Miniature swine model of phototoxicity testing

Photodermatology Photoimmunology and Photomedicine

Volumn 28, Issue 1, 2012, Pages 34-41

  Leigh, Heinz ^a   Forbes, Paul Donald ^b   Lawson, Charles ^a   Kim, Dae Young ^c   White, David ^a   Brown, Larry D ^a   Wehmeier, Dean R ^a   Liu, Jason ^a   Bouchard, Guy F ^a  

^a Sinclair Research Center LLC   (United States)

^b Aclairo PDG Inc   (United States)

^c UNIVERSITY OF MISSOURI   (United States)

Author keywords

Dermal; Miniswine; Phototoxicity

Indexed keywords

METHOXSALEN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; ERYTHEMA; FEMALE; IRRADIATION; MICROSCOPY; MINIPIG; NONHUMAN; PHOTOTOXICITY; PRIORITY JOURNAL; RADIATION EXPOSURE; SCORING SYSTEM; SKIN COLOR; SKIN PIGMENTATION; STRAIN DIFFERENCE; ULTRAVIOLET A RADIATION; ULTRAVIOLET B RADIATION;

EID: 84855179582     PISSN: 09054383     EISSN: 16000781     Source Type: Journal    
DOI: 10.1111/j.1600-0781.2011.00633.x     Document Type: Article

References (21)

1. U.S. FDA Center for Drug Evaluation and Research (CDER). Guidance for industry - photosafety testing. 2003.
2. Lambert LA, Warner WG, Kornhauser A. Animal models for phototoxicity testing. Toxicol Methods 1996; 6: 99-114.
3. Sambuco CP, Forbes PD. Quantitative assessment of phototoxicity in the skin of hairless mice. Food Chem Toxicol 1984; 22: 233-236.
4. Jacobs A. Use of nontraditional animals for evaluation of pharmaceutical products. Expert Opin Drug Metab Toxicol 2006; 2: 345-349.
5. Sambuco CP. Miniature swine as an animal model in photodermatology: factors influencing sunburn cell formation. Photodermatology 1985; 2: 144-150.
6. Morikawa F, Nakayama Y, Fukuda F etal. Techniques for evaluation of phototoxicity and photoallergy in laboratory animals and man. In: Fitzpatrick TB, ed. Sunlight and man. Tokyo: University of Tokyo Press, 1974, 529-557.
7. Solar Light Company. On-line product information. 2011. Available at (Nov 2, 2011).
8. Urbach F, Forbes PD. The historical basis of the MED as a measure of skin sensitivity to ultraviolet radiation. In: Hoenigsmann H, Knobler RM, Trautinger F, Jori G, eds Proceedings of the 12th International Congress on Photobiology (Vienna, Austria; September 1996); ISBN 88-7076-222-X. Milano, OEMF, 1998, 303-307.
9. Green AES, Miller JH. Measures of biologically effective radiation in the 280-340 region. In: Nachtway DS, ed. Impacts of climate change on the biosphere (CIAP Monograph 5, Part 1. Ultraviolet Radiation Effects, Ch 1-3). Springfield, VA: National Technical Information Service, 1975, 2-60; through 2-78.
10. Nachtwey DS. General aspects of dosimetry (Part 2.2.3). In: Nachtway DS, ed. Impacts of climatic change on the biosphere. (CIAP Monograph 5, Part 1 - Ultraviolet Radiation Effects, Chapters 1 through 3); DOT Document available through the National Technical Information Service. Springfield, VA: National Technical Information Service, 1975, 2-49; through 2-60.
11. Commission Internationale de l'Éclairage (CIE). CIE/ISO: draft standard 017.1/E:2009 ILV: international lighting vocabulary; CIE S- 007/E-1998; erythema reference action spectrum and standard erythema dose. CIE-International Commission on Illumination. 2009.
12. Webb AR, Slaper H, Koepke P, Schmalwiese AW. Know your standard: clarifying the CIE erythema action spectrum. Photochem Photobiol 2011; 87: 483-486.
13. Draize JH. Dermal toxicity, Appraisal of the safety of chemicals in foods, drugs, and cosmetics. Assoc. Food & Drug Officials of the United States, Bureau of Foods and Drugs, Austin, Texas. 1959, 46-59.
14. Am. Vet. Med. Association. AVMA Guidelines on Euthanasia (Formerly Report of the AVMA Panel on Euthanasia). June 2007.
15. Gad SC. Pigs and ferrets as models in toxicology and biological safety assessment. Int J Toxicol 2000; 19: 149-168.
16. Johnson BE, Mandell G, Daniels E Jr. Melanin and cellular reactions to ultraviolet radiation. Nat New Biol 1972; 235: 147-149.
17. Woodcock A, Magnus IA. The sunburn cell in mouse skin: preliminary quantitative studies on its production. Br J Dermatol 1976; 95: 459-468.
18. Agar N, Young AR. Melanogenesis: a photoprotective response to DNA damage? Mutat Res 2005; 571: 121-132.
19. Ferguson J. Fluoroquinolone photosensitization: a review of clinical and laboratory studies. Photochem Photobiol 1995; 62: 954-958.
20. Moseley H, Ferguson J. Which light source should be used for the investigation of clinical phototoxicity: monochromator or solar simulator? Photodermatol Photoimmunol Photomed 2010; 26: 3-6.
21. Murphy IM, Ferguson J. Fluoroquinolone phototoxicity: a comparison of moxifloxacin and lomefloxacin in normal volunteers. J Antimicrob Chemother 1999; 43 (Suppl. B): 77-82.