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Volumn 15, Issue 1, 2012, Pages 19-24

Metabolic disease drug discovery - "Hitting the target" is easier said than done

Author keywords

[No Author keywords available]

Indexed keywords

2,4 THIAZOLIDINEDIONE DERIVATIVE; ACARBOSE; DIPEPTIDYL PEPTIDASE IV INHIBITOR; EXENDIN 4; GLIBENCLAMIDE; GLIMEPIRIDE; GLIPIZIDE; GLUCAGON LIKE PEPTIDE 1 RECEPTOR AGONIST; HORMONE RECEPTOR STIMULATING AGENT; LINAGLIPTIN; LIRAGLUTIDE; MEGLITINIDE; METFORMIN; NATEGLINIDE; PIOGLITAZONE; REPAGLINIDE; ROSIGLITAZONE; SAXAGLIPTIN; SITAGLIPTIN; SULFONYLUREA; UNCLASSIFIED DRUG;

EID: 84855440149     PISSN: 15504131     EISSN: 19327420     Source Type: Journal    
DOI: 10.1016/j.cmet.2011.10.012     Document Type: Review
Times cited : (37)

References (50)
  • 2
    • 78651338445 scopus 로고    scopus 로고
    • Standards of medical care in diabetes - 2011
    • American Diabetes Association
    • American Diabetes Association Standards of medical care in diabetes - 2011 Diabetes Care 34 Suppl 1 2011 S11 S61
    • (2011) Diabetes Care , vol.34 , Issue.SUPPL. 1
  • 3
    • 79952050884 scopus 로고    scopus 로고
    • NIH proposes new drug development centre
    • N. Bristol NIH proposes new drug development centre Lancet 377 2011 705 706
    • (2011) Lancet , vol.377 , pp. 705-706
    • Bristol, N.1
  • 7
    • 0028803336 scopus 로고
    • Both subcutaneously and intravenously administered glucagon-like peptide i are rapidly degraded from the NH2-terminus in type II diabetic patients and in healthy subjects
    • C.F. Deacon, M.A. Nauck, M. Toft-Nielsen, L. Pridal, B. Willms, and J.J. Holst Both subcutaneously and intravenously administered glucagon-like peptide I are rapidly degraded from the NH2-terminus in type II diabetic patients and in healthy subjects Diabetes 44 1995 1126 1131
    • (1995) Diabetes , vol.44 , pp. 1126-1131
    • Deacon, C.F.1    Nauck, M.A.2    Toft-Nielsen, M.3    Pridal, L.4    Willms, B.5    Holst, J.J.6
  • 8
    • 0036290037 scopus 로고    scopus 로고
    • Dipeptidyl peptidase IV inhibition as an approach to the treatment and prevention of type 2 diabetes: A historical perspective
    • DOI 10.1016/S0006-291X(02)00359-5, PII S0006291X02003595
    • C.F. Deacon, and J.J. Holst Dipeptidyl peptidase IV inhibition as an approach to the treatment and prevention of type 2 diabetes: a historical perspective Biochem. Biophys. Res. Commun. 294 2002 1 4 (Pubitemid 34687205)
    • (2002) Biochemical and Biophysical Research Communications , vol.294 , Issue.1 , pp. 1-4
    • Deacon, C.F.1    Holst, J.J.2
  • 9
    • 2342599057 scopus 로고    scopus 로고
    • One Week's Treatment with the Long-Acting Glucagon-Like Peptide 1 Derivative Liraglutide (NN2211) Markedly Improves 24-h Glycemia and α- and β-Cell Function and Reduces Endogenous Glucose Release in Patients with Type 2 Diabetes
    • DOI 10.2337/diabetes.53.5.1187
    • K.B. Degn, C.B. Juhl, J. Sturis, G. Jakobsen, B. Brock, V. Chandramouli, J. Rungby, B.R. Landau, and O. Schmitz One week's treatment with the long-acting glucagon-like peptide 1 derivative liraglutide (NN2211) markedly improves 24-h glycemia and alpha- and beta-cell function and reduces endogenous glucose release in patients with type 2 diabetes Diabetes 53 2004 1187 1194 (Pubitemid 38569002)
    • (2004) Diabetes , vol.53 , Issue.5 , pp. 1187-1194
    • Degn, K.B.1    Juhl, C.B.2    Sturis, J.3    Jakobsen, G.4    Brock, B.5    Chandramouli, V.6    Rungby, J.7    Landau, B.R.8    Schmitz, O.9
  • 10
    • 0036391928 scopus 로고    scopus 로고
    • Rebuttal to Deacon and Holst: "metformin effects on dipeptidyl peptidase IV degradation of glucagon-like peptide-1" versus "dipeptidyl peptidase inhibition as an approach to the treatment and prevention of type 2 diabetes: A historical perspective"
    • H.-U. Demuth, S.A. Hinke, R.A. Pederson, and C.H. McIntosh Rebuttal to Deacon and Holst: "Metformin effects on dipeptidyl peptidase IV degradation of glucagon-like peptide-1" versus "Dipeptidyl peptidase inhibition as an approach to the treatment and prevention of type 2 diabetes: a historical perspective" Biochem. Biophys. Res. Commun. 296 2002 229 232
    • (2002) Biochem. Biophys. Res. Commun. , vol.296 , pp. 229-232
    • Demuth, H.-U.1    Hinke, S.A.2    Pederson, R.A.3    McIntosh, C.H.4
  • 11
    • 33644618433 scopus 로고    scopus 로고
    • The biology of incretin hormones
    • D.J. Drucker The biology of incretin hormones Cell Metab. 3 2006 153 165
    • (2006) Cell Metab. , vol.3 , pp. 153-165
    • Drucker, D.J.1
  • 12
    • 79952766376 scopus 로고    scopus 로고
    • Cardiovascular safety and diabetes drug development
    • D.J. Drucker, and A.B. Goldfine Cardiovascular safety and diabetes drug development Lancet 377 2011 977 979
    • (2011) Lancet , vol.377 , pp. 977-979
    • Drucker, D.J.1    Goldfine, A.B.2
  • 13
    • 0026648961 scopus 로고
    • Isolation and characterization of exendin-4, an exendin-3 analogue, from Heloderma suspectum venom. Further evidence for an exendin receptor on dispersed acini from guinea pig pancreas
    • J. Eng, W.A. Kleinman, L. Singh, G. Singh, and J.P. Raufman Isolation and characterization of exendin-4, an exendin-3 analogue, from Heloderma suspectum venom. Further evidence for an exendin receptor on dispersed acini from guinea pig pancreas J. Biol. Chem. 267 1992 7402 7405
    • (1992) J. Biol. Chem. , vol.267 , pp. 7402-7405
    • Eng, J.1    Kleinman, W.A.2    Singh, L.3    Singh, G.4    Raufman, J.P.5
  • 14
    • 0037850667 scopus 로고    scopus 로고
    • Effect on glycemic control of exenatide (synthetic exendin-4) additive to existing metformin and/or sulfonylurea treatment in patients with type 2 diabetes
    • DOI 10.2337/diacare.26.8.2370
    • M.S. Fineman, T.A. Bicsak, L.Z. Shen, K. Taylor, E. Gaines, A. Varns, D. Kim, and A.D. Baron Effect on glycemic control of exenatide (synthetic exendin-4) additive to existing metformin and/or sulfonylurea treatment in patients with type 2 diabetes Diabetes Care 26 2003 2370 2377 (Pubitemid 36993328)
    • (2003) Diabetes Care , vol.26 , Issue.8 , pp. 2370-2377
    • Fineman, M.S.1    Bicsak, T.A.2    Shen, L.Z.3    Taylor, K.4    Gaines, E.5    Varns, A.6    Kim, D.7    Baron, A.D.8
  • 16
    • 84855436804 scopus 로고    scopus 로고
    • New mechanisms and translational paradigms
    • B.H. Littman, R. Krishnan, Cambridge University Press Cambridge, UK
    • G. Gaich, and D. Moller New mechanisms and translational paradigms B.H. Littman, R. Krishnan, Translational Medicine and Drug Discovery 2011 Cambridge University Press Cambridge, UK 89 108
    • (2011) Translational Medicine and Drug Discovery , pp. 89-108
    • Gaich, G.1    Moller, D.2
  • 18
    • 67749104112 scopus 로고    scopus 로고
    • Treatment of type 2 diabetes with glucagon-like peptide-1 receptor agonists
    • K.B. Hansen, F.K. Knop, J.J. Holst, and T. Vilsbøll Treatment of type 2 diabetes with glucagon-like peptide-1 receptor agonists Int. J. Clin. Pract. 63 2009 1154 1160
    • (2009) Int. J. Clin. Pract. , vol.63 , pp. 1154-1160
    • Hansen, K.B.1    Knop, F.K.2    Holst, J.J.3    Vilsbøll, T.4
  • 19
    • 78650846239 scopus 로고    scopus 로고
    • Patent watch: The patent cliff steepens
    • C. Harrison Patent watch: the patent cliff steepens Nat. Rev. Drug Discov. 10 2011 12 13
    • (2011) Nat. Rev. Drug Discov. , vol.10 , pp. 12-13
    • Harrison, C.1
  • 20
    • 79959796830 scopus 로고    scopus 로고
    • Impact of the U.S. Food and Drug Administration cardiovascular assessment requirements on the development of novel antidiabetes drugs
    • B. Hirshberg, and I. Raz Impact of the U.S. Food and Drug Administration cardiovascular assessment requirements on the development of novel antidiabetes drugs Diabetes Care 34 Suppl 2 2011 S101 S106
    • (2011) Diabetes Care , vol.34 , Issue.SUPPL. 2
    • Hirshberg, B.1    Raz, I.2
  • 22
    • 66449084532 scopus 로고    scopus 로고
    • Torcetrapib induces aldosterone and cortisol production by an intracellular calcium-mediated mechanism independently of cholesteryl ester transfer protein inhibition
    • X. Hu, J.D. Dietz, C. Xia, D.R. Knight, W.T. Loging, A.H. Smith, H. Yuan, D.A. Perry, and J. Keiser Torcetrapib induces aldosterone and cortisol production by an intracellular calcium-mediated mechanism independently of cholesteryl ester transfer protein inhibition Endocrinology 150 2009 2211 2219
    • (2009) Endocrinology , vol.150 , pp. 2211-2219
    • Hu, X.1    Dietz, J.D.2    Xia, C.3    Knight, D.R.4    Loging, W.T.5    Smith, A.H.6    Yuan, H.7    Perry, D.A.8    Keiser, J.9
  • 24
    • 84855450159 scopus 로고    scopus 로고
    • International Diabetes Federation
    • International Diabetes Federation (2011). IDF Disease Atlas (http://www.diabetesatlas.org).
    • (2011) IDF Disease Atlas
  • 25
    • 83255187213 scopus 로고    scopus 로고
    • The efficacy and safety of liraglutide
    • K.-H. Jeong, and B.K. Yoo The efficacy and safety of liraglutide Int. J. Clin. Pharmacol. 33 2011 740 749
    • (2011) Int. J. Clin. Pharmacol. , vol.33 , pp. 740-749
    • Jeong, K.-H.1    Yoo, B.K.2
  • 26
    • 38349090575 scopus 로고    scopus 로고
    • The state of innovation in drug development
    • I. Kola The state of innovation in drug development Clin. Pharmacol. Ther. 83 2008 227 230
    • (2008) Clin. Pharmacol. Ther. , vol.83 , pp. 227-230
    • Kola, I.1
  • 27
    • 0023638829 scopus 로고
    • Glucagon-like peptide-1 7-36: A physiological incretin in man
    • B. Kreymann, G. Williams, M.A. Ghatei, and S.R. Bloom Glucagon-like peptide-1 7-36: a physiological incretin in man Lancet 2 1987 1300 1304 (Pubitemid 17156636)
    • (1987) Lancet , vol.2 , Issue.8571 , pp. 1300-1304
    • Kreymann, B.1    Williams, G.2    Ghatei, M.A.3    Bloom, S.R.4
  • 30
    • 68949209293 scopus 로고    scopus 로고
    • The current status and future perspectives of studies of cannabinoid receptor 1 antagonists as anti-obesity agents
    • H.K. Lee, E.B. Choi, and C.S. Pak The current status and future perspectives of studies of cannabinoid receptor 1 antagonists as anti-obesity agents Curr. Top. Med. Chem. 9 2009 482 503
    • (2009) Curr. Top. Med. Chem. , vol.9 , pp. 482-503
    • Lee, H.K.1    Choi, E.B.2    Pak, C.S.3
  • 32
    • 79956319051 scopus 로고    scopus 로고
    • Progress and challenges in translating the biology of atherosclerosis
    • P. Libby, P.M. Ridker, and G.K. Hansson Progress and challenges in translating the biology of atherosclerosis Nature 473 2011 317 325
    • (2011) Nature , vol.473 , pp. 317-325
    • Libby, P.1    Ridker, P.M.2    Hansson, G.K.3
  • 34
    • 78649842241 scopus 로고    scopus 로고
    • Genomics, type 2 diabetes, and obesity
    • M.I. McCarthy Genomics, type 2 diabetes, and obesity N. Engl. J. Med. 363 2010 2339 2350
    • (2010) N. Engl. J. Med. , vol.363 , pp. 2339-2350
    • McCarthy, M.I.1
  • 35
    • 0027215348 scopus 로고
    • Dipeptidyl-peptidase IV hydrolyses gastric inhibitory polypeptide, glucagon-like peptide-1(7-36)amide, peptide histidine methionine and is responsible for their degradation in human serum
    • R. Mentlein, B. Gallwitz, and W.E. Schmidt Dipeptidyl-peptidase IV hydrolyses gastric inhibitory polypeptide, glucagon-like peptide-1(7-36)amide, peptide histidine methionine and is responsible for their degradation in human serum Eur. J. Biochem. 214 1993 829 835 (Pubitemid 23188160)
    • (1993) European Journal of Biochemistry , vol.214 , Issue.3 , pp. 829-835
    • Mentlein, R.1    Gallwitz, B.2    Schmidt, W.E.3
  • 36
    • 34548561183 scopus 로고    scopus 로고
    • Fixing the paradigm for biopharmaceutical R&D: Where to start?
    • C.-P. Milne Fixing the paradigm for biopharmaceutical R&D: Where to start? Int. J. Biotechnol. 10 2008 404 415
    • (2008) Int. J. Biotechnol. , vol.10 , pp. 404-415
    • Milne, C.-P.1
  • 37
    • 72449153412 scopus 로고    scopus 로고
    • Can translational medicine bring us out of the R&D wilderness?
    • C.-P. Milne Can translational medicine bring us out of the R&D wilderness? Personalized Medicine 6 2009 543 553
    • (2009) Personalized Medicine , vol.6 , pp. 543-553
    • Milne, C.-P.1
  • 38
  • 39
    • 0027248866 scopus 로고
    • Normalization of fasting hyperglycaemia by exogenous glucagon-like peptide 1 (7-36 amide) in Type 2 (non-insulin-dependent) diabetic patients
    • M.A. Nauck, N. Kleine, C. Orskov, J.J. Holst, B. Willms, and W. Creutzfeldt Normalization of fasting hyperglycaemia by exogenous glucagon-like peptide 1 (7-36 amide) in type 2 (non-insulin-dependent) diabetic patients Diabetologia 36 1993 741 744 (Pubitemid 23218642)
    • (1993) Diabetologia , vol.36 , Issue.8 , pp. 741-744
    • Nauck, M.A.1    Kleine, N.2    Orskov, C.3    Holst, J.J.4    Willms, B.5    Creutzfeldt, W.6
  • 40
    • 78650753885 scopus 로고    scopus 로고
    • Incretin-based therapies for type 2 diabetes mellitus: Properties, functions, and clinical implications
    • M.A. Nauck Incretin-based therapies for type 2 diabetes mellitus: properties, functions, and clinical implications Am. J. Med. 124 1, Suppl 2011 S3 S18
    • (2011) Am. J. Med. , vol.124 , Issue.1 SUPPL.
    • Nauck, M.A.1
  • 44
    • 70249134919 scopus 로고    scopus 로고
    • Molecular networks as sensors and drivers of common human diseases
    • E.E. Schadt Molecular networks as sensors and drivers of common human diseases Nature 461 2009 218 223
    • (2009) Nature , vol.461 , pp. 218-223
    • Schadt, E.E.1


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