Life-threatening and fatal infections in children with acute myeloid leukemia: A report from the Children's Oncology Group

Journal of Pediatric Hematology/Oncology

Volumn 34, Issue 1, 2012, Pages

  Sung, Lillian ^a   Buxton, Allen ^b   Gamis, Alan ^c   Woods, William G ^d   Alonzo, Todd A ^e  

^a HOSPITAL FOR SICK CHILDREN   (Canada)

^b CHILDREN S ONCOLOGY GROUP   (United States)

^c CHILDREN S MERCY HOSPITAL   (United States)

^d EMORY UNIVERSITY   (United States)

^e UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

Author keywords

acute myeloid leukemia; children; infections

Indexed keywords

ASPARAGINASE; ASPARAGINASE 1; AZACITIDINE; CYCLOPHOSPHAMIDE; CYTARABINE; DAUNORUBICIN; DEXAMETHASONE; ETOPOSIDE; TIOGUANINE; UNCLASSIFIED DRUG; VINCRISTINE;

ACUTE GRANULOCYTIC LEUKEMIA; ALLOGENEIC STEM CELL TRANSPLANTATION; ARTICLE; BACTERIAL INFECTION; CANCER COMBINATION CHEMOTHERAPY; CANCER REGRESSION; CANCER SURVIVAL; CHILD; CHILDHOOD CANCER; CONTROLLED STUDY; DISEASE ASSOCIATION; DISEASE FREE SURVIVAL; DISEASE SEVERITY; DRUG EFFICACY; DRUG MEGADOSE; FEMALE; HUMAN; INDUCTION CHEMOTHERAPY; INFECTION RISK; MAJOR CLINICAL STUDY; MALE; MULTIPLE CYCLE TREATMENT; MYCOSIS; OVERALL SURVIVAL; PRESCHOOL CHILD; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; RISK ASSESSMENT; SCHOOL CHILD; VIRUS INFECTION;

FEMALE; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HUMANS; INFECTION; LEUKEMIA, MYELOID, ACUTE; LOGISTIC MODELS; MALE; TRANSPLANTATION, HOMOLOGOUS;

EID: 84855437634     PISSN: 10774114     EISSN: 15363678     Source Type: Journal    
DOI: 10.1097/MPH.0b013e31822817a6     Document Type: Article

References (15)

1. Sung L, Aplenc R, Zaoutis T, et al. Infections in pediatric acute myeloid leukemia: lessons learned and unresolved questions. Pediatr Blood Cancer. 2008;51:458-460.
2. Lehrnbecher T, Varwig D, Kaiser J, et al. Infectious complications in pediatric acute myeloid leukemia: analysis of the prospective multi-institutional clinical trial AML-BFM 93. Leukemia. 2004;18:72-77. (Pubitemid 38159441)
3. Brunet AS, Ploton C, Galambrun C, et al. Low incidence of sepsis due to viridans streptococci in a ten-year retrospective study of pediatric acute myeloid leukemia. Pediatr Blood Cancer. 2006;47:765-772. (Pubitemid 44476752)
4. Riley LC, Hann IM, Wheatley K, et al. Treatment-related deaths during induction and first remission of acute myeloid leukaemia in children treated on the Tenth Medical Research Council acute myeloid leukaemia trial (MRC AML10). The MCR Childhood Leukaemia Working Party. Br J Haematol. 1999;106:436-444. (Pubitemid 29450670)
5. Stevens RF, Hann IM, Wheatley K, et al. Marked improvements in outcome with chemotherapy alone in paediatric acute myeloid leukemia: results of the United Kingdom Medical Research Council's 10th AML trial. MRC Childhood Leukaemia Working Party. Br J Haematol. 1998;101: 130-140. (Pubitemid 28197786)
6. Woods WG, Kobrinsky N, Buckley JD, et al. Timed-sequential induction therapy improves postremission outcome in acute myeloid leukemia: a report from the Children's Cancer Group. Blood. 1996;87:4979-4989. (Pubitemid 26189839)
7. Woods WG, Neudorf S, Gold S, et al. A comparison of allogeneic bone marrow transplantation, autologous bone marrow transplantation, and aggressive chemotherapy in children with acute myeloid leukemia in remission. Blood. 2001;97:56-62. (Pubitemid 32061242)
8. Sung L, Gamis A, Alonzo TA, et al. Infections and association with different intensity of chemotherapy in children with acute myeloid leukemia. Cancer. 2009;115:1100-1108.
9. Alonzo TA, Kobrinsky NL, Aledo A, et al. Impact of granulocyte colony-stimulating factor use during induction for acute myelogenous leukemia in children: a report from the Children's Cancer Group. J Pediatr Hematol Oncol. 2002;24: 627-635. (Pubitemid 35285101)
10. Creutzig U, Zimmermann M, Reinhardt D, et al. Early deaths and treatment-related mortality in children undergoing therapy for acute myeloid leukemia: analysis of the multicenter clinical trials AML-BFM 93 and AML-BFM 98. J Clin Oncol. 2004;22:4384-4393. (Pubitemid 41185159)
11. Sung L, Lange BJ, Gerbing RB, et al. Microbiologically documented infections and infection-related mortality in children with acute myeloid leukemia. Blood. 2007;110: 3532-3539. (Pubitemid 350159617)
12. Gassas A, Grant R, Richardson S, et al. Predictors of viridans streptococcal shock syndrome in bacteremic children with cancer and stem-cell transplant recipients. J Clin Oncol. 2004;22:1222-1227. (Pubitemid 41079835)
13. Okamoto Y, Ribeiro RC, Srivastava DK, et al. Viridans streptococcal sepsis: clinical features and complications in childhood acute myeloid leukemia. J Pediatr Hematol Oncol. 2003;25:696-703. (Pubitemid 37087505)
14. Gamis AS, Howells WB, DeSwarte-Wallace J, et al. Alpha hemolytic streptococcal infection during intensive treatment for acute myeloid leukemia: a report from the Children's cancer group study CCG-2891. J Clin Oncol. 2000;18: 1845-1855. (Pubitemid 30261922)
15. Hamalainen S, Kuittinen T, Matinlauri I, et al. Neutropenic fever and severe sepsis in adult acute myeloid leukemia (AML) patients receiving intensive chemotherapy: causes and consequences. Leuk Lymphoma. 2008;49:495-501. (Pubitemid 351298333)