Estimating Renal Function in Older and Frail Patients: Implications for Drug Dosing

Journal of the American Medical Directors Association

Volumn 13, Issue 1, 2012, Pages

  Corsonello, Andrea ^a   Laino, Irma ^a   Garasto, Sabrina ^a   Antonelli Incalzi, Raffaele ^b,c  

^a INRCA   (Italy)

^b UNIVERSITY CAMPUS BIO MEDICO   (Italy)

^c San Raffaele Foundation   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

CREATININE; PRESCRIPTION DRUG;

CREATININE BLOOD LEVEL; CREATININE CLEARANCE; DRUG CLEARANCE; DRUG DOSE; FRAIL ELDERLY; GLOMERULUS FILTRATION RATE; HUMAN; KIDNEY FUNCTION; LETTER; NURSING HOME PATIENT;

EID: 84855201178     PISSN: 15258610     EISSN: 15389375     Source Type: Journal    
DOI: 10.1016/j.jamda.2011.06.008     Document Type: Letter

References (9)

1. Hanlon J.T., Wang X., Handler S.M., et al. Potentially inappropriate prescribing of primarily renally cleared medications for older Veterans Affairs nursing home patients. JAm Med Dir Assoc 2011, 12:377-383.
2. Huang S.M., Temple R., Xiao S., et al. When to conduct a renal impairment study during drug development: US Food and Drug Administration perspective. Clin Pharmacol Ther 2009, 86:475-479.
3. National Kidney Disease Education Program (NKDEP) and the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK). Chronic Kidney Disease and Drug Dosing:Information for Providers (Revised January 2010). Available at: Accessed June 10, 2011. http://www.nkdep.nih.gov/professionals/CKD_DrugDosing_508.pdf.
4. Stevens L.A., Nolin T.D., Richardson M.M., et al. Comparison of drug dosing recommendations based on measured GFR and kidney function estimating equations. Am J Kidney Dis 2009, 54:33-42.
5. Dowling T.C., Matzke G.R., Murphy J.E. Estimated GFR vs creatinine clearance for drug dosing. Am J Kidney Dis 2009, 54:984-985. author reply 985-986.
6. Cockcroft D.W., Gault M.H. Prediction of creatinine clearance from serum creatinine. Nephron 1976, 16:31-41.
7. Pedone C., Semeraro R., Chiurco D., et al. Reliability of equations to estimate glomerular filtration rate in the very old. Aging Clin Exp Res 2008, 20:496-502.
8. Corsonello A., Pedone C., Lattanzio F., et al. Agreement between equations estimatingglomerular filtration rate in elderly nursing home residents and inhospitalised patients:implications for drug dosing. Age Ageing 2011, doi: 10.1093/ageing/afr011.
9. Corsonello A., Pedone C., Lattanzio F., et al. Association between glomerular filtration rate and adverse drug reactions in elderly hospitalized patients: The role of the estimating equation. Drugs Aging 2011, 28:379-390.