Integrated transcriptomic and proteomic evaluation of gentamicin nephrotoxicity in rats

Toxicology and Applied Pharmacology

Volumn 258, Issue 1, 2012, Pages 124-133

  Com, Emmanuelle ^a,b   Boitier, Eric ^a   Marchandeau, Jean Pierre ^a   Brandenburg, Arnd ^c   Schroeder, Susanne ^d   Hoffmann, Dana ^e   Mally, Angela ^e   Gautier, Jean Charles ^a  

^a SANOFI   (France)

^b INSERM   (France)

^c GENEDATA AG   (Switzerland)

^d Nycomed GmbH   (Germany)

^e UNIVERSITY OF WÜRZBURG   (Germany)

Author keywords

Gentamicin; Nephrotoxicity; Proteomics; Transcriptomics

Indexed keywords

BIOLOGICAL MARKER; GENTAMICIN; GLYCINE AMIDINOTRANSFERASE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE 14; PLASMA RETINOL BINDING PROTEIN; PLASMA RETINOL BINDING PROTEIN PRECURSOR 4; T LYMPHOCYTE RECEPTOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD CELL; CELL ENERGY; CELL INFILTRATION; DISORDERS OF MITOCHONDRIAL FUNCTIONS; ENERGY YIELD; GENE EXPRESSION; HISTOPATHOLOGY; INFLAMMATION; KIDNEY; KIDNEY CELL; KIDNEY TUBULE DAMAGE; KIDNEY TUBULE NECROSIS; MALE; MASS SPECTROMETRY; MONONUCLEAR CELL; NEPHROTOXICITY; NONHUMAN; OXIDATIVE STRESS; PROTEIN SYNTHESIS; PROTEOMICS; RAT; TRANSCRIPTOMICS; TWO DIMENSIONAL GEL ELECTROPHORESIS;

ANIMALS; ANTI-BACTERIAL AGENTS; BIOLOGICAL MARKERS; GENE EXPRESSION PROFILING; GENTAMICINS; KIDNEY; MALE; PROTEOMICS; RATS; RATS, WISTAR;

RATTUS; RATTUS NORVEGICUS;

EID: 84855421692     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2011.10.015     Document Type: Article

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