Antithyroid drug-induced hematopoietic damage: A retrospective cohort study of agranulocytosis and pancytopenia involving 50,385 patients with Graves' disease

Journal of Clinical Endocrinology and Metabolism

Volumn 97, Issue 1, 2012, Pages

  Watanabe, Natsuko ^a   Narimatsu, Hiroto ^b   Noh, Jaeduk Yoshimura ^a   Yamaguchi, Takuhiro ^c   Kobayashi, Kazuhiko ^d   Kami, Masahiro ^e   Kunii, Yo ^a   Mukasa, Koji ^a   Ito, Kunihiko ^a   Ito, Koichi ^a  

^a ITO HOSPITAL   (Japan)

^b YAMAGATA UNIVERSITY   (Japan)

^c TOHOKU UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^d JR Tokyo General Hospital   (Japan)

^e UNIVERSITY OF TOKYO   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

GRANULOCYTE COLONY STIMULATING FACTOR; PROPYLTHIOURACIL; STEROID; THIAMAZOLE;

ADOLESCENT; ADULT; AGED; AGRANULOCYTOSIS; ANEMIA; ARTICLE; CHILD; CLINICAL FEATURE; COHORT ANALYSIS; CONTROLLED STUDY; FEMALE; GRAVES DISEASE; HUMAN; INCIDENCE; JAPAN; MAJOR CLINICAL STUDY; MALE; MEDICAL RECORD; PANCYTOPENIA; PRIORITY JOURNAL; RETROSPECTIVE STUDY; SCHOOL CHILD; THROMBOCYTOPENIA; TREATMENT OUTCOME;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; AGRANULOCYTOSIS; ANTITHYROID AGENTS; CHILD; COHORT STUDIES; FEMALE; GRAVES DISEASE; HEMATOPOIESIS; HUMANS; JAPAN; MALE; METHIMAZOLE; MIDDLE AGED; PANCYTOPENIA; PROPYLTHIOURACIL; RETROSPECTIVE STUDIES; TOKYO; YOUNG ADULT;

EID: 84855499793     PISSN: 0021972X     EISSN: 19457197     Source Type: Journal    
DOI: 10.1210/jc.2011-2221     Document Type: Article

References (20)

1. Cooper DS 2005 Antithyroid drugs. N Engl J Med 352:905-917 (Pubitemid 40300299)
2. Biswas N, Ahn YH, Goldman JM, Schwartz JM 1991 Aplastic anemia associated with antithyroid drugs. Am J Med Sci 301:190-194
3. Escobar-Morreale HF, Bravo P, García-Robles R, García-Laraña J, de la Calle H, Sancho JM 1997 Methimazole-induced severe aplastic anemia: unsuccessful treatment with recombinant human granulocyte-monocyte colony-stimulating factor. Thyroid 7:67-70 (Pubitemid 27132900)
4. Jakucs J, Pocsay G 2006 Successful treatment of methimazole-induced severe aplastic anemia with recombinant human granulocyte colony-stimulating factor and high-dosage steroids. J Endocrinol Invest 29:74-77 (Pubitemid 43355839)
5. Levine B, Rosenberg DV 1954 Aplastic anemia during the treatment of hyperthyroidism with tapazole. Ann Intern Med 41:844-848
6. López-Karpovitch X, Ulloa-Aguirre A, von Eiff C, Hurtado-Monroy R, Alanis A 1992 Treatment of methimazole-induced severe aplastic anemia with recombinant human granulocyte-monocyte colony-stimulating factor and glucocorticosteroids. Acta Haematol 87:148-150
7. Mezquita P, Luna V, Muñoz-Torres M, Torres-Vela E, Lopez-Rodriguez F, Callejas JL, Escobar-Jimenez F 1998 Methimazole-induced aplastic anemia in third exposure: successful treatment with recombinant human granulocyte colony-stimulating factor. Thyroid 8:791-794 (Pubitemid 28535690)
8. Moreb J, Shemesh O, Shilo S, Manor C, Hershko C 1983 Transient methimazole-induced bone marrow aplasia: in vitro evidence for a humoral mechanism of bone marrow suppression. Acta Haematol 69:127-131 (Pubitemid 13180880)
9. Pearce SH 2004 Spontaneous reporting of adverse reactions to carbimazole and propylthiouracil in the UK. Clin Endocrinol (Oxf) 61:589-594 (Pubitemid 39540360)
10. Richardson JS, Sarkany I, Campbell CD 1954 Fatal case of marrow aplasia after treatment with carbimazole; the effect of ACTH. Br Med J 1:364-365
11. Michallet M, Sobh M, Morisset S, Kraghel S, Nicolini FE, Thomas X, Bienvenu AL, Picot S, Nicolle MC, Vanhems P 2011 Risk factors for invasive aspergillosis in acute myeloid leukemia patients prophylactically treated with posaconazole. Med Mycol 49:681-687
12. Yamamoto A, Katayama Y, Tomiyama K, Hosoai H, Hirata F, Kimura F, Fujita K, Yasuda H 2004 Methimazole-induced aplastic anemia caused by hypocellular bone marrow with plasmacytosis. Thyroid 14:231-235 (Pubitemid 38452196)
13. Wilcox G, Wong R, Elliot PJ, Topliss DJ, Stockigt JR 2003 Recovery From Carbimazole-Induced Aplastic Anemia. Int J Endocrinol Metab 1:41-43
14. Abalovich M, Amino N, Barbour LA, Cobin RH, De Groot LJ, Glinoer D, Mandel SJ, Stagnaro-Green A 2007 Management of thyroid dysfunction during pregnancy and postpartum: an Endocrine Society Clinical Practice Guideline. J Clin Endocrinol Metab 92:S1-S47 (Pubitemid 47236338)
15. Momotani N, Yamashita R, Makino F, Noh JY, Ishikawa N, Ito K 2000 Thyroid function in wholly breast-feeding infants whose mothers take high doses of propylthiouracil. Clin Endocrinol (Oxf) 53:177-181 (Pubitemid 30643451)
16. Solomon DH 1986 Treatment of Graves' hyperthyroidism. In: Ingbar SH, Braverman LE, eds. Werner's the thyroid. 5th ed. Philadelphia: JB Lippincott; 987-1014
17. Fibbe WE, Claas FH, Van der Star-Dijkstra W, Schaafsma MR, Meyboom RH, Falkenburg JH 1986 Agranulocytosis induced by propylthiouracil: evidence of a drug dependent antibody reacting with granulocytes, monocytes and haematopoietic progenitor cells. Br J Haematol 64:363-373
18. Douer D, Eisenstein Z 1988 Methimazole-induced agranulocytosis: growth inhibition of myeloid progenitor cells by the patient's serum. Eur J Haematol 40:91-94 (Pubitemid 18096920)
19. Akamizu T, Ozaki S, Hiratani H, Uesugi H, Sobajima J, Hataya Y, Kanamoto N, Saijo M, Hattori Y, Moriyama K, Ohmori K, Nakao K 2002 Drug-induced neutropenia associated with anti-neutrophil cytoplasmic antibodies (ANCA): possible involvement of complement in granulocyte cytotoxicity. Clin Exp Immunol 127:92-98 (Pubitemid 34155463)
20. Andrès E, Kurtz JE, Perrin AE, Dufour P, Schlienger JL, Maloisel F 2001 Haematopoietic growth factor in antithyroid-drug-induced agranulocytosis. QJM 94:423-428 (Pubitemid 32776284)