Predictive gene signatures for bevacizumab and cetuximab as well as cytotoxic agents

International Journal of Clinical Pharmacology and Therapeutics

Volumn 50, Issue 1, 2012, Pages 70-71

  Fiebig, Heinz Herbert ^a   Vuaroqueaux, Vincent ^a   Korrat, Andre ^a   Foucault, Frederic ^a   Beckers, Thomas ^a  

^a CHARLES RIVER LABORATORIES   (United States)

Author keywords

Bevacizumab; Biomarker; Cetuximab; Gene signature; Xenograft models

Indexed keywords

BEVACIZUMAB; CETUXIMAB; CISPLATIN; DOCETAXEL; DOXORUBICIN; ETOPOSIDE; FLUOROURACIL; GEMCITABINE; IFOSFAMIDE; MITOMYCIN C; PACLITAXEL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BREAST CANCER; COLON CANCER; DRUG RESPONSE; GENE EXPRESSION PROFILING; GENE SIGNATURE; GENETIC PARAMETERS; HEAD AND NECK CANCER; KIDNEY CANCER; LUNG NON SMALL CELL CANCER; MALIGNANT NEOPLASTIC DISEASE; MOUSE; NONHUMAN; PANCREAS CANCER; PHARMACOGENETICS; STOMACH CANCER; TUMOR XENOGRAFT; VALIDATION STUDY;

ANIMALS; ANTIBODIES, MONOCLONAL; ANTIBODIES, MONOCLONAL, HUMANIZED; ANTINEOPLASTIC AGENTS; FEASIBILITY STUDIES; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; MICE; MICE, NUDE; NEOPLASMS; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84855180829     PISSN: 09461965     EISSN: None     Source Type: Journal    
DOI: 10.5414/CPP50070     Document Type: Article

References (4)

1. Fiebig HH, Metz T, Greiner T, Korrat A, Maurer M, Schüler J. Antitumor Activity of Avastin in a Panel of 100 Patient Derived Tumor Models in vivo in Relation to Proteomic Biomarker Profiles. Proc AACR-NCI-EORTC Conference, Molecular Targets and Cancer Therapeutics, A28, 2007.
2. Fiebig HH, Schüler J, Bausch N, Hofmann M, Metz T, Korrat A. Gene signatures developed from patient tumor explants grown in nude mice to predict tumor response to 11 cytotoxic drugs. Cancer Genomics Proteomics. 2007; 4: 197-209. PubMed
3. Korrat A, Greiner T, Maurer M, Metz T, Fiebig HH. Gene signature-based prediction of tumor response to cyclophosphamide. Cancer Genomics Proteomics. 2007; 4: 187-195. PubMed
4. Fiebig HH, Schüler J, Greiner T, Metz T, Bausch N, Korrat A. Determination of a 35 gene signature predictive for the effectiveness of Bevacizumab. Proc AACR-NCI-EORTC Conference, Molecular Targets and Cancer Therapeutics, B10, 2007.