Cerebral oxygen metabolism of rats using injectable 15 O-oxygen with a steady-state method

Journal of Cerebral Blood Flow and Metabolism

Volumn 32, Issue 1, 2012, Pages 33-40

  Kobayashi, Masato ^a,b   Mori, Tetsuya ^a   Kiyono, Yasushi ^a   Tiwari, Vijay Narayan ^a   Maruyama, Rikiya ^a   Kawai, Keiichi ^a,b   Okazawa, Hidehiko ^a  

^a UNIVERSITY OF FUKUI   (Japan)

^b KANAZAWA UNIVERSITY   (Japan)

Author keywords

15O gas PET; cerebral oxygen metabolism; hemoglobin containing vesicles; injectable 15O 2; steady state method

Indexed keywords

HEMOGLOBIN; OXYGEN 15; TRACER; WATER;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRAIN BLOOD FLOW; BRAIN BLOOD VOLUME; BRAIN INFARCTION SIZE; BRAIN OXYGEN CONSUMPTION; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; HEMODYNAMIC PARAMETERS; ISOTOPE LABELING; METABOLIC RATE; MIDDLE CEREBRAL ARTERY OCCLUSION; NEUROIMAGING; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; RADIOACTIVITY; RAT; STEADY STATE; SYRINGE;

ANIMALS; BLOOD VOLUME; CEREBRAL CORTEX; CEREBROVASCULAR CIRCULATION; INFARCTION, MIDDLE CEREBRAL ARTERY; MALE; OXYGEN; OXYGEN RADIOISOTOPES; POSITRON-EMISSION TOMOGRAPHY; RATS; RATS, SPRAGUE-DAWLEY;

EID: 84855340800     PISSN: 0271678X     EISSN: 15597016     Source Type: Journal    
DOI: 10.1038/jcbfm.2011.125     Document Type: Article

References (28)

1. Frackowiak RS, Lenzi GL, Jones T, Heather JD (1980) Quantitative measurement of regional cerebral blood flow and oxygen metabolism in man using 15O and positron emission tomography: theory, procedure, and normal values. J Comput Assist Tomogr 4:727-36 (Pubitemid 11247403)
2. Kanno I, Lammertsma AA, Heather JD, Gribbs JM, Rhodes CG, Clark JC, Jones T (1984) Measurement of cerebral blood flow using bolus inhalation of C15O2 and positron emission tomography: description of the method and its comparison with the C15O2 continuous inhalation method. J Cereb Blood Flow Metab 4:224-34 (Pubitemid 14080151)
3. Kobayashi M, Kiyono Y, Maruyama R, Mori T, Kawai K, Okazawa H (2011) Development of an H21 5O steady-state method combining a bolus and slow increasing injection with a multiprogramming syringe pump. J Cereb Blood Flow Metab 31:527-34
4. Kuge Y, Minematsu K, Yamaguchi T, Miyake Y (1995) Nylon monofilament for intraluminal middle cerebral artery occlusion in rats. Stroke 26:1655-7
5. Lammertsma AA, Heather JD, Jones T, Frackowiak RS, Lenzi GL (1982) A statistical study of the steady state technique for measuring regional cerebral blood flow and oxygen utilisation using 15O. J Comput Assist Tomogr 6:566-73 (Pubitemid 12123045)
6. Lammertsma AA, Jones T (1983) Correction for the presence of intravascular oxygen-15 in the steady-state technique for measuring regional oxygen extraction ratio in the brain: 1. Description of the method. J Cereb Blood Flow Metab 3:416-24 (Pubitemid 14182285)
7. Lammertsma AA, Wise RJ, Heather JD, Gibbs JM, Leenders KL, Frackowiak RS, Rhodes CG, Jones T (1983) Correction for the presence of intravas-cular oxygen-15 in the steady-state technique for measuring regional oxygen extraction ratio in the brain: 2. Results in normal subjects and brain tumour and stroke patients. J Cereb Blood Flow Metab 3: 425-31 (Pubitemid 14182286)
8. Longa EZ, Weinstein PR, Carlson S, Cummins R (1989) Reversible middle cerebral artery occlusion without craniectomy in rats. Stroke 20:84-91 (Pubitemid 19040218)
9. Magata Y, Temma T, Iida H, Ogawa M, Mukai T, Iida Y, Morimoto T, Konishi J, Saji H (2003) Development of injectable O-15 oxygen and estimation of rat OEF. J Cereb Blood Flow Metab 23:671-6 (Pubitemid 36713672)
10. Morton D, Safron JA, Rice DW, Wilson DM, White RD (1997) Effects of infusion rates in rats receiving repeated large volumes of saline solution intravenously. Lab Anim Sci 47:656-9
11. Ogata Y (2000) Characteristics and function of human hemoglobin vesicles as an oxygen carrier. Polym Adv Technol 11:205-9
12. Ohta S, Meyer E, Thompson CJ, Gjedde A (1992) Oxygen consumption of the living human brain measured after a single inhalation of positron emitting oxygen. J Cereb Blood Flow Metab 12:179-92
13. Ohta S, Meyer E, Fujita H, Reutens DC, Evans A, Gjedde A (1996) Cerebral water clearance in humans determined by PET: I. Theory and normal values. J Cereb Blood Flow Metab 16:765-80 (Pubitemid 26292045)
14. Okazawa H, Yamauchi H, Sugimoto K, Takahashi M, Toyoda H, Kishibe Y, Shio H (2001) Quantitative comparison of the bolus and steady-state methods for measurement of cerebral perfusion and oxygen metabolism: PET study using 15O-gas and water. J Cereb Blood Flow Metab 21:793-803 (Pubitemid 32613533)
15. Ouchi Y, Nobezawa S, Yoshikawa E, Futatsubashi M, Kanno T, Okada H, Torizuka T, Nakayama T, Tanaka K (2001) Postural effects on brain hemodynamics in unilateral cerebral artery occlusive disease: a positron emission tomography study. J Cereb Blood Flow Metab 21:1058-66 (Pubitemid 32823741)
16. Perles-Barbacaru AT, Lahrech H (2007) A new magnetic resonance imaging method for mapping the cerebral blood volume fraction: the rapid steady-state T1 method J Cereb. Blood Flow Metab 27:618-31
17. Phillips WT, Lemen L, Goins B, Rudolph AS, Klipper R, Fresne D, Jerabek PA, Emch ME, Martin C, Fox PT, McMahan CA (1997) Use of oxygen-15 to measure oxygen-carrying capacity of blood substitutes in vivo. Am J Physiol 272:2492-9
18. Sandor P, Put JC, de Jong W, de Wied D (1986) Continuous measurement of cerebral blood volume in rats with the photoelectric technique: effect of morphine and naloxone. Life Sci 39:1657-65 (Pubitemid 16007009)
19. Takeoka S, Teramura Y, Atoji T, Tsuchida E (2002) Effect of Hb-encapsulation with vesicles on H2O2 reaction and lipid peroxidation. Bioconjug Chem 13:1302-8 (Pubitemid 35420023)
20. Temma T, Magata Y, Kuge Y, Shimonaka S, Sano K, Katada Y, Kawashima H, Mukai T, Watabe H, Iida H, Saji H (2006) Estimation of oxygen metabolism in a rat model of permanent ischemia using positron emission tomography with injectable 15O-O2. J Cereb Blood Flow Metab 26:1577-83 (Pubitemid 44809086)
21. Temma T, Kuge Y, Sano K, Kamihashi J, Obokata N, Kawashima H, Magata Y, Saji H (2008) PET O-15 cerebral blood flow and metabolism after acute stroke in spontaneously hypertensive rats. Brain Res 1212:18-24
22. Tiwari VN, Kiyono Y, Kobayashi M, Mori T, Kudo T, Okazawa H, Fujibayashi Y (2010) Automatic labeling method for injectable 15O-oxygen using hemoglobin-containing liposome vesicles and its application for measurement of brain oxygen consumption by PET. Nucl Med Biol 37:77-83
23. Todd MM, Weeks JB, Warner DS (1993) Microwave fixation for the determination of cerebral blood volume in rats. J Cereb Blood Flow Metab 13:328-36 (Pubitemid 23067469)
24. Yamada R, Watanabe M, Omura T, Sato N, Shimizu K, Takahashi M, Ote K, Katabe A, Moriya T, Sakai K, Yamashita T, Tanaka E (2008) Development of a small animal PET scanner using DOI detectors. IEEE Trans Nucl Sci 55:906-11
25. Yamauchi H, Fukuyama H, Nagahama Y, Nabatame H, Nakamura K, Yamamoto Y, Yonekura Y, Konishi J, Kimura J (1996) Evidence of misery perfusion and risk for recurrent stroke in major cerebral arterial occlusive diseases from PET. J Neurol Neurosurg Psychiatry 61:18-25 (Pubitemid 26232022)
26. Yamauchi H, Fukuyama H, Nagahama Y, Katsumi Y, Okazawa H (1998) Cerebral hematocrit decreases with hemodynamic compromise in carotid artery occlusion. A PET study. Stroke 29:98-103 (Pubitemid 28046949)
27. Yamauchi H, Fukuyama H, Nagahama Y, Nabatame H, Ueno M, Nishizawa S, Konishi J, Shio H (1999) Significance of increased oxygen extraction fraction in 5-year prognosis of major cerebral arterial occlusive diseases. J Nucl Med 40:1992-8 (Pubitemid 30022012)
28. Zilles K, Wree A (1995) Cortex: areal and laminar structure. In: The Rat Nervous System (Paxinos G, eds), 2nd ed, San Diego, CA: Academic Press, Inc., 649-85