An assessment of the individual and collective effects of variants on height using twins and a developmentally informative study design

PLoS Genetics

Volumn 7, Issue 12, 2011, Pages

  Vrieze, Scott I ^a,b   McGue, Matt ^a   Miller, Michael B ^a   Legrand, Lisa N ^a   Schork, Nicholas J ^c   Iacono, William G ^a  

^a UNIVERSITY OF MINNESOTA   (United States)

^b VA MEDICAL CENTER   (United States)

^c SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACCURACY; ADOLESCENT; ADULT; ARTICLE; BODY HEIGHT; CHILD; CONTROLLED STUDY; DEVELOPMENTAL GENE; DEVELOPMENTAL GENETICS; FEMALE; GENETIC ASSOCIATION; GENETIC IDENTIFICATION; GENETIC VARIABILITY; GENOME ANALYSIS; GENOTYPE; GROWTH ACCELERATION; HERITABILITY; HUMAN; LIN28B GENE; MALE; PHENOTYPE; PREPUBERTY; SCHOOL CHILD; SEX DIFFERENCE; SINGLE NUCLEOTIDE POLYMORPHISM; TWINS; GENETICS; GENOTYPE ENVIRONMENT INTERACTION; META ANALYSIS; PUBERTY;

DNA BINDING PROTEIN; LIN28B PROTEIN, HUMAN;

ADOLESCENT; ADULT; BODY HEIGHT; CHILD; DNA-BINDING PROTEINS; FEMALE; GENE-ENVIRONMENT INTERACTION; GENETIC VARIATION; GENOME-WIDE ASSOCIATION STUDY; GENOTYPE; HUMANS; MALE; PHENOTYPE; POLYMORPHISM, SINGLE NUCLEOTIDE; PUBERTY; SEX FACTORS; YOUNG ADULT;

EID: 84855286275     PISSN: 15537390     EISSN: 15537404     Source Type: Journal    
DOI: 10.1371/journal.pgen.1002413     Document Type: Article

References (31)

1. Macgregor S, Cornes BK, Martin NG, Visscher PM, (2006) Bias, precision and heritability of self-reported and clinically measured height in Australian twins. Hum Genet 120: 571-580.
2. Silventoinen K, Sammalisto S, Perola M, Boomsma DI, Cornes BK, et al. (2003) Heritability of adult body height: A comparative study of twin cohorts in eight countries. Twin Res 6: 399-408.
3. Visscher PM, Hill WG, Wray NR, (2008) Heritability in the genomics era - concepts and misconceptions. Nat Rev Genet 9: 255-266.
4. Maher B, (2008) Personal genomes: The case of the missing heritability. Nature 456: 18-21.
5. Manolio TA, Collins FS, Cox NJ, Goldstein DB, Hindorff LA, et al. (2009) Finding the missing heritability of complex diseases. Nature 461: 747-753.
6. Yang JA, Benyamin B, McEvoy BP, Gordon S, Henders AK, et al. (2010) Common SNPs explain a large proportion of the heritability for human height. Nature Genetics 42: 565-U131.
7. Allen HL, Estrada K, Lettre G, Berndt SI, Weedon MN, et al. (2010) Hundreds of variants clustered in genomic loci and biological pathways affect human height. Nature 467: 832-838.
8. Okasha M, Gunnell D, Holly J, Smith GD, (2002) Childhood growth and adult cancer. Best Pract Res Cl En 16: 225-241.
9. Tanner JM, Whitehouse RH, Takaishi M, (1966) Standards from Birth to Maturity for Height, Weight, Height Velocity, and Weight Velocity: British Children, 1965. Part II. Archives of Disease in Childhood 41: 613-635.
10. Silventoinen K, Pietilainen KH, Tynelius P, Sorensen TIA, Kaprio J, et al. (2008) Genetic regulation of growth from birth to 18 years of age: The Swedish young male twins study. Am J Hum Biol 20: 292-298.
11. Iacono WG, McGue M, (2002) Minnesota Twin Family Study. Twin Res 5: 482-487.
12. Palmert MR, Boepple PA, (2001) Variation in the timing of puberty: Clinical spectrum and genetic investigation. J Clin Endocr Metab 86: 2364-2368.
13. Salem RM, O'Connor DT, Schork NJ, (2010) Curve-based multivariate distance matrix regression analysis: application to genetic association analyses involving repeated measures. Physiol Genomics 42: 236-247.
14. Pinheiro JC, Bates DM, (2000) Mixed-effects models in S and S-PLUS New York Springer pp. xvi 528.
15. Neale MC, Cardon LR, (1992) Methodology for genetic studies of twins and families Dortrecht, The Netherlands Kluwer Academic.
16. Visscher PM, Yang JA, Goddard ME, (2010) A Commentary on 'Common SNPs Explain a Large Proportion of the Heritability for Human Height' by Yanget al. (2010). Twin Research and Human Genetics 13: 517-524.
17. Petersen AC, Crockett L, Richards M, Boxer A, (1988) A self-report measure of pubertal status: reliability, validity, and initial norms. Journal of Youth and Adolescence 17: 117-133.
18. R Development Core Team (2011) R: A language and environment for statistical computing Vienna R Foundation for Statistical Computing.
19. Boker S, Neale M, Maes H, Wilde M, Spiegel M, et al. (2011) OpenMx: An Open Source Extended Structural Equation Modeling Framework. Psychometrika 76: 306-317 doi:10.1007/S11336-010-9200-6.
20. Miller MB, Basu S, Cunningham J, Oetting W, Schork NJ, et al. (submitted) The Minnesota Center for Twin and Family Research Genome-Wide Association Study.
21. Li Y, Willer CJ, Ding J, Scheet P, Abecasis GR, (2010) MaCH: Using Sequence and Genotype Data to Estimate Haplotypes and Unobserved Genotypes. Genet Epidemiol 34: 816-834.
22. Li Y, Willer C, Sanna S, Abecasis G, (2009) Genotype Imputation. Annu Rev Genom Hum G 10: 387-406.
23. Price AL, Patterson NJ, Plenge RM, Weinblatt ME, Shadick NA, et al. (2006) Principal components analysis corrects for stratification in genome-wide association studies. Nature Genetics 38: 904-909.
24. Li X, Basu S, Miller MB, Iacono WG, McGue M, (2011) A Rapid Generalized Least Squares Model for a Genome-Wide Quantitative Trait Association Analysis in Families. Hum Hered 71: 67-82.
25. Zhu H, Shah S, Shyh-Chang N, Shinoda G, Einhorn WS, et al. (2010) Lin28a transgenic mice manifest size and puberty phenotypes identified in human genetic association studies. Nature Genetics 42: 626-U106.
26. Widen E, Ripatti S, Cousminer DL, Surakka I, Lappalainen T, et al. (2010) Distinct Variants at LIN28B Influence Growth in Height from Birth to Adulthood. Am J Hum Genet 86: 773-782.
27. Hindorff LA, Sethupathy P, Junkins HA, Ramos EM, Mehta JP, et al. (2009) Potential etiologic and functional implications of genome-wide association loci for human diseases and traits. P Natl Acad Sci USA 106: 9362-9367.
28. Sovio U, Mook-Kanamori DO, Warrington NM, Lawrence R, Briollais L, et al. (2011) Association between Common Variation at the FTO Locus and Changes in Body Mass Index from Infancy to Late Childhood: The Complex Nature of Genetic Association through Growth and Development. PLoS Genet 7: e1001307 doi:10.1371/journal.pgen.1001307.
29. Uitterlinden AG, Perry JRB, Stolk L, Franceschini N, Lunetta KL, et al. (2009) Meta-analysis of genome-wide association data identifies two loci influencing age at menarche. Nature Genetics 41: 648-650.
30. Ong KK, Elks CE, Li SX, Zhao JH, Luan J, et al. (2009) Genetic variation in LIN28B is associated with the timing of puberty. Nature Genetics 41: 729-733.
31. Burt SA, McGue M, Demarte JA, Krueger RF, Iacono WG, (2006) Timing of menarche and the origins of conduct disorder. Arch Gen Psychiat 63: 890-896.