Levels of explanation in psychiatric and substance use disorders: Implications for the development of an etiologically based nosology

Molecular Psychiatry

Volumn 17, Issue 1, 2012, Pages 11-21

  Kendler, K S ^a  

^a VIRGINIA COMMONWEALTH UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

diagnosis; philosophy; psychiatric nosology

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR ALPHA1; ALDEHYDE DEHYDROGENASE; BRAIN DERIVED NEUROTROPHIC FACTOR; DISULFIRAM; DOPAMINE; GLUTAMATE RECEPTOR; NEUROPEPTIDE Y; TRANSMEMBRANE CONDUCTANCE REGULATOR;

ALCOHOLISM; ASTHMA; CHILD SEXUAL ABUSE; CLINICAL TRIAL (TOPIC); CONTROLLED CLINICAL TRIAL (TOPIC); CULTURAL FACTOR; CYSTIC FIBROSIS; DIAGNOSTIC AND STATISTICAL MANUAL OF MENTAL DISORDERS; DISEASE CLASSIFICATION; ELECTROENCEPHALOGRAPHY; ELECTROPHYSIOLOGY; ENVIRONMENTAL EXPOSURE; GABAERGIC SYSTEM; GENE MUTATION; GENETIC ASSOCIATION; GENETIC RISK; GENETIC VARIABILITY; HEREDITY; HUMAN; HYPERTENSION; LIFE EVENT; MAJOR DEPRESSION; MENTAL DISEASE; META ANALYSIS (TOPIC); NERVOUS SYSTEM FUNCTION; NON INSULIN DEPENDENT DIABETES MELLITUS; PARENTAL DEPRIVATION; PERSONALITY; PRIORITY JOURNAL; PSYCHOLOGICAL ASPECT; RANDOMIZED CONTROLLED TRIAL (TOPIC); REVIEW; RISK FACTOR; SCHIZOPHRENIA; SOCIAL ASPECT; SOCIOECONOMICS; SUBSTANCE ABUSE;

HUMANS; MENTAL DISORDERS; MODELS, BIOLOGICAL; SUBSTANCE-RELATED DISORDERS;

EID: 84855359174     PISSN: 13594184     EISSN: 14765578     Source Type: Journal    
DOI: 10.1038/mp.2011.70     Document Type: Review

References (132)

1. Kraepelin E. Die Erscheinungsformen des Irreseins: (the manifestations of insanity). History Psychiatry 1992; 3: 509-529.
2. Dretske F. Explaining Behavior: Reasons in a World of Causes. The MIT Press: Cambridge, MA, 1991, p24.
3. Robins E, Guze SB. Establishment of diagnostic validity in psychiatric illness: its application to schizophrenia. Am J Psychiatry 1970; 126: 983-987.
4. Murphy D. Philosophy of psychiatry. In: Zalta EN (ed.) The Stanford Encyclopedia of Philosophy. Fall 2010 ed. URL=/http://plato.stanford.edu/ archives/fall2010/entries/psychiatry/S; 2010.
5. Hyman SE. The diagnosis of mental disorders: the problem of reification. Annu Rev Clin Psychol 2010; 6: 155-179.
6. Kandel ER. A new intellectual framework for psychiatry. Am J Psychiatry 1998; 155: 457-469. (Pubitemid 28207439)
7. Carter KC. The Rise of Causal Concepts of Disease: Case Histories. Ashgate Publishing Company: Surrey, UK, 2003.
8. Meynert T. Psychiatry: A Clinical Treatise on Diseases of the Fore-Brain Based upon a Study of Its Structure, Functions, and Nutrition. Nabu Press: Charleston, SC, 2010.
9. Kraepelin E. Psychiatry: A Textbook for Students and Physicians (Translation of the 6th Edition of Psychiatrie-Translator Volume 1-Helga Metoui). Translator Volume 1-Helga Metoui; Translation of the 6th Edition of Psychiatrie ed. Science History Publications: Canton, MA, 1990.
10. American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders, 2nd edn. American Psychiatric Association: Washington, DC, 1968.
11. Meltzer HY, Stahl SM. The dopamine hypothesis of schizophrenia: a review. Schizophr Bull 1976; 2: 19-76.
12. Mendels J, Cochrane C. Nosology of depression-endogenousreactive concept. Am J Psychiatry 1968; 124(11S): 1-11.
13. Berrettini W. Bipolar disorder and schizophrenia: convergent molecular data. Neuromolecular Med 2004; 5: 109-117. (Pubitemid 38391960)
14. Andrews G, Charney D, Sirovatka PJ, Regier DA. Stress-induced and Fear Circuitry Disorders: Refining the Research Agenda for DSM-V. First ed. American Psychiatric Publishing, 2008.
15. Murphy D. Psychiatry in the Scientific Image (Philosophical Psychopathology), 1st edn. MIT Press: Cambridge, MA, 2006.
16. Kendler KS, Aggen S, Knudsen GP, Roysamb E, Neale M, Reichborn-Kjennerud T. Am J Psychiatry 2011; 168: 29-39.
17. Goldberg DP, Krueger RF, Andrews G, Hobbs MJ. Emotional disorders: cluster 4 of the proposed meta-structure for DSM-V and ICD-11. Psychol Med 2009; 39: 2043-2059.
18. Krueger RF, South SC. Externalizing disorders: cluster 5 of the proposed meta-structure for DSM-V and ICD-11. Psychol Med 2009; 39: 2061-2070.
19. Prescott CA, Kendler KS. Genetic and environmental contributions to alcohol abuse and dependence in a populationbased sample of male twins. Am J Psychiatry 1999; 156: 34-40. (Pubitemid 29034877)
20. Kendler KS, Prescott CA, Neale MC, Pedersen NL. Temperance board registration for alcohol abuse in a national sample of Swedish male twins, born 1902 to 1949. Arch Gen Psychiatry 1997; 54: 178-184. (Pubitemid 27074306)
21. Heath AC, Bucholz KK, Madden PA, Dinwiddie SH, Slutske WS, Bierut LJ et al. Genetic and environmental contributions to alcohol dependence risk in a national twin sample: consistency of findings in women and men. Psychol Med 1997; 27: 1381-1396. (Pubitemid 27494104)
22. Pickens RW, Svikis DS, McGue M, Lykken DT, Heston LL, Clayton PJ. Heterogeneity in the inheritance of alcoholism. A study of male and female twins. Arch Gen Psychiatry 1991; 48: 19-28.
23. Kendler KS, Myers J, Prescott CA. Specificity of genetic and environmental risk factors for symptoms of cannabis, cocaine, alcohol, caffeine, and nicotine dependence. Arch Gen Psychiatry 2007; 64: 1313-1320. (Pubitemid 350074829)
24. Slutske WS, Heath AC, Dinwiddie SH, Madden PA, Bucholz KK, Dunne MP et al. Common genetic risk factors for conduct disorder and alcohol dependence. J Abnorm Psychol 1998; 107: 363-374. (Pubitemid 28369246)
25. Kendler KS, Prescott CA, Myers J, Neale MC. The structure of genetic and environmental risk factors for common psychiatric and substance use disorders in men and women. Arch Gen Psychiatry 2003; 60: 929-937. (Pubitemid 37122313)
26. Koopmans JR, Slutske WS, van Baal GC, Boomsma DI. The influence of religion on alcohol use initiation: evidence for genotype X environment interaction. Behav Genet 1999; 29: 445-453. (Pubitemid 30368321)
27. Heath AC, Jardine R, Martin NG. Interactive effects of genotype and social environment on alcohol consumption in female twins. J Stud Alcohol 1989; 50: 38-48. (Pubitemid 19066884)
28. Dick DM, Agrawal A, Schuckit MA, Bierut L, Hinrichs A, Fox L et al. Marital status, alcohol dependence, and GABRA2: evidence for gene-environment correlation and interaction. J Stud Alcohol 2006; 67: 185-194. (Pubitemid 43277286)
29. Dick DM, Rose RJ, Viken RJ, Kaprio J, Koskenvuo M. Exploring gene-environment interactions: socioregional moderation of alcohol use. J Abnorm Psychology 2001; 110: 625-632. (Pubitemid 33049425)
30. Rose RJ, Dick DM, Viken And RJ, Kaprio J. Gene-environment interaction in patterns of adolescent drinking: regional residency moderates longitudinal influences on alcohol use. Alcohol Clin Exp Res 2001; 25: 637-643. (Pubitemid 32448621)
31. Crabb DW, Matsumoto M, Chang D, You M. Overview of the role of alcohol dehydrogenase and aldehyde dehydrogenase and their variants in the genesis of alcohol-related pathology. Proc Nutr Soc 2004; 63: 49-63. (Pubitemid 38543873)
32. Kendler KS. Reflections on the relationship between psychiatric genetics and psychiatric nosology. Am J Psychiatry 2006; 163: 1138-1146. (Pubitemid 44464439)
33. Chen WJ, Loh EW, Hsu YP, Chen CC, Yu JM, Cheng AT. Alcohol-metabolising genes and alcoholism among Taiwanese Han men: independent effect of ADH2, ADH3 and ALDH2. Br J Psychiatry 1996; 168: 762-767.
34. Higuchi S, Matsushita S, Imazeki H, Kinoshita T, Takagi S, Kono H. Aldehyde dehydrogenase genotypes in Japanese alcoholics. Lancet 1994; 343: 741, .
35. Hinrichs AL, Wang JC, Bufe B, Kwon JM, Budde J, Allen R et al. Functional variant in a bitter-taste receptor (hTAS2R16) influences risk of alcohol dependence. Am J Hum Genet 2006; 78: 103-111. (Pubitemid 41833163)
36. Wang JC, Hinrichs AL, Bertelsen S, Stock H, Budde JP, Dick DM et al. Functional variants in TAS2R38 and TAS2R16 influence alcohol consumption in high-risk families of African-American origin. Alcohol Clin Exp Res 2007; 31: 209-215. (Pubitemid 46155219)
37. Enoch MA. The role of GABA(A) receptors in the development of alcoholism. Pharmacol Biochem Behav 2008; 90: 95-104.
38. Bierut LJ, Agrawal A, Bucholz KK, Doheny KF, Laurie C, Pugh E et al. A genome-wide association study of alcohol dependence. Proc Natl Acad Sci USA 2010; 107: 5082-5087.
39. Kalsi G, Prescott CA, Kendler KS, Riley BP. Unraveling the molecular mechanisms of alcohol dependence. Trends Genet 2009; 25: 49-55.
40. Dick DM, Bierut L, Hinrichs A, Fox L, Bucholz KK, Kramer J et al. The role of GABRA2 in risk for conduct disorder and alcohol and drug dependence across developmental stages. Behav Genet 2006; 36: 577-590. (Pubitemid 43967652)
41. Chen CC, Lu RB, Chen YC, Wang MF, Chang YC, Li TK et al. Interaction between the functional polymorphisms of the alcohol-metabolism genes in protection against alcoholism. Am J Hum Genet 1999; 65: 795-807.
42. Newlin DB, Thomson JB. Alcohol challenge with sons of alcoholics: a critical review and analysis. Psychol Bull 1990; 108: 383-402.
43. Schuckit MA, Smith TL. An 8-year follow-up of 450 sons of alcoholic and control subjects. Arch Gen Psychiatry 1996; 53: 202-210. (Pubitemid 26085201)
44. Schuckit MA. Low level of response to alcohol as a predictor of future alcoholism. Am J Psychiatry 1994; 151: 184-189.
45. Porjesz B, Rangaswamy M, Kamarajan C, Jones KA, Padmanabhapillai A, Begleiter H. The utility of neurophysiological markers in the study of alcoholism. Clin Neurophysiol 2005; 116: 993-1018.
46. Giancola PR, Moss HB, Martin CS, Kirisci L, Tarter RE. Executive cognitive functioning predicts reactive aggression in boys at high risk for substance abuse: a prospective study. Alcohol Clin Exp Res 1996; 20: 740-744. (Pubitemid 26186943)
47. Giancola PR, Martin CS, Tarter RE, Pelham WE, Moss HB. Executive cognitive functioning and aggressive behavior in preadolescent boys at high risk for substance abuse/dependence. J Stud Alcohol 1996; 57: 352-359. (Pubitemid 26184023)
48. Corral MM, Holguin SR, Cadaveira F. Neuropsychological characteristics in children of alcoholics: familial density. J Stud Alcohol 1999; 60: 509-513. (Pubitemid 29275439)
49. Knop J, Goodwin DW, Jensen P, Penick E, Pollock V, Gabrielli W et al. A 30-year follow-up study of the sons of alcoholic men. Acta Psychiatr Scand Suppl 1993; 370: 48-53. (Pubitemid 23063722)
50. Peterson JB, Finn PR, Pihl RO. Cognitive dysfunction and the inherited predisposition to alcoholism. J Stud Alcohol 1992; 53: 154-160.
51. Volkow N, Wang G-J, Begletier H, Porjesz B, Fowler JS, Logan J et al. Subjects with a genetic risk for alcoholism have decreased activity in the orbitfrontal cortex and high levels of DA D2 receptors. J Nuclear Med 2003; 44: 66P.
52. Volkow ND, Wang GJ, Begleiter H, Hitzemann R, Pappas N, Burr G et al. Regional brain metabolic response to lorazepam in subjects at risk for alcoholism. Alcohol Clin Exp Res 1995; 19: 510-516.
53. Rangaswamy M, Porjesz B, Ardekani BA, Choi SJ, Tanabe JL, Lim KO et al. A functional MRI study of visual oddball: evidence for frontoparietal dysfunction in subjects at risk for alcoholism. Neuroimage 2004; 21: 329-339. (Pubitemid 38115024)
54. Hill SY, Wang S, Kostelnik B, Carter H, Holmes B, McDermott M et al. Disruption of orbitofrontal cortex laterality in offspring from multiplex alcohol dependence families. Biol Psychiatry 2009; 65: 129-136.
55. Sher KJ, Grekin ER, Williams NA. The development of alcohol use disorders. Annu Rev Clin Psychol 2005; 1: 493-523. (Pubitemid 43843960)
56. Szlemko WJ, Wood JW, Thurman PJ. Native Americans and alcohol: past, present, and future. J Gen Psychol 2006; 133: 435-451. (Pubitemid 44825398)
57. Dick DM, Smith G, Olausson P, Mitchell SH, Leeman RF, O'Malley SS et al. Understanding the construct of impulsivity and its relationship to alcohol use disorders. Addict Biol 2010; 15: 217-226.
58. Dubow EF, Boxer P, Huesmann LR. Childhood and adolescent predictors of early and middle adulthood alcohol use and problem drinking: the Columbia County Longitudinal Study. Addiction 2008; 103(Suppl 1): 36-47. (Pubitemid 351559578)
59. Englund MM, Egeland B, Oliva EM, Collins WA. Childhood and adolescent predictors of heavy drinking and alcohol use disorders in early adulthood: a longitudinal developmental analysis. Addiction 2008; 103(Suppl 1): 23-35. (Pubitemid 351551212)
60. Goldman MS. Expectancy and risk for alcoholism: the unfortunate exploitation of a fundamental characteristic of neurobehavioral adaptation. Alcoholism-Clin Exp Res 2002; 26: 737-746. (Pubitemid 34522684)
61. Goldman MS, Del Boca FK, Darkes J. Alcohol expectancy theory: the application of cognitive neuroscience. In: Leonard KE, Blane HT (eds). Psychological Theories of Drinking and Alcoholism, 2nd edn. Guilford Press: NY, 1999, pp 203-246.
62. Reich RR, Below MC, Goldman MS. Explicit and implicit measures of expectancy and related alcohol cognitions: a meta-analytic comparison. Psychol Addict Behav 2010; 24: 13-25.
63. Goldman MS, Darkes J. Alcohol expectancy multiaxial assessment: a memory network-based approach. Psychol Assess 2004; 16: 4-15. (Pubitemid 38339679)
64. Jones BT, Corbin W, Fromme K. A review of expectancy theory and alcohol consumption. Addiction 2001; 96: 57-72. (Pubitemid 32099340)
65. Cooper ML. Motivations for alcohol use among adolescents: development and validation of a four-factor model. Psychol Assess 1994; 6: 117-128. (Pubitemid 24281660)
66. Abbey A, Smith MJ, Scott RO. The relationship between reasons for drinking alcohol and alcohol consumption: an interactional approach. Addict Behav 1993; 18: 659-670. (Pubitemid 24026395)
67. Farber PD, Khavari KA, Douglass FM. A factor analytic study of reasons for drinking: empirical validation of positive and negative reinforecement dimensions. J Consult Clin Psychol 1980; 48: 780-781.
68. Tennant C, Bernardi E. Childhood loss in alcoholics and narcotic addicts. Br J Addict 1988; 83: 695-703.
69. Kendler KS, Neale MC, Prescott CA, Kessler RC, Heath AC, Corey LA et al. Childhood parental loss and alcoholism in women: a causal analysis using a twin-family design. Psychol Med 1996; 26: 79-95. (Pubitemid 26031805)
70. Jacob T, Johnson S. Parenting influences on the development of alcohol abuse and dependence. Alcohol Health Res World 1997; 21: 204-209. (Pubitemid 127709502)
71. Kendler KS, Myers J, Prescott CA. Parenting and adult mood, anxiety and substance use disorders in female twins: an epidemiological, multi-informant, retrospective study. Psychol Med 2000; 30: 281-294. (Pubitemid 30245792)
72. Fergusson DM, Mullen PE. Childhood Sexual Abuse: An Evidence Based Perspective. Sage Publications: Thousand Oaks, CA, 1999.
73. Kendler KS, Bulik CM, Silberg J, Hettema JM, Myers J, Prescott CA. Childhood sexual abuse and adult psychiatric and substance use disorders in women: an epidemiological and cotwin control analysis. Arch Gen Psychiatry 2000; 57: 953-959.
74. Nelson EC, Heath AC, Madden PA, Cooper ML, Dinwiddie SH, Bucholz KK et al. Association between self-reported childhood sexual abuse and adverse psychosocial outcomes: results from a twin study. Arch Gen Psychiatry 2002; 59: 139-145. (Pubitemid 34137383)
75. Jacob T, Waterman B, Heath A, True W, Bucholz KK, Haber R et al. Genetic and environmental effects on offspring alcoholism-new insights using an offspring-of-twins design. Arch Gen Psychiatry 2003; 60: 1265-1272. (Pubitemid 37494080)
76. Cadoret RJ, O'Gorman TW, Troughton E, Heywood E. Alcoholism and antisocial personality. Interrelationships, genetic and environmental factors. Arch Gen Psychiatry 1985; 42: 161-167. (Pubitemid 15246358)
77. Haller MM, Chassin L. The reciprocal influences of perceived risk for alcoholism and alcohol use over time: evidence for aversive transmission of parental alcoholism. J Stud Alcohol Drugs 2010; 71: 588-596.
78. Maes HH, Woodard CE, Murrelle L, Meyer JM, Silberg JL, Hewitt JK et al. Tobacco, alcohol and drug use in eight-to sixteen-yearold twins: the Virginia twin study of adolescent behavioral development. J Stud Alcohol 1999; 60: 293-305. (Pubitemid 29214829)
79. Kendler KS, Schmitt JE, Aggen SH, Prescott CA. Genetic and environmental influences on alcohol, caffeine, cannabis, and nicotine use from adolescence to middle adulthood. Arch Gen Psychiatry 2008; 65: 674-682. (Pubitemid 351787238)
80. Kendler KS, Liu XQ, Gardner CO, McCullough ME, Larson D, Prescott CA. Dimensions of religiosity and their relationship to lifetime psychiatric and substance use disorders. Am J Psychiatry 2003; 160: 496-503. (Pubitemid 41094258)
81. Weitzman ER, Folkman A, Folkman MP, Wechsler H. The relationship of alcohol outlet density to heavy and frequent drinking and drinking-related problems among college students at eight universities. Health Place 2003; 9: 1-6. (Pubitemid 36279439)
82. Moreira MT, Smith LA, Foxcroft D. Social norms interventions to reduce alcohol misuse in university or college students. Cochrane Database Syst Rev 2009; (8): CD006748.
83. World Drink Trends. International Beverage Alcohol Consumption and Production Trends 2002. Produktschap voor Gedistilleerde Dranken: Henley-on-Thames, Oxfordshire, 2002.
84. Room R, Makela K. Typologies of the cultural position of drinking. J Stud Alcohol 2000; 61: 475-483. (Pubitemid 30246963)
85. Wilsnack RW, Vogeltanz ND, Wilsnack SC, Harris TR, Ahlstrom S, Bondy S et al. Gender differences in alcohol consumption and adverse drinking consequences: cross-cultural patterns. Addiction 2000; 95: 251-265. (Pubitemid 30111246)
86. Zemore SE. Acculturation and alcohol among Latino adults in the United States: a comprehensive review. Alcohol Clin Exp Res 2007; 31: 1968-1990. (Pubitemid 350150753)
87. Wagenaar AC, Salois MJ, Komro KA. Effects of beverage alcohol price and tax levels on drinking: a meta-analysis of 1003 estimates from 112 studies. Addiction 2009; 104: 179-190.
88. Chaloupka FJ, Grossman M, Saffer H. The effects of price on alcohol consumption and alcohol-related problems. Alcohol Res Health 2002; 26: 22-34.
89. Mohler-Kuo M, Rehm J, Heeb JL, Gmel G. Decreased taxation, spirits consumption and alcohol-related problems in Switzerland. J Stud Alcohol 2004; 65: 266-273. (Pubitemid 38585856)
90. Plant EJ, Plant M. A 'leap in the dark?'-lessons for the United Kingdom from past extensions of bar opening hours. Int J Drug Pol 2005; 16: 363-368. (Pubitemid 41750461)
91. Campbell CA, Hahn RA, Elder R, Brewer R, Chattopadhyay S, Fielding P et al. The effectiveness of limiting alcohol outlet density as a means of reducing excessive alcohol consumption and alcohol-related harms. Am J Prevent Med 2009; 37: 556-569.
92. Popova S, Giesbrecht N, Bekmuradov D, Patra J. Hours and days of sale and density of alcohol outlets: impacts on alcohol consumption and damage: a systematic review. Alcohol Alcoholism 2009; 44: 500-516.
93. Hill AB. The environment and disease: association or causation? Proc R Soc Med 1965; 58: 295-300.
94. Kuhn TS. Objectivity, value judgment, and theory choice. The Essential Tension: Selected Studies in Scientific Tradition and Change. The University of Chicago Press: Chicago, IL, 1977, pp 320-339.
95. Woodward J. Making Things Happen. Oxford University Press: New York, 2003.
96. Hitchcock C, Woodward J. Explanatory generalizatoins, part II: plumbing explanatory depth. Nous 2003; 37: 181-199.
97. Lakatos I. Falsification and the methodology of scientific research programmes. In: Lakatos I, Musgrave A (eds). Criticism and the Growth of Knowledge. Cambridge University Press: London, 1970. pp 91-197.
98. Gatti U, Tremblay RE, Vitaro F, McDuff P. Youth gangs, delinquency and drug use: a test of the selection, facilitation, and enhancement hypotheses. J Child Psychol Psychiat 2005; 46: 1178-1190. (Pubitemid 44202676)
99. Hawkins JD, Herrenkohl T, Farrington DP, Brewer D, Catalano RF, Harachi TW. A review of predictors of youth violence. In: Loeber R, Farrington DP (eds). Serious & Violent Juvenile Offenders: Risk Factors and Successful Interventions. Sage Publications: London, 1998. pp 106-146.
100. Sampson RJ, Raudenbush SW, Earls F. Neighborhoods and violent crime: a multilevel study of collective efficacy. Science 1997; 277: 918-924. (Pubitemid 27366670)
101. Kendler KS, Jacobson K, Myers JM, Eaves LJ. A genetically informative developmental study of the relationship between conduct disorder and peer deviance in males. Psychol Med 2008; 38: 1001-1011. (Pubitemid 351769219)
102. Shyn SI, Hamilton SP. The genetics of major depression: moving beyond the monoamine hypothesis. Psychiatr Clin North Am 2010; 33: 125-140.
103. Wray NR, Pergadia ML, Blackwood DH, Penninx BW, Gordon SD, Nyholt DR et al. Genome-wide association study of major depressive disorder: new results, meta-analysis, and lessons learned. Mol Psychiatry 2010; e-pub ahead of print November 2010
104. Sullivan PF, Neale MC, Kendler KS. Genetic epidemiology of major depression: review and meta-analysis. Am J Psychiatry 2000; 157: 1552-1562.
105. Kendler KS, Kessler RC, Walters EE, MacLean C, Neale MC, Heath AC et al. Stressful life events, genetic liability, and onset of an episode of major depression in women. Am J Psychiatry 1995; 152: 833-842.
106. Nugent NR, Tyrka AR, Carpenter LL, Price LH. Gene-environment interactions: early life stress and risk for depressive and anxiety disorders. Psychopharmacology (Berl) 2011; 214: 175-196.
107. Lorenzetti V, Allen NB, Fornito A, Yucel M. Structural brain abnormalities in major depressive disorder: a selective review of recent MRI studies. J Affect Disord 2009; 117: 1-17.
108. Videbech P, Ravnkilde B. Hippocampal volume and depression: a meta-analysis of MRI studies. Am J Psychiatry 2004; 161: 1957-1966. (Pubitemid 39441394)
109. Gutman DA, Holtzheimer PE, Behrens TE, Johansen-Berg H, Mayberg HS. A tractography analysis of two deep brain stimulation white matter targets for depression. Biol Psychiatry 2009; 65: 276-282.
110. Kendler KS, Gatz M, Gardner C, Pedersen NL. Personality and major depression: a Swedish longitudinal, population-based twin study. Arch Gen Psychiatry 2006; 63: 1113-1120. (Pubitemid 44498390)
111. Butler AC, Chapman JE, Forman EM, Beck AT. The empirical status of cognitive-behavioral therapy: a review of meta-analyses. Clin Psychol Rev 2006; 26: 17-31. (Pubitemid 41803609)
112. Kendler KS, Gardner CO, Prescott CA. Toward a comprehensive developmental model for major depression in women. Am J Psychiatry 2002; 159: 1133-1145. (Pubitemid 34743253)
113. Kendler KS, Gardner CO, Prescott CA. Toward a comprehensive developmental model for major depression in men. Am J Psychiatry 2006; 163: 115-124. (Pubitemid 43050112)
114. Cong E, Li Y, Shao C, Chen J, Wu W, Shang X et al. CONVERGE consortium. Childhood sexual abuse and major depression in China. 2011 (in review).
115. Brown GW, Harris TO. Social Origins of Depression: A Study of Psychiatric Disorder in Women. Tavistock: London, 1978.
116. Kendler KS, Karkowski LM, Prescott CA. Stressful life events and major depression: risk period, long-term contextual threat, and diagnostic specificity. J Nerv Ment Dis 1998; 186: 661-669. (Pubitemid 29103863)
117. Kendler KS, Karkowski LM, Prescott CA. Causal relationship between stressful life events and the onset of major depression. Am J Psychiatry 1999; 156: 837-841. (Pubitemid 29260336)
118. Kendler KS, Hettema JM, Butera F, Gardner CO, Prescott CA. Life event dimensions of loss, humiliation, entrapment, and danger in the prediction of onsets of major depression and generalized anxiety. Arch Gen Psychiatry 2003; 60: 789-796. (Pubitemid 36960910)
119. Dooley D, Catalano R, Wilson G. Depression and unemployment: panel findings from the Epidemiologic Catchment Area study. Am J Community Psychol 1994; 22: 745-765.
120. Kleinman A. Culture and depression. N Engl J Med 2004; 351: 951-953. (Pubitemid 39166254)
121. Andrews G, Goldberg DP, Krueger RF, Carpenter WT, Hyman SE, Sachdev P et al. Exploring the feasibility of a meta-structure for DSM-V and ICD-11: could it improve utility and validity? Psychol Med 2009; 39: 1993-2000.
122. Kendler KS. Toward a scientific psychiatric nosology. Strengths and limitations. Arch Gen Psychiatry 1990; 47: 969-973.
123. Kendler KS, Zachar P, Craver C. What kinds of things are psychiatric disorders? Psychol Med 2010; 1-8; e-pub ahead of print 22 September 2010.
124. Boyd R. Homeostasis, species, and higher taxa. In: Wilson RA (ed). Species: New Interdisciplinary Essays. The MIT Press, A Bradford Book: Cambridge, MA, 1999, pp 141-185.
125. Kendler KS. Explanatory models for psychiatric illness. Am J Psychiatry 2008; 165: 695-702. (Pubitemid 351810538)
126. Wimsatt WC. Emergence as non-aggregativity and the biases of reductionisms. Foundations Sci 2000; 5: 269-297.
127. Mitchell SD. Integrative pluralism. Biol Philosophy 2002; 17: 55-70.
128. Schaffner KF. Psychiatry and Molecular Biology: Reductionistic Approaches to Schizophrenia in Philosophical Perspectives on Psychiatric Diagnostic Classification. Johns Hopkins University Press: Baltimore, 1994.
129. Sauer U, Heinemann M, Zamboni N. Genetics. Getting closer to the whole picture. Science 2007; 316: 550-551. (Pubitemid 46683128)
130. Bechtel W. Discovering Cell Mechanisms: The Creation of Modern Cell Biology. Cambridge University Press: Cambridge, UK, 2005.
131. Kendler KS, Schaffner KF. The dopamine hypothesis of schizophrenia: an historical and philosophical analysis. Philosophy Psychol Psychiatry 2011; 18: 41-63.
132. Lacasse JR, Leo J. Serotonin and depression: a disconnect between the advertisements and the scientific literature. PLoS Med 2005; 2: e392.