Effects of topically applied agents on intra-oral wound healing in a rat model: A clinical and histomorphometric study

International Journal of Dental Hygiene

Volumn 9, Issue 1, 2011, Pages 9-16

  Hammad, H M ^a   Hammad, M M ^a   Abdelhadi, I N ^b   Khalifeh, M S ^a  

^a JORDAN UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Jordan)

^b Private Practice   (Jordan)

Author keywords

Allantoin; Chlorhexidine; Hyaluronan; Oral wound healing

Indexed keywords

ALLANTOIN; CHLORHEXIDINE; DERMATOLOGICAL AGENT; HYALURONIC ACID; TOPICAL ANTIINFECTIVE AGENT;

ANIMAL; ARTICLE; COMPARATIVE STUDY; DRUG EFFECT; FOLLOW UP; GEL; HYDROCOLLOID DRESSING; MALE; PALATE; PERIODONTIC DEVICE; RANDOMIZATION; RAT; TOPICAL DRUG ADMINISTRATION; WISTAR RAT; WOUND HEALING;

ADMINISTRATION, TOPICAL; ALLANTOIN; ANIMALS; ANTI-INFECTIVE AGENTS, LOCAL; BANDAGES, HYDROCOLLOID; CHLORHEXIDINE; DERMATOLOGIC AGENTS; FOLLOW-UP STUDIES; GELS; HYALURONIC ACID; MALE; PALATE; PERIODONTAL DRESSINGS; RANDOM ALLOCATION; RATS; RATS, WISTAR; WOUND HEALING;

EID: 84855504797     PISSN: 16015029     EISSN: 16015037     Source Type: Journal    
DOI: 10.1111/j.1601-5037.2009.00410.x     Document Type: Article

References (47)

1. Bakaéen GS, Strahan JD. Effects of a 1% chlorhexidine gel during the healing phase after inverse bevel mucogingival flap surgery. J Clin Periodontol 1980; 7: 20-5.
2. Zambon JJ, Ciancio SG, Mather ML, Charles CH. The effect of an antimicrobial mouthrinse on early healing of gingival flap surgery wounds. J Periodontol 1989; 60: 31-4.
3. Nyman S, Rosling B, Lindhe J. Effect of professional tooth cleaning on healing after periodontal surgery. J Clin Periodontol 1975; 2: 80-6.
4. Lambert PM, Morris HF, Ochi S. The influence of 0.12% chlorhexidine digluconate rinses on the incidence of infectious complications and implant success. Oral Maxillofac Surg 1997; 55(12 Suppl 5): 25-30.
5. Farnoush A. Techniques for the protection and coverage of the donor sites in free soft tissue grafts. J Periodontol 1978; 49: 403-5.
6. Kozlovsky A, Artzi Z, Hirshberg A, Israeli-Tobias C, Reich L. Effect of local antimicrobial agents on excisional palatal wound healing: a clinical and histomorphometric study in rats. J Clin Periodontol 2007; 34: 164-71.
7. Denton GW. Chlorhexidine. In: Block SS, ed. Disinfection, Sterilization and Preservation. Philadelphia, Lea and Febiger, 1991, 274-289.
8. Jones CG. Chlorhexidine: is it still the gold standard? Periodontol 2000 1997; 15: 55-62.
9. Chen WY, Abatangelo G. Functions of hyaluronan in wound repair. Wound Repair Regen 1999; 7: 79-89.
10. Moseley R, Waddington RJ, Embery G. Hyaluronan and its potential role in periodontal healing. Dent Update 2002; 29: 144-8.
11. Rahemtulla F. Proteoglycans of oral tissues. Crit Rev Oral Biol Med 1992; 3: 135-62.
12. Goa KL, Benfield P. Hyaluronic acid. A review of its pharmacology and use as a surgical aid in ophthalmology, and its therapeutic potential in joint disease and wound healing. Drugs 1994; 47: 536-66.
13. Jentsch H, Pomowski R, Kundt G, Göcke R. Treatment of gingivitis with hyaluronan. J Clin Periodontol 2003; 30: 159-64.
14. Pistorius A, Martin M, Willershausen B, Rockmann P. The clinical application of hyaluronic acid in gingivitis therapy. Quintessence Int 2005; 36: 531-8.
15. de Araújo Nobre M, Cintra N, Maló P. Peri-implant maintenance of immediate function implants: a pilot study comparing hyaluronic acid and chlorhexidine. Int J Dent Hyg 2007; 5: 87-94.
16. Nolan A, Baillie C, Badminton J, Rudralingham M, Seymour RA. The efficacy of topical hyaluronic acid in the management of recurrent aphthous ulceration. J Oral Pathol Med 2006; 35: 461-5.
17. Kim K, Park J, Rhee S. Structural and functional basis for (S)-allantoin formation in the ureide pathway. J Biol Chem 2007; 282: 23457-64.
18. MacKay D, Miller AL. Nutritional support for wound healing. Altern Med Rev 2003; 8: 359-77.
19. Foster S, Tyler VE. Tyler's Honest Herbal: A Sensible Guide to the Use of Herbs and Related Remedies. New York, The Haworth Herbal Press, 1999.
20. Draelos ZD. Cosmeceutical botanicals: part 1. In: Dover JS, ed. Procedures in Cosmetic Dermatology, Cosmeceuticals. Philadelphia, Elsevier Saunders, 2005, 71-78.
21. Akema FineChemicals. Allantoin CTFA. Available at: http://www.akema.it/allantoin.htm. Accessed March 24, 2009.
22. Margraf HW, Covey TH Jr. A trial of silver-zinc-allantoinate in the treatment of leg ulcers. Arch Surg 1977; 112: 699-704.
23. Department of Health and Human Services, U.S. Food and Drug Administration (FDA). Code of Federal Regulations, Title 21, Volume 5: Food and Drugs, Part 310: New Drugs. Available at: http://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?fr=310.534. Accessed March 24, 2009.
24. Institute of Laboratory Animal Resources, Commission on Life Sciences. Guide for the Care and Use of Laboratory Animals. Washington, DC, National Academy Press, National Research Council, 1996.
25. Kahnberg KE, Thilander H. Healing of experimental excisional wounds in the rat palate. (I) Histological study of the interphase in wound healing after sharp dissection. Int J Oral Surg 1982; 11: 44-51.
26. Bodner L, Dayan D, Pinto Y, Hammel I. Characteristics of palatal wound healing in desalivated rats. Arch Oral Biol 1993; 38: 17-21.
27. Bodner L, Dayan D. Epithelium and connective tissue regeneration during palatal wound healing in desalivated rats: a comparative study. Comp Biochem Physiol A Physiol 1995; 111: 415-9.
28. Robson MC, Heggers JP. Quantitative Bacteriology and Inflammatory Mediators in Soft Tissue. Soft and Hard Tissue Repair. New York, Praeger, 1984.
29. Penhallow K. A review of studies that examine the impact of infection on the normal wound healing process. J Wound Care 2005; 14: 123-6.
30. Tenenhaus M, Bhavsar D, Rennekampff HO. Diagnosis and surgical management in wound bacterial burden. In: Granick MS, Gamelli RL, eds. Surgical Wound Healing and Management. New York, Informa Healthcare USA, Inc, 2007, 29-37.
31. Häkkinen L, Uitto VJ, Larjava H. Cell biology of gingival wound healing. Periodontol 2000 2000; 24: 127-52.
32. Damour O, Hua SZ, Lasne F, Villain M, Rousselle P, Collombel C. Cytotoxicity evaluation of antiseptics and antibiotics on cultured human fibroblasts and keratinocytes. Burns 1992; 18: 479-85.
33. Pucher JJ, Daniel JC. The effects of chlorhexidine digluconate on human fibroblasts in vitro. J Periodontol 1992; 63: 526-32.
34. Mariotti AJ, Rumpf DA. Chlorhexidine-induced changes to human gingival fibroblast collagen and non-collagen protein production. J Periodontol 1999; 70: 1443-8.
35. Hidalgo E, Dominguez C. Mechanisms underlying chlorhexidine-induced cytotoxicity. Toxicol In Vitro 2001; 15: 271-6.
36. Bassetti C, Kallenberger A. Influence of chlorhexidine rinsing on the healing of oral mucosa and osseous lesions. J Clin Periodontol 1980; 7: 443-56.
37. Salami A, Imosemi I, Owoeye O. A comparison of the effect of chlorhexidine, tap water and normal saline on healing wounds. Int J Morphol 2006; 24: 673-6.
38. Asboe-Jörgensen V, Attström R, Lang NP, Löe H. Effect of a chlorhexidine dressing on the healing after periodontal surgery. J Periodontol 1974; 45: 13-7.
39. Hamp SE, Rosling B, Lindhe J. Effect of chlorhexidine on gingival wound healing in the dog. A histometric study. J Clin Periodontol 1975; 2: 143-52.
40. Othman S, Haugen E, Gjermo P. The effect of chlorhexidine supplementation in a periodontal dressing. Acta Odontol Scand 1989; 47: 361-6.
41. Lang N, Schild U, Brägger U. Effect of chlorhexidine (0.12%) rinses on periodontal tissue healing after tooth extraction. (I). Clinical parameters. J Clin Periodontol 1994; 21: 415-21.
42. Metin M, Tek M, Sener I. Comparison of two chlorhexidine rinse protocols on the incidence of alveolar osteitis following the surgical removal of impacted third molars. J Contemp Dent Pract 2006; 7: 79-86.
43. Torres-Lagares D, Infante-Cossio P, Gutierrez-Perez J, Romero-Ruiz M, Garcia-Calderon M, Serrera-Figallo M. Intra-alveolar chlorhexidine gel for the prevention of dry socket in mandibular third molar surgery. A pilot study. Med Oral Patol Oral Cir Bucal 2006; 11: E179-84.
44. Hita-Iglesias P, Torres-Lagares D, Flores-Ruiz R, Magallanes-Abad N, Basallote-Gonzalez M, Gutierrez-Perez JL. Effectiveness of chlorhexidine gel versus chlorhexidine rinse in reducing alveolar osteitis in mandibular third molar surgery. J Oral Maxillofac Surg 2008; 66: 441-5.
45. Schiott CR, Löe H, Jensen SB, Kilian M, Davies RM, Glavind K. The effect of chlorhexidine mouthrinses on the human oral flora. J Periodontal Res 1970; 5: 84-9.
46. Hjeljord LG, Rolla G, Bonesvoll P. Chlorhexidine-protein interactions. J Periodontal Res Suppl 1973; 12: 11-6.
47. Kornman KS. The role of supragingival plaque in the prevention and treatment of periodontal diseases. A review of current concepts. J Periodontal Res Suppl 1986; 2l: 5-22.