Huperzine A derivative M3 protects PC12 cells against sodium nitroprusside-induced apoptosis

Acta Pharmacologica Sinica

Volumn 33, Issue 1, 2012, Pages 34-40

  Ning, Na ^a   Hu, Jin Feng ^a   Yuan, Yu He ^a   Zhang, Xin Yuan ^a   Dai, Jun Gui ^a   Chen, Nai Hong ^a  

^a INSTITUTE OF MATERIA MEDICA   (China)

Author keywords

apoptosis; Hsp70; huperzine A; M3; PC12 cell; quercetin; ROS; sodium nitroprusside

Indexed keywords

CASPASE 3; HEAT SHOCK PROTEIN 70; HUPERZINE A; IODIDE; LIPOCORTIN 5; M3 (DRUG); MALONALDEHYDE; NITROPRUSSIDE SODIUM; QUERCETIN; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL STRAIN; CELL VIABILITY; CONTROLLED STUDY; FLUOROPHOTOMETRY; NONHUMAN; RAT;

ALKALOIDS; ANIMALS; ANTIOXIDANTS; APOPTOSIS; CELL SURVIVAL; HSP70 HEAT-SHOCK PROTEINS; HUMANS; MALONDIALDEHYDE; MOLECULAR STRUCTURE; NEUROPROTECTIVE AGENTS; NITRIC OXIDE DONORS; NITROPRUSSIDE; PC12 CELLS; QUERCETIN; RATS; REACTIVE OXYGEN SPECIES; SESQUITERPENES;

EID: 84855417119     PISSN: 16714083     EISSN: 17457254     Source Type: Journal    
DOI: 10.1038/aps.2011.147     Document Type: Article

References (18)

1. Abdulwahid Al, Ahmad KH. Environmental toxins and Parkinson's disease: putative roles of impaired electron transport chain and oxidative stress. Toxicol Ind Health 2010; 26: 121-8.
2. Bonda DJ, Wang X, Perry G, Smith MA, Zhu X. Mitochondrial dynamics in Alzheimer's disease: opportunities for future treatment strategies. Drugs Aging 2010; 27: 181-92.
3. Thirumalai D, Lorimer GH. Chaperonin mediated protein folding. Annu Rev Biophys Biomol Struct 2001; 30: 245-69.
4. Hartl FU. Molecular chaperones in cellular protein folding. Nature 1996; 381: 571-9.
5. Pytlowany M, Strosznajder JB, Jesko H, Cakała M, Strosznajder RP. Molecular mechanism of PC12 cell death evoked by sodium nitro-prusside, a nitric oxide donor. Acta Biochim Pol 2008; 55: 339-47. (Pubitemid 351947548)
6. Yoko Hirata. Manganese-induced apoptosis in PC12 cells. Neuro-toxicol Teratol 2002; 24: 639-53.
7. Lahiri DK, Ge YW. Role of the APP promoter in Alzheimer's disease: cell type-specifc expression of the β-amyloid precursor protein. Ann N Y Acad Sci 2004; 1030: 310-6. (Pubitemid 40378928)
8. Zhang HY, Tang XC. Neuroprotective effects of huperzine A: new therapeutic targets for neurodegenerative disease. Trends Pharmacol Sci 2006; 27: 619-25. (Pubitemid 44738090)
9. Zhang HY, Brimijoin S, Tang XC. Apoptosis induced by beta-amyloid25-35 in acetylcholinesterase-overexpressing neuroblastoma cells. Acta Pharmacol Sin 2003; 24: 853-8.
10. Zhang XY, Zou JH, Dai JG. Microbial transformation of (-)-huperzine A. Tetrahedron Lett 2010; 51: 3840-2.
11. Malinski T. Nitric oxide and nitroxidative stress in Alzheimer's disease. J Alzheimers Dis 2007; 11: 207-18. (Pubitemid 47018067)
12. Imam SZ, el-Yazal J, Newport GD, Itzhak Y, Cadet JL, Slikker W Jr, et al. Methamphetamine-induced dopaminergic neurotoxicity: role of peroxynitrite and neuroprotective role of antioxidants and peroxynitrite decomposition catalysts. Ann N Y Acad Sci 2001; 939: 366-80. (Pubitemid 32620088)
13. Hishiya A, Takayama S. Molecular chaperones as regulators of cell death. Oncogene 2008; 27: 6489-506.
14. Tutar L, Tutar Y. Heat shock proteins, an overview. Curr Pharm Biotechnol 2010; 11: 216-22.
15. Kabakov AE, Gabai VL. Heat-shock proteins maintain the viability of ATP-deprived cells: what is the mechanism? Trends Cell Biol 1994; 4: 193-6. (Pubitemid 24152415)
16. Gabai VL, Meriin AB, Yaglom JA, Volloch VZ, Sherman MY. Role of Hsp70 in regulation of stress-kinase JNK: implications in apoptosis and aging. FEBS Lett 1998; 438: 1-4. (Pubitemid 28517824)
17. Kumar Y, Tatu U. Stress protein fux during recovery from simulated ischemia: induced heat shock protein 70 confers cytoprotection by suppressing JNK activation and inhibiting apoptotic cell death. Proteomics 2003; 3: 513-26. (Pubitemid 36428303)
18. Kim YM, de Vera ME, Watkins SS, Billiar TR. Nitric oxide protects cultured rat hepatocytes from tumor necrosis factor induced apo pto-sis by inducing heat shock protein 70 expression. J Biol Chem 1997; 272: 1402-11. (Pubitemid 27034647)