Expression of mismatch repair gene PMS2 in nasopharyngeal carcinoma and regulation by glycogen synthase kinase-3β in vivo and in vitro

Auris Nasus Larynx

Volumn 39, Issue 1, 2012, Pages 71-76

  Fang, Jugao ^a   Lei, Wenbin ^b   Huang, Xiaoming ^b   Li, Pingdong ^a   Chen, Xiaohong ^a   Zhu, Xiaolin ^b   Wen, Weiping ^b   Li, Huabin ^b  

^a CAPITAL MEDICAL UNIVERSITY   (China)

^b THE FIRST AFFILIATED HOSPITAL OF SUN YAT SEN UNIVERSITY   (China)

Author keywords

CNE 2 cell; Glycogen synthase kinase 3 ; Mismatch repair gene; Nasopharyngeal carcinoma; PMS2

Indexed keywords

CISPLATIN; GLYCOGEN SYNTHASE KINASE 3BETA; MISMATCH REPAIR PROTEIN PMS2; SMALL INTERFERING RNA;

ADULT; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CANCER TISSUE; CARCINOGENESIS; CHEMOSENSITIZATION; CLINICAL ARTICLE; CONTROLLED STUDY; DOWN REGULATION; ENZYME ACTIVITY; ENZYME INACTIVATION; ENZYME PHOSPHORYLATION; ENZYME REGULATION; FEMALE; FLOW CYTOMETRY; GENE; GENE EXPRESSION REGULATION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; IN VIVO STUDY; MALE; MISMATCH REPAIR; NASOPHARYNX CARCINOMA; PMS2 GENE; PROTEIN SYNTHESIS; PROTEIN SYNTHESIS REGULATION; RNA INTERFERENCE; SIGNAL TRANSDUCTION;

ADENOSINE TRIPHOSPHATASES; ADULT; APOPTOSIS; CARCINOMA; CELL LINE, TUMOR; CISPLATIN; DNA MISMATCH REPAIR; DNA REPAIR ENZYMES; DNA-BINDING PROTEINS; FEMALE; GLYCOGEN SYNTHASE KINASE 3; HUMANS; LOSS OF HETEROZYGOSITY; MALE; MICROSATELLITE INSTABILITY; MIDDLE AGED; NASOPHARYNGEAL NEOPLASMS; TRANSFECTION;

EID: 84855355901     PISSN: 03858146     EISSN: 18791476     Source Type: Journal    
DOI: 10.1016/j.anl.2011.02.009     Document Type: Article

References (16)

1. Chou J., Lin Y.C., Kim J., You L., Xu Z., He B., et al. Nasopharyngeal carcinoma-review of the molecular mechanisms of tumorigenesis. Head Neck 2008, 30:946-963.
2. Jiricny J. The multifaceted mismatch-repair system. Nat Rev Mol Cell Biol 2006, 7:335-346.
3. Liu B., Parsons R., Papadopoulos N., Nicolaides N.C., Lynch H.T., Watson P., et al. Analysis of mismatch repair genes in hereditary nonpolyposis colorectal cancer patients. Nat Med 1996, 2:169-174.
4. Geisler J.P., Goodheart M.J., Sood A.K., Holmes R.J., Hatterman-Zogg M.A., Buller R.E. Mismatch repair gene expression defects contribute to microsatellite instability in ovarian carcinoma. Cancer 2003, 98:2199-2206.
5. Huang D.P., Lo K.W., van Hasselt C.A., Woo J.K., Choi P.H., Leung S.F., et al. A region of homozygous deletion on chro mosome 9p21-22 in primary nasopharyngeal carcinoma. Cancer Res 1994, 54:4003-4006.
6. Hui A.B., Lo K.W., Leung S.F., Choi P.H., Fong Y., Lee J.C., et al. Loss of heterozygosity on the arm of chromosome 11 in nasopharyngeal carcinoma. Cancer Res 1996, 56:3225-3229.
7. Peiró G., Diebold J., Lohse P., Ruebsamen H., Lohse P., Baretton G.B., et al. Microsatellite instability, loss of heterozygosity, and loss of hMLH1 and hMSH2 protein expression in endometrial carcinoma. Hum Pathol 2002, 33:347-354.
8. Kim L., Kimmel A.R. GSK3, a master switch regulating cell-fate specification and tumorigenesis. Curr Opin Genet Dev 2000, 10:508-514.
9. Zhang Y., Shu Y.M., Wang S.F., Da B.H., Wang Z.H., Li H.B. Stabilization of mismatch repair gene PMS2 by glycogen synthase kinase 3β is implicated in the treatment of cervical carcinoma. BMC Cancer 2010, 10:58.
10. Huang X.M., Dai C.B., Mou Z.L., Wang L.J., Wen W.P., Lin S.G., et al. Overproduction of cyclin D1 is dependent on activated mTORC1 signal in nasopharyngeal carcinoma: implication for therapy. Cancer Lett 2009, 279:47-56.
11. Luo J. Glycogen synthase kinase 3β (GSK3β) in tumorigenesis and cancer chemotherapy. Cancer Lett 2009, 273:194-200.
12. Swart R., Ruf I.K., Sample J., Longnecker R. Latent membrane protein 2A-mediated effects on the phosphatidylinositol 3-kinase/Akt pathway. J Virol 2000, 74:10838-10845.
13. Morrison J.A., Klingelhutz A.J., Raab-Traub N. Epstein-Barr virus latent membrane protein 2A activates β-catenin signaling in epithelial cells. J Virol 2003, 77:12276-12284.
14. Morrison J.A., Gulley M.L., Pathmanathan R., Raab-Traub N. Differential signaling pathways are activated in the Epstein-Barr virus-associated malignancies nasopharyngeal carcinoma and Hodgkin lymphoma. Cancer Res 2004, 64:5251-5260.
15. Gill S., Lindor N.M., Burgart L.J., Smalley R., Leontovich O., French A.J., et al. Isolated loss of PMS2 expression in colorectal cancers: frequency, patient age, and familial aggregation. Clin Cancer Res 2005, 11:6466-6471.
16. Gibson S.L., Narayanan L., Hegan D.C., Buermeyer A.B., Liskay R.M., Glazer P.M. Overexpression of the DNA mismatch repair factor. PMS2, confers hypermutability and DNA damage tolerance. Cancer Lett 2006, 244:195-202.