Preliminary experience with the use of bendamustine: A peculiar skin rash as the commonest side effect

Hematology/ Oncology and Stem Cell Therapy

Volumn 4, Issue 4, 2011, Pages 157-160

  Malipatil, Baswantrao ^a   Ganesan, Prasanth ^a   Sundersingh, Shirley ^a   Sagar, Tenali Gnana ^a  

^a Department of Medical Oncology   (India)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIHISTAMINIC AGENT; BENDAMUSTINE; CYCLOPHOSPHAMIDE; DOXORUBICIN; EMOLLIENT AGENT; FLUDARABINE; PREDNISOLONE; RITUXIMAB; VINCRISTINE;

ADULT; AGED; ALOPECIA; ANEMIA; BONE MARROW SUPPRESSION; CANCER COMBINATION CHEMOTHERAPY; CHEMOTHERAPY INDUCED EMESIS; CHRONIC LYMPHATIC LEUKEMIA; CLINICAL ARTICLE; DISEASE COURSE; DRUG ERUPTION; DRUG FEVER; DRUG SAFETY; DRUG TOLERABILITY; DRUG USE; EOSINOPHILIA; ERYTHEMA; FATIGUE; FEBRILE NEUTROPENIA; FEMALE; FOLLICULAR LYMPHOMA; HUMAN; HUMAN CELL; HUMAN TISSUE; INDIA; LOBAR PNEUMONIA; MALE; MONOTHERAPY; MULTIPLE CYCLE TREATMENT; NAUSEA; NEUTROPENIA; PAPULAR RASH; PRURITUS; RETROSPECTIVE STUDY; REVIEW; THROMBOCYTOPENIA; TREATMENT RESPONSE;

EID: 84855480362     PISSN: 16583876     EISSN: None     Source Type: Journal    
DOI: 10.5144/1658-3876.2011.157     Document Type: Review

References (12)

1. Gandhi V, Burger JA. Bendamustine in B-cell Malignancies: The new 46-year-old kid on the block. Clin Cancer Res 2009;15:7456-746.
2. Friedberg JW, Cohen P, Chen L, Robinson KS, Forero-Torres A, La Casce AS, Fayad LE, Bessudo A, Camacho ES, Williams ME, van der Jagt RH, Oliver JW, Cheson BD. Bendamustine in patients with rituximab-refractory indolent and transformed non-Hodgkin's lymphoma: results from a phase II multicenter, single-agent study. J Clin Oncol. 2008 Jan 10;26(2):204-10.
3. Robinson KS, Williams ME, van der Jagt RH, Cohen P, Herst JA, Tulpule A, Schwartzberg LS, Lemieux B, Cheson BD. Phase II multicenter study of bendamustine plus rituximab in patients with relapsed indolent B-cell and mantle cell non-Hodgkin's lymphoma. J Clin Oncol 2008;26:4473-9.
4. Knauf WU, Lissichkov T, Aldaoud A, Liberati A, Loscertales J, Herbrecht R, Juliusson G, Postner G, Gercheva L, Goranov S, Becker M, Fricke HJ, Huguet F, Del Giudice I, Klein P, Tremmel L, Merkle K, Montillo M. Phase III randomized study of bendamustine compared with chlorambucil in previously untreated patients with chronic lymphocytic leukemia. J Clin Oncol 2009;27:4378-84.
5. Rummel MJ, von Gruenhagen U, Niederle N. Bendamustine plus rituximab versus CHOP Plus Rituximab in the First-Line-Treatment of Patients with Follicular, Indolent and Mantle Cell Lymphomas: Results of a Randomized Phase III study of the study group indolent lymphomas (StiL). ASH Annual Meeting Abstracts 2008;112:2596.
6. Hallek M, Cheson BD, Catovsky D, Caligaris-Cappio F, Dighiero G, Döhner H, Hillmen P, Keating MJ, Montserrat E, Rai KR, Kipps TJ; International Workshop on Chronic Lymphocytic Leukemia. Guidelines for the diagnosis and treatment of chronic lymphocytic leukemia: a report from the International Workshop on Chronic Lymphocytic Leukemia updating the National Cancer Institute-Working Group 1996 guidelines. Blood. 2008 Jun 15;111(12):5446-56.
7. Cheson BD, Horning SJ, Coiffier B, Shipp MA, Fisher RI, Connors JM, Lister TA, Vose J, Grillo-López A, Hagenbeek A, Cabanillas F, Klippensten D, Hiddemann W, Castellino R, Harris NL, Armitage JO, Carter W, Hoppe R, Canellos GP. Report of an international workshop to standardize response criteria for non-Hodgkin's lymphomas. NCI Sponsored International Working Group. J Clin Oncol. 1999 Apr;17(4):1244.
8. Treanda [package insert] Available from: http://www.treanda.com/pdf/TREANDA_final_PI.pdf (accessed on 2011 May 5th)
9. Alamdari HS, Pinter-Brown L, Cassarino DS, Chiu MW. Severe cutaneous interface drug eruption associated with bendamustine. Dermatology Online Journal 2010;16 (7): 1
10. Weed RI. Exaggerated delayed hypersensitivity to mosquito bites in chronic lymphocytic leukaemia. Blood 1965; 26: 257-268.
11. Barzilai A, Shapiro D, Goldberg I, Yacob-Hirsch Y, Diaz-Cascajo C, Meytes D, et al. Insect bite-like reaction in patients with hematologic malignant neoplasms. Arch Dermatol 1999; 135: 1503-1507.
12. Lee A, Thomson J. Drug-induced skin reactions. In: Lee A, editor. Adverse drug reactions. 2nd ed. London. Pharmaceutical Press; 2006.