Fatty acyl-gramicidin S derivatives with both high antibiotic activity and low hemolytic activity

Bioorganic and Medicinal Chemistry Letters

Volumn 22, Issue 1, 2012, Pages 106-109

  Tamaki, Makoto ^a   Fujinuma, Kenta ^a   Harada, Takuji ^a   Takanashi, Kazumasa ^a   Shindo, Mitsuno ^b   Kimura, Masahiro ^b   Uchida, Yoshiki ^b  

^a TOHO UNIVERSITY   (Japan)

^b OSAKA SHOIN WOMEN'S UNIVERSITY   (Japan)

Author keywords

Fatty acyl gramicidin S analogue; High antibiotic activity; Low hemolytic activity; Structure activity relationship

Indexed keywords

FATTY ACYL GRAMICIDIN S DERIVATIVE; GRAMICIDIN S; UNCLASSIFIED DRUG;

ANTIMICROBIAL ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG SYNTHESIS; GRAM NEGATIVE BACTERIUM; GRAM POSITIVE BACTERIUM; HEMOLYSIS; MICROBIAL SENSITIVITY TEST; NONHUMAN; STRUCTURE ACTIVITY RELATION;

ANIMALS; ANTI-BACTERIAL AGENTS; BLOOD CELLS; CHEMISTRY, PHARMACEUTICAL; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DESIGN; GRAM-NEGATIVE BACTERIA; GRAM-POSITIVE BACTERIA; GRAMICIDIN; HEMOLYSIS; LYSINE; MICROBIAL SENSITIVITY TESTS; MODELS, CHEMICAL; SHEEP; STRUCTURE-ACTIVITY RELATIONSHIP;

NEGIBACTERIA; POSIBACTERIA;

EID: 84655169699     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2011.11.062     Document Type: Article

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