Improved histone deacetylase inhibitors as therapeutics for the neurodegenerative disease Friedreich's ataxia: A new synthetic route

Pharmaceuticals

Volumn 4, Issue 12, 2011, Pages 1578-1590

  Xu, Chunping ^a   Soragni, Elisabetta ^a   Jacques, Vincent ^b   Rusche, James R ^b   Gottesfeld, Joel M ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

^b REPLIGEN CORPORATION   (United States)

Author keywords

Click chemistry; Friedreich's ataxia; HDAC inhibitor

Indexed keywords

3 [1[2 [(1H INDOL 6 YL)OXY]ETHYL] 1H 1,2,3 TRIAZOL 4 YL] N (2 AMINOPHENYL)ACRYLAMIDE; 3 [1[3 (1H INDOL 6 YL)ALLYL] 1H 1,2,3 TRIAZOL 4 YL] N (2 AMINOPHENYL)ACRYLAMIDE; BENZAMIDE DERIVATIVE; ENTINOSTAT; FRATAXIN; HISTONE DEACETYLASE INHIBITOR; MESSENGER RNA; N (2 AMINOPHENYL) 3 (1 CINNAMYL 1H 1,2,3 TRIAZOL 4 YL)ACRYLAMIDE; PIMELIC O AMINOBENZAMIDE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; BLOOD BRAIN BARRIER; CHEMICAL MODIFICATION; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG BRAIN LEVEL; DRUG CYTOTOXICITY; DRUG HALF LIFE; DRUG METABOLISM; DRUG PENETRATION; DRUG STRUCTURE; DRUG SYNTHESIS; FRIEDREICH ATAXIA; FXN GENE; GENE; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; RAT;

EID: 84855270023     PISSN: None     EISSN: 14248247     Source Type: Journal    
DOI: 10.3390/ph4121578     Document Type: Article

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