Efficacy of immunohistological methods in detecting functionally viable mechanoreceptors in the remnant stumps of injured anterior cruciate ligaments and its clinical importance

Knee Surgery, Sports Traumatology, Arthroscopy

Volumn 20, Issue 1, 2012, Pages 75-80

  Bali, Kamal ^a   Dhillon, Mandeep S ^a   Vasistha, R K ^a   Kakkar, Nandita ^a   Chana, Rishi ^b   Prabhakar, Sharad ^a  

^a POSTGRADUATE INSTITUTE OF MEDICAL EDUCATION AND RESEARCH   (India)

^b Mater Hospital   (Australia)

Author keywords

ACL reconstruction; Anterior cruciate ligament; Immunohistology; NFP; Proprioception; S 100

Indexed keywords

DIAGNOSTIC AGENT; MONOCLONAL ANTIBODY; NEUROFILAMENT PROTEIN; PROTEIN S 100;

ADOLESCENT; ADULT; ANTERIOR CRUCIATE LIGAMENT; ARTICLE; COMPARATIVE STUDY; DRUG ANTAGONISM; FEMALE; HUMAN; IMMUNOHISTOCHEMISTRY; INJURY; INNERVATION; KNEE INJURY; MALE; MECHANORECEPTOR; MIDDLE AGED; NERVE ENDING; PATHOLOGY; PROPRIOCEPTION; VALIDATION STUDY;

ADOLESCENT; ADULT; ANTERIOR CRUCIATE LIGAMENT; ANTIBODIES, MONOCLONAL; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; KNEE INJURIES; MALE; MECHANORECEPTORS; MIDDLE AGED; NERVE ENDINGS; NEUROFILAMENT PROTEINS; PROPRIOCEPTION; S100 PROTEINS; YOUNG ADULT;

EID: 84855191701     PISSN: 09422056     EISSN: 14337347     Source Type: Journal    
DOI: 10.1007/s00167-011-1526-9     Document Type: Article

References (23)

1. Adachi N, Ochi M, Uchio Y, Iwasa J, Ryoke K, Kuriwaka M (2002) Mechanoreceptors in the anterior cruciate ligament contribute to the joint position sense. Acta Orthop Scand 73: 330-334.
2. Adachi N, Ochi M, Uchio Y, Sumen Y (2000) Anterior cruciate ligament augmentation under arthroscopy. A minimum 2-year follow-up in 40 patients. Arch Orthop Trauma Surg 120: 128-133.
3. Barrett DS (1991) Proprioception and function after anterior cruciate ligament reconstruction. J Bone Joint Surg Br 73: 833-837.
4. Biedert RM, Stauffer E, Friederich NF (1992) Occurrence of free nerve endings in the soft tissue of the knee joint. A histologic investigation. Am J Sports Med 20: 430-433.
5. Borsa PA, Lephart SM, Irrgang JJ, Safran MR, Fu FH (1997) The effects of joint position and direction of joint motion on proprioceptive sensibility in anterior cruciate ligament-deficient athletes. Am J Sports Med 25: 336-340.
6. Del Valle ME, Harwin SF, Maestro A et al (1998) Immunohistochemical analysis of mechanoreceptors in the human posterior cruciate ligament: a demonstration of its proprioceptive role and clinical relevance. J Arthroplasty 13: 916-922.
7. Denti M, Monteleone M, Berardi A, Panni AS (1994) Anterior cruciate ligament mechanoreceptors. Clin Orthop Relat Res 308: 29-32.
8. Dhillon MS, Bali K, Vasistha RK (2010) Immunohistological evaluation of the proprioceptive potential of the residual stump of an injured anterior cruciate ligament. Int Orthop 34: 737-741.
9. Georgoulis AD, Pappa L, Moebius U et al (2001) The presence of proprioceptive mechanoreceptors in the remnants of ruptured ACL as possible source of reinnervation of ACL autograft. Knee Surg Sports Traumatol Arthrosc 9: 364-368.
10. Halata Z, Rettig T, Schulze W (1985) The ultrastructure of sensory nerve endings in human knee joint capsule. Anat. Embryol(Berl) 172: 265-275.
11. Hogervorst T, Brand RA (1998) Mechanoreceptors in joint function. J Bone Joint Surg Am 80: 1365-1378.
12. Johansson H, Sjolander P, Sojka P (1991) A sensory role for the cruciate ligaments. Clin Orthop Relat Res 268: 161-178.
13. Johansson H, Sjolander P, Sojka P (1991) Receptors in knee joint and their role in biomechanics of joint. Crit Rev Biomed Eng 18: 341-368.
14. Kennedy JC, Alexander IJ, Hayes KC (1982) Nerve supply of the human knee and its functional importance. Am J Sports Med 10: 329-335.
15. Krauspe R, Schmidt M, Schaible HG (1992) Sensory innervation of the anterior cruciate ligament. An electrophysiological study of the response properties of single identified mechanoreceptors in the cat. J Bone Joint Surg Am 74: 390-397.
16. Krauspe R, Schmitz F, Zöller G, Drenckhahn D (1995) Distribution of neurofilament-positive nerve fibres and sensory endings in the human anterior cruciate ligament. Arch Orthop Trauma Surg 114: 194-198.
17. Lee BI, Kwon SW, Kim JB et al (2008) Comparison of clinical results according to amount of preserved remnant in arthroscopic anterior cruciate ligament reconstruction using quadrupled hamstring graft. Arthroscopy 24: 560-568.
18. Lee BI, Min KD, Choi HS et al (2009) Immunohistochemical study of mechanoreceptors in the tibial remnant of the ruptured anterior cruciate ligament in human knees. Knee Surg Sports Traumatol Arthrosc 17: 1095-1101.
19. Ochi M, Adachi N, Deie M, Kanaya A (2006) Anterior cruciate ligament augmentation procedure with a 1-incision technique: anteromedial bundle or posterolateral bundle reconstruction. Arthroscopy 22: 463. e1-5.
20. Schultz RA, Miller DC, Kerr CS, Micheli L (1984) Mechanoreceptors in human cruciate ligaments. A histological study. J Bone Joint Surg Am 66: 1072-1076.
21. Schutte MJ, Dabezies EJ, Zimny ML, Happel LT (1987) Neural anatomy of the human anterior cruciate ligament. J Bone Joint Surg Am 69: 243-247.
22. Shimizu T, Takahashi T, Wada Y et al (1999) Regeneration process of mechanoreceptors in the reconstructed anterior cruciate ligament. Arch Orthop Trauma Surg 119: 405-409.
23. Zimny ML, Schutte M, Dabezies E (1986) Mechanoreceptors in the human anterior cruciate ligament. Anat Rec 214: 204-209.