.
3. Bono R., Vincenti M., Schiliro T., Traversi D., Pignata C., Scursatone E., Dotti G., Gilli G. Cotinine and N-(2-hydroxyethyl)valine as markers of passive exposure to tobacco smoke in, children. J Expo Anal Environ Epidemiol; 2005, 15:66-73.
4. Bono R., Vincenti M., Schiliro T., Scursatone E., Pignata C., Gilli G. N-Methylenvaline in a group of subjects occupationally exposed to formaldehyde. Toxicol Lett; 2006, 161:10-17.
5. Bono R., Degan R., Pazzi M., Romanazzi V., Rovere R. Benzene and formaldehyde in air of two Winter Olympic venues of "Torino 2006". Environ Int; 2010, 36:269-275.
6. Bono R., Romanazzi V., Munnia A., Piro S., Allione A., Ricceri F., Guarrera S., Pignata C., Matullo G., Wang P., Giese R.W., Peluso M. Malondialdehyde-deoxyguanosine adduct formation in workers of pathology wards: the role of air formaldehyde exposure. Chem Res Toxicol; 2010, 23:1342-1348.
7. Carraro E., Gasparini S., Petrini T., Oitana P., Gilli G. Immune response prevalence to formaldehyde-human serum albumin molecular adduct in a healthy population. J Environ Pathol Toxicol Oncol; 1997, 16:215-218.
8. Chaw Y.F., Crane L.E., Lange P., Shapiro R. Isolation and identification of cross-links from formaldehyde-treated nucleic acids. Biochemistry; 1980, 19:5525-5531.
9. Costa S., Coelho P., Costa C., Silva S., Mayan O., Santos L.S., Gaspar J., Teixeira J.P. Genotoxic damage in pathology anatomy laboratory workers exposed to formaldehyde. Toxicology; 2008, 252:40-48.
10. Daher N., Saleh R., Jaroudi E., Sheheitli H., Badr T., Sepetdjian E., Al Rashidi M., Saliba N., Shihadeh A. Comparison of carcinogen, carbon monoxide, and ultrafine particle emissions from narghile waterpipe and cigarette smoking: Sidestream smoke measurements and assessment of second-hand smoke emission factors. Atmos Environ; 2010, 44:8-14.
11. Di Novi C., Minniti D., Barbaro S., Zampirolo M.G., Cimino A., Bussolati G. Vacuum-based preservation of surgical specimens: an environmentally-safe step towards a formalin-free hospital. Sci Total Environ; 2010, 408:3092-3095.
12. Doi S., Suzuki S., Morishita M., Yamada M., Kanda Y., Torii S., Sakamoto T. The prevalence of IgE sensitization to formaldehyde in asthmatic children. Allergy; 2003, 58:668-671.
13. Duhayon S., Hoet P. Van Maele-Fabry G and Lison D. Carcinogenic potential of formaldehyde in occupational settings: a critical assessment and possible impact on occupational exposure levels. Int Arch Occup Environ Health; 2008, 81:695-710.
14. Eller P.M. Niosh manual of analytical methods; 1984, 188:6-Chas. 3rd Edition.
15. Goulding R. Formaldehyde (Environmental Health Criteria 89) - WHO. 1989;111:1-38.
16. Hauptmann M., Lubin J.H., Stewart P.A., Hayes R.B., Blair A. Mortality from solid cancers among workers in formaldehyde industries. Am J Epidemiol; 2004, 159:1117-1130.
17. Heck H.D., Casanova M., Starr T.B. Formaldehyde toxicity-new understanding. Crit Rev Toxicol; 1990, 20:397-426.
18. IARC, International Agency for Research on Cancer - Monogr. Eval. Carcinog. Risks Hum., Formaldehyde, 2-butoxyethanol and 1-tert-butoxypropan-2-ol. I.A.R.C. Monograph. Lyon, France. 2006, 88, 1-478.
19. Kautiainen A., Tornqvist M., Svensson K., Ostermangolkar S. Adducts of Malonaldehyde and a Few Other Aldehydes to Hemoglobin. Carcinogenesis; 1989, 10:2123-2130.
20. Kelly T.J., Smith D.L., Satola J. Emission rates of formaldehyde from materials and consumer products found in California homes. Environ Sci Technol; 1999, 33:81-88.
21. Kim H., Kim Y.D., Cho S.H. Formaldehyde exposure levels and serum antibodies to formaldehyde-human serum albumin of Korean medical students. Arch Environ Health; 1999, 54:115-118.
22. Lu K., Collins L.B., Ru H.Y., Bermudez E., Swenberg J.A. Distribution of DNA Adducts Caused by Inhaled Formaldehyde Is Consistent with Induction of Nasal Carcinoma but Not Leukemia. Toxicol Sci; 2010, 116:441-451.
23. McGwin G., Lienert J., Kennedy J.I. Formaldehyde exposure and asthma in children: a systematic review. Environ Health Perspect; 2010, 118:313-317.
24. Miraglia N., Assennato G., Clonfero E., Fustinoni S., Sannolo N. Biologically effective dose biomarkers. G Ital Med Lav Ergon; 2004, 26:298-301.
25. Nielsen G.D., Wolkoff P. Cancer effects of formaldehyde: a proposal for an indoor air guideline value. Arch Toxicol; 2010, 84:423-446.
26. Orsiere T. Sari-Minodier I. Iarmarcovai G and Botta A. Genotoxic risk assessment of pathology and anatomy laboratory workers exposed to formaldehyde by use of personal air sampling and analysis of DNA damage in peripheral lymphocytes. Mutat Res; 2006, 605:30-41.
27. Pala M., Ugolini D., Ceppi M., Rizzo F., Maiorana L., Bolognesi C., Schiliro T., Gilli G., Bigatti P., Bono R., Vecchio D. Occupational exposure to formaldehyde and biological monitoring of Research Institute workers. Cancer Detect Prev; 2008, 32:121-126.
28. Saito Y., Nishio K., Yoshida Y., Niki E. Cytotoxic effect of formaldehyde with free radicals via increment of cellular reactive oxygen species. Toxicology; 2005, 210:235-245.
29. Schmid O., Speit G. Genotoxic effects induced by formaldehyde in human blood and implications for the interpretation of biomonitoring studies. Mutagenesis; 2007, 22:69-74.
30. Shaham J., Bomstein Y., Meltzer A., Kaufman Z., Palma E., Ribak J. DNA - protein crosslinks, a biomarker of exposure to formaldehyde - in vitro and in vivo, studies. Carcinogenesis; 1996, 17:121-125.
31. Shaham J., Bomstein Y., Gurvich R., Rashkovsky M., Kaufman Z. DNA-protein crosslinks and p53 protein expression in relation to occupational exposure to formaldehyde. Occup Environ Med; 2003, 60:403-409.
32. Speit G., Schutz P., Hogel J., Schmid O. Characterization of the genotoxic potential of formaldehyde in V79 cells. Mutagenesis; 2007, 22:387-394.
33. Thrasher J.D., Broughton A., Micevich P. Antibodies and immune profiles of individuals occupationally exposed to formaldehyde: six case reports. Am J Ind Med; 1988, 14:479-488.
34. Thrasher J.D., Broughton A., Madison R. Immune activation and autoantibodies in humans with long-term inhalation exposure to formaldehyde. Arch Environ Health; 1990, 45:217-223.
35. Tornqvist M., Mowrer J., Jensen S., Ehrenberg L. Monitoring of environmental cancer initiators through hemoglobin adducts by a modified Edman degradation method. Anal Biochem; 1986, 154:255-266.
36. Tornqvist M., Kautiainen A. Adducted proteins for identification of endogenous electrophiles. Environ Health Perspect; 1993, 99:39-44.
37. Zhang L., Steinmaus C., Eastmond D.A., Xin X.K., Smith M.T. Formaldehyde exposure and leukemia: a new meta-analysis and potential mechanisms. Mutat Res; 2009, 681:150-168.
38. Zhitkovich A., Costa M. A simple, sensitive assay to detect DNA-protein crosslinks in intact cells and, in vivo. Carcinogenesis; 1992, 13:1485-1489.