Development of a novel ketoprofen transdermal patch: Effect of almond oil as penetration enhancers on in-vitro and ex-vivo penetration of ketoprofen through rabbit skin

Pakistan Journal of Pharmaceutical Sciences

Volumn 25, Issue 1, 2012, Pages 227-232

  Hussain, Abid ^a   Khan, Gul Majid ^a   Shah, Shefaat Ullah ^a   Shah, Kifayat Ullah ^a   Rahim, Nauman ^a   Wahab, Abdul ^a   Asim Ur Rehman, ^a  

^a GOMAL UNIVERSITY   (Pakistan)

Author keywords

In vitro ex vivo penetration; Ketoprofen; Penetration enhancers; Transdermal patch and gel

Indexed keywords

ALMOND OIL; KETOPROFEN;

ANALYSIS OF VARIANCE; ANIMAL EXPERIMENT; ARTICLE; ARTIFICIAL MEMBRANE; BATCH PROCESS; CONTROLLED STUDY; DRUG CONSISTENCY; DRUG FORMULATION; DRUG MECHANISM; DRUG PENETRATION; DRUG RELEASE; DRUG STABILITY; DRUG TRANSPORT; GEL; HUMAN; HUMAN EXPERIMENT; KINETICS; NONHUMAN; NORMAL HUMAN; PARTICLE SIZE; PH; PHARMACOLOGICAL PARAMETERS; RABBIT; SKIN IRRITATION; SKIN PENETRATION; SPREADIBILITY; TRANSDERMAL PATCH;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CHEMISTRY, PHARMACEUTICAL; DRUG STABILITY; GELS; KETOPROFEN; PARTICLE SIZE; PLANT OILS; RABBITS; SKIN; SKIN ABSORPTION; TRANSDERMAL PATCH;

EID: 84855360780     PISSN: 1011601X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (9)

1. Beatrice MM, Kenneth AW, Michael SR (2001). Veterinary drug delivery: Potential for skin penetration Enhancement. Adv. Drug Del. Rev., 50: 205-227.
2. Charles SA and Bozena BM (2000). Percutaneous penetration enhancers: Local versus transdermal activity. Res. Focus, 3: 36-41.
3. Das MK, Bhattacharya A and Ghoshal SK (2006). Transdermal delivery of trazodone hydrochloride from acrylic films prepared from aqueous latex. Ind. J. Pharm. Sci., 68(1): 41-46.
4. ICH Harmonized Tripartite Guidelines (2003). Stability testing of new drug substances and products Q1A(R2), Available at: http://www.fda.gov/ Regulatory Information/Guidances/ucm128179.htm accessed on Feb 12, 2011.
5. Khan GM and Zhu JB (1999). Studies on drug release kinetics from ibuprofen-carbomer hydrophilic matrix tablets: influence of co-excipients on release rate of the drug. J. Contr. Rel., 57: 197-203.
6. Khan GM and Zhu JB (2001). Evaluation of Ethocel Premium ethyl cellulose derivatives with different molecular weighs as controlled release matrix forming functional polymers for Ibuprofen. The sciences. 1: 361-367.
7. Rajesh K and Pitchaimani R (2006). Formulation of transdermal drug delivery system. Curr. Drug Discov. Technol., 3: 279-285.
8. Ramesh G, VamshiVishnu Y, Kishan V and Madhusan RY (2007). Development of nitrendipine transdermal patches. Current Drug Delivery. 4:69-76.
9. Shivhare UD, Jain kb, Mathur VB, Bhusari KP, Roy AA and Sharad. formulation development and evaluation of diclofenacsodium gel using water soluble polyacrylamide polymer. Digest J. Nanomat. Biostruct., 4: 285-290.