Minimally invasive quantification of lymph flow in mice and rats by imaging depot clearance of near-infrared albumin

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 302, Issue 2, 2012, Pages

  Karlsen, Tine V ^a   McCormack, Emmet ^a   Mujic, Maja ^a   Tenstad, Olav ^a   Wiig, Helge ^a  

^a UNIVERSITY OF BERGEN   (Norway)

Author keywords

[No Author keywords available]

Indexed keywords

BOVINE SERUM ALBUMIN; ENDOTHELIN 1; FLUORESCENT DYE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CALCULATION; CAPILLARY PERMEABILITY; CONTROLLED STUDY; DISSOCIATION CONSTANT; FEMALE; LYMPH FLOW; LYMPHEDEMA; MALE; MINIMALLY INVASIVE PROCEDURE; MOUSE; NEAR INFRARED SPECTROSCOPY; NONHUMAN; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; RAT; REPRODUCIBILITY;

ALBUMINS; ANIMALS; FEMALE; FLUORESCENT DYES; LYMPH; LYMPHATIC SYSTEM; MICE; RADIOPHARMACEUTICALS; RATS;

EID: 84855327154     PISSN: 03636135     EISSN: 15221539     Source Type: Journal    
DOI: 10.1152/ajpheart.00842.2011     Document Type: Article

References (36)

1. Abbas AK, Lichtman AH, Pillai S. Cellular and Molecular Immunology. Philadelphia, PA: Elsevier, 2007.
2. Aukland K, Reed RK. Interstitial-lymphatic mechanisms in the control of extracellular fluid volume. Physiol Rev 73: 1-78, 1993.
3. Avery M, Nathanson SD, Hetzel FW. Lymph flow from murine footpad tumors before and after sublethal hyperthermia. Radiat Res 132: 50-53, 1992.
4. Cherrick GR, Stein SW, Leevy CM, Davidson CS. Indocyanine green: observations on its physical properties, plasma decay, and hepatic extraction. J Clin Invest 39: 592-600, 1960.
5. Curry FR, Rygh CB, Karlsen T, Wiig H, Adamson RH, Clark JF, Lin YC, Gassner B, Thorsen F, Moen I, Tenstad O, Kuhn M, Reed RK. Atrial natriuretic peptide modulation of albumin clearance and contrast agent permeability in mouse skeletal muscle and skin: role in regulation of plasma volume. J Physiol 588: 325-339, 2010.
6. Gashev AA, Nagai T, Bridenbaugh EA. Indocyanine green and lymphatic imaging: current problems. Lymphat Res Biol 8: 127-130, 2010.
7. Graves EE, Yessayan D, Turner G, Weissleder R, Ntziachristos V. Validation of in vivo fluorochrome concentrations measured using fluorescence molecular tomography (Abstract). J Biomed Opt 10: 44019, 2005.
8. Harrell MI, Iritani BM, Ruddell A. Tumor-induced sentinel lymph node lymphangiogenesis and increased lymph flow precede melanoma metastasis. Am J Pathol 170: 774-786, 2007.
9. Hofmann M, McCormack E, Mujic M, Rossberg M, Bernd A, Bereiter-Hahn J, Gjertsen BT, Wiig H, Kippenberger S. Increased plasma colloid osmotic pressure facilitates the uptake of therapeutic macromolecules in a xenograft tumor model. Neoplasia 11: 812-822, 2009.
10. Jain R, Dandekar P, Patravale V. Diagnostic nanocarriers for sentinel lymph node imaging. J Control Rel 138: 90-102, 2009.
11. Karkkainen MJ, Saaristo A, Jussila L, Karila KA, Lawrence EC, Pajusola K, Bueler H, Eichmann A, Kauppinen R, Kettunen MI, Yla-Herttuala S, Finegold DN, Ferrell RE, Alitalo K. A model for gene therapy of human hereditary lymphedema. Proc Natl Acad Sci USA 98: 12677-12682, 2001.
12. Karlsen TV, Karkkainen MJ, Alitalo K, Wiig H. Transcapillary fluid balance consequences of missing initial lymphatics studied in a mouse model of primary lymphoedema. J Physiol 574: 583-596, 2006.
13. Kwon S, Sevick-Muraca EM. Noninvasive quantitative imaging of lymph function in mice. Lymphat Res Biol 5: 219-231, 2007.
14. Levick JR. An Introduction to Cardiovascular Physiology. London, UK: Arnold, 2003.
15. McCormack E, Micklem DR, Pindard LE, Silden E, Gallant P, Belenkov A, Lorens JB, Gjertsen BT. In vivo optical imaging of acute myeloid leukemia by green fluorescent protein: time-domain autofluorescence decoupling, fluorophore quantification, and localization. Mol Imaging 6: 193-204, 2007.
16. Modi S, Stanton AW, Mortimer PS, Levick JR. Clinical assessment of human lymph flow using removal rate constants of interstitial macromolecules: a critical review of lymphoscintigraphy. Lymphat Res Biol 5: 183-202, 2007.
17. Modi S, Stanton AW, Svensson WE, Peters AM, Mortimer PS, Levick JR. Human lymphatic pumping measured in healthy and lymphoedematous arms by lymphatic congestion lymphoscintigraphy. J Physiol 583: 271-285, 2007.
18. Nathanson SD, Avery M, Anaya P, Sarantou T, Hetzel FW. Lymphatic diameters and radionuclide clearance in a murine melanoma model. Arch Surg 132: 311-315, 1997.
19. Nathanson SD, Nelson L, Karvelis KC. Rates of flow of technetium 99m-labeled human serum albumin from peripheral injection sites to sentinel lymph nodes. Ann Surg Oncol 3: 329-335, 1996.
20. O'Mahony S, Rose SL, Chilvers AJ, Ballinger JR, Solanki CK, Barber RW, Mortimer PS, Purushotham AD, Peters AM. Finding an optimal method for imaging lymphatic vessels of the upper limb. Eur J Nucl Med Mol Imaging 31: 555-563, 2004.
21. Pain SJ, Barber RW, Ballinger JR, Solanki CK, O'Mahony S, Mortimer PS, Purushotham A, Peters AM. Side-to-side symmetry of radioprotein transfer from tissue space to systemic vasculature following subcutaneous injection in normal subjects and patients with breast cancer. Eur J Nucl Med Mol Imaging 30: 657-661, 2003.
22. Proulx ST, Luciani P, Derzsi S, Rinderknecht M, Mumprecht V, Leroux JC, Detmar M. Quantitative imaging of lymphatic function with liposomal indocyanine green. Cancer Res 70: 7053-7062, 2010.
23. Reed RK, Johansen S, Noddeland H. Turnover rate of interstitial albumin in rat skin and skeletal muscle. Effects of limb movements and motor activity. Acta Physiol Scand 125: 711-718, 1985.
24. Sakai H, Ikomi F, Ohhashi T. Effects of endothelin on spontaneous contractions in lymph vessels. Am J Physiol Heart Circ Physiol 277: H459-H466, 1999.
25. Sharma R, Wang W, Rasmussen JC, Joshi A, Houston JP, Adams KE, Cameron A, Ke S, Kwon S, Mawad ME, Sevick-Muraca EM. Quantitative imaging of lymph function. Am J Physiol Heart Circ Physiol 292: H3109-H3118, 2007.
26. Sharma R, Wendt JA, Rasmussen JC, Adams KE, Marshall MV, Sevick-Muraca EM. New horizons for imaging lymphatic function. Ann NY Acad Sci 1131: 13-36, 2008.
27. Slavin SA, Van den Abbeele AD, Losken A, Swartz MA, Jain RK. Return of lymphatic function after flap transfer for acute lymphedema. Ann Surg 229: 421-427, 1999.
28. Strand SE, Persson BR. Quantitative lymphoscintigraphy I: basic concepts for optimal uptake of radiocolloids in the parasternal lymph nodes of rabbits. J Nucl Med 20: 1038-1046, 1979.
29. Tammela T, Alitalo K. Lymphangiogenesis: Molecular mechanisms and future promise. Cell 140: 460-476, 2000.
30. Wahl RL, Geatti O, Liebert M, Wilson B, Shreve P, Beers BA. Kinetics of interstitially administered monoclonal antibodies for purposes of lymphoscintigraphy. J Nucl Med 28: 1736-1744, 1987.
31. Wiig H, Aukland K, Tenstad O. Isolation of interstitial fluid from rat mammary tumors by a centrifugation method. Am J Physiol Heart Circ Physiol 284: H416-H424, 2003.
32. Wiig H, Lund T. Relationship between interstitial fluid volume and pressure (compliance) in hypothyroid rats. Am J Physiol Heart Circ Physiol 281: H1085-H1092, 2001.
33. Wiig H, Reed RK. Compliance of the interstitial space in rats. II. Studies on skin. Acta Physiol Scand 113: 307-315, 1981.
34. Zhao J, van Helden DF. ET-1-associated vasomotion and vasospasm in lymphatic vessels of the guinea-pig mesentery. Br J Pharmacol 140: 1399-1413, 2003.
35. Zhou Q, Wood R, Schwarz EM, Wang YJ, Xing L. Near-infrared lymphatic imaging demonstrates the dynamics of lymph flow and lymphangiogenesis during the acute versus chronic phases of arthritis in mice. Arthrit Rheum 62: 1881-1889, 2010.
36. Aarli V, Reed RK, Aukland K. Effect of longstanding venous stasis and hypoproteinaemia on lymph flow in the rat tail. Acta Physiol Scand 142: 1-9, 1991.