The structure and function of the macula in patients with advanced retinitis pigmentosa

Investigative Ophthalmology and Visual Science

Volumn 52, Issue 11, 2011, Pages 8425-8432

  Vámos, Rita ^a   Tátrai, Erika ^a   Németh, János ^a   Holder, Graham E ^b,c   DeBuc, Delia Cabrera ^d   Somfai, Gábor Márk ^a  

^a SEMMELWEIS UNIVERSITY   (Hungary)

^b MOORFIELDS EYE HOSPITAL   (United Kingdom)

^c UNIVERSITY COLLEGE LONDON   (United Kingdom)

^d UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; ARTICLE; CELL FUNCTION; CLINICAL ARTICLE; CONTROLLED STUDY; ELECTRORETINOGRAPHY; FEMALE; HUMAN; MALE; OPTICAL COHERENCE TOMOGRAPHY; PRIORITY JOURNAL; RETINA GANGLION CELL; RETINA INNER PLEXIFORM LAYER; RETINA MACULA LUTEA; RETINA OUTER MOLECULAR LAYER; RETINAL NERVE FIBER LAYER THICKNESS; RETINITIS PIGMENTOSA; VISION; VISUAL SYSTEM PARAMETERS; ADOLESCENT; MIDDLE AGED; NERVE FIBER; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; RETINA CONE; VISUAL ACUITY;

ADOLESCENT; ADULT; ELECTRORETINOGRAPHY; FEMALE; HUMANS; MACULA LUTEA; MALE; MIDDLE AGED; NERVE FIBERS; RETINAL CONE PHOTORECEPTOR CELLS; RETINAL GANGLION CELLS; RETINITIS PIGMENTOSA; TOMOGRAPHY, OPTICAL COHERENCE; VISUAL ACUITY; YOUNG ADULT;

EID: 84855402726     PISSN: 01460404     EISSN: 15525783     Source Type: Journal    
DOI: 10.1167/iovs.11-7780     Document Type: Article

References (36)

1. Hartong DT, Berson EL, Dryja TP. Retinitis pigmentosa. Lancet. 2006;368:1795-1809.
2. Milam AH, Li ZY, Fariss RN. Histopathology of the human retina in retinitis pigmentosa. Prog Retin Eye Res. 1998;17:175-205.
3. Huang D, Swanson EA, Lin CP, et al. Optical coherence tomography. Science. 1991;254:1178-1181.
4. Aleman TS, Cideciyan AV, Sumaroka A, et al. Inner retinal abnormalities in X-linked retinitis pigmentosa with RPGR mutations. Invest Ophthalmol Vis Sci. 2007;48:4759-4765.
5. Hood DC, Lin CE, Lazow MA, Locke KG, Zhang X, Birch DG. Thickness of receptor and post-receptor retinal layers in patients with retinitis pigmentosa measured with frequency-domain optical coherence tomography. Invest Ophthalmol Vis Sci. 2009;50: 2328-2336.
6. Lim JI, Tan O, Fawzi AA, Hopkins JJ, Gil-Flamer JH, Huang D. A pilot study of Fourier-domain optical coherence tomography of retinal dystrophy patients. Am J Ophthalmol. 2008;146:417-426.
7. Witkin AJ, Ko TH, Fujimoto JG, et al. Ultra-high resolution optical coherence tomography assessment of photoreceptors in retinitis pigmentosa and related diseases. Am J Ophthalmol. 2006;142: 945-952.
8. Oishi A, Otani A, Sasahara M, et al. Retinal nerve fiber layer thickness in patients with retinitis pigmentosa. Eye. 2009;23:561-566.
9. Walia S, Fishman GA. Retinal nerve fiber layer analysis in RP patients using Fourier-domain OCT. Invest Ophthalmol Vis Sci. 2008;49:3525-3528.
10. Walia S, Fishman GA, Edward DP, Lindeman M. Retinal nerve fiber layer defects in RP patients. Invest Ophthalmol Vis Sci. 2007;48: 4748-4752.
11. Cabrera Fernandez D, Salinas HM, Puliafito CA. Automated detection of retinal layer structures on optical coherence tomography images. Opt Express. 2005;13:10200-10216.
12. Tatrai E, Ranganathan S, Ferencz M, Cabrera DeBuc D, Somfai GM. Comparison of retinal thickness by Fourier-domain optical coherence tomography and OCT retinal image analysis software segmentation analysis derived from Stratus optical coherence tomography images. J Biomed Opt. 2011;16:056004.
13. Early Treatment Diabetic Retinopathy Study design and baseline patient characteristics. ETDRS report number 7. Ophthalmology. 1991;98:741-756.
14. Cabrera DeBuc D, Somfai GM, Ranganathan S, Tatrai E, Ferencz M, Puliafito CA. Reliability and reproducibility of macular segmentation using a custom-built optical coherence tomography retinal image analysis software. J Biomed Opt. 2009;14:064023.
15. Massin P, Erginay A, Haouchine B, Mehidi AB, Paques M, Gaudric A. Retinal thickness in healthy and diabetic subjects measured using optical coherence tomography mapping software. Eur J Ophthalmol. 2002;12:102-108.
16. Massin P, Vicaut E, Haouchine B, Erginay A, Paques M, Gaudric A. Reproducibility of retinal mapping using optical coherence tomography. Arch Ophthalmol. 2001;119:1135-1142.
17. Hood DC, Bach M, Brigell M, et al. ISCEV standard for clinical multifocal electroretinography (2011 edition): http://www.iscevwiki. org/twiki/pub/Main/MultifocalERGStandard2011/2011mfERGs Standard6-15-11.pdf. Last accessed August 7, 2011.
18. Popovic P, Jarc-Vidmar M, Hawlina M. Abnormal fundus autofluorescence in relation to retinal function in patients with retinitis pigmentosa. Graefes Arch Clin Exp Ophthalmol. 2005;243:1018-1027.
19. Robson AG, Saihan Z, Jenkins SA, et al. Functional characterisation and serial imaging of abnormal fundus autofluorescence in patients with retinitis pigmentosa and normal visual acuity. Br J Ophthalmol. 2006;90:472-479.
20. Greenstein VC, Holopigian K, Seiple W, Carr RE, Hood DC. Atypical multifocal ERG responses in patients with diseases affecting the photoreceptors. Vision Res. 2004;44:2867-2874.
21. Hood DC, Frishman LJ, Saszik S, Viswanathan S. Retinal origins of the primate multifocal ERG: implications for the human response. Invest Ophthalmol Vis Sci. 2002;43:1673-1685.
22. Gerth C, Wright T, Heon E, Westall CA. Assessment of central retinal function in patients with advanced retinitis pigmentosa. Invest Ophthalmol Vis Sci. 2007;48:1312-1318.
23. Green DM, Swets JA. Signal Detection Theory and Psychophysics. Los Altos, CA: Peninsula Publishing; 1988 reprint edition.
24. Santos A, Humayun MS, de Juan E Jr, et al. Preservation of the inner retina in retinitis pigmentosa. A morphometric analysis. Arch Ophthalmol. 1997;115:511-515.
25. van Velthoven ME, Faber DJ, Verbraak FD, van Leeuwen TG, de Smet MD. Recent developments in optical coherence tomography for imaging the retina. Prog Retin Eye Res. 2007;26:57-77.
26. Drexler W, Fujimoto JG. State-of-the-art retinal optical coherence tomography. Prog Retin Eye Res. 2008;27:45-88.
27. Ishikawa H, Stein DM, Wollstein G, Beaton S, Fujimoto JG, Schuman JS. Macular segmentation with optical coherence tomography. Invest Ophthalmol Vis Sci. 2005;46:2012-2017.
28. Shahidi M, Wang Z, Zelkha R. Quantitative thickness measurement of retinal layers imaged by optical coherence tomography. Am J Ophthalmol. 2005;139:1056-1061.
29. Cabrera DeBuc D, Salinas HM, Ranganathan S, et al. Improving image segmentation performance and quantitative analysis via a computer-aided grading methodology for optical coherence tomography retinal image analysis. J Biomed Opt. 2010;15:046015.
30. Hood DC, Holopigian K, Greenstein V, et al. Assessment of local retinal function in patients with retinitis pigmentosa using the multi-focal ERG technique. Vision Res. 1998;38:163-179.
31. Hood DC, Odel JG, Chen CS, Winn BJ. The multifocal electroretinogram. J Neuroophthalmol. 2003;23:225-235.
32. Robson AG, Egan CA, Luong VA, Bird AC, Holder GE, Fitzke FW. Comparison of fundus autofluorescence with photopic and scotopic fine-matrix mapping in patients with retinitis pigmentosa and normal visual acuity. Invest Ophthalmol Vis Sci. 2004;45: 4119-4125.
33. Lima LH, Cella W, Greenstein VC, et al. Structural assessment of hyperautofluorescent ring in patients with retinitis pigmentosa. Retina. 2009;29:1025-1031.
34. Wakabayashi T, Sawa M, Gomi F, Tsujikawa M. Correlation of fundus autofluorescence with photoreceptor morphology and functional changes in eyes with retinitis pigmentosa. Acta Ophthalmol. 2010;88:e177-e183.
35. Wolsley CJ, Silvestri G, O'Neill J, Saunders KJ, Anderson RS. The association between multifocal electroretinograms and OCT retinal thickness in retinitis pigmentosa patients with good visual acuity. Eye. 2009;23:1524-1531.
36. Kohler K, Hartmann JA, Werts D, Zrenner E. Histological studies of retinal degeneration and biocompatibility of subretinal implants [in German]. Ophthalmologe. 2001;98:364-368.