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Bioorganic and Medicinal Chemistry Letters

Volumn 22, Issue 1, 2012, Pages 591-596

Design and combinatorial synthesis of a novel kinase-focused library using click chemistry-based fragment assembly

(3) Irie, Takayuki a Fujii, Ikuo b Sawa, Masaaki a

a 1 5 5 Minatojima Minamimachi (Japan)

b Osaka Prefecture University (Japan)

Author keywords

Click chemistry; Fragment evolution; Kinase inhibitors; Kinase privileged fragment; Triazoles

Indexed keywords

ALKYNE; AZIDE; CD135 ANTIGEN; GLYCOGEN SYNTHASE KINASE 3BETA; KINASE FOCUSED EVOLVED FRAGMENT LIBRARY; PROTEIN KINASE; PROTEIN KINASE INHIBITOR; STAUROSPORINE; TRIAZOLE; TRIAZOLE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL STRUCTURE; CLICK CHEMISTRY; COMBINATORIAL CHEMISTRY; CONTROLLED STUDY; CYCLOADDITION; DRUG DESIGN; DRUG POTENCY; DRUG SCREENING; ENZYME ACTIVITY; FRAGMENTATION REACTION; HUMAN; HUMAN CELL; IC 50; ONE POT SYNTHESIS; PEPTIDE LIBRARY; PROTEIN ASSEMBLY;

ADENOSINE TRIPHOSPHATE; CHEMISTRY, PHARMACEUTICAL; CLICK CHEMISTRY; COMBINATORIAL CHEMISTRY TECHNIQUES; DRUG DESIGN; DRUG EVALUATION, PRECLINICAL; ENZYME INHIBITORS; FMS-LIKE TYROSINE KINASE 3; GENE EXPRESSION PROFILING; GLYCOGEN SYNTHASE KINASE 3; HUMANS; INHIBITORY CONCENTRATION 50; MODELS, CHEMICAL; MODELS, MOLECULAR; MOLECULAR CONFORMATION; TRIAZOLES;

EID: 84655163505 PISSN: 0960894X EISSN: 14643405 Source Type: Journal
DOI: 10.1016/j.bmcl.2011.10.076 Document Type: Article

Times cited : (17)

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