A small-scale anatomic model for testicular radiation dosimetry for radionuclides localized in the human testes

Journal of Nuclear Medicine

Volumn 53, Issue 1, 2012, Pages 72-81

  Larsson, Erik ^a   Meerkhan, Suaad A ^a   Strand, Sven Erik ^a   Jönsson, Bo Anders ^a  

^a LUND UNIVERSITY   (Sweden)

Author keywords

Dosimetry; Monte Carlo; S factors; Small scale; Testes

Indexed keywords

ASTATINE 211; FLUORINE 18; INDIUM 111; IODINE 125; IODINE 131; LUTETIUM 177; RADIOISOTOPE; TECHNETIUM 99M; YTTRIUM 90;

ARTICLE; COMPARATIVE STUDY; CONTROLLED STUDY; DOSE CALCULATION; DOSIMETRY; ELECTRON TRANSPORT; MONTE CARLO METHOD; PHOTON; PRIORITY JOURNAL; RADIATION ABSORPTION; RADIATION DOSE; RADIATION ENERGY; RADIOACTIVITY; SEMINIFEROUS TUBULE; SPERMATOGONIUM; TESTIS;

HUMANS; MALE; MODELS, ANATOMIC; RADIATION DOSAGE; RADIOISOTOPES; RADIOMETRY; SEMINIFEROUS EPITHELIUM; TESTIS;

EID: 84855383677     PISSN: 01615505     EISSN: None     Source Type: Journal    
DOI: 10.2967/jnumed.111.095133     Document Type: Article

References (40)

1. Jackson C, Jackson H, Bock M, Morris ID, Sharma HL. Metal radionuclides and the testis. Int J Radiat Biol. 1991;60:851-858.
2. Hoyes KP, Cox M, Jackson C, Sharma HL, Morris ID, Hendry JH. Localization of indium-114m in the rodent testis. Int J Radiat Biol. 1992;62:381-382. Available at: http://informahealthcare.com/toc/rab/62/3. Accessed November 1, 2011.
3. Jönsson B-A, Strand S-E, Emanuelsson H, Larsson BS. Tissue, cellular, and subcellular distribution of indium radionuclides in the rat. Biophysical Aspects of Auger Processes: AAPM Symposium Series No. 8. Woodbury, NY: American Institute of Physics; 1992:249-272.
4. Nettleton JS, Lawson RS, Prescott MC, Morris ID. Uptake, localization, and dosimetry of In-111 and Tl-201 in human testes. J Nucl Med. 2004;45:138-146. (Pubitemid 47611620)
5. Shen S, Meredith R, Duan J, et al. Testicular uptake and radiation dose in patients receiving Zevalin and Pretarget CC49Fusion protein. Cancer Biother Radiopharm. 2005;20:110-118. (Pubitemid 40478530)
6. 90Y- ibritumomab tiuxetan. J Nucl Med. 2009;50:644-652.
7. 90Y-ibritumomab tiuxetan (Zevalin). Eur J Nucl Med Mol Imaging. 2009;36:1745-1757.
8. Rowley MJ, Leach DR, Warner GA, Heller CG. Effect of graded doses of ionizing radiation on the human testis. Radiat Res. 1974;59:665-678.
9. Nonstochastic effects of ionizing radiation: ICRP publication 41. Ann ICRP. 1984;41(3).
10. Yousif L, Blettner M, Hammer G. amp, l P, Zeeb H. Testicular cancer risk associated with occupational radiation exposure: a systematic literature review. J Radiol Prot. 2010;30:389-406.
11. Health Risks from Exposure to Low Levels of Ionizing Radiation: BEIR VII Phase 2. Washington, DC: BEIR; 2006.
12. International Commission on Radiological Protection (ICRP). The 2007 recommendations of the International Commission on Radiological Protection. ICRP publication 103. Ann ICRP. 2007;37(2-4).
13. Oakberg EF. Duration of spermatogenesis in the mouse and timing of stages of the cycle of the seminiferous epithelium. Am J Anat. 1956;99:507-516.
14. Meistrich ML. Critical components of testicular function and sensitivity to disruption. Biol Reprod. 1986;34:17-28. (Pubitemid 16129708)
15. Rao DV, Narra V, Howell RW, Lanka V, Sastry KSR. Induction of sperm head abnormalities by incorporated radionuclides: dependence on subcellular distribution, type of radiation, dose rate, and presence of radioprotectors. Radiat Res. 1991;125:89-97.
16. Meistrich ML, Samuels RC. Reduction in sperm levels after testicular irradiation of the mouse: a comparison with man. Radiat Res. 1985;102:138-147.
17. Meistrich ML, Reid B, Barcellona W. Changes in sperm nuclei during spermiogenesis and epididymal maturation. Exp Cell Res. 1976;99:72-78.
18. Hendry JH. Survival of cells in mammalian tissues after low doses of irradiation: a short review. Int J Radiat Biol Relat Stud Phys Chem Med. 1988;53: 89-94. (Pubitemid 18036556)
19. Holstein AF, Schulze W, Davidoff M. Understanding spermatogenesis is a prerequisite for treatment. Reprod Biol Endocrinol. 2003;1:107.
20. International Commission on Radiological Protection (ICRP). ICRP publication 89: basic anatomical and physiological data for use in radiological protection-reference values. Ann ICRP. 2002;32(3-4).
21. Mescher AL. Junqueira's Basic Histology: Text and Atlas. 12th ed. New York, NY: McGraw Hill Medical; 2009.
22. Hoyes KP, Hendry H, Sharma M. Transferrin-mediated uptake of plutonium by spermatogenic tubules. Int J Radiat Biol. 1996;70:467-471. (Pubitemid 26359813)
23. Hoyes KP, Johnson C, Johnston RE, et al. Testicular toxicity of the transferrin binding radionuclide 114mIn in adult and neonatal rats. Reprod Toxicol. 1995;9:297-305.
24. Hoyes KP, Nettleton JS, Lawson RS, Morris ID. Transferrin-dependent uptake and dosimetry of Auger-emitting diagnostic radionuclides in human spermatozoa. J Nucl Med. 1998;39:895-899.
25. Jönsson BA. Biokinetics and localization of some In-111-radiopharmaceuticals in rats at the macroscopic and microscopic level: an approach towards small scale dosimetry [doctoral thesis]. Lund, Sweden: Lund University; 1991.
26. 111In- labeled radiopharmaceuticals in rat tissues. J Nucl Med. 1992;33:1825-1833.
27. Hoyes KP, Sharma HL, Jackson H, Hendry JH, Morris ID. Spermatogenic and mutagenic damage after paternal exposure to systemic indium-114m. Radiat Res. 1994;139:185-193. (Pubitemid 24262437)
28. Beatty BG, Paxton RJ, Sheibani K, et al. Testis Imaging with In-111-labeled anticarcinoembryonic antigen monoclonal antibody: identification of carcinoembryonic antigen in normal germ cells. Cancer Res. 1986;46:6503-6508. (Pubitemid 17221808)
29. 111In-labeled F(ab′)2 in patients with colorectal cancer. Antibody Immunoconj Radiopharm. 1991;4:587-593.
30. Wiseman GA, Leigh BR, Erwin WD, et al. Radiation dosimetry results from a phase II trial of ibritumomab tiuxetan (Zevalin) radioimmunotherapy for patients with non-Hodgkin's lymphoma and mild thrombocytopenia. Cancer Biother Radiopharm. 2003;18:165-178. (Pubitemid 36538585)
31. 90Y- radiolabelled ibritumomab tiuxetan (Zevalin). Eur J Nucl Med Mol Imaging. 2007;34:616-622.
32. Absorbed-dose specification in nuclear medicine (report 67). J ICRU. 2002;2: 1-110.
33. Howell RW, Neti PV, Pinto M, Gerashchenko BI, Narra VR, Azzam EI. Challenges and progress in predicting biological responses to incorporated radioactivity. Radiat Prot Dosimetry. 2006;122:521-527. (Pubitemid 47090518)
34. Loevinger R, Berman M. A Revised Schema for Calculation of the Absorbed Dose from Biologically Distributed Radionuclides: MIRD Pamphlet No. 1, Revised. New York, NY: Society of Nuclear Medicine; 1976.
35. Snyder W, Ford M, Warner G, Scott J. "S," Absorbed Dose per Unit Cumulated Activity for Selected Radionuclides and Organs. New York, NY: Society of Nuclear Medicine; 1975.
36. X-5 Monte Carlo Team. MCNP: A General Monte Carlo N-Particle Transport Code, Version 5, Volume I - Overview and Theory. Los Alamos, NM: Los Alamos National Laboratory; 2003 (revised 2008).
37. Hendricks J. MCNPX, Version 2.6.0 Extensions LA-UR-08-2216. Los Alamos, NM: Los Alamos National Laboratory; 2008.
38. Stabin MG, da Luz LC. Decay data for internal and external dose assessment. Health Phys. 2002;83:471-475. (Pubitemid 35015004)
39. Jönsson L, Liu X, Jönsson B-A, Ljungberg M, Strand S-E. A dosimetry model for the small intestine incorporating intestinal wall activity and cross-doses. J Nucl Med. 2002;43:1657-1664. (Pubitemid 35424991)
40. Liu G, Gong P, Zhao H, Wang Z, Gong S, Cai L. Effect of low-level radiation on the death of male germ cells. Radiat Res. 2006;165:379-389.