A comprehensive review of biochemical and molecular evidences from animal and human studies on the role of oxidative stress in aging: An epiphenomenon or the cause

Asian Journal of Animal and Veterinary Advances

Volumn 7, Issue 1, 2012, Pages 1-19

  Momtaz, Saeideh ^a,b   Abdollahi, Mohammad ^b,c  

^a UNIVERSITY OF PRETORIA   (South Africa)

^b TEHRAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^c TEHRAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

Aging; Animal; Human; Mechanisms; Oxidative stress; Toxicity

Indexed keywords

ANIMALIA;

EID: 84855179230     PISSN: 16839919     EISSN: None     Source Type: Journal    
DOI: 10.3923/ajava.2012.1.19     Document Type: Article

References (135)

1. Abdollahi, M., S. Mostafalou, S. Pournourmohammadi and S. Shadnia, 2004. Oxidative stress and cholinesterase inhibition in saliva and plasma of rats following sub-chronic exposure to malathion. Camp. Biochem. Physiol. C: Toxicol. Pharmacal., 137: 29-34.
2. Abdollahi, M., B. Larijani, R. Rahimi and P. Salari, 2005. Role of oxidative stress in osteoporosis. Therapy, 2: 787-796.
3. Afshari, M., B. Larijani, A. Rezaie, A. Mojtahedi and M.J. Zamani et al., 2004. Ineffectiveness of allopurinol in reduction of oxidative stress in diabetic patients; a randomized, double-blind placebo-controlled clinical trial. Biomed. Pharmacother., 58: 546-550.
4. Alarcon de la Lastra, C. and I. Villegas, 2005. Resveratrol as an anti-inflammatory and anti-aging agent: Mechanisms and clinical implications. Mol. Nutr. Food Res., 49: 405-430.
5. Ames, B.N., M.K. Shigenaga and T.M. Hagen, 1993. Oxidants, antioxidants and the degenerative diseases of aging. Proc. Natl. Acad. Sci., 90: 7915-7922.
6. Andersen, H.R., J.B. Nielsen, F. Nielsen and P. Grandjean, 1997. Antioxidative enzyme activities in human erythrocytes. Clin. Chern., 43: 562-568.
7. Atwood, C.S., S.V. Meethal, T. Liu, A.C. Wilson, M. Gallego, M.A. Smith and R.L. Bowen, 2005. Dysregulation of the hypothalamic-pituitary-gonadal axis with menopause and andropause promotes neurodegenerative senescence. J. Neuropathol. Exp. Neural., 64: 93-103.
8. Bagchi, D.C., K. Sen, M. Bagchi and M. Atalay, 2004. Anti-angiogenic, antioxidant and anti-carcinogenic properties of a novel anthocyanin-rich berry extract formula. Biochemistry, 69: 75-80.
9. Balaban, R.S., S. Nemoto and T. Finkel, 2005. Mitochondria, oxidants and aging. Cell, 120: 483-495.
10. Barger, J.L., T. Kayo, J.M. Vann, E.B. Arias and J. Wang et al., 2008. A low dose of dietary resveratrol partially mimics caloric restriction and retards aging parameters in mice. Plos One, 3: 1-10.
11. Baur, J.A. and D.A. Sinclair, 2006. Therapeutic potential of resveratrol: The in vivo evidence. Nature Rev. Drug Discov., 5: 493-506.
12. Bauza, E., C. Dal Farra, A. Berghi, G. Oberto, D. Peyronel and N. Domloge, 2002. Date palm kernel exhibits anti aging properties and significantly reduces skin wrinkles. Int. J. Tissue React., 24: 131-136.
13. Bedard, K. and K.H. Krause, 2007. The NOX family of ROB-generating NADPH oxidases: Physiology and pathophysiology. Physiol. Rev., 87: 245-313.
14. Ben-Porath, I. and R.A. Weinberg, 2005. The signals and pathways activating cellular senescence. Int. J. Biochem. Cell. B., 37: 961-976.
15. Bjorneboe, A., G.E. Bjorneboe and C.A. Drevon, 1990. Absorption, transport and distribution of vitamin E. J. Nutr., 120: 233-242.
16. Burdon, R.H., 1995. Superoxide and hydrogen peroxide in relation to mammalian cell proliferation. Free Radic. Biol. Med., 18: 775-794.
17. Beckman, K.B. and B.N. Ames, 1998. The free radical theory of aging matures. Physiol. Rev., 78: 547-581.
18. Campisi, J., 2001. Cellular senescence as a tumor-suppressor mechanism. Trends Cell Biol., 11: 827-831.
19. Campisi, J. and F. d'Adda di Fagagna, 2007. Cellular senescence: When bad things happen to good cells. Nat. Rev. Mol. Cell. Biol., 8: 729-740.
20. Chen, Q., A. Fischer, J.D. Reagan, L.J. Yan and B.N. Ames, 1995. Oxidative DNA damage and senescence of human diploid fibroblast cells. Proc. Natl. Acad. Sci. USA, 92: 4337-4341.
21. Chen, Q.M., J.C. Bartholomew, J. Campisi, M. Acosta, J.D. Reagan and B.N. Ames, 1998. Molecular analysis of H2O2-induced senescent-like growth arrest in normal human fibroblasts: p53 and Rb control G1 arrest but not cell replication. Biochem. J., 332: 43-50.
22. Cheng, Y., L.H. Shen and J.T. Zhang, 2005. Anti-amnestic and anti-aging effects of ginsenoside Rg1 and Rb1 and its mechanism of action. Acta Pharmacal. Sin., 26: 143-149.
23. Chiu, T.M., C.C. Huang, T.J. Lin, J.Y. Fang, N.L. Wu and C.F. Hung, 2009. In vitro and in vivo anti-photoaging effects of an isoflavone extract from soybean cake. J. Ethnopharmacol., 126: 108-113.
24. Cho, S., S. Lee, M.J. Lee, D.H. Lee, C.H. Won, S.M. Kim and J.H. Chung, 2009. Dietary aloe vera supplementation improves facial wrinkles and elasticity and it increases the type I procollagen gene expression in human skin in vivo. Ann. Dermatol., 21: 6-11.
25. Choi, K.T., 2008. Botanical characteristics, pharmacological effects and medicinal components of Korean Panax ginseng C A Meyer. Acta Pharmacal. Sin., 29: 1109-1118.
26. Chow, C.K., 1991. Vitamin E and oxidative stress. Free Radic. Biol. Med., 11: 215-232.
27. Chung, H.Y., B. Sung, K.J. Jung, Y. Zou and B.P. Yu, 2006. The molecular inflammatory process in aging. Antioxid. Redox Signaling, 8: 572-581.
28. Colavitti, R. and T. Finkel, 2005. Reactive oxygen species as mediators of cellular senescence. IUBMB Life, 57: 277-281.
29. Collado, M., M.A. Blasco and M. Serrano, 2007. Cellular senescence in cancer and aging. Cell, 130: 223-233.
30. Coquet, C., E. Bauza, G. Oberto, A. Berghi and A.M. Farnet et al., 2005. Quercus suber cork extract displays a tensor and smoothing effect on human skin: An in vivo study. Drugs Exp. Clin. Res., 31: 89-99.
31. D'Archivio, M., C. Filesi, R. Di Benedetto, R. Gargiulo, C. Giovannini and R. Masella, 2007. Polyphenols, dietary sources and bioavailability. Ann. 1st Super Sanita, 43: 348-361.
32. De Haan, J.B., F. Cristiano, R.C. Iannello and I. Kola, 1995. Cu/Zn-superoxide dismutase and glutathione peroxidase during aging. Biochem. Mol. Biol. Int., 35: 1281-1297.
33. Denu, J.M., 2003. Linking chromatin function with metabolic networks: Sir2 family of NAD+dependent deacetylases. Trends Biochem. Sci., 28: 41-48.
34. Dhar, H.L., 2009. General practitioner's section approach to anti-aging. Bombay Hasp. J., 51: 68-72.
35. Droge, W., 2002. Free radicals in the physiological control of cell function. Phsyol. Rev., 82: 47-95.
36. Dweck, A. C., 2009. The internal and external use of medicinal plants. Clin. Dermatol., 27: 148-158.
37. Eicker, J., V. Kurten, S. Wild, G. Riss, R. Goralczyk, J. Krutmann and M. Berneburg, 2003. Betacarotene supplementation protects from photoaging-associated mitochondrial DNA mutation. Photochem. Photobiol. Sci., 2: 655-659.
38. Forsyth, N.R., A.P. Evans, J.W. Shay and W.E. Wright, 2003. Developmental differences in the immortalization of lung fibroblasts by telomerase. Aging Cell, 2: 235-243.
39. Furuse, K., 1987. Vitamin E: Biological and clinical aspects of topical treatment. Cosmet. Toiletries, 102: 99-116.
40. Gaby, A.R., 1996. Ginkgo biloba extract: A review. Altern. Med. Rev., 1: 236-242.
41. Galli, R.L., B. Shukitt-Hale, K.A. Youdim and J.A. Joseph, 2002. Fruit polyphenolics and brain aging: Nutritional interventions targeting age-related neuronal and behavioral deficits. Ann. N.Y. Acad. Sci., 959: 128-132.
42. Goth, L., 1989. Effect of age, sex and smoking on serum catalase activity. Acta Biol. Hung., 40: 395-399.
43. Halliwell, B. and J.M.C. Gutteridge, 2007. Free Radicals in Biology and Medicine. 4th Edn., Oxford University Press, Oxford.
44. Harman, D., 1956. Aging: A theory based on free radical and radiation chemistry. J. Gerontal., 11: 298-300.
45. Harman, D., 1981. The aging process. Proc. Natl. Acad. Sci. USA., 78: 7124-7128.
46. Hasani-Ranjbar, S., B. Larijani and M. Abdollahi, 2009. A systematic review of the potential herbal sources of future drugs effective in oxidant-related diseases. Inflamm. Allergy Drug Targets, 8: 2-10.
47. Hasani-Ranjbar, S., H. Vahidi, S. Taslimi, N. Karimi, B. Larijani and M. Abdollahi, 2010a. A systematic review on the efficacy of herbal medicines in the management of human druginduced hyperprolactinemia; potential sources for the development of novel drugs. Int. J. Pharmacal., 6: 691-695.
48. Hasani-Ranjbar, S., N. Nayebi, B. Larijani and M. Abdollahi, 2010b. A systematic review of the efficacy and safety of Teucrium species; from anti-oxidant to anti-diabetic effects. Int. J. Pharmacal., 6: 315-325.
49. Hasani-Ranjbar, S., B. Larijani and M. Abdollahi, 2011. Recent update on animal and human evidences of promising antidiabetic medicinal plants: A mini-review of targeting new drugs. Asian J. Anim. Vet. Adv., 6: 1271-1275.
50. INK4a. Mol. Cell, 14: 501-513.
51. Ho, Y.S., K.F. So and R.C.C. Chang, 2010. Anti-aging herbal medicine-How and why can they be used in aging-associated neurodegenerative diseases?. Ageing Res. Rev., 9: 354-362.
52. Holliday, R., 2006. Aging is no longer an unsolved problem in biology. Ann. N.Y. Acad. Sci. USA., 1067: 1-9.
53. Hsu, S., 2005. Green tea and the skin. J. Am. Acad. Dermatol., 52: 1049-1059.
54. Huang, N., B. Lineberger and M. Steiner, 1988. á-tocopherol, a potent modulator of endothelial cell function. Thrombosis Res., 50: 547-557.
55. Ina, M.E., G. Kanbak and E. Sunal, 2001. Antioxidant enzyme activities and malondialdehyde levels related to aging. Clin. Chim. Acta, 305: 75-80.
56. Itahana, K., Y. Zou, Y. ltahana, J.L. Martinez and C. Beausejour et al., 2003. Control of the replicative life span of human fibroblasts by p16 and the polycomb protein Bmi-1. Mol. Cell Biol., 23: 389-401.
57. Iwasa, H., J. Han and F. Ishikawa, 2003. Mitogen-activated protein kinase p38 defines the common senescence-signalling pathway. Genes Cells, 8: 131-144.
58. Izzo, A.A. and E. Ernst, 2009. Interactions between herbal medicines and prescribed drugs: An updated systematic review. Drugs, 69: 1777-1798.
59. Kagan, V., E. Witt, R. Goldman, G. Scita and L. Packer, 1992. Ultraviolet light-induced generation of vitamin E radicals and their recycling. A possible photosensitizing effect of vitamin E in skin. Free Radic. Res. Commun., 16: 51-64.
60. Kajbaf, F., M. Mojtahedzadeh and M. Abdollahi, 2007. Mechanisms underlying stress-induced hyperglycemia in critically ill patients. Therapy, 4: 97-106.
61. Kang, T.H., H.M. Park, Y.B. Kim, H. Kim and N. Kim et al., 2009. Effects of red ginseng extract on UVB irradiation-induced skin aging in hairless mice. J. Ethnopharmacol., 123: 446-451.
62. Karami-Mohajeri, S. and M. Abdollahi, 2010. Toxic influence of organophosphate, carbamate and organochlorine pesticides on cellular metabolism of lipids, proteins and carbohydrates: A systematic review. Hum. Exp. Toxicol., 30: 1119-1140.
63. Khan, S.G., S.K. Katiyar, R. Agarwal and H. Mukhata, 1992. Enhancement of antioxidant and phase II enzymes by oral feeding of green tea polyphenols in drinking water to SKH-1 hairless mice: Possible role in cancer prevention. Cancer Res., 52: 4050-4052.
64. Kim, S.Y., S.J. Kim, J.Y. Lee, W.G. Kim, W.S. Park, Y.C. Sim and S.J. Lee, 2004. Protective effects of dietary soy isoflavones against UV-induced skin-aging in hairless mouse model. J. Am. Coli. Nutr., 23: 157-162.
65. Kimura, M., K. Umegaki, Y. Kasuya, A. Sugisawa and M. Higuchi, 2002. The relation between single/double or repeated tea catechin ingestions and plasma antioxidant activity in humans. Eur. J. Clin. Nutr., 56: 1186-1193.
66. Kregel, K.C. and H.J. Zhang, 2007. An integrated view of oxidative stress in aging: Basic mechanisms, functional effects and pathological considerations. AJP, 292: R18-R36.
67. Larijani, B., M. Salimi, N. Pourkhalili, A. Mohammadirad, M. Baeeri, A. Nili-Ahmadabadi and M. Abdollahi, 2011. Positive response of isolated rat pancreatic islets to LMOD; hopes for better transplant outcome and graft function. Asian J. Anim. Vet. Adv., 6: 1019-1025.
68. Lee, A. C., B.E. Fenster, H. Ito, K. Takeda and N.S. Bae, 1999. Ras proteins induce senescence by altering the intracellular levels of reactive oxygen species. J. Biol. Chern., 274: 7936-7940.
69. Lee, S., J.M. Lim, M.H. Jin, H.K. Park and E.J. Lee et al., 2006. Partially purified paeoniflorin exerts protective effects on UV-induced DNA damage and reduces facial wrinkles in human skin. J. Cosmet. Sci., 57: 57-64.
70. Lin, S.J., P.A. Defossez and L. Guarente, 2000. Requirement of NAD and SIR2 for Life-span extension by calorie restriction in Saccharomyces cerevisiae. Science, 289: 2126-2128.
71. Lopez-Lazaro, M., 2007. Dual role of hydrogen peroxide in cancer: possible relevance to cancer chemoprevention and therapy. Cancer Lett., 252: 1-8.
72. Lu, T. and T. Finkel, 2008. Free radicals and senescence. Exp. Cell Res., 314: 1918-1922.
73. Lundberg, A.S., W.C. Hahn, P. Gupta and R.A. Weinberg, 2000. Genes involved in senescence and immortalization. Curr. Opin. Cell Biol., 12: 705-709.
74. Malekirad, A.A., N. Hosseini, M. Bayrami, T. Hashemi, K. Rahzani and M. Abdollahi, 2011. Benefit of lemon verbena in healthy subjects, targeting diseases associated with oxidative stress. Asian J. Anim. Vet. Adv., 6: 953-957.
75. Manach, C., A. Scalbert, C. Morand, C. Remesy and L. Jimenez, 2004. Polyphenols: Food sources and bioavailability. Am. J. Clin. Nutr., 79: 727-747.
76. Masoro, E.J., 1995. Aging: Current Concepts. In: Handbook of Physiology, Section 11: Aging, Masoro, E.J. (Ed.). Oxford University Press, New York, pp: 1-21.
77. Mayer, P., 1993. The effect of vitamin Eon the skin. Cosmet. Toiletries., 108: 99-109.
78. McCall, M.R. and B. Frei, 1999. Can antioxidant vitamins materially reduce oxidative damage in humans? Free Radic. Biol. Med., 26: 1034-1053.
79. McConnell, B.B., M. Starborg, S. Brookes and G. Peters, 1998. Inhibitors of cyclin-dependent kinases induce features of replicative senescence in early passage human diploid fibroblasts. Curr. Biol., 8: 351-354.
80. Meydani, M., 1992. Protective role of dietary vitamin Eon oxidative stress in aging. Age, 15: 89-93.
81. Migliaccio, E., M. Giorgio, S. Mele, G. Pelicci and P. Reboldi et al., 1999. The p66shc adaptor protein controls oxidative stress response and life span in mammals. Nature, 402: 309-313.
82. Mirshafiey, A. and M. Mohsenzadegan, 2008. The role of reactive oxygen species in immunopathogenesis of rheumatoid arthritis. Iran J. Allergy Asthma lmmunol., 7: 195-202.
83. Mohammadi, M., S. Atashpour, N. Pourkhalili, A. Nili-Ahmadabadi and M. Baeeri et al., 2011. Comparative improvement in function of isolated rat langerhans islets by various phosphodiesterase 3, 4 and 5 inhibitors. Asian J. Anim. Vet. Adv., 6: 1233-1240.
84. Mohammadirad, A. and M. Abdollahi, 2011. A systematic review on oxidant/antioxidant imbalance in aluminum toxicity. Int. J. Pharmacal., 7: 12-21.
85. Mohammadirad, A., H.R. Khorram-Khorshid, F. Gharibdoost and M. Abdollahi, 2011. Setarud (!MOD™) as a multiherbal drug with promising benefits in animal and human studies: A comprehensive review of biochemical and cellular evidences. Asian J. Anim. Vet. Adv., 6: 1185-1192.
86. Mohseni-Salehi-Monfared, S.S., B. Larijani and M. Abdollahi, 2009. Islet transplantation and antioxidant management: A systematic review. World J. Gastroenterol., 15: 1153-1161.
87. Momtaz, S. and M. Abdollahi, 2010. An update on pharmacology of Satureja species: From antioxidant, antimicrobial, antidiabetes and anti -hyperlipidemic to reproductive stimulation. Int. J. Pharmacal., 6: 346-353.
88. Mousavi, S., M. Mojtahedzadeh and M. Abdollahi, 2010. Place of iron chelators like desferrioxamine and deferasirox in management of hyperoxia-induced lung injury: A systematic review. Int. J. Pharmacal., 6: 326-337.
89. Nachbar, F. and H.C. Korting, 1995. The role of vitamin E in normal and damaged skin. J. Mol. Med. (Berl), 73: 7-17.
90. Najafi, A., M. Mojtahedzadeh, A. Mahmoodpoor, M. Aghamohammadi and A. Ahmadi et al., 2009. Effect of N-acetylcysteine on microalbuminuria in patients with acute respiratory distress syndrome. Arch. Med. Sci., 5: 408-414.
91. Nunomura, A., R.J. Castellani, X. Zhu, P.I. Moreira, G. Perry and M.A. Smith, 2006. Involvement of oxidative stress in Alzheimer disease J. Neuropathol. Exp. Neural., 65: 631-641.
92. Ohta, H., K. Matsumoto, M. Shimizu and H. Watanabe, 1994. Paeoniflorin attenuates learning impairment of aged rats in operant brightness discrimination task. Pharmacal. Biochem. Behav., 49: 213-217.
93. Oken, B.S., D.M. Storzbach and J.A. Kaye, 1998. The efficacy of ginkgo biloba on cognitive function in alzheimer disease. Arch. Neural., 55: 1409-1415.
94. Olshansky, S.J., L. Hayflick and B.A. Carnes, 2002. Position statement on human aging. J. Gerontal. A Biol. Sci. Med. Sci., 57: B292-B297.
95. Ongusaha, P.P., T. Ouchi, K.T. Kim, E. Nytko and J.C. Kwak et al., 2003. BRCA1 shifts p53- mediated cellular outcomes towards irreversible growth arrest. Oncogene, 22: 3749-3758.
96. Pantoja, C. and M. Serrano, 1999. Murine fibroblasts lacking p21 undergo senescence and are resistant to transformation by oncogenic Ras. Oncogene, 18: 4974-4982.
97. Parrinello, S., E. Samper, A. Krtolica, J. Goldstein, S. Melov and J. Campisi, 2003. Oxygen sensitivity severely limits the replicative lifespan of murine fibroblasts. Nat. Cell. Biol., 5: 741-747.
98. Peng, C., H.Y. Chan, Y. Huang, H. Yu and Z.Y. Chen, 2011. Apple polyphenols extend the mean lifespan of Drosophila melanogaster. J. Agric. Food Chern., 59: 2097-2106.
99. Perry, E.K., A.T. Pickering, W.W. Wang, P.J. Houghton and N.S. Perry, 1999. Medical plants and Alzheimers disease: From ethnobotany to phytotherapy. J. Pharmacy Pharmacal., 51: 527-534.
100. Prior, R.L. and G. Cao, 1999. In vivo total antioxidant capacity: Comparison of different analytical methods. Free Radic Biol. Med., 27: 1173-1181.
101. Pryor, W.A., W. Stahl and C.L. Rock, 2000. Beta carotene: From biochemistry to clinical trials. Nutr. Rev., 58: 39-53.
102. Radfar, M., B. Larijani, M. Hadjibabaie, B. Rajabipour, A. Mojtahedi and M. Abdollahi, 2005. Effects ofpentoxifylline on oxidative stress and levels of EGF and NO in blood of diabetic type-2 patients: A randomized, double-blind placebo-controlled clinical trial. Biomed. Pharmacother., 59: 302-306.
103. Rahimi, R., S. Nikfar, B. Larijani and M. Abdollahi, 2005. A review on the role of antioxidants in the management of diabetes and its complications. Biomed. Pharmacother., 59: 365-373.
104. Rahimi, R., S. Mozaffari and M. Abdollahi, 2009. On the use of herbal medicines in management of inflammatory bowel diseases: A systematic review of animal and human studies. Dig. Dis. Sci., 54: 471-480.
105. Rahimi, R., S. Ghiasi, H. Azimi, S. Fakhari and M. Abdollahi, 2010. A review of the herbal phosphodiesterase inhibitors: Future perspective of new drugs. Cytokine, 49: 123-129.
106. Rastegarpanah, M., N. Omidzohour, H. Vahedi, R. Malekzadeh, F. Hashemian, T. Safarnavadeh and M. Abdollahi, 2011. Management of human ulcerative colitis by Saturex™: A randomized controlled trial. Int. J. Pharmacal., 7: 516-521.
107. Rezaie, A., R.D. Parker and M. Abdollahi, 2007. Oxidative stress and pathogenesis of inflammatory bowel disease: An epiphenomenon or the cause. Dig. Dis. Sci., 52: 2015-2021.
108. Rivers, J.K., 2008. The role of cosmeceuticals in antiaging therapy. Skin Therapy Lett., 13: 5-9.
109. Roob, J.M., G. Khoshsorur, A. Tiran, J.H. Horina, H. Holzer and B.M. Winklhoffer-Roob, 2000. Vitamin E attenuates oxidative stress induced by intravenous iron in patients on hemodialysis. J. Am. Soc. Nephrol., 11: 539-549.
110. Rastegarpanah, M., N. Omidzohour, H. Vahedi, R. Malekzadeh, F. Hashemian, T. Safarnavadeh and M. Abdollahi, 2011. Management of human ulcerative colitis by SaturexTM: A randomized controlled trial. Int. J. Pharmacal., 7: 516-521.
111. Sangeetha, P., M. Balu, D. Haripriya and C. Panneerselvam, 2005. Age associated changes in erythrocyte membrane surface charge: Modulatory role of grape seed proanthocyanidins. Exp. Gerontol., 40: 820-828.
112. Schmitt-Schillig, S., S. Schaffer, C.C. Weber, G.P. Eckert and G.P. Muller, 2005. Flavonoids and the aging brain. J. Physiol. Pharmacal., 56: 23-36.
113. Serra, V., T. von Zglinicki, M. Lorenz and G. Saretzki, 2003. Extracellular superoxide dismutase is a major antioxidant in human fibroblasts and slows telomere shortening. J. Biol. Chern., 278: 6824-6830.
114. Serrano, M., A.W. Lin, M.E. McCurrach, D. Beach and S.W. Lowe, 1997. Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p161NK4a. Cell, 88: 593-602.
115. Shadnia, S., E. Azizi, R. Hosseini, S. Khoei and S. Fouladdel et al., 2005. Evaluation of oxidative stress and genotoxicity in organophosphorus insecticide formulators. Hum. Exp. Toxicol., 24: 439-445.
116. Shadnia, S., S. Ashrafivand, S. Mostafalou and M. Abdollahi, 2011. N-acetylcysteine a novel treatment for acute human organophosphate poisoning. Int. J. Pharmacal., 7: 732-735.
117. Shay, J.W. and B. Roninson, 2004. Hallmarks of senescence in carcinogenesis and cancer therapy. Oncogene, 23: 2919-2933.
118. Shukitt-Hale, B., V. Cheng and J.A. Joseph, 2009. Effects of blackberries on motor and cognitive function in aged rats. Nutr. Neurosci., 12: 135-140.
119. Sies, H., 1985. Oxidative Stress: Introductory Remarks. In: Oxidative Stress, Sies, H. (Ed.), Academic Press, San Diego, New York, London, pp: 1-8.
120. Smith, J.V. and Y. Luo, 2004. Studies on molecular mechanisms of Ginkgo biloba extract. Applied Microbial. Biotechnol., 64: 465-472.
121. Sohal, R.S. and W.C. Orr, 1992. Relationship between antioxidants, prooxidants and the aging procen. Ann. N.Y. Acad. Sci., 663: 71-84.
122. Soltaninejad, K. and M. Abdollahi, 2009. Current opinion on the science of organophosphate pesticides and toxic stress: A systematic review. Med. Sci. Manit., 15: RA75-90.
123. Takahashi, A., N. Ohtani, K. Yamakoshi, S. Iida and H. Tahara et al., 2006. Mitogenic signalling and the p16INK4a-Rb pathway cooperate to enforce irreversible cellular senescence. Nat. Cell Biol., 8: 1291-1297.
124. Terman, A. and U. Brunk, 2006. Oxidative stress, accumulation of biological Garbage and aging. Antioxid. Redox Signal., 8: 197-204.
125. Unno, K., F. Takabayashi, T. Kishido and N. Oku, 2004. Suppressive effect of green tea catechins on morphologic and functional regression of the brain in aged mice with accelerated senescence (SAMP10). Exp. Gerontal., 39: 1027-1034.
126. Veskoukis, A.S., A.M. Tsatsakis and D. Kouretas, 2012. Dietary oxidative stress and antioxidant defense with an emphasis on plant extract administration. Cell Stress Chaperon, 17: 11-21.
127. Vijg, J., 2000. Somatic mutations and aging: A re-evaluation. Mutat. Res., 44 7: 117-135.
128. Von Zglinicki, T., 2002. Oxidative stress shortens telomeres. Trends Biochem. Sci., 27: 339-344.
129. Werninghaus, K., R.M. Handjani and B.A. Gilchrest, 1991. Protective effect of alpha-tocopherol in carrier liposomes on ultraviolet-mediated human epidermal cell damage in vitro. Photodermatol Photoimmunol Photomed. 8: 236-242.
130. Wick, G., 2002. Anti-aging medicine: Does it exist? A critical discussion of anti-aging health products. Exp. Gerontal., 37: 1137-1140.
131. Wright, W.E. and J.W. Shay, 2001. Cellular senescence as a tumor-protection mechanism: The essential role of counting. Curr. Opin. Gen. Dev., 11: 98-103.
132. Wu, Z., J.V. Smith, V. Paravasivam, P. Buiko, I. Khan, J.R. Cypser and Y. Luo, 2002. Ginkgo biloba extract EGb 761 increases stress resistance and extends life span of Caenorhabditis elegans. Cell. Mol. Biol., 48: 725-731.
133. Xiang, L., K. Sun, J. Lu, Y. Weng, A. Taoka, Y. Sakagami and J. Qi, 2011. Anti-aging effects of phloridzin an apple polyphenol, on yeast via the SOD and Sir2 genes. Biosci Biotechnol Biochem., 75: 854-858.
134. Zaveri, N.T., 2006. Green tea and its polyphenolic catechins: Medicinal uses in cancer and noncancer applications. Life Sci., 78: 2073-2080.
135. Zdanov, S., F. Debacq-Chainiaux, J. Remade and O. Toussaint, 2006. Identification ofp38MAPKdependent genes with changed transcript abundance in H2O2- induced premature senescence of IMR-90 hTERT human fibroblasts. FEBS Lett., 580: 6455-6463.