메뉴 건너뛰기




Volumn 5, Issue 4, 2011, Pages 989-998

Effect of pioglitazone and ramipril on biomarkers of low-grade inflammation and vascular function in nondiabetic patients with increased cardiovascular risk and an activated inflammation: Results from the PIOace study

Author keywords

Cardiovascular pharmacology; Clinical trial; Hypertension; Inflammation; Pioglitazone

Indexed keywords

2,4 THIAZOLIDINEDIONE DERIVATIVE; ANTIDIABETIC AGENT; ANTIHYPERTENSIVE AGENT; BIOLOGICAL MARKER; PIOGLITAZONE; PLACEBO; RAMIPRIL;

EID: 84855365023     PISSN: None     EISSN: 19322968     Source Type: Journal    
DOI: 10.1177/193229681100500422     Document Type: Article
Times cited : (5)

References (39)
  • 1
    • 0037316809 scopus 로고    scopus 로고
    • Epidemiology of the metabolic syndrome
    • Meigs JB. Epidemiology of the metabolic syndrome. Curr Diab Rep. 2003;3(1):73-9.
    • (2003) Curr Diab Rep , vol.3 , Issue.1 , pp. 73-79
    • Meigs, J.B.1
  • 3
    • 33845914986 scopus 로고    scopus 로고
    • Mechanisms linking obesity with cardiovascular disease
    • Van Gaal LF, Mertens L, De Block CE. Mechanisms linking obesity with cardiovascular disease. Nature. 2006;444:875-80.
    • (2006) Nature , vol.444 , pp. 875-880
    • Van Gaal, L.F.1    Mertens, L.2    De Block, C.E.3
  • 4
    • 63649110025 scopus 로고    scopus 로고
    • Cardiovascular effects of disturbed insulin activity in metabolic syndrome and in type 2 diabetes patients
    • Forst T, Hohberg C, Pfützner A. Cardiovascular effects of disturbed insulin activity in metabolic syndrome and in type 2 diabetes patients. Horm Metab Res. 2009;41(2):123-31.
    • (2009) Horm Metab Res , vol.41 , Issue.2 , pp. 123-131
    • Forst, T.1    Hohberg, C.2    Pfützner, A.3
  • 6
    • 34047266814 scopus 로고    scopus 로고
    • The link between abdominal obesity, metabolic syndrome and cardiovascular disease
    • Ritchie SA, Connell JM. The link between abdominal obesity, metabolic syndrome and cardiovascular disease. Nutr Metab Cardiovasc Dis. 2007;17(4):319-26.
    • (2007) Nutr Metab Cardiovasc Dis , vol.17 , Issue.4 , pp. 319-326
    • Ritchie, S.A.1    Connell, J.M.2
  • 7
    • 33845864967 scopus 로고    scopus 로고
    • Adipocytes as regulators of energy balance and glucose homeostasis
    • Rosen ED, Spiegelman BM. Adipocytes as regulators of energy balance and glucose homeostasis. Nature. 2006;444(7121):847-53.
    • (2006) Nature , vol.444 , Issue.7121 , pp. 847-853
    • Rosen, E.D.1    Spiegelman, B.M.2
  • 9
    • 0036021736 scopus 로고    scopus 로고
    • Postprandial hyperglycemia: Noxious effects on the vessel wall
    • Hanefeld M. Postprandial hyperglycemia: noxious effects on the vessel wall. Int J Clin Pract Suppl. 2002;129:45-50.
    • (2002) Int J Clin Pract Suppl , vol.129 , pp. 45-50
    • Hanefeld, M.1
  • 10
    • 22744439545 scopus 로고    scopus 로고
    • Contribution of basal and post-prandial hyperglycemia to micro- and macrovascular complications in people with type 2 diabetes
    • Home P. Contribution of basal and post-prandial hyperglycemia to micro- and macrovascular complications in people with type 2 diabetes. Curr Res Med Opin. 2005;21(7):989-98.
    • (2005) Curr Res Med Opin , vol.21 , Issue.7 , pp. 989-998
    • Home, P.1
  • 12
    • 33748748206 scopus 로고    scopus 로고
    • Effect of rosiglitazone on the frequency of diabetes in patients with impaired glucose tolerance or impaired fasting glucose: A randomised controlled trial
    • DREAM (Diabetes REduction Assessment with ramipril and rosiglitazone Medication) Trial Investigators, Erratum in: Lancet. 2006;368(9549):1770
    • DREAM (Diabetes REduction Assessment with ramipril and rosiglitazone Medication) Trial Investigators, Gerstein HC, Yusuf S, Bosch J, Pogue J, Sheridan P, Dinccag N, Hanefeld M, Hoogwerf B, Laakso M, Mohan V, Shaw J, Zinman B, Holman RR. Effect of rosiglitazone on the frequency of diabetes in patients with impaired glucose tolerance or impaired fasting glucose: a randomised controlled trial. Lancet. 2006;368(9541):1096-105. Erratum in: Lancet. 2006;368(9549):1770.
    • (2006) Lancet , vol.368 , Issue.9541 , pp. 1096-1105
    • Gerstein, H.C.1    Yusuf, S.2    Bosch, J.3    Pogue, J.4    Sheridan, P.5    Dinccag, N.6    Hanefeld, M.7    Hoogwerf, B.8    Laakso, M.9    Mohan, V.10    Shaw, J.11    Zinman, B.12    Holman, R.R.13
  • 13
    • 0034688194 scopus 로고    scopus 로고
    • Effects of an angiotensin-converting-enzyme inihibitor, ramipril, on cardiovascular events in high-risk patients
    • The Heart Outcomes Prevention Evaluation Study Investigators
    • Yusuf S, Sleight P, Pogue J, Bosch J, Davies R, Dagenais G. Effects of an angiotensin-converting-enzyme inihibitor, ramipril, on cardiovascular events in high-risk patients. The Heart Outcomes Prevention Evaluation Study Investigators. N Engl J Med. 2000;342(3):145-53.
    • (2000) N Engl J Med , vol.342 , Issue.3 , pp. 145-153
    • Yusuf, S.1    Sleight, P.2    Pogue, J.3    Bosch, J.4    Davies, R.5    Dagenais, G.6
  • 15
    • 33846273797 scopus 로고    scopus 로고
    • Anti-inflammatory effect of pioglitazone and/or simvastatin in high cardiovascular risk patients with elevated high sensitivity C-reactive protein: The PIOSTAT Study
    • Hanefeld M, Marx N, Pfützner A, Baurecht W, Lübben G, Kargiannis E, Stier U, Forst T. Anti-inflammatory effect of pioglitazone and/or simvastatin in high cardiovascular risk patients with elevated high sensitivity C-reactive protein: the PIOSTAT Study. J Am Coll Cardiol. 2007;49(3):290-7.
    • (2007) J Am Coll Cardiol , vol.49 , Issue.3 , pp. 290-297
    • Hanefeld, M.1    Marx, N.2    Pfützner, A.3    Baurecht, W.4    Lübben, G.5    Kargiannis, E.6    Stier, U.7    Forst, T.8
  • 16
    • 0021813187 scopus 로고
    • Homeostasis model assessment: Insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man
    • Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC. Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia. 1985;28(7):412-9.
    • (1985) Diabetologia , vol.28 , Issue.7 , pp. 412-419
    • Matthews, D.R.1    Hosker, J.P.2    Rudenski, A.S.3    Naylor, B.A.4    Treacher, D.F.5    Turner, R.C.6
  • 17
    • 0034061181 scopus 로고    scopus 로고
    • Relation between insulin resistance and carotid intima-media thickness and stenosis in non-diabetic subjects. Results from a cross-sectional study in Malmö, Sweden
    • Hedblad B, Nilsson P, Janzon L, Berglund G. Relation between insulin resistance and carotid intima-media thickness and stenosis in non-diabetic subjects. Results from a cross-sectional study in Malmö, Sweden. Diabet Med. 2000;17(4):299-307.
    • (2000) Diabet Med , vol.17 , Issue.4 , pp. 299-307
    • Hedblad, B.1    Nilsson, P.2    Janzon, L.3    Berglund, G.4
  • 18
    • 33645277645 scopus 로고    scopus 로고
    • High-sensitivity C-reactive protein as cardiovascular risk marker in patients with diabetes mellitus
    • Pfützner A, Forst T. High-sensitivity C-reactive protein as cardiovascular risk marker in patients with diabetes mellitus. Diab Technol Ther. 2006;8(1):28-36.
    • (2006) Diab Technol Ther , vol.8 , Issue.1 , pp. 28-36
    • Pfützner, A.1    Forst, T.2
  • 19
    • 18844366928 scopus 로고    scopus 로고
    • Pioglitazone decreases carotid intima-media thickness independently of glycemic control in patients with type 2 diabetes mellitus: Results from a controlled randomized study
    • Langenfeld MR, Forst T, Hohberg C, Kann P, Lübben G, Konrad T, Füllert S, Sachara C, Pfützner A. Pioglitazone decreases carotid intima-media thickness independently of glycemic control in patients with type 2 diabetes mellitus: results from a controlled randomized study. Circulation. 2005;111(19):2525-31.
    • (2005) Circulation , vol.111 , Issue.19 , pp. 2525-2531
    • Langenfeld, M.R.1    Forst, T.2    Hohberg, C.3    Kann, P.4    Lübben, G.5    Konrad, T.6    Füllert, S.7    Sachara, C.8    Pfützner, A.9
  • 23
    • 20444495375 scopus 로고    scopus 로고
    • Improvement of cardiovascular risk markers by pioglitazone is independent from glycemic control: Results from the pioneer study
    • Pfützner A, Marx N, Lübben G, Langenfeld M, Walcher D, Konrad T, Forst T. Improvement of cardiovascular risk markers by pioglitazone is independent from glycemic control: results from the pioneer study. J Am Coll Cardiol. 2005;45(12):1925-31.
    • (2005) J Am Coll Cardiol , vol.45 , Issue.12 , pp. 1925-1931
    • Pfützner, A.1    Marx, N.2    Lübben, G.3    Langenfeld, M.4    Walcher, D.5    Konrad, T.6    Forst, T.7
  • 24
    • 39449108262 scopus 로고    scopus 로고
    • Comparison of fixed-dose rosiglitazone/metformin combination therapy with sulphonylurea plus metformin in overweight individuals with type 2 diabetes inadequately controlled on metformin alone
    • Hamann A, Garcia-Puig J, Paul G, Donaldson J, Stewart M. Comparison of fixed-dose rosiglitazone/metformin combination therapy with sulphonylurea plus metformin in overweight individuals with type 2 diabetes inadequately controlled on metformin alone. Exp Clin Endocrinol Diabetes. 2008;116(1):6-13.
    • (2008) Exp Clin Endocrinol Diabetes , vol.116 , Issue.1 , pp. 6-13
    • Hamann, A.1    Garcia-Puig, J.2    Paul, G.3    Donaldson, J.4    Stewart, M.5
  • 25
    • 43549097824 scopus 로고    scopus 로고
    • The IRIS V study: Pioglitazone improves systemic chronic inflammation in patients with type 2 diabetes under daily routine conditions
    • Karagiannis E, Pfützner A, Forst T, Lübben G, Roth W, Grabellus M, Flannery M, Schöndorf T. The IRIS V study: pioglitazone improves systemic chronic inflammation in patients with type 2 diabetes under daily routine conditions. Diabetes Technol Ther. 2008;10(3):206-12.
    • (2008) Diabetes Technol Ther , vol.10 , Issue.3 , pp. 206-212
    • Karagiannis, E.1    Pfützner, A.2    Forst, T.3    Lübben, G.4    Roth, W.5    Grabellus, M.6    Flannery, M.7    Schöndorf, T.8
  • 29
    • 33847675510 scopus 로고    scopus 로고
    • The effect of pioglitazone on recurrent myocardial infarction in 2,445 patients with type 2 diabetes and previous myocardial infarction: Results from the PROactive (PROactive 05) Study
    • PROactive Investigators
    • Erdmann E, Dormandy JA, Charbonnel B, Massi-Benedetti M, Moules IK, Skene AM; PROactive Investigators. The effect of pioglitazone on recurrent myocardial infarction in 2,445 patients with type 2 diabetes and previous myocardial infarction: results from the PROactive (PROactive 05) Study. J Am Coll Cardiol. 2007;49(17):1772-80.
    • (2007) J Am Coll Cardiol , vol.49 , Issue.17 , pp. 1772-1780
    • Erdmann, E.1    Dormandy, J.A.2    Charbonnel, B.3    Massi-Benedetti, M.4    Moules, I.K.5    Skene, A.M.6
  • 30
    • 33947539408 scopus 로고    scopus 로고
    • Effects of pioglitazone in patients with type 2 diabetes with or without previous stroke: Results from PROactive (PROspective pioglitAzone Clinical Trial In macroVascular Events 04)
    • PROactive Investigators
    • Wilcox R, Bousser MG, Betteridge DJ, Schernthaner G, Pirags V, Kupfer S, Dormandy J. PROactive Investigators. Effects of pioglitazone in patients with type 2 diabetes with or without previous stroke: results from PROactive (PROspective pioglitAzone Clinical Trial In macroVascular Events 04). Stroke. 2007;38(3):865-73.
    • (2007) Stroke , vol.38 , Issue.3 , pp. 865-873
    • Wilcox, R.1    Bousser, M.G.2    Betteridge, D.J.3    Schernthaner, G.4    Pirags, V.5    Kupfer, S.6    Dormandy, J.7
  • 31
    • 33947304608 scopus 로고    scopus 로고
    • Effect of simvastatin and/or pioglitazone on insulin resistance, insulin secretion, adiponectin, and proinsulin levels in nondiabetic patients at cardiovascular risk - The PIOSTAT Study
    • Forst T, Pfützner A, Lübben G, Weber M, Marx N, Karagiannis E, Köhler C, Baurecht W, Hohberg C, Hanefeld M. Effect of simvastatin and/or pioglitazone on insulin resistance, insulin secretion, adiponectin, and proinsulin levels in nondiabetic patients at cardiovascular risk - the PIOSTAT Study. Metabolism. 2007;56(4):491-6.
    • (2007) Metabolism , vol.56 , Issue.4 , pp. 491-496
    • Forst, T.1    Pfützner, A.2    Lübben, G.3    Weber, M.4    Marx, N.5    Karagiannis, E.6    Köhler, C.7    Baurecht, W.8    Hohberg, C.9    Hanefeld, M.10
  • 32
    • 3142781955 scopus 로고    scopus 로고
    • Prevention of type 2 diabetes through inhibition of the renin-angiotensin system
    • Scheen AJ. Prevention of type 2 diabetes through inhibition of the renin-angiotensin system. Drugs. 2005;64(22):2537-65.
    • (2005) Drugs , vol.64 , Issue.22 , pp. 2537-2565
    • Scheen, A.J.1
  • 33
    • 4444353804 scopus 로고    scopus 로고
    • Pioglitazone reduces blood pressure in non-dipping diabetic patients
    • Negro R, Dazzi D, Hassan H, Pezzarossa A. Pioglitazone reduces blood pressure in non-dipping diabetic patients. Minerva Endocrinol. 2004;29(1):11-7.
    • (2004) Minerva Endocrinol , vol.29 , Issue.1 , pp. 11-17
    • Negro, R.1    Dazzi, D.2    Hassan, H.3    Pezzarossa, A.4
  • 34
    • 34548485061 scopus 로고    scopus 로고
    • Effects of thiazolidinediones on blood pressure
    • Giles TD, Sander AG. Effects of thiazolidinediones on blood pressure. Curr Hypertens Rep. 2007;9(4):332-7.
    • (2007) Curr Hypertens Rep , vol.9 , Issue.4 , pp. 332-337
    • Giles, T.D.1    Sander, A.G.2
  • 36
    • 33845535490 scopus 로고    scopus 로고
    • The IRIS III study: Pioglitazone improves metabolic control and blood pressure in patients with type 2 diabetes without increasing body weight
    • Schöndorf T, Forst T, Hohberg C, Pahler S, Link C, Roth W, Pfützner A. The IRIS III study: pioglitazone improves metabolic control and blood pressure in patients with type 2 diabetes without increasing body weight. Diab Obes Metab. 2007;9(1):132-3.
    • (2007) Diab Obes Metab , vol.9 , Issue.1 , pp. 132-133
    • Schöndorf, T.1    Forst, T.2    Hohberg, C.3    Pahler, S.4    Link, C.5    Roth, W.6    Pfützner, A.7
  • 37
    • 34250792345 scopus 로고    scopus 로고
    • Circadian rhythm of blood pressure: Non-dipping pattern and cardiovascular risk
    • Article in Italian
    • Cicconetti P, Donadio C, Pazzaglia MC, D'Ambrosio F, Marigliano V. [Circadian rhythm of blood pressure: non-dipping pattern and cardiovascular risk][Article in Italian]. Recenti Prog Med. 2007;98(7-8):401-6.
    • (2007) Recenti Prog Med , vol.98 , Issue.7-8 , pp. 401-406
    • Cicconetti, P.1    Donadio, C.2    Pazzaglia, M.C.3    D'Ambrosio, F.4    Marigliano, V.5
  • 38
    • 0027984267 scopus 로고
    • "Non-dipping"related to cardiovascular events in essential hypertensive patients
    • Zweiker R, Eber B, Schumacher M, Toplak H, Klein W. "Non- dipping"related to cardiovascular events in essential hypertensive patients. Acta Med Austriaca. 1994;21(3):86-9.
    • (1994) Acta Med Austriaca , vol.21 , Issue.3 , pp. 86-89
    • Zweiker, R.1    Eber, B.2    Schumacher, M.3    Toplak, H.4    Klein, W.5
  • 39
    • 79952464386 scopus 로고    scopus 로고
    • Rosuvastatin, inflammation, C-reactive protein, JUPITER, and primary prevention of cardiovascular disease - A perspective
    • Kones R. Rosuvastatin, inflammation, C-reactive protein, JUPITER, and primary prevention of cardiovascular disease - a perspective. Drug Des Devel Ther. 2010;4:383-413.
    • (2010) Drug des Devel Ther , vol.4 , pp. 383-413
    • Kones, R.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.