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Volumn 22, Issue 1, 2012, Pages 300-304

3-Heterocyclyl quinolone inhibitors of the HCV NS5B polymerase

Author keywords

3 Heterocyclyl quinolone analogs; HCV; NNI 2 binders; NS5B polymerase inhibitors

Indexed keywords

1,2,4 OXADIAZOLE DERIVATIVE; ANTIVIRUS AGENT; NONSTRUCTURAL PROTEIN 5B; QUINOLONE DERIVATIVE;

EID: 84655164833     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2011.11.013     Document Type: Article
Times cited : (20)

References (12)
  • 6
    • 84655176017 scopus 로고    scopus 로고
    • While protein binding and solubility of the lead ester series was not evaluated, the improvement in replicon potency with the addition of polar moieties at the C7 position is attributed to reduced protein binding properties.
    • While protein binding and solubility of the lead ester series was not evaluated, the improvement in replicon potency with the addition of polar moieties at the C7 position is attributed to reduced protein binding properties.
  • 10
    • 84655177720 scopus 로고    scopus 로고
    • Kumar, D. V.; Rai, R.; Young, W. B.; Hu, H, Riggs, J. R.; Ton, T. L.; Green, M. J.; Hart, B. P.; Brameld, K. A.; Dener, J. M. US 2007/0287699 and WO 2007/130499
    • Kumar, D. V.; Rai, R.; Young, W. B.; Hu, H, Riggs, J. R.; Ton, T. L.; Green, M. J.; Hart, B. P.; Brameld, K. A.; Dener, J. M. US 2007/0287699 and WO 2007/130499.
  • 11
    • 84655166048 scopus 로고    scopus 로고
    • In general, the 7-position piperazine substituted compounds had low stability in human liver microsomes with 20-50% remaining after a 1 h incubation.
    • In general, the 7-position piperazine substituted compounds had low stability in human liver microsomes with 20-50% remaining after a 1 h incubation.
  • 12
    • 0026771973 scopus 로고
    • Regiochemistry assignment of the substituted tetrazole which was the major reaction product is based on
    • Regiochemistry assignment of the substituted tetrazole which was the major reaction product is based on J.S. Sawyer, R.F. Baldwin, L.E. Rinkema, C.R. Roman, and J.H. Fleisch J. Med. Chem. 35 1992 1200
    • (1992) J. Med. Chem. , vol.35 , pp. 1200
    • Sawyer, J.S.1    Baldwin, R.F.2    Rinkema, L.E.3    Roman, C.R.4    Fleisch, J.H.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.