Identification of oxazolidinediones and thiazolidinediones as potent 17β-hydroxysteroid dehydrogenase type 3 inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 22, Issue 1, 2012, Pages 504-507

  Harada, Koichiro ^a   Kubo, Hideki ^a   Tanaka, Akio ^a   Nishioka, Kazuhiko ^a  

^a SUMITOMO CHEMICAL CO LTD   (Japan)

Author keywords

17 Hydroxysteroid dehydrogenase type 3 inhibitors; Oxazolidinedione; Prostate cancer; Thiazolidinedione

Indexed keywords

17BETA HYDROXYSTEROID DEHYDROGENASE TYPE 3; 2,4 THIAZOLIDINEDIONE DERIVATIVE; 5 (3 BROMO 4 HYDROXYBENZYL) 3 (4 METHOXYPHENYL) 1,3 THIAZOL 2 ONE; 5 (3 BROMO 4 HYDROXYBENZYLIDENE) 3 (4 METHOXYPHENYL) 2 THIOXO 1,3 THIAZOLIDIN 4 ONE; ANDROGEN RECEPTOR; ANTINEOPLASTIC AGENT; ENZYME INHIBITOR; ESTROGEN RECEPTOR ALPHA; GLUCOCORTICOID RECEPTOR; ISOENZYME; OXAZOLIDINEDIONE DERIVATIVE; RHODAMINE; TESTOSTERONE 17BETA DEHYDROGENASE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; BIOLOGICAL ACTIVITY; ENZYME INHIBITION; HIGH THROUGHPUT SCREENING; HUMAN; HUMAN CELL; IN VITRO STUDY; PROSTATE CANCER; STRUCTURE ACTIVITY RELATION;

17-HYDROXYSTEROID DEHYDROGENASES; CARBON; CELL NUCLEUS; CHEMISTRY, PHARMACEUTICAL; DRUG DESIGN; ENZYME INHIBITORS; GENES, REPORTER; HELA CELLS; HUMANS; INHIBITORY CONCENTRATION 50; ISOENZYMES; MALE; MODELS, CHEMICAL; MODELS, MOLECULAR; MOLECULAR CONFORMATION; OXAZOLES; PROSTATE; PROSTATIC NEOPLASMS; THIAZOLIDINEDIONES;

EID: 84655165018     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2011.10.095     Document Type: Article

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