RNA-binding activity of the rat calmodulin-binding PEP-19 protein and of the long PEP-19 isoform

International Journal of Molecular Medicine

Volumn 29, Issue 2, 2012, Pages 141-145

  Saladino, Patrizia ^a   Di Liegro, Carlo Maria ^a   Proia, Patrizia ^a   Sala, Anna ^a   Schiera, Gabriella ^a   Lo Cicero, Alessandra ^a   Di Liegro, Italia ^a  

^a UNIVERSITY OF PALERMO   (Italy)

Author keywords

Calmodulin; H1 ; Histone variants; Long PEP 19 isoform; PEP 19; RNA binding proteins

Indexed keywords

BRAIN PROTEIN; CALCIUM; CALMODULIN; HISTONE H1; LONG PEP 19 ISOFORM PROTEIN; MESSENGER RNA; PEP 19 PROTEIN; RNA; UNCLASSIFIED DRUG;

ARTICLE; BRAIN DEVELOPMENT; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN FUNCTION; RAT; RNA BINDING; RNA METABOLISM;

ANIMALS; BINDING, COMPETITIVE; CALMODULIN; CALMODULIN-BINDING PROTEINS; NERVE TISSUE PROTEINS; PROTEIN BINDING; PROTEIN ISOFORMS; RATS; RATS, SPRAGUE-DAWLEY; RNA; RNA PROCESSING, POST-TRANSCRIPTIONAL; RNA-BINDING PROTEINS;

EID: 84855210536     PISSN: 11073756     EISSN: 1791244X     Source Type: Journal    
DOI: 10.3892/ijmm.2011.819     Document Type: Article

References (25)

1. Kornberg RD and Lorch Y: Twenty-five years of the nucleosome, fundamental particle of the eukaryote chromosome. Cell 98: 285-294, 1999. (Pubitemid 29380564)
2. Ahmad K and Henikoff S: The histone variant H3.3 marks active chromatin by replication-independent nucleosome assembly. Mol Cell 9: 1191-1200, 2002. (Pubitemid 34722299)
3. Gao FB: Messenger RNAs in dendrites: localization, stability, and implications for neuronal function. Bioessays 20: 70-78, 1998.
4. Kuhl D and Skehel P: Dendritic localization of mRNAs. Curr Opin Neurobiol 8: 600-606, 1998. (Pubitemid 28488421)
5. Derrigo M, Cestelli A, Savettieri G and Di Liegro I: RNA-protein interactions in the control of stability and localization of messenger RNA. Int J Mol Med 5: 111-123, 2000.
6. Gjerset R, Gorka C, Hasthorpe S, Lawrence JJ and Eisen H: Developmental and hormonal regulation of protein H1° in rodents. Proc Natl Acad Sci USA 79: 2333-2337, 1982. (Pubitemid 12161315)
7. Cestelli A, Castiglia D, Di Liegro CM and Di Liegro I: Qualitative differences in nuclear proteins correlate with neuronal terminal differentiation. Cell Mol Neurobiol 12: 33-43, 1992.
8. Ponte I, Martinez P, Ramirez A, Jorcano JL, Monzó M and Suau P: Transcriptional activation of histone H1 zero during neuronal terminal differentiation. Brain Res Dev Brain Res 80: 35-44, 1994. (Pubitemid 24228908)
9. Pina B and Suau P: Changes in histones H2A and H3 variant composition in differentiating and mature rat brain cortical neurons. Dev Biol 123: 51-58, 1987.
10. Castiglia D, Cestelli A, Scaturro M, Nastasi T and Di Liegro I: H1° and H3.3b mRNA levels in developing rat brain. Neurochem Res 19: 1531-1537, 1994. (Pubitemid 24370071)
11. Scaturro M, Nastasi T, Raimondi L, Bellafiore M, Cestelli A and Di Liegro I: H1° RNA-binding proteins specifically expressed in the rat brain. J Biol Chem 273: 22788-22791, 1998. (Pubitemid 28399853)
12. Castiglia D, Scaturro M, Nastasi T, Cestelli A and Di Liegro I: PIPPin, a putative RNA-binding protein specifically expressed in the rat brain. Biochem Biophys Res Commun 218: 390-394, 1996. (Pubitemid 26034544)
13. Nastasi T, Scaturro M, Bellafiore M, Raimondi L, Beccari S, Cestelli A and Di Liegro I: PIPPin is a brain-specific protein that contains a cold-shock domain and binds specifically to H1° and H3.3 mRNAs. J Biol Chem 274: 24087-24093, 1999.
14. Nastasi T, Muzi P, Beccari S, Bellafiore M, Dolo V, Bologna M, Cestelli A and Di Liegro I: Specific neurons of brain cortex and cerebellum are PIPPin positive. Neuroreport 11: 2233-2236, 2000. (Pubitemid 30485568)
15. Sala A, Scaturro M, Proia P, Schiera G, Balistreri E, Aflalo- Rattenbach R, Créau N and Di Liegro I: Cloning of a rat-specific long PCP4/PEP19 isoform. Int J Mol Med 19: 501-509, 2007.
16. Ziai R, Pan YC, Hulmes JD, Sangameswaran L and Morgan JI: Isolation, sequence, and developmental profile of a brain-specific polypeptide, PEP-19. Proc Natl Acad Sci USA 83: 8420-8423, 1986. (Pubitemid 17182512)
17. Slemmon JR, Morgan JI, Fullerton SM, Danho W, Hilbush BS and Wengenack TM: Camstatins are peptide antagonists of calmodulin based upon a conserved structural motif in PEP-19, neurogranin, and neuromodulin. J Biol Chem 271: 15911-15917, 1996. (Pubitemid 26236200)
18. Johanson RA, Sarau HM, Foley JJ and Slemmon JR: Calmodulin-binding peptide PEP-19 modulates activation of calmodulin kinase II in situ. J Neurosci 20: 2860-2866, 2000. (Pubitemid 30220311)
19. Markossian KA and Kurganov BI: Protein folding, misfolding, and aggregation. Formation of inclusion bodies and aggresomes. Biochemistry 69: 971-984, 2004.
20. Raimondi L, D'Asaro M, Proia P, Nastasi T and Di Liegro I: RNA-binding ability of PIPPin requires the entire protein. J Cell Mol Med 7: 35-42, 2003. (Pubitemid 37123374)
21. Castiglia D, Gristina R, Scaturro M and Di Liegro I: Cloning and analysis of cDNA for rat histone H1°. Nucleic Acids Res 21: 1674, 1993. (Pubitemid 23146345)
22. Burd CG and Dreyfuss G: Conserved structures and diversity of functions of RNA-binding proteins. Science 265: 615-621, 1994. (Pubitemid 24268271)
23. Hall KB: RNA-protein interactions. Curr Opin Struct Biol 12: 283-288, 2002.
24. Scaturro M, Cestelli A, Castiglia D, Nastasi T and Di Liegro I: Posttranscriptional regulation of H1 zero and H3.3B histone genes in differentiating rat cortical neurons. Neurochem Res 20: 969-976, 1995.
25. Wei P, Blundon JA, Rong Y, Zakharenko SS and Morgan JI: Impaired locomotor learning and altered cerebellar synaptic plasticity in pep-19/pcp4-null mice. Mol Cell Biol 31: 2838-2844, 2011.