Immunophenotype and increased presence of CD4 +CD25 + regulatory T cells in patients with acute lymphoblastic leukemia

Oncology Letters

Volumn 3, Issue 2, 2012, Pages 421-424

  Wu, Cui Ping ^a   Qing, Xi ^a   Wu, Cui Yun ^a   Zhu, Hong ^a   Zhou, Hai Yan ^a  

^a HAINAN MEDICAL UNIVERSITY   (China)

Author keywords

Acute lymphoblastic leukemia; CD4 +CD25 + regulatory T cell; Immunophenotype; Interleukin 10; Interleukin 2; Transforming growth factor

Indexed keywords

CD14 ANTIGEN; CD19 ANTIGEN; CD2 ANTIGEN; CD20 ANTIGEN; CD22 ANTIGEN; CD3 ANTIGEN; CD33 ANTIGEN; CD34 ANTIGEN; CD4 ANTIGEN; CD7 ANTIGEN; HLA DR ANTIGEN; INTERLEUKIN 10; INTERLEUKIN 2; INTERLEUKIN 2 RECEPTOR ALPHA; MICROSOMAL AMINOPEPTIDASE; STEM CELL FACTOR RECEPTOR; TRANSFORMING GROWTH FACTOR BETA;

ACUTE LYMPHOBLASTIC LEUKEMIA; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOKINE RELEASE; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IMMUNOPHENOTYPING; PROTEIN EXPRESSION; REGULATORY T LYMPHOCYTE;

EID: 84855215688     PISSN: 17921074     EISSN: 17921082     Source Type: Journal    
DOI: 10.3892/ol.2011.499     Document Type: Article

References (15)

1. Han X and Bueso-Ramos CE: Advances in the pathological diagnosis and biology of acute lymphoblastic leukemia. Ann Diagn Pathol 9: 239-257, 2005.
2. Onciu M: Acute lymphoblastic leukemia. Hematol Oncol Clin North Am 23: 655-674, 2009.
3. Qiu Y, Wang G, Liu YJ, and Shan LJ: Analysis of immunophenotypes of acute lymphoblastic leukemia by three color flow cytometry. Zhongguo Shi Yan Xue Ye Xue Za Zhi 17: 442-444, 2009.
4. Sakaguchi S, Sakaguchi N, Asano M, Itoh M and Toda M: Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases. J Immunol 155: 1151-1164, 1995.
5. Krawczyńska A and Robak T: Monoclonal antibodies in diagnosis of acute leukemias. Przegl Lek 53: 20-25, 1996.
6. Nachman J: Clinical characteristics, biologic features and outcome for young adult patients with acute lymphoblastic leukaemia. Br J Haematol 130: 166-173, 2005.
7. + regulatory T cells - review. Zhongguo Shi Yan Xue Ye Xue Za Zhi 13: 1137-1140, 2005.
8. Gupta S: Immune homeostasis: regulatory T cells (Treg) and molecules. J Clin Immunol 28: 617-618, 2008.
9. Gershon RK and Kondo K: Infectious immunological tolerance. Immunology 21: 903-914, 1971.
10. Berendt MJ and North RJ: T-cell-mediated suppression of anti-tumor immunity: an explanation for progressive growth of an immunogenic tumor. J Exp Med 151: 69-80, 1980.
11. Zhang L, Dermawan KT, Jin ML, Xiong SD and Chu YW: Does chemotherapy augment anti-tumor immunotherapy by preferential impairment of regulatory T cells? Med Hypotheses 71: 802-804, 2008.
12. Marshall NA, Christie LE, Munro LR, Culligan DJ, Johnston PW, Barker RN, and Vickers MA: Immunosuppressive regulatory T cells are abundant in the reactive lymphocytes of Hodgkin lymphoma. Blood 103: 1755-1762, 2004.
13. + Foxp3+ regulatory T cells. Front Biosci 13: 1440-1446, 2008.
14. Sabat R, Grütz G, Warszawska K, Kirsch S, Witte E, Wolk K and Geginat J: Biology of interleukin-10. Cytokine Growth Factor Rev 21: 331-344, 2010.
15. Meulmeester E and Ten Dijke P: The dynamic roles of TGF-β in cancer. J Pathol 223: 205-218, 2011.