Discovery of inhibitors and substrates of brassinin hydrolase: Probing selectivity with dithiocarbamate bioisosteres

Bioorganic and Medicinal Chemistry

Volumn 20, Issue 1, 2012, Pages 225-233

  Pedras, M Soledade C ^a   Minic, Zoran ^a   Hossain, Sajjad ^a  

^a UNIVERSITY OF SASKATCHEWAN   (Canada)

Author keywords

Brassinin hydrolase; Detoxification; Naphthalenylmethyl carbamate; Naphthalenylmethyl carbonate; Naphthalenylmethyl dithiocarbamate; Paldoxin; Phytoalexin; Ser Ser Lys catalytic triad

Indexed keywords

1 METHYLBRASSININ; ANTIFUNGAL AGENT; BRASSININ; BRASSININ HYDROLASE; BRASSITIN; CYCLOBRASSININ; DITHIOCARBAMIC ACID DERIVATIVE; FUNGAL ENZYME; METHYL 1 METHYL N' (3 INDOYLMETHYL)CARBAMATE; METHYL N (1 NAPHTHALENYLMETHYL)CARBAMATE; METHYL N (1 NAPHTHALENYLMETHYL)CARBONATE; METHYL N (1 NAPHTHALENYLMETHYL)DITHIOCARBAMATE; METHYL N (2 NAPHTHALENYLMETHYL)CARBAMATE; METHYL N (2 NAPHTHALENYLMETHYL)CARBONATE; METHYL N (2 NAPHTHALENYLMETHYL)DITHIOCARBAMATE; METHYL N' (3 INDOYLMETHYL)CARBAMATE; METHYL N' (3 INDOYLMETHYL)THIONECARBAMATE; UNCLASSIFIED DRUG;

ALTERNARIA; ALTERNARIA BRASSICICOLA; ANTIFUNGAL ACTIVITY; ARTICLE; CATALYSIS; CHEMICAL STRUCTURE; CONTROLLED STUDY; DETOXIFICATION; ENZYME SPECIFICITY; GEL FILTRATION; HYDROLYSIS; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; SYNTHESIS;

ALTERNARIA; ANTIFUNGAL AGENTS; DRUG DESIGN; DRUG EVALUATION, PRECLINICAL; ENZYME ACTIVATION; ENZYME INHIBITORS; HYDROLASES; INDOLES; KINETICS; SUBSTRATE SPECIFICITY; THIOCARBAMATES;

ALTERNARIA BRASSICICOLA;

EID: 84855204456     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2011.11.009     Document Type: Article

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