Loss of capacity to recover from acidosis on repeat exercise in chronic fatigue syndrome: A case-control study

European Journal of Clinical Investigation

Volumn 42, Issue 2, 2012, Pages 186-194

  Jones, David E J ^a   Hollingsworth, Kieren G ^a,b   Jakovljevic, Djordje G ^a,b   Fattakhova, Gulnar ^a,b   Pairman, Jessie ^a,b   Blamire, Andrew M ^a,b   Trenell, Michael I ^a,b   Newton, Julia L ^a,b  

^a NEWCASTLE UNIVERSITY   (United Kingdom)

^b NEWCASTLE UNIVERSITY   (United Kingdom)

Author keywords

Chronic fatigue syndrome; Exercise; Fatigue; Muscle bioenergetics; Muscle function

Indexed keywords

ACIDOSIS; ADULT; ANAEROBIC EXERCISE; ARTICLE; CARDIOPULMONARY EXERCISE TEST; CASE CONTROL STUDY; CHRONIC FATIGUE SYNDROME; CLINICAL ARTICLE; CONTROLLED STUDY; EXERCISE; FEMALE; FUNCTIONAL STATUS; HEART RATE; HUMAN; MALE; MUSCLE CONTRACTION; MUSCLE FUNCTION; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PH; PRIORITY JOURNAL; REPEAT PROCEDURE;

ACIDOSIS; ADULT; CASE-CONTROL STUDIES; EXERCISE; EXERCISE TEST; EXERCISE TOLERANCE; FATIGUE SYNDROME, CHRONIC; FEMALE; GREAT BRITAIN; HUMANS; MALE; MIDDLE AGED; OXYGEN CONSUMPTION; TIME FACTORS;

EID: 84855504732     PISSN: 00142972     EISSN: 13652362     Source Type: Journal    
DOI: 10.1111/j.1365-2362.2011.02567.x     Document Type: Article

References (40)

1. National Institute for Health and Clinical Excellence (2010) Chronic Fatigue Syndrome/Myalgic Encephalomyelitis (or encephalopathy); Diagnosis and management of CFS/ME in adults and children. Available at: Accessed on 18 January 2011.
2. Costigan A, Elliott C, McDonald C, Newton JL. Orthostatic symptoms predict functional capacity in Chronic Fatigue Syndrome implications for management. QJM 2010;103:589-95.
3. VanNess JM, Stevens SR, Bateman L, Stiles TL, Snell CR. Postexertional malaise in women with chronic fatigue syndrome. J Womens Health 2009;19:239-44.
4. Kent-Braun JA, Sarma KR, Weiner MW, Massie B, Miller RG. Central basis of muscle fatigue in chronic fatigue syndrome. Neurology 1993;43:125-31.
5. McCulley KK, Sisto SA, Natelson BH. Use of exercise as a treatment of chronic fatigue syndrome. Sports Med 1996;21:35-48.
6. Gibson H, Carroll N, Clague JE, Edwards RH. Exercise performance and fatiguability in patients with chronic fatigue syndrome. J Neurol Neurosurg Psychiatry 1993;56:993-8.
7. Lloyd AR, Gandevia SC, Hales JP. Muscle performance, voluntary activation, twitch properties and perceived effort in normal subjects and patients with the chronic fatigue syndrome. Brain 1991;114:85-98.
8. Lloyd AR, Hales JP, Gandevia SC. Muscle strength, endurance and recovery in the post-infection fatigue syndrome. J Neurol Neurosurg Psychiatry 1998;51:1316-22.
9. Stokes MJ, Cooper RG, Edwards RH. Normal muscle strength and fatigability in patients with effort syndromes. BMJ 1988;297:1014-7.
10. Rutherford OM, White PD. Human quadriceps strength and fatiguability in patients with post viral fatigue. J Neurol Neurosurg Psychiatry 1991;54:961-4.
11. Make B, Jones JF. Impairment of patients with chronic fatigue syndrome. J Chronic fatigue syndrome 1997;3:43-55.
12. De Becker P, Roeykens J, Reynders M, McGregor N, Meirleir K. Exercise capacity in chronic fatigue syndrome. Arch Intern Med 2000;160:3270-7.
13. Edwards RH, Gibson H, Clague JE, Helliwell T. Muscle physiology and histopathology in chronic fatigue syndrome. In: Bock GR, Whelan J, eds. Chronic Fatigue Syndrome. Chichester, England: John Wiley & Sons Ltd, 1993:102-31.
14. White PD, Goldsmith KA, Johnson AL, Potts L, Walwyn R, DeCesare JC et al. Comparison of adaptive pacing therapy, cognitive behaviour therapy, graded exercise therapy, and specialist medical care for chronic fatigue syndrome (PACE): a randomised trial. Lancet 2011;377:823-36.
15. Lane RJ, Barrett MC, Taylor DJ, Kemp GJ, Lodi R. Heterogeneity in chronic fatigue syndrome: evidence from magnetic resonance spectroscopy of muscle. Neuromuscul Disord 1998;8:204-9.
16. Schillings ML, Kalkman MS, van der Werf SP, van Engelen BGM, Bleijenberg G, Zwarts MJ. Diminished central activation during maximal voluntary contraction in chronic fatigue syndrome. Clin Neurophysiol 2004;115:2518-24.
17. Nijs J, De Meirleir K, Duquet W. Kinesiophobia in chronic fatigue syndrome: assessment and association with disability. Arch Phys Med Rehabil 2004;85:1586-92.
18. Jones DEJ, Hollingsworth K, Blamire AM, Taylor R, Newton JL. Abnormalities in pH handling by peripheral muscle and potential regulation by the autonomic nervous system in chronic fatigue syndrome. J Intern Med 2010;26:394-401.
19. Newton JL, Okonkwo O, Sutcliffe K, Seth A, Shin J, Jones DEJ. Symptoms of autonomic dysfunction in chronic fatigue syndrome. QJM 2007;100:519-26.
20. Rowe PC, Calkins H. Neurally mediated hypotension and chronic fatigue syndrome. Am J Med 1998;105:15S-21S.
21. Schondorf R, Freeman R. The importance of orthostatic intolerance in the chronic fatigue syndrome. Am J Med Sci 1999;317:117-23.
22. Winkler AS, Blair D, Marsden JT, Peters TJ, Wessely S, Cleare AJ. Autonomic function and serum erythropoietin levels in chronic fatigue syndrome. J Psychosom Res 2004;56:179-83.
23. Hollingsworth K, Jones DEJ, Taylor R, Blamire A, Newton JL. Impaired cardiovascular response to standing in chronic fatigue syndrome. Eur J Clin Invest 2010;40:608-15.
24. Evering RMH, Weering MGH, Goothuis-Oudshoorn KC. Daily physical activity of patients with chronic fatigue syndrome: a systematic review. Clin Rehabil 2011;25:112-33.
25. Nijs J, Aelbrecht S, Meeus M, Van Oosterwijck J, Zinzen E, Clarys P. Tired of being inactive: a systematic literature review of physical activity, exercise capacity and muscle strength in patients with chronic fatigue syndrome. Disabil Rehabil 2010; PMID: 21166613 [Epub ahead of print].
26. Burton C, Knoop H, Popovic N, Sharpe M, Bleijenberg G. Reduced complexity of activity patterns in patients with Chronic Fatigue Syndrome: a case-control study. Biopsychosoc Med 2009;3:7.
27. Newton JL, Pairman J, Hallsworth K, Moore S, Plötz T, Trenell MI. Physical activity intensity but not sedentary activity is reduced in chronic fatigue syndrome and is associated with autonomic regulation. QJM 2011; PMID: 21382927 [Epub ahead of print].
28. Hollingsworth K, Newton JL, Taylor R, Blamire A, Jones DEJ. Loss of capacity to recover from acidosis in repeat exercise is strongly associated with fatigue in primary biliary cirrhosis. J Hepatol 2010;53:155-61.
29. Jones DE, Gray JC, Newton JL. Perceived fatigue is comparable between diseases. QJM 2009;102:617-24.
30. Fukuda K, Straus SE, Hickie I, Sharpe MC, Dobbins JG, Komaroff A. The chronic fatigue syndrome: a comprehensive approach to its definition and study. Ann Intern Med 1994;121:953-9.
31. Fisk JD, Ritvo PG, Ross L, Haase DA, Marrie TJ, Schlech WF. Measuring the functional impact of fatigue: initial validation of the fatigue impact scale. Clin Infect Dis 1994;18:S79-83.
32. Vanhamme L, Van Huffel S, Van Hecke P, Van Ormondt D. Time domain quantification of series of biomedical magnetic resonance spectroscopy signals. J Magn Reson 1999;140:120-30.
33. Beaver WL, Wasserman K, Whipp BJ. A new method for detecting anaerobic threshold by gas exchange. J Appl Physiol 1986;60:2020-7.
34. Nijs J, Vanherberghen K, Duquet W, De Meirleir K. Chronic fatigue syndrome: lack of association between pain-related fear of movement and exercise capacity and disability. Phys Ther 2004;84:696-705.
35. Trenell MI, Sue CM, Kemp GJ, Sachinwalla T, Thompson C. Aerobic exercise and muscle metabolism in patients with mitochondrial myopathy. Muscle Nerve 2006;33:524-31.
36. Kardos A, Taylor DJ, Thompson C, Styles P, Hands L, Collin J et al. Sympathetic denervation of the upper limb improves forearm exercise performance and skeletal muscle bioenergetics. Circulation 2000;101:2716-20.
37. Dudley CR, Taylor DJ, Ng LL, Kemp GJ, Ratcliffe PJ, Radda GK et al. Evidence for abnormal Na+/H+ antiport activity detected by phosphorus nuclear magnetic resonance spectroscopy in exercising skeletal muscle of patients with essential hypertension. Clin Sci 1990;79:491-7.
38. Nijs J, Van Oosterwijck J, Meeus M, Lambrecht L, Metzger K, Frémont M et al. Unravelling the nature of postexertional malaise in myalgic encephalomyelitis/chronic fatigue syndrome: the role of elastase, complement C4a and interleukin-1beta. J Intern Med 2010;267:418-35.
39. Meeus M, Roussel NA, Truijen S, Nijs J. Reduced pressure pain thresholds in response to exercise in chronic fatigue syndrome but not in chronic low back pain: an experimental study. Rehabil Med 2010;42:884-90.
40. Van Oosterwijck J, Nijs J, Meeus M, Lefever I, Huybrechts L, Lambrecht L et al. Pain inhibition and postexertional malaise in myalgic encephalomyelitis/chronic fatigue syndrome: an experimental study. J Intern Med 2010;268:265-78.