Nucleolin antisense oligodeoxynucleotides induce apoptosis and may be used as a potential drug for nasopharyngeal carcinoma therapy

Oncology Reports

Volumn 27, Issue 1, 2012, Pages 94-100

  Wu, Cheng Der ^a   Chou, Hung Wen ^a   Kuo, Yuan Sung ^a,b   Lu, Ruei Min ^a   Hwang, Yu Chyi ^a   Wu, Han Chung ^a,c   Lin, Chin Tarng ^a,b  

^a NATIONAL TAIWAN UNIVERSITY   (Taiwan)

^b NATIONAL TAIWAN UNIVERSITY HOSPITAL   (Taiwan)

^c INSTITUTE OF CELLULAR AND ORGANISMIC BIOLOGY   (Taiwan)

Author keywords

Anti sense oligodeoxynucleotides; Apoptosis; Nasopharyngeal carcinoma; Nucleolin

Indexed keywords

ANTISENSE OLIGODEOXYNUCLEOTIDE; MESSENGER RNA; NUCLEOLIN; NUCLEOLIN ANTISENSE OLIGODEOXYNUCLEOTIDE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTISENSE THERAPY; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CANCER INHIBITION; CELL VIABILITY; CONTROLLED STUDY; FEMALE; GENE EXPRESSION REGULATION; GENE SILENCING; GENETIC TRANSFECTION; HISTOPATHOLOGY; HUMAN; HUMAN CELL; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; MALE; MOUSE; NASOPHARYNX CARCINOMA; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; STROMA CELL; TUMOR XENOGRAFT;

ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; CARCINOMA; CELL LINE, TUMOR; FEMALE; GENE KNOCKDOWN TECHNIQUES; HUMANS; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; IN SITU NICK-END LABELING; MICE; MICE, SCID; NASOPHARYNGEAL NEOPLASMS; OLIGODEOXYRIBONUCLEOTIDES, ANTISENSE; PHOSPHOPROTEINS; REAL-TIME POLYMERASE CHAIN REACTION; RNA, MESSENGER; RNA-BINDING PROTEINS; TRANSFECTION; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84855276410     PISSN: 1021335X     EISSN: 17912431     Source Type: Journal    
DOI: 10.3892/or.2011.1476     Document Type: Article

References (27)

1. Ferlay J, Shin HR, Bray F, Forman D, Mathers C and Parkin DM: Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008. Int J Cancer 127: 2893-2917, 2010.
2. Lin CT, Chan WY, Chen W, et al.: Characterization of seven newly established nasopharyngeal carcinoma cell lines. Lab Invest 68: 716-727, 1993.
3. Lin CT, Wong CI, Chan WY, et al.: Establishment and characterization of two nasopharyngeal carcinoma cell lines. Lab Invest 62: 713-724, 1990.
4. Lee YC, Hwang YC, Chen KC, et al.: Effect of Epstein-Barr virus infection on global gene expression in nasopharyngeal carcinoma. Funct Integr Genomics 7: 79-93, 2007.
5. Mongelard F and Bouvet P: Nucleolin: a multiFACeTed protein. Trends Cell Biol 17: 80-86, 2007. (Pubitemid 46199181)
6. Bartova E, Horakova AH, Uhlirova R, et al.: Structure and epigenetics of nucleoli in comparison with non-nucleolar compartments. J Histochem Cytochem 58: 391-403, 2010.
7. Srivastava M, Fleming PJ, Pollard HB and Burns AL: Cloning and sequencing of the human nucleolin cDNA. FEBS Lett 250: 99-105, 1989. (Pubitemid 19154186)
8. Derenzini M, Sirri V, Trere D and Ochs RL: The quantity of nucleolar proteins nucleolin and protein B23 is related to cell doubling time in human cancer cells. Lab Invest 73: 497-502, 1995.
9. Roussel P and Hernandez-Verdun D: Identification of Ag-NOR proteins, markers of proliferation related to ribosomal gene activity. Exp Cell Res 214: 465-472, 1994. (Pubitemid 24310804)
10. Sirri V, Roussel P, Trere D, Derenzini M and Hernandez-Verdun D: Amount variability of total and individual Ag-NOR proteins in cells stimulated to roliferate. J Histochem Cytochem 43: 887-893, 1995.
11. Bennett CF and Swayze EE: RNA targeting therapeutics: molecular mechanisms of antisense oligonucleotides as a therapeutic platform. Annu Rev Pharmacol Toxicol 50: 259-293, 2010.
12. Di Cresce C and Koropatnick J: Antisense treatment in human prostate cancer and melanoma. Curr Cancer Drug Targets 10: 555-565, 2010.
13. Wu HC, Huang PH, Chiu CY and Lin CT: G protein beta2 subunit antisense oligonucleotides inhibit cell proliferation and disorganize microtubule and mitotic spindle organization. J Cell Biochem 83: 136-146, 2001.
14. Hau P, Jachimczak P and Bogdahn U: Treatment of malignant gliomas with TGF-beta2 antisense oligonucleotides. Expert Rev Anticancer Ther 9: 1663-1674, 2009.
15. Tamm I: AEG-35156, an antisense oligonucleotide against X-linked inhibitor of apoptosis for the potential treatment of cancer. Curr Opin Investig Drugs 9: 638-646, 2008.
16. Chi KN, Zoubeidi A and Gleave ME: Custirsen (OGX-011): a second-generation antisense inhibitor of clusterin for the treatment of cancer. Expert Opin Investig Drugs 17: 1955-1962, 2008.
17. Ito MK: ISIS 301012 gene therapy for hypercholesterolemia: sense, antisense, or nonsense? Ann Pharmacother 41: 1669-1678, 2007.
18. Liao SK, Perng YP, Shen YC, Chung PJ, Chang YS and Wang CH: Chromosomal abnormalities of a new nasopharyngeal carcinoma cell line (NPC-BM1) derived from a bone marrow metastatic lesion. Cancer Genet Cytogenet 103: 52-58, 1998. (Pubitemid 128712620)
19. Yao KT, Zhang HY, Zhu HC, et al.: Establishment and characterization of two epithelial tumor cell lines (HNE-1 and HONE-1) latently infected with Epstein-Barr virus and derived from nasopharyngeal carcinomas. Int J Cancer 45: 83-89, 1990.
20. Cancer Institute, Laboratory of Tumor Viruses and Laboratory of Cell Biology, Chinese Academy of Medical Sciences and Chungshan Medical College: Establishment of an epithelial cell line and fusiform cell line from a patient with nasopharyngeal carcinoma. Sci Sin 21: 113-132, 1978.
21. Chu YW, Yang PC, Yang SC, et al.: Selection of invasive and metastatic subpopulations from a human lung adenocarcinoma cell line. Am J Respir Cell Mol Biol 17: 353-360, 1997.
22. Chen CM, Chiang SY and Yeh NH: Increased stability of nucleolin in proliferating cells by inhibition of its self-cleaving activity. J Biol Chem 266: 7754-7758, 1991.
23. Sengupta TK, Bandyopadhyay S, Fernandes DJ and Spicer EK: Identification of nucleolin as an AU-rich element binding protein involved in bcl-2 mRNA stabilization. J Biol Chem 279: 10855-10863, 2004. (Pubitemid 38401575)
24. Otake Y, Sengupta TK, Bandyopadhyay S, Spicer EK and Fernandes DJ: Drug-induced destabilization of bcl-2 mRNA: a new approach for inducing apoptosis in tumor cells. Curr Opin Investig Drugs 5: 616-622, 2004.
25. Otake Y, Soundararajan S, Sengupta TK, et al.: Overexpression of nucleolin in chronic lymphocytic leukemia cells induces stabilization of bcl2 mRNA. Blood 109: 3069-3075, 2007. (Pubitemid 46482108)
26. Takagi M, Absalon MJ, McLure KG and Kastan MB: Regulation of p53 translation and induction after DNA damage by ribosomal protein L26 and nucleolin. Cell 123: 49-63, 2005. (Pubitemid 41414528)
27. Ugrinova I, Monier K, Ivaldi C, et al.: Inactivation of nucleolin leads to nucleolar disruption, cell cycle arrest and defects in centrosome duplication. BMC Mol Biol 8: 66, 2007.