Early mortality in adults initiating antiretroviral therapy (ART) in low- and middle-income countries (LMIC): A systematic review and meta-analysis

PLoS ONE

Volumn 6, Issue 12, 2011, Pages

  Gupta, Amita ^a,b   Nadkarni, Girish ^b   Yang, Wei Teng ^a   Chandrasekhar, Aditya ^a   Gupte, Nikhil ^a,c   Bisson, Gregory P ^d   Hosseinipour, Mina ^e   Gummadi, Naveen ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b JOHNS HOPKINS BLOOMBERG SCHOOL OF PUBLIC HEALTH   (United States)

^c Byramjee Jeejeebhoy Medical College   (India)

^d UNIVERSITY OF PENNSYLVANIA   (United States)

^e UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIRETROVIRUS AGENT; CD4 ANTIGEN; VIRUS RNA;

AFRICA; AGE; ANEMIA; ASIA; BODY MASS; CD4 LYMPHOCYTE COUNT; CENTRAL AMERICA; CHRONIC DIARRHEA; DEVELOPING COUNTRY; EMBASE; FOLLOW UP; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; INFORMATION PROCESSING; LOWEST INCOME GROUP; MEDLINE; META ANALYSIS; MORTALITY; OBSERVATIONAL STUDY; OPPORTUNISTIC INFECTION; PROBABILITY; REVIEW; SEX DIFFERENCE; SOUTH AMERICA; SYSTEMATIC REVIEW; TREATMENT OUTCOME; TUBERCULOSIS; WASTING SYNDROME; ADULT; CAUSE OF DEATH; ECONOMICS; HIGHLY ACTIVE ANTIRETROVIRAL THERAPY; MALE; POVERTY; PROPORTIONAL HAZARDS MODEL; RISK; RISK FACTOR; STATISTICS; SURVIVAL;

ADULT; ANTIRETROVIRAL THERAPY, HIGHLY ACTIVE; CAUSE OF DEATH; DEVELOPING COUNTRIES; HIV INFECTIONS; HUMANS; MALE; ODDS RATIO; POVERTY; PROPORTIONAL HAZARDS MODELS; RISK FACTORS; SURVIVAL ANALYSIS;

EID: 84855278771     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0028691     Document Type: Review

References (68)

1. Joint United Nations Programme on HIV and AIDS (UNAIDS) (2007) Financial Resources Required to Achieve, Universal Access to HIV Prevention, Treatment Care and Support. Available: http://data.unaids.org/pub/Report/2007/JC1678_Fin_Res_Req_en.pdf.
2. Palella FJ Jr, Delaney KM, Moorman AC, Loveless MO, Fuhrer J, et al. (1998) Declining morbidity and mortality among patients with advanced human immunodeficiency virus infection. HIV Outpatient Study Investigators. N Engl J Med 338: 853-860.
3. Severe P, Leger P, Charles M, Noel F, Bonhomme G, et al. (2005) Antiretroviral therapy in a thousand patients with AIDS in Haiti. N Engl J Med 353: 2325-2334.
4. Stringer JS, Zulu I, Levy J, Stringer EM, Mwango A, et al. (2006) Rapid scale-up of antiretroviral therapy at primary care sites in Zambia: feasibility and early outcomes. JAMA 296: 782-793.
5. Braitstein P, Brinkhof MW, Dabis F, Schechter M, Boulle A, et al. (2006) Mortality of HIV-1-infected patients in the first year of antiretroviral therapy: comparison between low-income and high-income countries. Lancet 367: 817-824.
6. Lawn SD, Harries AD, Anglaret X, Myer L, Wood R, (2008) Early mortality among adults accessing antiretroviral treatment programmes in sub-Saharan Africa. AIDS 22: 1897-1908.
7. Higgins JP, Thompson SG, (2002) Quantifying heterogeneity in a meta-analysis. Stat Med 21: 1539-1558.
8. Parmar MK, Torri V, Stewart L, (1998) Extracting summary statistics to perform meta-analyses of the published literature for survival endpoints. Stat Med 17: 2815-2834.
9. Whitehead A, Whitehead J, (1991) A general parametric approach to the meta-analysis of randomized clinical trials. Stat Med 10: 1665-1677.
10. DerSimonian R, Laird N, (1986) Meta-analysis in clinical trials. Control Clin Trials 7: 177-188.
11. Begg CB, Mazumdar M, (1994) Operating characteristics of a rank correlation test for Publication bias. Biometrics 50: 1088-1101.
12. Wester CW, Kim S, Bussmann H, Avalos A, Ndwapi N, et al. (2005) Initial response to highly active antiretroviral therapy in HIV-1C-infected adults in a public sector treatment program in Botswana. J Acquir Immune Defic Syndr 40: 336-343.
13. Lawn SD, Harries AD, Wood R, (2010) Strategies to reduce early morbidity and mortality in adults receiving antiretroviral therapy in resource-limited settings. Curr Opin HIV AIDS 5: 18-26.
14. Kitahata MM, Gange SJ, Abraham AG, Merriman B, Saag MS, et al. (2009) Effect of early versus deferred antiretroviral therapy for HIV on survival. N Engl J Med 360: 1815-1826.
15. Sterne JA, May M, Costagliola D, de Wolf F, Phillips AN, et al. (2009) Timing of initiation of antiretroviral therapy in AIDS-free HIV-1-infected patients: a collaborative analysis of 18 HIV cohort studies. Lancet 373: 1352-1363.
16. Granich RM, Gilks CF, Dye C, De Cock KM, Williams BG, (2009) Universal voluntary HIV testing with immediate antiretroviral therapy as a strategy for elimination of HIV transmission: a mathematical model. Lancet 373: 48-57.
17. Wong EB, Omar T, Setlhako G, Osih R, Murdoch D, et al. (2010) Causes of Death in ART-treated Adults: a Post-Mortem Study from Johannesburg. XVIII International AIDS Conference. Vienna, Austria.
18. Blanco JR, Caro AM, Perez-Cachafeiro S, Gutierrez F, Iribarren JA, et al. (2010) HIV infection and aging. AIDS Rev 12: 218-230.
19. Deeks SG, (2011) HIV infection, inflammation, immunosenescence, and aging. Annu Rev Med 62: 141-155.
20. Alibhai A, Kipp W, Saunders LD, Senthilselvan A, Kaler A, et al. (2010) Gender-related mortality for HIV-infected patients on highly active antiretroviral therapy (HAART) in rural Uganda. Int J Womens Health 2: 45-52.
21. Kumarasamy N, Venkatesh KK, Cecelia AJ, Devaleenol B, Saghayam S, et al. (2008) Gender-based differences in treatment and outcome among HIV patients in South India. J Womens Health 17: 1471-1475.
22. Nicastri E, Leone S, Angeletti C, Palmisano L, Sarmati L, et al. (2007) Sex issues in HIV-1-infected persons during highly active antiretroviral therapy: a systematic review. J Antimicrob Chemother 60: 724-732.
23. Djomand G, Roels T, Ellerbrock T, Hanson D, Diomande F, et al. (2003) Virologic and immunologic outcomes and programmatic challenges of an antiretroviral treatment pilot project in Abidjan, Cote d'Ivoire. AIDS 17 (Suppl 3): S5-15.
24. Yu JK, Bong CN, Chen SC, Dzimadzi R, Lu DY, et al. (2008) Outcomes in HIV-infected patients who develop tuberculosis after starting antiretroviral treatment in Malawi. Int J Tuberc Lung Dis 12: 692-694.
25. Sterne JA, Sutton AJ, Ioannidis JP, Terrin N, Jones DR, et al. (2011) Recommendations for examining and interpreting funnel plot asymmetry in meta-analyses of randomised controlled trials. BMJ 343: d4002.
26. Alemu AW, Sebastian MS, (2010) Determinants of survival in adult HIV patients on antiretroviral therapy in Oromiyaa, Ethiopia. Glob Health Action 3 doi:10.3402/gha.v3i0.5398.
27. Sanne IM, Westreich D, Macphail AP, Rubel D, Majuba P, et al. (2009) Long term outcomes of antiretroviral therapy in a large HIV/AIDS care clinic in urban South Africa: a prospective cohort study. J Int AIDS Soc 12: 38.
28. Abaasa AM, Todd J, Ekoru K, Kalyango JN, Levin J, et al. (2008) Good adherence to HAART and improved survival in a community HIV/AIDS treatment and care programme: the experience of The AIDS Support Organization (TASO), Kampala, Uganda. BMC Health Serv Res 8: 241.
29. Banda AC, Makombe SD, Jahn A, Tweya H, Chuka S, et al. (2008) Antiretroviral therapy in the Malawi defence force: access, treatment outcomes and impact on mortality. PLoS One 3: e1445.
30. Bisson GP, Nthobatsong R, Thakur R, Lesetedi G, Vinekar K, et al. (2008) The use of HAART is associated with decreased risk of death during initial treatment of cryptococcal meningitis in adults in Botswana. J Acquir Immune Defic Syndr 49: 227-229.
31. Boulle A, Bock P, Osler M, Cohen K, Channing L, et al. (2008) Antiretroviral therapy and early mortality in South Africa. Bull World Health Organ 86: 678-687.
32. Bussmann H, Wester CW, Ndwapi N, Grundmann N, Gaolathe T, et al. (2008) Five-year outcomes of initial patients treated in Botswana's National Antiretroviral Treatment Program. AIDS 22: 2303-2311.
33. Hoffmann CJ, Fielding KL, Charalambous S, Sulkowski MS, Innes C, et al. (2008) Antiretroviral therapy using zidovudine, lamivudine, and efavirenz in South Africa: tolerability and clinical events. AIDS 22: 67-74.
34. Johannessen A, Naman E, Ngowi BJ, Sandvik L, Matee MI, et al. (2008) Predictors of mortality in HIV-infected patients starting antiretroviral therapy in a rural hospital in Tanzania. BMC Infect Dis 8: 52.
35. Laurent C, Bourgeois A, Mpoudi-Ngole E, Ciaffi L, Kouanfack C, et al. (2008) Tolerability and effectiveness of first-line regimens combining nevirapine and lamivudine plus zidovudine or stavudine in Cameroon. AIDS Res Hum Retroviruses 24: 393-399.
36. MacPherson P, Moshabela M, Martinson N, Pronyk P, (2009) Mortality and loss to follow-up among HAART initiators in rural South Africa. Trans R Soc Trop Med Hyg 103: 588-593.
37. Marazzi MC, Liotta G, Germano P, Guidotti G, Altan AD, et al. (2008) Excessive early mortality in the first year of treatment in HIV type 1-infected patients initiating antiretroviral therapy in resource-limited settings. AIDS Res Hum Retroviruses 24: 555-560.
38. Mulenga LB, Kruse G, Lakhi S, Cantrell RA, Reid SE, et al. (2008) Baseline renal insufficiency and risk of death among HIV-infected adults on antiretroviral therapy in Lusaka, Zambia. AIDS 22: 1821-1827.
39. Mzileni MO, Longo-Mbenza B, Chephe TJ, (2008) Mortality and causes of death in HIV-positive patients receiving antiretroviral therapy at Tshepang Clinic in Doctor George Mukhari Hospital. Pol Arch Med Wewn 118: 548-554.
40. Toure S, Kouadio B, Seyler C, Traore M, Dakoury-Dogbo N, et al. (2008) Rapid scaling-up of antiretroviral therapy in 10 000 adults in Cote d'Ivoire: 2-year outcomes and determinants. AIDS 22: 873-882.
41. Karcher H, Omondi A, Odera J, Kunz A, Harms G, (2007) Risk factors for treatment denial and loss to follow-up in an antiretroviral treatment cohort in Kenya. Trop Med Int Health 12: 687-694.
42. Makombe SD, Harries AD, Yu JK, Hochgesang M, Mhango E, et al. (2007) Outcomes of tuberculosis patients who start antiretroviral therapy under routine programme conditions in Malawi. Int J Tuberc Lung Dis 11: 412-416.
43. Makombe SD, Jahn A, Tweya H, Chuka S, Yu JK, et al. (2007) A national survey of the impact of rapid scale-up of antiretroviral therapy on health-care workers in Malawi: effects on human resources and survival. Bull World Health Organ 85: 851-857.
44. Bekker LG, Myer L, Orrell C, Lawn S, Wood R, (2006) Rapid scale-up of a community-based HIV treatment service: programme performance over 3 consecutive years in Guguletu, South Africa. S Afr Med J 96: 315-320.
45. Etard JF, Ndiaye I, Thierry-Mieg M, Gueye NF, Gueye PM, et al. (2006) Mortality and causes of death in adults receiving highly active antiretroviral therapy in Senegal: a 7-year cohort study. AIDS 20: 1181-1189.
46. Ferradini L, Jeannin A, Pinoges L, Izopet J, Odhiambo D, et al. (2006) Scaling up of highly active antiretroviral therapy in a rural district of Malawi: an effectiveness assessment. Lancet 367: 1335-1342.
47. Lawn SD, Myer L, Bekker LG, Wood R, (2006) CD4 cell count recovery among HIV-infected patients with very advanced immunodeficiency commencing antiretroviral treatment in sub-Saharan Africa. BMC Infect Dis 6: 59.
48. Zachariah R, Fitzgerald M, Massaquoi M, Pasulani O, Arnould L, et al. (2006) Risk factors for high early mortality in patients on antiretroviral treatment in a rural district of Malawi. AIDS 20: 2355-2360.
49. Bourgeois A, Laurent C, Mougnutou R, Nkoue N, Lactuock B, et al. (2005) Field assessment of generic antiretroviral drugs: a prospective cohort study in Cameroon. Antivir Ther 10: 335-341.
50. Coetzee D, Hildebrand K, Boulle A, Maartens G, Louis F, et al. (2004) Outcomes after two years of providing antiretroviral treatment in Khayelitsha, South Africa. AIDS 18: 887-895.
51. Weidle PJ, Malamba S, Mwebaze R, Sozi C, Rukundo G, et al. (2002) Assessment of a pilot antiretroviral drug therapy programme in Uganda: patients' response, survival, and drug resistance. Lancet 360: 34-40.
52. Ruan Y, Xing H, Wang X, Tang H, Wang Z, et al. (2010) Virologic outcomes of first-line HAART and associated factors among Chinese patients with HIV in three sentinel antiretroviral treatment sites. Trop Med Int Health 15: 1357-1363.
53. Chasombat S, McConnell MS, Siangphoe U, Yuktanont P, Jirawattanapisal T, et al. (2009) National expansion of antiretroviral treatment in Thailand, 2000-2007: program scale-up and patient outcomes. J Acquir Immune Defic Syndr 50: 506-512.
54. Morineau G, Vun MC, Barennes H, Wolf RC, Song N, et al. (2009) Survival and quality of life among HIV-positive people on antiretroviral therapy in Cambodia. AIDS Patient Care STDS 23: 669-677.
55. Ferradini L, Laureillard D, Prak N, Ngeth C, Fernandez M, et al. (2007) Positive outcomes of HAART at 24 months in HIV-infected patients in Cambodia. AIDS 21: 2293-2301.
56. Corey DM, Kim HW, Salazar R, Illescas R, Villena J, et al. (2007) Brief report: effectiveness of combination antiretroviral therapy on survival and opportunistic infections in a developing world setting: an observational cohort study. J Acquir Immune Defic Syndr 44: 451-455.
57. O'Brien DP, Venis S, Greig J, Shanks L, Ellman T, et al. (2010) Provision of antiretroviral treatment in conflict settings: the experience of Medecins Sans Frontieres. Confl Health 4: 12.
58. Tuboi SH, Schechter M, McGowan CC, Cesar C, Krolewiecki A, et al. (2009) Mortality during the first year of potent antiretroviral therapy in HIV-1-infected patients in 7 sites throughout Latin America and the Caribbean. J Acquir Immune Defic Syndr 51: 615-623.
59. Calmy A, Pinoges L, Szumilin E, Zachariah R, Ford N, et al. (2006) Generic fixed-dose combination antiretroviral treatment in resource-poor settings: multicentric observational cohort. AIDS 20: 1163-1169.
60. Rougemont M, Stoll BE, Elia N, Ngang P, (2009) Antiretroviral treatment adherence and its determinants in Sub-Saharan Africa: a prospective study at Yaounde Central Hospital, Cameroon. AIDS Res Ther 6: 21.
61. De Beaudrap P, Etard JF, Ecochard R, Diouf A, Dieng AB, et al. (2008) Change over time of mortality predictors after HAART initiation in a Senegalese cohort. Eur J Epidemiol 23: 227-234.
62. Nakanjako D, Kiragga A, Ibrahim F, Castelnuovo B, Kamya MR, et al. (2008) Sub-optimal CD4 reconstitution despite viral suppression in an urban cohort on Antiretroviral Therapy (ART) in sub-Saharan Africa: Frequency and clinical significance. AIDS Res Ther 5: 23.
63. Lowrance D, Makombe S, Harries A, Yu J, Aberle-Grasse J, et al. (2007) Lower early mortality rates among patients receiving antiretroviral treatment at clinics offering cotrimoxazole prophylaxis in Malawi. J Acquir Immune Defic Syndr 46: 56-61.
64. Jerene D, Endale A, Hailu Y, Lindtjoorn B, (2006) Predictors of early death in a cohort of Ethiopian patients treated with HAART. BMC Infect Dis 6: 136.
65. Libamba E, Makombe S, Mhango E, de Ascurra Teck O, Limbambala E, et al. (2006) Supervision, monitoring and evaluation of nationwide scale-up of antiretroviral therapy in Malawi. Bull World Health Organ 84: 320-326.
66. Madec Y, Laureillard D, Pinoges L, Fernandez M, Prak N, et al. (2007) Response to highly active antiretroviral therapy among severely immuno-compromised HIV-infected patients in Cambodia. AIDS 21: 351-359.
67. Brinkhof MW, Dabis F, Myer L, Bangsberg DR, Boulle A, et al. (2008) Early loss of HIV-infected patients on potent antiretroviral therapy programmes in lower-income countries. Bull World Health Organ 86: 559-567.
68. Palombi L, Marazzi MC, Guidotti G, Germano P, Buonomo E, et al. (2009) Incidence and predictors of death, retention, and switch to second-line regimens in antiretroviral-treated patients in sub-Saharan African sites with comprehensive monitoring availability. Clin Infect Dis 48: 115-122.