Circulating levels of persistent organic pollutants (POPs) and carotid atherosclerosis in the elderly

Environmental Health Perspectives

Volumn 120, Issue 1, 2012, Pages 38-43

  Monica Lind, P ^a   van Bavel, Bert ^b   Salihovic, Samira ^b   Lind, Lars ^a  

^a UPPSALA UNIVERSITY   (Sweden)

^b ÖREBRO UNIVERSITY   (Sweden)

Author keywords

Atherosclerosis; Atherosclerotic plaques; Persistent organic pollutants (POPs); Pesticides

Indexed keywords

1,1 DICHLORO 2,2 BIS(4 CHLOROPHENYL)ETHYLENE; 2,2',4,4' TETRACHLOROBIPHENYL; ANTIHYPERTENSIVE AGENT; CHLORDANE; DIOXIN; GLUCOSE; HEXACHLOROBENZENE; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; LOW DENSITY LIPOPROTEIN CHOLESTEROL; POLYBROMINATED DIPHENYL ETHER; POLYCHLORINATED BIPHENYL; TRIACYLGLYCEROL;

AGED; ARTERIAL WALL THICKNESS; ARTICLE; ATHEROSCLEROTIC PLAQUE; BODY MASS; CAROTID ATHEROSCLEROSIS; CHOLESTEROL BLOOD LEVEL; CHROMATOGRAPHY; CROSS-SECTIONAL STUDY; DIASTOLIC BLOOD PRESSURE; DRUG USE; ECHOGRAPHY; GENDER; GLUCOSE BLOOD LEVEL; HEART INFARCTION; HUMAN; MAJOR CLINICAL STUDY; MASS SPECTROMETRY; PERSISTENT ORGANIC POLLUTANT; POLLUTANT; PREVALENCE; PRIORITY JOURNAL; QUALITY CONTROL; SMOKING; SYSTOLIC BLOOD PRESSURE; TRIACYLGLYCEROL BLOOD LEVEL; WAIST CIRCUMFERENCE;

AGED; ATHEROSCLEROSIS; CAROTID ARTERIES; CAROTID ARTERY DISEASES; CROSS-SECTIONAL STUDIES; DIOXINS; ENVIRONMENTAL POLLUTANTS; HALOGENATED DIPHENYL ETHERS; HUMANS; MYOCARDIAL INFARCTION; PESTICIDES; POLYCHLORINATED BIPHENYLS; PREVALENCE; RISK FACTORS;

EID: 84855247551     PISSN: 00916765     EISSN: 15529924     Source Type: Journal    
DOI: 10.1289/ehp.1103563     Document Type: Article

References (45)

1. Andersson J, Sundstrom J, Kurland L, Gustavsson T, Hulthe J, Elmgren A, et al. 2009. The carotid artery plaque size and echogenicity are related to different cardiovascular risk factors in the elderly: the Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUS) study. Lipids 44(5):397-403.
2. Bell FP, Iverson F, Arnold D, Vidmar TJ. 1994. Long-term effects of Aroclor 1254 (PCBs) on plasma lipid and carnitine concentrations in rhesus monkey. Toxicology 89(2):139-153.
3. Bernert JT, Turner WE, Patterson DG Jr, Needham LL. 2007. Calculation of serum "total lipid" concentrations for the adjustment of persistent organohalogen toxicant measurements in human samples. Chemosphere 68(5):824-831.
4. Bourghardt J, Wilhelmson AS, Alexanderson C, De Gendt K, Verhoeven G, Krettek A, et al. 2010. Androgen receptor-dependent and independent atheroprotection by testosterone in male mice. Endocrinology 151(11):5428-5437.
5. Chase KH, Wong O, Thomas D, Berney BW, Simon RK. 1982. Clinical and metabolic abnormalities associated with occupational exposure to polychlorinated biphenyls (PCBs). J Occup Med 24(2):109-114.
6. Dalton TP, Kerzee JK, Wang B, Miller M, Dieter MZ, Lorenz JN, et al. 2001. Dioxin exposure is an environmental risk factor for ischemic heart disease. Cardiovasc Toxicol 1(4):285-298.
7. Davidsson L, Fagerberg B, Bergstrom G, Schmidt C. 2010. Ultrasound-assessed plaque occurrence in the carotid and femoral arteries are independent predictors of cardiovascular events in middle-aged men during 10 years of follow-up. Atherosclerosis 209(2):469-473.
8. Dobson AJ. 2002. An Introduction to Generalized Linear Models. 2nd ed. Boca Raton, FL:Chapman and Hall/CRC.
9. El-Barghouty NM, Levine T, Ladva S, Flanagan A, Nicolaides A. 1996. Histological verification of computerised carotid plaque characterisation. Eur J Vasc Endovasc Surg 11(4):414-416.
10. Everett CJ, Mainous AG III, Frithsen IL, Player MS, Matheson EM. 2008. Association of polychlorinated biphenyls with hypertension in the 1999-2002 National Health and Nutrition Examination Survey. Environ Res 108(1):94-97.
11. Flesch-Janys D, Berger J, Gurn P, Manz A, Nagel S, Waltsgott H, et al. 1995. Exposure to polychlorinated dioxins and furans (PCDD/F) and mortality in a cohort of workers from a herbicide-producing plant in Hamburg, Federal Republic of Germany. Am J Epidemiol 142(11):1165-1175.
12. Gaskins AJ, Schisterman EF. 2009. The effect of lipid adjustment on the analysis of environmental contaminants and the outcome of human health risks. Methods Mol Biol 580:371-381.
13. Goncharov A, Haase RF, Santiago-Rivera A, Morse G, McCaffrey RJ, Rej R, et al. 2008. High serum PCBs are associated with elevation of serum lipids and cardiovascular disease in a Native American population. Environ Res 106(2):226-239.
14. Gregoraszczuk EL, Milczarek K, Wojtowicz AK, Berg V, Skaare JU, Ropstad E. 2008. Steroid secretion following exposure of ovarian follicular cells to three different natural mixtures of persistent organic pollutants (POPs). Reprod Toxicol 25(1):58-66.
15. Ha MH, Lee DH, Son HK, Park SK, Jacobs DR Jr. 2009. Association between serum concentrations of persistent organic pollutants and prevalence of newly diagnosed hypertension: results from the National Health and Nutrition Examination Survey 1999-2002. J Hum Hypertens 23(4):274-286.
16. Haase RF, McCaffrey RJ, Santiago-Rivera AL, Morse GS, Tarbell A. 2009. Evidence of an age-related threshold effect of polychlorinated biphenyls (PCBs) on neuropsychological functioning in a Native American population. Environ Res 109(1):73-85.
17. Hulthe J, Wikstrand J, Emanuelsson H, Wiklund O, de Feyter PJ, Wendelhag I. 1997. Atherosclerotic changes in the carotid artery bulb as measured by B-mode ultrasound are associated with the extent of coronary atherosclerosis. Stroke 28(6):1189-1194.
18. Kanagawa Y, Matsumoto S, Koike S, Tajima B, Fukiwake N, Shibata S, et al. 2008. Association of clinical findings in Yusho patients with serum concentrations of polychlorinated biphenyls, polychlorinated quarterphenyls and 2,3,4,7,8-pentachlorodibenzofuran more than 30 years after the poisoning event. Environ Health 7:47; doi:10.1186/1476-069X-7-47 [Online 2 October 2008].
19. Kim KY, Kim DS, Lee SK, Lee IK, Kang JH, Chang YS, et al. 2010. Association of low-dose exposure to persistent organic pollutants with global DNA hypomethylation in healthy Koreans. Environ Health Perspect 118:370-374.
20. Kolovou G, Giannakopoulou V, Vasiliadis Y, Bilianou H. 2011. Effects of estrogens on atherogenesis. Curr Vasc Pharmacol 9(2):244-257.
21. Kopf PG, Huwe JK, Walker MK. 2008. Hypertension, cardiac hypertrophy, and impaired vascular relaxation induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin are associated with increased superoxide. Cardiovasc Toxicol 8(4):181-193.
22. Kraemer SA, Arthur KA, Denison MS, Smith WL, DeWitt DL. 1996. Regulation of prostaglandin endoperoxide H synthase-2 expression by 2,3,7,8,-tetrachlorodibenzo-p-dioxin. Arch Biochem Biophys 330(2):319-328.
23. Kratz M. 2005. Dietary cholesterol, atherosclerosis and coronary heart disease. Handb Exp Pharmacol (170):195-213.
24. Lee DH, Lee IK, Porta M, Steffes M, Jacobs DR Jr. 2007. Relationship between serum concentrations of persistent organic pollutants and the prevalence of metabolic syndrome among non-diabetic adults: results from the National Health and Nutrition Examination Survey 1999-2002. Diabetologia 50(9):1841-1851.
25. Lee DH, Lind L, Jacobs DR Jr, Salihovic S, van Bavel B, Lind PM. 2011a. Associations of persistent organic pollutants with abdominal obesity in the elderly: the Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUS) study. Environ Int; doi:10.1016/j.envint.2011.07.010 [Online 10 August 2011].
26. Lee DH, Lind PM, Jacobs DR Jr, Salihovic S, van Bavel B, Lind L. 2011b. Polychlorinated biphenyls and organochlorine pesticides in plasma predict development of type 2 diabetes in the elderly: the Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUS) study. Diabetes Care 34(8):1778-1784.
27. Letcher RJ, Bustnes JO, Dietz R, Jenssen BM, Jorgensen EH, Sonne C, et al. 2010. Exposure and effects assessment of persistent organohalogen contaminants in Arctic wildlife and fish. Sci Total Environ 408(15):2995-3043.
28. Liang Q, Wendelhag I, Wikstrand J, Gustavsson T. 2000. A multiscale dynamic programming procedure for boundary detection in ultrasonic artery images. IEEE Trans Med Imaging 19(2):127-142.
29. Lind L, Andersson J, Ronn M, Gustavsson T. 2007. The echogenecity of the intima-media complex in the common carotid artery is closely related to the echogenecity in plaques. Atherosclerosis 195(2):411-414.
30. Lind L, Fors N, Hall J, Marttala K, Stenborg A. 2005. A comparison of three different methods to evaluate endothelium-dependent vasodilation in the elderly: the Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUS) study. Arterioscler Thromb Vasc Biol 25(11):2368-2375.
31. Lind PM, Lind L. 2011. Circulating levels of bisphenol A and phthalates are related to carotid atherosclerosis in the elderly. Atherosclerosis 218(1):207-213.
32. Lind PM, Orberg J, Edlund UB, Sjoblom L, Lind L. 2004. The dioxin-like pollutant PCB 126 (3,3',4,4',5-pentachlorobiphenyl) affects risk factors for cardiovascular disease in female rats. Toxicol Lett 150(3):293-299.
33. Ohtake F, Baba A, Fujii-Kuriyama Y, Kato S. 2008. Intrinsic AhR function underlies cross-talk of dioxins with sex hormone signalings. Biochem Biophys Res Commun 370(4):541-546.
34. O'Leary DH, Polak JF, Kronmal RA, Manolio TA, Burke GL, Wolfson SK Jr. 1999. Carotid-artery intima and media thickness as a risk factor for myocardial infarction and stroke in older adults. Cardiovascular Health Study Collaborative Research Group. N Engl J Med 340(1):14-22.
35. Park JY, Shigenaga MK, Ames BN. 1996. Induction of cytochrome P4501A1 by 2,3,7,8-tetrachlorodibenzo-p-dioxin or indolo(3,2-b)carbazole is associated with oxidative DNA damage. Proc Natl Acad Sci USA 93(6):2322-2327.
36. Puga A, Hoffer A, Zhou S, Bohm JM, Leikauf GD, Shertzer HG. 1997. Sustained increase in intracellular free calcium and activation of cyclooxygenase-2 expression in mouse hepatoma cells treated with dioxin. Biochem Pharmacol 54(12):1287-1296.
37. Puga A, Sartor MA, Huang MY, Kerzee JK, Wei YD, Tomlinson CR, et al. 2004. Gene expression profiles of mouse aorta and cultured vascular smooth muscle cells differ widely, yet show common responses to dioxin exposure. Cardiovasc Toxicol 4(4):385-404.
38. Rönn M, Lind L, Bavel BV, Salihovic S, Michaelsson K, Lind PM. 2011. Circulating levels of persistent organic pollutants associate in divergent ways to fat mass measured by DXA in humans. Chemosphere 85(3):335-343.
39. Sandau CD, Sjodin A, Davis MD, Barr JR, Maggio VL, Waterman AL, et al. 2003. Comprehensive solid-phase extraction method for persistent organic pollutants. Validation and application to the analysis of persistent chlorinated pesticides. Anal Chem 75(1):71-77.
40. Sergeev AV, Carpenter DO. 2005. Hospitalization rates for coronary heart disease in relation to residence near areas contaminated with persistent organic pollutants and other pollutants. Environ Health Perspect 113:756-761.
41. Sergeev AV, Carpenter DO. 2010. Residential proximity to environmental sources of persistent organic pollutants and first-time hospitalizations for myocardial infarction with comorbid diabetes mellitus: a 12-year population-based study. Int J Occup Med Environ Health 23(1):5-13.
42. Shertzer HG, Nebert DW, Puga A, Ary M, Sonntag D, Dixon K, et al. 1998. Dioxin causes a sustained oxidative stress response in the mouse. Biochem Biophys Res Commun 253(1):44-48.
43. Uemura H, Arisawa K, Hiyoshi M, Kitayama A, Takami H, Sawachika F, et al. 2009. Prevalence of metabolic syndrome associated with body burden levels of dioxin and related compounds among Japan's general population. Environ Health Perspect 117:568-573.
44. Van den Berg M, Birnbaum L, Bosveld AT, Brunstrom B, Cook P, Feeley M, et al. 1998. Toxic equivalency factors (TEFs) for PCBs, PCDDs, PCDFs for humans and wildlife. Environ Health Perspect 106:775-792.
45. Wohlin M, Sundstrom J, Andren B, Larsson A, Lind L. 2009. An echolucent carotid artery intima-media complex is a new and independent predictor of mortality in an elderly male cohort. Atherosclerosis 205(2):486-491.