Aging impairs vasodilatory responses in rats

Korean Journal of Anesthesiology

Volumn 61, Issue 6, 2011, Pages 506-510

  Kim, Soon Yul ^a   Park, Jong Taek ^a   Park, Jae Kyun ^a   Lee, Jeong Soo ^b   Choi, Jae Chan ^a  

^a Yonsei University Wonju College of Medicine   (South Korea)

^b Yonsei University College of Medicine   (South Korea)

Author keywords

Acetylcholine; Aging; Endothelium; Nitric oxide; P1075; Sodium nitroprusside

Indexed keywords

2 CYANO 1 (1,1 DIMETHYLPROPYL) 3 (3 PYRIDYL)GUANIDINE; ACETYLCHOLINE; ENDOTHELIAL NITRIC OXIDE SYNTHASE; NITROPRUSSIDE SODIUM;

AGING; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; ENDOTHELIAL DYSFUNCTION; IN VITRO STUDY; MUSCLE ISOMETRIC CONTRACTION; NONHUMAN; RAT; SIGNAL TRANSDUCTION; VASCULAR ENDOTHELIUM; VASCULAR RING; VASCULARIZATION; VASODILATATION;

EID: 84855303407     PISSN: 20056419     EISSN: 20057563     Source Type: Journal    
DOI: 10.4097/kjae.2011.61.6.506     Document Type: Article

References (18)

1. Lakatta EG, Levy D. Arterial and cardiac aging: major shareholders in cardiovascular disease enterprise: Part I: aging arteries: a 'set up' for vascular disease. Circulation 2003; 107: 139-46.
2. Hongo K, Nakagomi T, Kassell NF, Sasaki T, Lehman M, Vollmer DG, et al. Effects of aging and hypertension on endothelium-dependent vascular relaxation in rat carotid artery. Stroke 1988; 19: 892-7.
3. Koga T, Takata Y, Kobayashi K, Takishita S, Yamashita Y, Fujishima M. Age and hypertension promote endothelium-dependent contractions to acetylcholine in the aorta of the rat. Hypertension 1989; 14: 542-8.
4. Küng CF, Lüscher TF. Different mechanisms of endothelial dysfunction with aging and hypertension in rat aorta. Hypertension 1995; 25: 194-200.
5. Matz RL, de Sotomayor MA, Schott C, Stoclet JC, Andriantsitohaina R. Vascular bed heterogeneity in age-related endothelial dysfunction with respect to NO and eicosanoids. Br J Pharmacol 2000; 131: 303-11.
6. Brandes RP, Fleming I, Busse R. Endothelial aging. Cardiovasc Res 2005; 66: 286-94.
7. Van der Loo B, Labugger R, Skepper JN, Bachschmid M, Kilo J, Powell JM, et al. Enhanced peroxynitrite formation is associated with vascular aging. J Exp Med 2000; 192: 1731-44.
8. Matz RL, Andriantsitohaina R. Age-related endothelial dysfunction: potential implications for pharmacotherapy. Drugs Aging 2003; 20: 527-50.
9. Fleming I, Busse R. NO: the primary EDRF. J Mol Cell Cardiol 1999; 31: 5-14.
10. Nagao T, Vanhoutte PM. Hyperpolarization as a mechanism for endothelium dependent relaxations in porcine coronary artery. J Physiol 1992; 445: 355-67.
11. Hardman JG, Limbird LE, Molinoff PB, Ruddon RW, Gilman AG. Goodman & Gilman's the pharmacological basis of therapeutics. 9th ed. Edited by the McGraw-Hill Companies: New York, Wonsiewicz and McCurdy publishers. 1996, p 143.
12. Boulanger CM, Morrison KJ, Vanhoutte PM. Mediation by M3-muscarinic receptors of both endothelium-dependent contraction and relaxation to acetylcholine in the aorta of the spontaneously hypertensive rat. Br J Pharmacol 1994; 112: 519-24.
13. Moncada S, Palmer RM, Higgs EA. Nitric oxide: physiology, pathophysiology and pharmacology. Pharmacol Rev 1991; 43: 109-42.
14. Murad F. Cyclic guanosine monophosphate as a mediator of vasodilation. J Clin Invest 1986; 78: 1-5.
15. Kowaluk EA, Seth P, Fung HL. Metabolic activation of sodium nitroprusside to nitric oxide in vascular smooth muscle. J Pharmacol Exp Ther 1992; 262: 916-22.
16. Bates JN, Baker MT, Guerra R Jr, Harrison DG. Nitric oxide generation from nitroprusside by vascular tissue. Evidence that reduction of the nitroprusside anion and cyanide loss are required. Biochem Pharmacol 1991; 42 Suppl: S157-65.
17. Steinberg MI, Ertel P, Smallwood JK, Wyss V, Zimmerman K. The relation between vascular relaxant and cardiac electrophysiological effects of pinacidil. J Cardiovasc Pharmacol 1988; 12 Suppl: S30-40.
18. Quast U. Do the K+ channel openers relax smooth muscle by opening K+ channels? Trends Pharmacol Sci 1993; 14: 332-7.