Investigation of the Effects of α1-Adrenoceptor Antagonism and L-Type Calcium Channel Blockade on Ejaculation and Vas Deferens and Seminal Vesicle Contractility In Vitro

Journal of Sexual Medicine

Volumn 9, Issue 1, 2012, Pages 159-168

  De Almeida Kiguti, Luiz Ricardo ^a   Pupo, André Sampaio ^a  

^a SÃO PAULO STATE UNIVERSITY UNESP   (Brazil)

Author keywords

Ejaculatory Latency; L Type Calcium Channels; Premature Ejaculation; Seminal Vesicle; Vas Deferens

Indexed keywords

NIFEDIPINE; NIGULDIPINE; NORADRENALIN; TAMSULOSIN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; COPULATION; DRUG ANTAGONISM; EJACULATION; FEMALE; IC 50; IN VITRO STUDY; LATENT PERIOD; MALE; MATING; NONHUMAN; PRIORITY JOURNAL; RAT; SEMINAL VESICLE; TENSION; VAS DEFERENS;

EID: 84855342334     PISSN: 17436095     EISSN: 17436109     Source Type: Journal    
DOI: 10.1111/j.1743-6109.2011.02410.x     Document Type: Article

References (53)

1. Althof SE. Prevalence, characteristics and implications of premature ejaculation/rapid ejaculation. J Urol 2006;175:842-8.
2. Ralph DJ, Wylie KR. Ejaculatory disorders and sexual function. BJU Int 2005;95:1181-6.
3. Bettocchi C, Verze P, Palumbo F, Arcaniolo D, Mirone V. Ejaculatory disorders: Pathophysiology and management. Nat Clin Pract Urol 2008;5:93-103.
4. McMahon CG, Althof SE, Waldinger MD, Porst H, Dean J, Sharlip ID, Adaikan PG, Becher E, Broderick GA, Buvat J, Dabees K, Giraldi A, Giuliano F, Hellstrom WJ, Incrocci L, Laan E, Meuleman E, Perelman MA, Rosen RC, Rowland DL, Segraves R. An evidence-based definition of lifelong premature ejaculation: Report of the International Society for Sexual Medicine (ISSM) ad hoc committee for the definition of premature ejaculation. J Sex Med 2008;5:1590-606.
5. Rowland D, McMahon CG, Abdo C, Chen J, Jannini E, Waldinger MD, Ahn TY. Disorders of orgasm and ejaculation in men. J Sex Med 2010;7:1668-86.
6. Carson C, Wyllie M. Improved ejaculatory latency, control and sexual satisfaction when PSD502 is applied topically in men with premature ejaculation: Results of a phase III, double-blind, placebo-controlled study. J Sex Med 2010;7:3179-89.
7. McMahon CG. The etiology and management of premature ejaculation. Nat Clin Pract Urol 2005;2:426-33.
8. McMahon CG, Althof SE, Kaufman JM, Buvat J, Levine SB, Aquilina JW, Tesfaye F, Rothman M, Rivas DA, Porst H. Efficacy and safety of dapoxetine for the treatment of premature ejaculation: Integrated analysis of results from five phase 3 trials. J Sex Med 2011;8:524-39.
9. Giuliano F, Clement P. Serotonin and premature ejaculation: From physiology to patient management. Eur Urol 2006;50:454-66.
10. Althof SE, Abdo CH, Dean J, Hackett G, McCabe M, McMahon CG, Rosen RC, Sadovsky R, Waldinger M, Becher E, Broderick GA, Buvat J, Goldstein I, El-Meliegy AI, Giuliano F, Hellstrom WJ, Incrocci L, Jannini EA, Park K, Parish S, Porst H, Rowland D, Segraves R, Sharlip I, Simonelli C, Tan HM, International Society for Sexual Medicine. International Society for Sexual Medicine's guidelines for the diagnosis and treatment of premature ejaculation. J Sex Med 2010;7:2947-69.
11. Carro-Juarez M, Rodriguez-Manzo G. The spinal pattern generator for ejaculation. Brain Res Rev 2008;58:106-20.
12. Coolen LM, Allard J, Truitt WA, McKenna KE. Central regulation of ejaculation. Physiol Behav 2004;83:203-15.
13. Avellar MC, Lazari MF, Porto CS. Expression and function of G-protein-coupled receptors in the male reproductive tract. An Acad Bras Cienc 2009;81:321-44.
14. Hellstrom WJ, Giuliano F, Rosen RC. Ejaculatory dysfunction and its association with lower urinary tract symptoms of benign prostatic hyperplasia and BPH treatment. Urology 2009;74:15-21.
15. Sanbe A, Tanaka Y, Fujiwara Y, Tsumura H, Yamauchi J, Cotecchia S, Koike K, Tsujimoto G, Tanoue A. Alpha1-adrenoceptors are required for normal male sexual function. Br J Pharmacol 2007;152:332-40.
16. Amobi N, Guillebaud J, Smith CH. Comparative effects of T-type and L-type Ca(2+)-antagonists against noradrenaline-induced contractions of human vas deferens. BJU Int 2010;106:578-85.
17. Guh JH, Chueh SC, Ko FN, Teng CM. Characterization of alpha 1-adrenoceptor subtypes in tension response of human prostate to electrical field stimulation. Br J Pharmacol 1995;115:142-6.
18. Boselli C, Bianchi L, Barbieri A, Grana E. Effect of calcium antagonists on the response to noradrenaline in the whole and bisected rat vas deferens. J Auton Pharmacol 1998;18:297-306.
19. Silva MA, Megale A, Avellar MC, Porto CS. Expression and pharmacological characterization of alpha1-adrenoceptors in rat seminal vesicle. Eur J Pharmacol 1999;381:141-9.
20. Catterall WA, Perez-Reyes E, Snutch TP, Striessnig J. International Union of Pharmacology. XLVIII. Nomenclature and structure-function relationships of voltage-gated calcium channels. Pharmacol Rev 2005;57:411-25.
21. Godfraind T, Miller R, Wibo M. Calcium antagonism and calcium entry blockade. Pharmacol Rev 1986;38:321-416.
22. Pupo AS. Functional effects of castration on alpha1-adrenoceptors in rat vas deferens. Eur J Pharmacol 1998;351:217-23.
23. Belevych AE, Zima AV, Vladimirova IA, Hirata H, Jurkiewicz A, Jurkiewicz NH, Shuba MF. TTX-sensitive Na(+) and nifedipine-sensitive Ca(2+) channels in rat vas deferens smooth muscle cells. Biochim Biophys Acta 1999;1419:343-52.
24. Castillo CJ, Lafayette S, Caricati-Neto A, Sette M, Jurkiewicz NH, García AG, Jurkiewicz A. Low dihydropyridine receptor density in vasa deferentia of castrated rats. Br J Pharmacol 1992;105:257-8.
25. Powers RE, Colucci WS. An increase in putative voltage dependent calcium channel number following reserpine treatment. Biochem Biophys Res Commun 1985;132:844-9.
26. Fovaeus M, Andersson KE, Hedlund H. Calcium channel blockade and contractile responses in the isolated human vas deferens. J Urol 1987;138:654-8.
27. Blakeley AG, Brown DA, Cunnane TC, French AM, McGrath JC, Scott NC. Effects of nifedipine on electrical and mechanical responses of rat and guinea pig vas deferens. Nature 1981;294:759-61.
28. Park SY, Lee MY, Keum EM, Myung SC, Kim SC. Ionic currents in single smooth muscle cells of the human vas deferens. J Urol 2004;172:628-33.
29. Birowo P, Uckert S, Kedia GT, Sonnenberg JE, Thon WF, Rahardjo D, Kuczyk MA. Characterization of the effects of various drugs likely to affect smooth muscle tension on isolated human seminal vesicle tissue. Urology 2010;75:974-8.
30. Kubota Y, Hashitani H, Fukuta H, Sasaki S, Kohri K, Suzuki H. Mechanisms of excitatory transmission in circular smooth muscles of the guinea pig seminal vesicle. J Urol 2003;169:390-5.
31. Boer R, Grassegger A, Schudt C, Glossmann H. (+)-Niguldipine binds with very high affinity to Ca2+ channels and to a subtype of alpha 1-adrenoceptors. Eur J Pharmacol 1989;172:131-45.
32. Maggi CA, Grimaldi G, Meli A. The effects of nifedipine and verapamil on spontaneous and carbachol-stimulated contractions of rat urinary bladder "in vivo". Arch Int Pharmacodyn Ther 1982;257:288-94.
33. Smits GJ, Kitzen JM, Perrone MH, Cox BF. Angiotensin subtype 1 blockade selectively potentiates adenosine subtype 2-mediated vasodilation. Hypertension 1993;22:221-30.
34. Gaggi R, Dall'Olio R, Roncada P, Gianni AM. Effects of isradipine and darodipine on serotonergic system of the rat brain. Pharmacol Biochem Behav 1995;51:183-7.
35. McIntosh TK, Barfield RJ. Brain monoaminergic control of male reproductive behavior. I. Serotonin and the post-ejaculatory refractory period. Behav Brain Res 1984;12:255-65.
36. McIntosh TK, Barfield RJ. Brain monoaminergic control of male reproductive behavior. II. Dopamine and the post-ejaculatory refractory period. Behav Brain Res 1984;12:267-73.
37. McIntosh TK, Barfield RJ. Brain monoaminergic control of male reproductive behavior. III. Norepinephrine and the post-ejaculatory refractory period. Behav Brain Res 1984;12:275-81.
38. Gaggi R, Dall'Olio R, Roncada P, Gianni AM. Peculiar effects of isradipine and darodipine on the rat brain dopaminergic system. Gen Pharmacol 1995;26:303-8.
39. Furukawa K, Rosario DJ, Smith DJ, Chapple CR, Uchiyama T, Chess-Williams R. Alpha 1A-adrenoceptor-mediated contractile responses of the human vas deferens. Br J Pharmacol 1995;116:1605-10.
40. Noble AJ, Chess-Williams R, Couldwell C, Furukawa K, Uchyiuma T, Korstanje C, Chapple CR. The effects of tamsulosin, a high affinity antagonist at functional alpha 1A- and alpha 1D-adrenoceptor subtypes. Br J Pharmacol 1997;120:231-8.
41. Kava MS, Blue DR Jr, Vimont RL, Clarke DE, Ford AP. Alpha1L-adrenoceptor mediation of smooth muscle contraction in rabbit bladder neck: A model for lower urinary tract tissues of man. Br J Pharmacol 1998;123:1359-66.
42. Takayanagi I, Konno F, Toru T, Takahashi R. Difference in mode of action of alpha 1-adrenoceptor antagonists on some vascular smooth muscles and efficacy. Jpn J Pharmacol 1986;42:237-41.
43. Reynolds VL, Stump DG, Holson JF. Assessing the toxicological significance of ejaculatory plugs as a clinical observation in rat toxicology studies: CNS-mediated increases in plug production vs. gustatory-mediated decreases in plug consumption. Reprod Toxicol 2010;29:271-8.
44. Carballada R, Esponda P. Role of fluid from seminal vesicles and coagulating glands in sperm transport into the uterus and fertility in rats. J Reprod Fertil 1992;95:639-48.
45. Kim SW, Lee SH, Paick JS. In vivo rat model to measure hypogastric nerve stimulation-induced seminal vesicle and vasal pressure responses simultaneously. Int J Impot Res 2004;16:427-32.
46. Giuliano F, Bernabe J, Droupy S, Alexandre L, Allard J. A comparison of the effects of tamsulosin and alfuzosin on neurally evoked increases in bladder neck and seminal vesicle pressure in rats. BJU Int 2004;93:605-8.
47. Beyer C, Contreras JL, Larsson K, Olmedo M, Morali G. Patterns of motor and seminal vesicle activities during copulation in the male rat. Physiol Behav 1982;29:495-500.
48. Lepor H. Phase III multicenter placebo-controlled study of tamsulosin in benign prostatic hyperplasia. Tamsulosin Investigator Group. Urology 1998;51:892-900.
49. Hellstrom WJ, Sikka SC. Effects of acute treatment with tamsulosin versus alfuzosin on ejaculatory function in normal volunteers. J Urol 2006;176:1529-33.
50. Hisasue S, Furuya R, Itoh N, Kobayashi K, Furuya S, Tsukamoto T. Ejaculatory disorder caused by alpha-1 adrenoceptor antagonists is not retrograde ejaculation but a loss of seminal emission. Int J Urol 2006;13:1311-6.
51. Giuliano F, Clement P. Neuroanatomy and physiology of ejaculation. Annu Rev Sex Res 2005;16:190-216.
52. Smith JF, Walsh TJ, Turek PJ. Ejaculatory duct obstruction. Urol Clin North Am 2008;35:221-7.
53. Hellstrom WJ, Sikka SC. Effects of alfuzosin and tamsulosin on sperm parameters in healthy men: Results of a short-term, randomized, double-blind, placebo-controlled, crossover study. J Androl 2009;30:469-74.