Evaluation of the sensitivity and specificity of 11C-metomidate positron emission tomography (PET)-CT for lateralizing aldosterone secretion by Conn's adenomas

Journal of Clinical Endocrinology and Metabolism

Volumn 97, Issue 1, 2012, Pages 100-109

  Burton, Timothy J ^a   Mackenzie, Isla S ^a   Balan, Kottekkattu ^b   Koo, Brendan ^b   Bird, Nick ^b   Soloviev, Dmitri V ^a   Azizan, Elena A B ^a   Aigbirhio, Franklin ^a   Gurnell, Mark ^c   Brown, Morris J ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b ADDENBROOKE S HOSPITAL   (United Kingdom)

^c UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ALDOSTERONE; DEXAMETHASONE; FLUDROCORTISONE; METOMIDATE C 11; RADIOPHARMACEUTICAL AGENT; STEROID; UNCLASSIFIED DRUG;

ADRENAL INCIDENTALOMA; ADRENAL VEIN SAMPLING; ADULT; ALDOSTERONE RELEASE; ARTICLE; CLINICAL ARTICLE; COMPUTER ASSISTED EMISSION TOMOGRAPHY; COMPUTER ASSISTED TOMOGRAPHY; CONTROLLED STUDY; GOLD STANDARD; HUMAN; IMAGE ANALYSIS; IMAGE QUALITY; INTERMETHOD COMPARISON; PRIMARY HYPERALDOSTERONISM; PRIORITY JOURNAL; RECEIVER OPERATING CHARACTERISTIC; SAMPLING; SENSITIVITY AND SPECIFICITY; TUMOR VOLUME;

EID: 84855509223     PISSN: 0021972X     EISSN: 19457197     Source Type: Journal    
DOI: 10.1210/jc.2011-1537     Document Type: Article

References (37)

1. Gordon RD, Stowasser M, Tunny TJ, Klemm SA, Rutherford JC 1994 High incidence of primary aldosteronism in 199 patients referred with hypertension. Clin Exp Pharmacol Physiol 21:315-318 (Pubitemid 24201225)
2. Stowasser M, Gordon RD, Gunasekera TG, Cowley DC, Ward G, Archibald C, Smithers BM 2003 High rate of detection of primary aldosteronism, including surgically treatable forms, after 'non-selective'screening of hypertensive patients. J Hypertens 21:2149-2157 (Pubitemid 38296877)
3. Lim PO, Dow E, Brennan G, Jung RT, MacDonald TM 2000 High prevalence of primary aldosteronism in the Tayside hypertension clinic population. J Hum Hypertens 14:311-315 (Pubitemid 30311512)
4. Abdelhamid S, Müller-Lobeck H, Pahl S, Remberger K, Bönhof JA, Walb D, Röckel A 1996 Prevalence of adrenal and extra-adrenal Conn syndrome in hypertensive patients. Arch Intern Med 156: 1190-1195 (Pubitemid 26197664)
5. Fardella CE, Mosso L, Gómez-Sánchez C, Cortés P, Soto J, Gómez L, Pinto M, Huete A, Oestreicher E, Foradori A, Montero J 2000 Primary hyperaldosteronism in essential hypertensives: prevalence, biochemical profile, and molecular biology. J Clin Endocrinol Metab 85:1863-1867 (Pubitemid 32269290)
6. Rossi GP 2011 A comprehensive review of the clinical aspects of primary aldosteronism. Nat Rev Endocrinol 7:485-495
7. Young Jr WF 2007 Clinical practice. the incidentally discovered adrenal mass. N Engl J Med 356:601-610 (Pubitemid 46220820)
8. Toniato A, Bernante P, Rossi GP, Pelizzo MR 2006 The role of adrenal venous sampling in the surgical management of primary aldosteronism. World J Surg 30:624-627
9. Harvey A, Kline G, Pasieka JL 2006 Adrenal venous sampling in primary hyperaldosteronism: comparison of radiographic with biochemical success and the clinical decision-making with "less than ideal" testing. Surgery 140:847-853; discussion 853-845
10. Rubello D, Bui C, Casara D, Gross MD, Fig LM, Shapiro B 2002 Functional scintigraphy of the adrenal gland. Eur J Endocrinol 147: 13-28 (Pubitemid 34814735)
11. Bergström M, Sörensen J, Kahn TS, Juhlin C, Eriksson B, Sundin A, Bonasera TA, Fasth K, Långström B 1999 PET with [11C]-metomidate for the visualization of adrenocortical tumors and discrimination from other lesions. Clin Positron Imaging 2:339
12. Bergström M, Juhlin C, Bonasera TA, Sundin A, Rastad J, Akerström G, Långström B 2000 PET imaging of adrenal cortical tumors with the 11β-hydroxylase tracer 11C-metomidate. J Nucl Med 41: 275-282 (Pubitemid 30091347)
13. Minn H, Salonen A, Friberg J, Roivainen A, Viljanen T, Långsjö J, Salmi J, Välimäki M, Någren K, Nuutila P 2004 Imaging of adrenal incidentalomas with PET using (11)C-metomidate and (18)F-FDG. J Nucl Med 45:972-979 (Pubitemid 47611684)
14. Zettinig G, Mitterhauser M, Wadsak W, Becherer A, Pirich C, Vierhapper H, Niederle B, Dudczak R, Kletter K 2004 Positron emission tomography imaging of adrenal masses: (18)F-fluorodeoxyglucose and the 11β-hydroxylase tracer (11)C-metomidate. Eur J Nucl Med Mol Imaging 31:1224-1230 (Pubitemid 39222485)
15. Bergström M, Bonasera TA, Lu L, Bergström E, Backlin C, Juhlin C, Långström B 1998 In vitro and in vivo primate evaluation of carbon-11-etomidate and carbon-11-metomidate as potential tracers for PET imaging of the adrenal cortex and its tumors. J NuclMed 39:982-989 (Pubitemid 28270112)
16. Hennings J, Lindhe O, Bergström M, Långström B, Sundin A, Hellman P 2006 [11C]metomidate positron emission tomography of adrenocortical tumors in correlation with histopathological findings. J Clin Endocrinol Metab 91:1410-1414
17. Mitterhauser M, Wadsak W, Langer O, Schmaljohann J, Zettinig G, Dudczak R, Viernstein H, Kletter K 2003 Comparison of three different purification methods for the routine preparation of [11C] Metomidate. Appl Radiat Isot 59:125-128 (Pubitemid 36993606)
18. Burton TJ, Cope G, Wang J, Sim JC, Azizan EA, O'Shaughnessy KM, Brown MJ 2009 Expression of the epithelial Na(+) channel and other components of an aldosterone response pathway in human adrenocortical cells. Eur J Pharmacol 613:176-181
19. Azizan EA, Newhouse S, Burton TJ, Brown MJ 2010 Microarray analysis of potassium and sodium transport abnormalities in aldosterone- producing adenomas (APA). J Hum Hypertens 24:690-691
20. Burton TJ, Azizan EA, Brown MJ 2011 Investigating the function of an aldosterone response pathway in primary human adrenocortical cells obtained from Conn's and phaeochromocytoma patients. Eur J Pharmacol 657:184-189
21. Brown MJ 2010 Secondary hypertension. In: Warrell DA, Cox TM, Firth JD, eds. Oxford Textbook of Medicine. Oxford: Oxford University Press; 3057-3070
22. Ganguly A 1998 Primary aldosteronism. N Engl J Med 339:1828-1834 (Pubitemid 29005789)
23. Varga I, Rácz K, Kiss R, Fütö L, Tóth M, Sergev O, Gláz E 1993 Direct inhibitory effect of etomidate on corticosteroid secretion in human pathologic adrenocortical cells. Steroids 58:64-68
24. Weber MM, Lang J, Abedinpour F, Zeilberger K, Adelmann B, Engelhardt D 1993 Different inhibitory effect of etomidate and ke- toconazole on the human adrenal steroid biosynthesis. Clin Invest 71:933-938 (Pubitemid 23327482)
25. Hennings J, Sundin A, Hägg A, Hellman P 2010 11C-metomidate positron emission tomography after dexamethasone suppression for detection of small adrenocortical adenomas in primary aldosteronism. Langenbecks Arch Surg 395:963-967
26. Boggaram V, Zuber MX, Waterman MR 1984 Turnover of newly synthesized cytochromes P-450scc and P-45011β and adrenodoxin in bovine adrenocortical cells in monolayer culture: effect of adrenocorticotropin. Arch Biochem Biophys 231:518-523 (Pubitemid 14120242)
27. Allan CA, Kaltsas G, Perry L, Lowe DG, Reznek R, Carmichael D, Monson JP 2000 Concurrent secretion of aldosterone and cortisol from an adrenal adenoma - value of MRI in diagnosis. Clin Endocrinol (Oxf) 53:749-753 (Pubitemid 32098017)
28. Rossi GP 2010 Prevalence and diagnosis of primary aldosteronism. Curr Hypertens Rep 12:342-348
29. Wang T, Satoh F, Morimoto R, Nakamura Y, Sasano H, Auchus RJ, Edwards MA, Rainey WE 2011 Gene expression profiles in aldosterone- producing adenomas and adjacent adrenal glands. Eur J Endocrinol 164:613-619
30. Tsagarakis S, Kokkoris P, Roboti C, Malagari C, Kaskarelis J, Vlassopoulou V, Alevizaki C, Thalassinos N 1998 The low-dose dexamethasone suppression test in patients with adrenal incidentalomas: comparisons with clinically euadrenal subjects and patients with Cushing's syndrome. Clin Endocrinol (Oxf) 48:627-633 (Pubitemid 28253000)
31. Abdelmannan D, Aron DC 2010 Adrenal incidentalomas and subclinical Cushing's syndrome. Rev Endocr Metab Disord 11:135-140
32. Kline GA, Harvey A, Jones C, Hill MH, So B, Scott-Douglas N, Pasieka JL 2008 Adrenal vein sampling may not be a gold-standard diagnostic test in primary aldosteronism: final diagnosis depends upon which interpretation rule is used. Variable interpretation of adrenal vein sampling. Int Urol Nephrol 40:1035-1043
33. Mulatero P, Bertello C, Sukor N, Gordon R, Rossato D, Daunt N, Leggett D, Mengozzi G, Veglio F, Stowasser M 2010 Impact of different diagnostic criteria during adrenal vein sampling on reproducibility of subtype diagnosis in patients with primary aldosteronism. Hypertension 55:667-673
34. Funder JW, Carey RM, Fardella C, Gomez-Sanchez CE, Mantero F, Stowasser M, Young Jr WF, Montori VM; American Endocrine Society 2008 Case detection, diagnosis, and treatment of patients with primary aldosteronism. J Clin Endocrinol Metab 93:3266-3281
35. Ettlinger DE, Wadsak W, Mien LK, Machek M, Wabnegger L, Rendl G, Karanikas G, Viernstein H, Kletter K, Dudczak R, Mitterhauser M 2006 [18F]FETO: metabolic considerations. Eur J Nucl Med Mol Imaging 33:928-931
36. Hahner S, Stuermer A, Kreissl M, Reiners C, Fassnacht M, Haenscheid H, Beuschlein F, Zink M, Lang K, Allolio B, Schirbel A 2008 [123 I]Iodometomidate for molecular imaging of adrenocortical cytochrome P450 family 11B enzymes. J Clin Endocrinol Metab 93: 2358-2365 (Pubitemid 351831559)
37. Choi M, Scholl UI, Yue P, Björklund P, Zhao B, Nelson-Williams C, Ji W, Cho Y, Patel A, Men CJ, Lolis E, Wisgerhof MV, Geller DS, Mane S, Hellman P, Westin G, Åkerström G, Wang W, Carling T, Lifton RP 2011 K+ channel mutations in adrenal aldosterone-producing adenomas and hereditary hypertension. Science 331:768-772