Sodium nitroprusside enhanced cardiopulmonary resuscitation prevents post-resuscitation left ventricular dysfunction and improves 24-hour survival and neurological function in a porcine model of prolonged untreated ventricular fibrillation

Resuscitation

Volumn 82, Issue SUPPL. 2, 2011, Pages

  Schultz, Jason ^a,b   Segal, Nicolas ^a,b   Kolbeck, James ^a,b   Caldwell, Emily ^a,b   Thorsgard, Marit ^a,b   McKnite, Scott ^a,b   Aufderheide, Tom P ^c   Lurie, Keith G ^a,b   Yannopoulos, Demetris ^a,b  

^a UNIVERSITY OF MINNESOTA MEDICAL SCHOOL   (United States)

^b HENNEPIN COUNTY MEDICAL CENTER   (United States)

^c MEDICAL COLLEGE OF WISCONSIN   (United States)

Author keywords

Cardiopulmonary resuscitation; Left ventricular function; Neurological function; Survival; Vasodilation

Indexed keywords

ISOFLURANE; NITROPRUSSIDE SODIUM;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; HEART ARREST; HEART FIBRILLATION; HEART LEFT VENTRICLE EJECTION FRACTION; HEART LEFT VENTRICLE FAILURE; NEUROLOGIC EXAMINATION; NONHUMAN; PRIORITY JOURNAL; RESUSCITATION; SURVIVAL RATE; SWINE;

ANIMALS; CARDIOPULMONARY RESUSCITATION; DISEASE MODELS, ANIMAL; FEMALE; HEART ARREST; NERVOUS SYSTEM PHYSIOLOGICAL PHENOMENA; NITROPRUSSIDE; SWINE; TIME FACTORS; VASODILATOR AGENTS; VENTRICULAR DYSFUNCTION, LEFT; VENTRICULAR FIBRILLATION; VENTRICULAR FUNCTION, LEFT;

EID: 84855172046     PISSN: 03009572     EISSN: 18731570     Source Type: Journal    
DOI: 10.1016/S0300-9572(11)70149-6     Document Type: Article

References (36)

1. Nichol G, Aufderheide TP, Eigel B, et al. Regional systems of care for out-of-hospital cardiac arrest: A policy statement from the American Heart Association. Circulation 2010, 121:709-729.
2. Olasveengen TM, Sunde K, Brunborg C, Thowsen J, Steen PA, Wik LS Intravenous drug administration during out-of-hospital cardiac arrest: a randomized trial. JAMA 2009, 302:2222-2229.
3. Cummin RO From concept to standard-of-care? Review of the clinical experience with automated external defibrillators. Ann Emerg Med 1989, 18:1269-1275.
4. Janata A, Weihs W, Vet M, et al. Cold aortic flush and chest compressions enable good neurologic outcome after 15 min of ventricular fibrillation in cardiac arrest in pigs. Crit Care Med 2010, 38:1637-1643.
5. Högler S, Sterz F, Sipos W, et al. Distribution of neuropathological lesions in pig brains after different durations of cardiac arrest. Resuscitation 2010, 81:1577-1583.
6. Aufderheide TP, Frascone RJ, Wayne MA, et al. Standard cardiopulmonary resuscitation versus active compression-decompression cardiopulmonary resuscitation with augmentation of negative intrathoracic pressure for out-of-hospital cardiac arrest: a randomised trial. Lancet 2011, 377:301-311.
7. Wolcke BB, Mauer DK, Schoefmann MF, et al. Comparison of standard cardiopulmonary resuscitation versus the combination of active compression-decompression cardiopulmonary resuscitation and an inspiratory impedance threshold device for out-of-hospital cardiac arrest. Circulation 2003, 108:2201-2205.
8. Niemann JT, Rosborough JP, Ung S, Criley JM Hemodynamic effects of continuous abdominal binding during cardiac arrest and resuscitation. Am J Cardiol 1984, 53:269-274.
9. Zhou M, Ran Q, Liu Y, Li Y, Liu T, Shen H Effects of sustained abdominal aorta compression on coronary perfusion pressures and restoration of spontaneous circulation during cardiopulmonary resuscitation in swine. Resuscitation 2011.
10. Yannopoulos D, Matsuura T, Schultz J, Rudser K, Halperin HR, Lurie KG Sodium nitroprusside enhanced cardiopulmonary resuscitation improves survival with good neurological function in a porcine model of prolonged cardiac arrest. Crit Care Med 2011, 39:1269-1274.
11. Schultz J, Segal N, Caldwell E, et al. Sodium nitroprusside enhanced CPR improves resuscitation rates after prolonged untreated cardiac arrest in two porcine models. Crit Care Med 2011, in press.
12. Marino BS, Yannopoulos D, Sigurdsson G, et al. Spontaneous breathing through an inspiratory impedance threshold device augments cardiac index and stroke volume index in a pediatric porcine model of hemorrhagic hypovolemia. Crit Care Med 2004, 32:S398-S405.
13. Quinones MA, Waggoner AD, Reduto LA, et al. A new, simplified and accurate method for determining ejection fraction with two-dimensional echocardiography. Circulation 1981, 64:744-753.
14. Gonzalez MM, Berg RA, Nadkarni VM, et al. Left ventricular systolic function and outcome after in-hospital cardiac arrest. Circulation 2008, 117:1864-1872.
15. Kern K, Zuercher M, Cragun D, et al. Myocardial microcirculatory dysfunction after prolonged ventricular fibrillation and resuscitation. Crit Care Med 2008, 36:S418-S421.
16. Tang W, Weil MH, Sun S, Noc M, Yang L, Gazmuri RJ Epinephrine increases the severity of postresuscitation myocardial dysfunction. Circulation 1995, 92:3089-3093.
17. Kern K, Helwig R, Rhee K, Berg R Myocardial dysfunction after resuscitation after cardiac arrest: an example of global myocardial stunning. J Am Coll Card 1996, 28:232-240.
18. Idris H, Roberts L, Caruso L, et al. Oxidant injury occurs early after cardiac arrest, cardiopulmonary resuscitation, and reperfusion. Crit Care Med 2005, 33:2043-2048.
19. Xie J, Weil M, Sun S, et al. High-energy defibrillation increases the severity of postresuscitation myocardial dysfunction. Circulation 1997, 96:683-688.
20. Neumar RW, Nolan JP, Adrie C, et al. Post-cardiac arrest syndrome: epidemiology, pathophysiology, treatment, and prognostication. A consensus statement from the International Liaison Committee on Resuscitation (American Heart Association, Australian and New Zealand Council on Resuscitation, European Resuscitation Council, Heart and Stroke Foundation of Canada, InterAmerican Heart Foundation, Resuscitation Council of Asia, and the Resuscitation Council of Southern Africa); the American Heart Association Emergency Cardiovascular Care Committee; the Council on Cardiovascular Surgery and Anesthesia; the Council on Cardiopulmonary, Perioperative, and Critical Care; the Council on Clinical Cardiology; and the Stroke Council. Circulation 2008, 118:2452-2483.
21. Ferenc M, Neumann F Efficacy of primary PCI: the microvessel perspective. Eur Heart J 2005, 7(Suppl):14-19.
22. Halperin HR, Lee K, Zviman M, et al. Outcomes from low versus high-flow cardiopulmonary resuscitation in a swine model of cardiac arrest. Am J Emerg Med 2010, 28:195-202.
23. Lurie KG, Coffeen P, Shultz J, McKnite S, Detloff B, Mulligan K Improving active compression-decompression cardiopulmonary resuscitation with an inspiratory impedance valve. Circulation 1995, 91:1629-1632.
24. Aufderheide TP, Frascone RJ, Wayne MA, et al. Comparative effectiveness of an impedance threshold device and active compression decompression CPR versus standard CPR for treatment of out-of-hospital cardiac arrest. Lancet 2011, 377:301-311.
25. Voelckel WG, Lurie KG, Sweeney M, et al. Effects of active compression-decompression cardiopulmonary resuscitation with the inspiratory threshold valve in a young porcine model of cardiac arrest. Pediat Res 2002, 51:523-527.
26. Ali IS, Gandhi M, Finegan BA, Koshal A, Clanachan AS Cardioprotection by activation of NO/cGMP pathway after cardioplegic arrest and 8-hour storage. Ann Thorac Surg 1998, 65:1303-1309.
27. Tesic MB, Stankovic G, Vukcevic V, Ostojic MC The use of intracoronary sodium nitroprusside to treat no-reflow after primary percutaneous coronary intervention in acute myocardial infarction. Herz 2010, 35:114-118.
28. Paulus WJ, Vantrimpont PJ, Shah AM Acute effects of nitric oxide on left ventricular relaxation and diastolic distensibility in humans. Assessment by bicoronary sodium nitroprusside infusion. Circulation 1994, 89:2070-2078.
29. Nichol G, Stiell IG The impact of first-responder defibrillation. JAMA 1994, 271:504-505.
30. Stiell IG, Wells GA, Field B, et al. Advanced cardiac life support in out-of-hospital cardiac arrest. N Engl J Med 2004, 351:647-656.
31. Valenzuela TD, Roe DJ, Nichol G, Clark LL, Spaite DW, Hardman RG Outcomes of rapid defibrillation by security officers after cardiac arrest in casinos. N Engl J Med 2000, 343:1206-1209.
32. Group THaCAS Mild therapeutic hypothermia to improve neurologic outcome after cardiac arrest. N Engl J Med 2002, 346:549-556.
33. Bernard SA, Gray TW, Buist MD, et al. Treatment of comatose survivors of out-of-hospital cardiac arrest with induced hypothermia. N Engl J Med 2002, 346:557-563.
34. Salom J, Orti M, Centeno J, Torregrosa G, Alborch E Reduction of infract size by the NO donors sodium nitroprusside and permine/NO after transient focal cerebral ischemia in rats. Brain Res 2000, 865:149-156.
35. Shaffner DH, Eleff SM, Brambrink AM, et al. Effect of arrest time and cerebral perfusion pressure during cardiopulmonary resuscitation on cerebral blood flow, metabolism, adenosine triphosphate recovery, and pH in dogs. Crit Care Med 1999, 27:1335-1342.
36. Schultz J, Kolbeck J, Segal N, McKnite S, Caldwell E, Yannopoulos D Sodium nitroprusside enhanced cardiopulmonary resuscitation (SNPeCPR) improves vital organ perfusion pressures and carotid blood flow in a porcine model of cardiac arrest. Resuscitation 2011, accepted manuscript.