Altered brain serotonergic neurotransmission following caffeine withdrawal produces behavioral deficits in rats

Pakistan Journal of Pharmaceutical Sciences

Volumn 25, Issue 1, 2012, Pages 21-25

  Khaliq, Saima ^b   Haider, Saida ^a   Naqvi, Faizan ^a   Perveen, Tahira ^a   Saleem, Sadia ^a   Haleem, Darakhshan Jabeen ^a  

^a UNIVERSITY OF KARACHI   (Pakistan)

^b FEDERAL URDU UNIVERSITY OF ARTS   (Pakistan)

Author keywords

Caffeine; Depression; Memory; Serotonin

Indexed keywords

5 HYDROXYINDOLEACETIC ACID; CAFFEINE; SEROTONIN;

AMNESIA; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BEHAVIOR DISORDER; BRAIN; BRAIN LEVEL; CONTROLLED STUDY; DEPRESSION; FORCED SWIMMING TEST; IMMOBILIZATION; MAZE TEST; MEMORY; NONHUMAN; RAT; SEROTONINERGIC SYSTEM;

ANIMALS; BRAIN; CAFFEINE; DEPRESSION; DISEASE MODELS, ANIMAL; HUMANS; HYDROXYINDOLEACETIC ACID; IMMOBILITY RESPONSE, TONIC; MAZE LEARNING; MEMORY DISORDERS; RATS; RATS, WISTAR; SEROTONIN; SUBSTANCE WITHDRAWAL SYNDROME; SYNAPTIC TRANSMISSION;

EID: 84855406687     PISSN: 1011601X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (33)

1. Bernstein GA, Carroll ME, Crosby RD, Perwien AR, Go FS and Benowitz NL (1994). Caffeine effects on learning, performance, and anxiety in normal school-age children. J. Am. Acad. Child Adolesc. Psychiatry, 33(3): 407-415. (Pubitemid 24073283)
2. Bernstein GA, Carroll ME, Dean NW, Crosby RD, Perwien AR and Benowitz NL. (1998). Caffeine withdrawal in normal school-age children. J. Am. Acad. Child Adolesc. Psychiatry, 37(8): 858-65. (Pubitemid 28354820)
3. Bruce MS. (1990). The anxiogenic effects of caffeine. Postgard Med. J., 66: 581-584.
4. Cacciatore R, Helbling A, Jost C and Hess B. (1996). Episodic headache, diminished performance and depressive mood. Schweiz. Rundsch. Med. Prax., 85(22): 727-729. (Pubitemid 126599757)
5. Corrodi H, Fuxem K and Jonsson. (1972) Effect of caffeine on central monoamines neurons. J. Pharm. Pharmacol., 24(2): 155-158.
6. Cunha RA and Agostinho PM. (2010). Chronic caffeine consumption prevents memory disturbance in different animals models of memory decline. J. Alzheimers Dis. Ahead to print.
7. Fernstrom MH, Bazil CW and Fernstrom JD. (1984). Caffeine injection raises brain trypytophan level, but does not stimulate the rate of serotonin in rat brain. Life Sci., 35(12): 1241-1247. (Pubitemid 14068961)
8. Greden JF (1974). Anxiety or caffeinism: A diagnostic dilemma. Am. J. Psychiatry, 131: 1089-1092.
9. Hadfield MG and Milio C (1989) Caffeine and regional brain monoamine utilization in mice. Life Sci., 45(26): 2637-2644. (Pubitemid 20012144)
10. Haider S, Khaliq S, Ahmed SP and Haleem DJ (2006). Long term tryptophan administration enhances cognitive performance and increases 5HT metabolism in the hippocampus of female rats.Amino Acids, 31:1-6.
11. Haider S, Shameem S, Ahmed SP, Perveen T and Haleem DJ (2005). Repeated administration of lead decreases brain 5HT metabolism and produces memory deficits in rats. Cellular & Molecular Biology, 10: 669-676. (Pubitemid 43161691)
12. Haleem DJ and Haider S (1996). Food restriction decreases serotonin and its syntheses rate in the hypothalamus. Neuroreport, 7: 1153-1156. (Pubitemid 26227029)
13. Haleem DJ, Yasmeen A, Haleem MA and Zafar A (1995). 24h withdrawal following repeated administration of caffeine attenuates brain serotonin but not tryptophan in rat brain: implications for caffeine induced depression. Life Sci., 57(19): 285-292.
14. Hughes JR, Higgins ST, Bickel WK, Hunt WK, Fenwick JW, Gulliver SB and Mireault GC (1991). Caffeine self-administration, withdrawal, and adverse effects among coffee drinkers. Arch. Gen. Psychiatry, 48(7): 611-617.
15. Khaliq S, Haider S, Ahmed SP, Perveen T and Haleem DJ (2006). Relationship of brain tryptophan and serotonin in improving cognitive performance in rats. Pak. J. Pharm. Sci., 19(1): 11-15.
16. Kirch DG, Taylor TR, Gerhardt GA, Benowitz NL, Stephen C and Wyatt RJ (1990). Effect of chronic caffeine administration on monoamine and monoaminines metabolite concentrations in brain. Neuropharmacology, 29(6): 599-602. (Pubitemid 20194700)
17. Kyle J, Fox HC and Whalley LJ (2010). Caffeine, cognition and socioeconomic status. J. Alzheimers, ahead to print.
18. Lieberman HR, Wurtman RJ, Ernde CG, Roberto C, Coviella I.G (1987). The effect of low doses of caffeine on human performance and mood. Psycho-pharmacology, 92: 308-312. (Pubitemid 17100477)
19. Lieberman HR, Tharion WJ, Shukitt-Hale B, Speckman KL and Tulley R (2002). Effects of caffeine, sleep loss, and stress on cognitive performance and mood during U.S. Navy SEAL training. Psychopharmacology, (Berl)., 164(3): 250-261.
20. MacIntosh BR and Wright BM (1995). Caffeine ingestion and performance of a 1,500-metre swim. Can. J. Appl. Physiol., 20(2): 168-177.
21. Morris RGM (1981). Spatial localization does not require the presence of local cues. Learning and Motivation, 12: 239-260.
22. Nehlig A (2010). Is caffeine a cognitive enhancer? J. Alzheimers Dis., Ahead to print.
23. Owens MJ and Nemeroff CB (1994). Role of serotonin in the pathophysiology of depression: Focus on the serotonin transporter. Clin. Chem., 40(2): 288-295. (Pubitemid 24072594)
24. Papolos DF, Yu YM, Rosenbaum E and Lachman HM (1996). Modulation of learned helplessness by 5-hydroxytryptamine2A receptor antisense oligodeoxy-nucleotides. Psychiatry Res., 63(2-3): 197-203. (Pubitemid 26276611)
25. Porsolt RD, Bertin A and Jalfre M (1977). Behavioral despair in mice: A primary screening test for antidepressants. Arch. Int. Pharmacodyn. Ther., 229(2): 327-236.
26. Porter R.J, Lunn BS and O'Brien JT (2003). Effects of acute tryptophan depletion on cognitive functions in Alzheimer's disease and in the healthy elderly. Psychol. Med., 33(1): 41-49. (Pubitemid 36113399)
27. Prediger RD, Pamplona FA, Fernandes D and Takahashi RN (2005). Caffeine improves spatial learning deficits in an animal model of attention deficit hyperactivity disorder (ADHD) - The spontaneously caffeine hypertensive rats. Int. J. Neuropsychopharmacol., 8(4): 583-594. (Pubitemid 41400889)
28. Rogers PJ, Heatherley SV, Hayward RC, Seers HE, Hill J and Kane M (2005). Effects of caffeine and caffeine withdrawal on mood and cognitive performance degraded by sleep restriction. Psychopharmacology (Berl)., 179(4): 742-752. (Pubitemid 40767895)
29. Schmitt JA, Wingen M, Ramaekers JG, Evers EA and Riedel WJ (2006). Serotonin and human cognitive performance. Curr. Pharm. Des., 12(20): 2473-2486. (Pubitemid 44026030)
30. Silverman K, Evans SM, Strain EC and Griffiths RR (1992). Withdrawal syndrome after the double-blind cessation of caffeine consumption. N. Engl. J. Med., 327(16): 1109-1114.
31. Tarnopolsky MA (1994). Caffeine and endurance performance. Sports Med., 18(2): 109-125.
32. Valzelli L and Bernasconi S (1973). Behavioral and neurochemical effects of caffeine in normal and aggressive mice. Pharmacology Biochemistry and Behavior, 1(3): 251-254.
33. Wilkosc M, Hauser J, Tomaszewska M, Dmitrzak-Weglarz M, Skibinska M, Szczepankiewicz A and Borkowska A (2010). Influence of dopaminergic and serotonergic genes on working memory in healthy subjects. Acta Neurobiol. Exp. (Wars). 70(1): 86-94.