-
2
-
-
2342471392
-
Activating Mutations in the Epidermal Growth Factor Receptor Underlying Responsiveness of Non-Small-Cell Lung Cancer to Gefitinib
-
DOI 10.1056/NEJMoa040938
-
Lynch TJ, Bell DW, Sordella R, et al. Activating mutations in the epidermal growth factor receptor underlying responsiveness of nonsmall- cell lung cancer to gefitinib. N Engl J Med 2004;350:2129-2139. (Pubitemid 38637993)
-
(2004)
New England Journal of Medicine
, vol.350
, Issue.21
, pp. 2129-2139
-
-
Lynch, T.J.1
Bell, D.W.2
Sordella, R.3
Gurubhagavatula, S.4
Okimoto, R.A.5
Brannigan, B.W.6
Harris, P.L.7
Haserlat, S.M.8
Supko, J.G.9
Haluska, F.G.10
Louis, D.N.11
Christiani, D.C.12
Settleman, J.13
Haber, D.A.14
-
3
-
-
2342624080
-
EGFR mutations in lung, cancer: Correlation with clinical response to gefitinib therapy
-
DOI 10.1126/science.1099314
-
Paez JG, Janne PA, Lee JC, et al. EGFR mutations in lung cancer: correlation with clinical response to gefitinib therapy. Science 2004;304: 1497-1500. (Pubitemid 38720929)
-
(2004)
Science
, vol.304
, Issue.5676
, pp. 1497-1500
-
-
Paez, J.G.1
Janne, P.A.2
Lee, J.C.3
Tracy, S.4
Greulich, H.5
Gabriel, S.6
Herman, P.7
Kaye, F.J.8
Lindeman, N.9
Boggon, T.J.10
Naoki, K.11
Sasaki, H.12
Fujii, Y.13
Eck, M.J.14
Sellers, W.R.15
Johnson, B.E.16
Meyerson, M.17
-
4
-
-
4444344330
-
EGF receptor gene mutations are common in lung cancers from "never smokers" and are associated with sensitivity of tumors to gefitinib and erlotinib
-
DOI 10.1073/pnas.0405220101
-
Pao W, Miller V, Zakowski M, et al. EGF receptor gene mutations are common in lung cancers from "neversmokers" and are associated with sensitivity of tumors to gefitinib and erlotinib. Proc Natl Acad Sci U S A 2004;101:13306-13311. (Pubitemid 39209661)
-
(2004)
Proceedings of the National Academy of Sciences of the United States of America
, vol.101
, Issue.36
, pp. 13306-13311
-
-
Pao, W.1
Miller, V.2
Zakowski, M.3
Doherty, J.4
Politi, K.5
Sarkaria, I.6
Singh, B.7
Heelan, R.8
Rusch, V.9
Fulton, L.10
Mardis, E.11
Kupfer, D.12
Wilson, R.13
Kris, M.14
Varmus, H.15
-
5
-
-
33846202907
-
Molecular mechanisms of epidermal growth factor receptor (EGFR) activation and response to gefitinib and other EGFR-targeting drugs
-
DOI 10.1158/1078-0432.CCR-06-0646
-
Ono M, Kuwano M. Molecular mechanisms of epidermal growth factor receptor activation and response to gefitinib and other EGFR-targeting drugs. Clin Cancer Res 2006;12:7242-7251. (Pubitemid 46095395)
-
(2006)
Clinical Cancer Research
, vol.12
, Issue.24
, pp. 7242-7251
-
-
Ono, M.1
Kuwano, M.2
-
6
-
-
77953930730
-
Gefitinib or chemotherapy for non-small-cell lung cancer with mutated EGFR
-
Maemondo M, Inoue A, Kobayashi K, et al. Gefitinib or chemotherapy for non-small-cell lung cancer with mutated EGFR. N Engl J Med 2010;362:2380-2388.
-
(2010)
N. Engl. J. Med.
, vol.362
, pp. 2380-2388
-
-
Maemondo, M.1
Inoue, A.2
Kobayashi, K.3
-
7
-
-
75249087060
-
Gefitinib versus cisplatin plus docetaxel in patients with non-small-cell lung cancer harbouring mutations of the epidermal growth factor receptor WJTOG3405: An open label randomized phase 3 trial
-
Mitsudomi T, Morita S, Yatabe Y, et al. Gefitinib versus cisplatin plus docetaxel in patients with non-small-cell lung cancer harbouring mutations of the epidermal growth factor receptor (WJTOG3405): an open label, randomized phase 3 trial. Lancet Oncol 2010;11:121-128.
-
(2010)
Lancet Oncol.
, vol.11
, pp. 121-128
-
-
Mitsudomi, T.1
Morita, S.2
Yatabe, Y.3
-
8
-
-
69949162760
-
Gefitinib or carboplatinpaclitaxel in pulmonary adenocarcinoma
-
Mok TS, Wu YL, Thongprasert S, et al. Gefitinib or carboplatinpaclitaxel in pulmonary adenocarcinoma. N Engl J Med 2009;361:947-957.
-
(2009)
N. Engl. J. Med.
, vol.361
, pp. 947-957
-
-
Mok, T.S.1
Wu, Y.L.2
Thongprasert, S.3
-
9
-
-
33746789922
-
Prospective phase II study of gefitinib for chemotherapy-naïve patients with advanced non-small-cell lung cancer with epidermal growth factor receptor gene mutations
-
DOI 10.1200/JCO.2005.05.4692
-
Inoue A, Suzuki T, Fukuhara T, et al. Prospective phase II study of gefitinib for chemotherapy-naive patients with advanced non-small-cell lung cancer with epidermal growth factor receptor gene mutations. J Clin Oncol 2006;24:3340-3346. (Pubitemid 46638887)
-
(2006)
Journal of Clinical Oncology
, vol.24
, Issue.21
, pp. 3340-3346
-
-
Inoue, A.1
Suzuki, T.2
Fukuhara, T.3
Maemondo, M.4
Kimura, Y.5
Morikawa, N.6
Watanabe, H.7
Saijo, Y.8
Nukiwa, T.9
-
10
-
-
33750205340
-
A phase II trial of gefitinib as first-line therapy for advanced non-small cell lung cancer with epidermal growth factor receptor mutations
-
DOI 10.1038/sj.bjc.6603393, PII 6603393
-
Asahina H, Yamazaki K, Kinoshita I, et al. A phase II trial of gefitinib as first-line therapy for advanced non-small cell lung cancer with epidermal growth factor receptor mutations. Br J Cancer 2006;95:998-1004. (Pubitemid 44606825)
-
(2006)
British Journal of Cancer
, vol.95
, Issue.8
, pp. 998-1004
-
-
Asahina, H.1
Yamazaki, K.2
Kinoshita, I.3
Sukoh, N.4
Harada, M.5
Yokouchi, H.6
Ishida, T.7
Ogura, S.8
Kojima, T.9
Okamoto, Y.10
Fujita, Y.11
Dosaka-Akita, H.12
Isobe, H.13
Nishimura, M.14
-
11
-
-
33845262077
-
Gefitinib for non-small-cell lung cancer patients with epidermal growth factor receptor gene mutations screened by peptide nucleic acid-locked nucleic acid PCR clamp
-
DOI 10.1038/sj.bjc.6603466, PII 6603466
-
Sutani A, Nagai Y, Udagawa K, et al. Gefitinib for non-small-cell lung cancer patients with epidermal growth factor receptor gene mutations screened by peptide nucleic acid-locked nucleic acid PCR clamp. Br J Cancer 2006;95:1483-1489. (Pubitemid 44863350)
-
(2006)
British Journal of Cancer
, vol.95
, Issue.11
, pp. 1483-1489
-
-
Sutani, A.1
Nagai, Y.2
Udagawa, K.3
Uchida, Y.4
Koyama, N.5
Murayama, Y.6
Tanaka, T.7
Miyazawa, H.8
Nagata, M.9
Kanazawa, M.10
Hagiwara, K.11
Kobayashi, K.12
-
12
-
-
34249752278
-
Prospective validation for prediction of gefitinib sensitivity by epidermal growth factor receptor gene mutation in patients with non-small cell lung cancer
-
PII 0124389420070100000006
-
Yoshida K, Yatabe Y, Park JY, et al. Prospective validation for prediction of gefitinib sensitivity by epidermal growth factor receptor gene mutation in patients with non-small cell lung cancer. J Thorac Oncol 2007;2:22-28. (Pubitemid 47163924)
-
(2007)
Journal of Thoracic Oncology
, vol.2
, Issue.1
, pp. 22-28
-
-
Yoshida, K.1
Yatabe, Y.2
Park, J.Y.3
Shimizu, J.4
Horio, Y.5
Matsuo, K.6
Kosaka, T.7
Mitsudomi, T.8
Hida, T.9
-
13
-
-
34247619676
-
Phase II prospective study of the efficacy of gefitinib for the treatment of stage III/IV non-small cell lung cancer with EGFR mutations, irrespective of previous chemotherapy
-
DOI 10.1016/j.lungcan.2007.01.025, PII S0169500207000785
-
Sunaga N, Tomizawa Y, Yanagitani N, et al. Phase II prospective study of the efficacy of gefitinib for the treatment of stage III/IV non-small cell lung cancer with EGFR mutations, irrespective of previous chemotherapy. Lung Cancer 2007;56:383-389. (Pubitemid 46679091)
-
(2007)
Lung Cancer
, vol.56
, Issue.3
, pp. 383-389
-
-
Sunaga, N.1
Tomizawa, Y.2
Yanagitani, N.3
Iijima, H.4
Kaira, K.5
Shimizu, K.6
Tanaka, S.7
Suga, T.8
Hisada, T.9
Ishizuka, T.10
Saito, R.11
Dobashi, K.12
Mori, M.13
-
14
-
-
40349111048
-
Multicentre prospective phase II trial of gefitinib for advanced non-small cell lung cancer with epidermal growth factor receptor mutations: Results of the West Japan Thoracic Oncology Group trial (WJTOG0403)
-
DOI 10.1038/sj.bjc.6604249, PII 6604249
-
Tamura K, Okamoto I, Kashii T, et al. Multicentre prospective phase II trial of gefitinib for advanced non-small cell lung cancer with epidermal growth factor receptor mutations: results of the West Japan Thoracic Oncology Group trial (WJTOG0403). Br J Cancer 2008;98:907-914. (Pubitemid 351341609)
-
(2008)
British Journal of Cancer
, vol.98
, Issue.5
, pp. 907-914
-
-
Tamura, K.1
Okamoto, I.2
Kashii, T.3
Negoro, S.4
Hirashima, T.5
Kudoh, S.6
Ichinose, Y.7
Ebi, N.8
Shibata, K.9
Nishimura, T.10
Katakami, N.11
Sawa, T.12
Shimizu, E.13
Fukuoka, J.14
Satoh, T.15
Fukuoka, M.16
-
15
-
-
67349144683
-
Prospective phase II study of gefitinib in non-small cell lung cancer with epidermal growth factor receptor gene mutations
-
Sugio K, Uramoto H, Onitsuka T, et al. Prospective phase II study of gefitinib in non-small cell lung cancer with epidermal growth factor receptor gene mutations. Lung Cancer 2009;64:314-318.
-
(2009)
Lung Cancer
, vol.64
, pp. 314-318
-
-
Sugio, K.1
Uramoto, H.2
Onitsuka, T.3
-
16
-
-
45149084723
-
First-line gefitinib in patients with advanced non-small-cell lung cancer harboring somatic EGFR mutations
-
Sequist LV, Martins RG, Spigel D, et al. First-line gefitinib in patients with advanced non-small-cell lung cancer harboring somatic EGFR mutations. J Clin Oncol 2008;26:2442-2449.
-
(2008)
J. Clin. Oncol.
, vol.26
, pp. 2442-2449
-
-
Sequist, L.V.1
Martins, R.G.2
Spigel, D.3
-
17
-
-
78649280568
-
The emerging role of epidermal growth factor receptor EGFR inhibitors in first-line treatment for patients with advanced non-small cell lung cancer positive for EGFR mutations
-
Okamoto I, Mitsudomi T, Nakagawa K, et al. The emerging role of epidermal growth factor receptor (EGFR) inhibitors in first-line treatment for patients with advanced non-small cell lung cancer positive for EGFR mutations. Ther Adv Med Oncol 2010;2:301-307.
-
(2010)
Ther. Adv. Med. Oncol.
, vol.2
, pp. 301-307
-
-
Okamoto, I.1
Mitsudomi, T.2
Nakagawa, K.3
-
18
-
-
65649128973
-
Mutation-specific antibodies for the detection of EGFR mutations in non-small-cell lung cancer
-
Yu J, Kane S, Wu J, et al. Mutation-specific antibodies for the detection of EGFR mutations in non-small-cell lung cancer. Clin Cancer Res 2009;15:3023-3028.
-
(2009)
Clin. Cancer Res.
, vol.15
, pp. 3023-3028
-
-
Yu, J.1
Kane, S.2
Wu, J.3
-
19
-
-
77953720122
-
Molecular diagnosis of activating EGFR mutations in non-small-cell lung cancer using mutation- specific antibodies for immunohistochemical analysis
-
Kawahara A, Yamamoto C, Nakashima K, et al. Molecular diagnosis of activating EGFR mutations in non-small-cell lung cancer using mutation- specific antibodies for immunohistochemical analysis. Clin Cancer Res 2010;15:3163-3170.
-
(2010)
Clin. Cancer Res.
, vol.15
, pp. 3163-3170
-
-
Kawahara, A.1
Yamamoto, C.2
Nakashima, K.3
-
20
-
-
77954224784
-
Immunohistochemical detection of EGFR mutation using mutation-specific antibodies in lung cancer
-
Kitamura A, Hosoda W, Sasaki E, et al. Immunohistochemical detection of EGFR mutation using mutation-specific antibodies in lung cancer. Clin Cancer Res 2010;16:3349-3355.
-
(2010)
Clin. Cancer Res.
, vol.16
, pp. 3349-3355
-
-
Kitamura, A.1
Hosoda, W.2
Sasaki, E.3
-
21
-
-
77958198161
-
Novel epidermal growth factor receptor mutation-specific antibodies for non-small cell lung cancer
-
Kato Y, Peled N, Wynes MW, et al. Novel epidermal growth factor receptor mutation-specific antibodies for non-small cell lung cancer. J Thorac Oncol 2010;5:1551-1558.
-
(2010)
J. Thorac. Oncol.
, vol.5
, pp. 1551-1558
-
-
Kato, Y.1
Peled, N.2
Wynes, M.W.3
-
22
-
-
79957676308
-
The usefulness of mutation-specific antibodies in detecting epidermal growth factor receptor mutations and in predicting response to tyrosine kinase inhibitor therapy in lung adenocarcinoma
-
Kozu Y, Tsuta K, Kohno T, et al. The usefulness of mutation-specific antibodies in detecting epidermal growth factor receptor mutations and in predicting response to tyrosine kinase inhibitor therapy in lung adenocarcinoma. Lung Cancer 2011;73:45-50.
-
(2011)
Lung Cancer
, vol.73
, pp. 45-50
-
-
Kozu, Y.1
Tsuta, K.2
Kohno, T.3
-
23
-
-
77649140830
-
Assessment of EGFR mutation status in lung adenocarcinoma by immunohistochemistry using antibodies specific to the two major forms of mutant EGFR
-
Brevet M, Arcila M, Ladanyi M. Assessment of EGFR mutation status in lung adenocarcinoma by immunohistochemistry using antibodies specific to the two major forms of mutant EGFR. J Mol Diagn 2010; 12:169-176.
-
(2010)
J. Mol. Diagn.
, vol.12
, pp. 169-176
-
-
Brevet, M.1
Arcila, M.2
Ladanyi, M.3
-
24
-
-
33750356541
-
Classification of hepatitis B virus genotypes by the PCR-Invader method with genotype-specific probes
-
DOI 10.1016/j.jviromet.2006.07.014, PII S0166093406002709
-
Tadokoro K, Kobayashi M, Yamaguchi T, et al. Classification of hepatitis B virus genotypes by the PCR-Invader method with genotypespecific probes. J Virol Methods 2006;138:30-39. (Pubitemid 44633445)
-
(2006)
Journal of Virological Methods
, vol.138
, Issue.1-2
, pp. 30-39
-
-
Tadokoro, K.1
Kobayashi, M.2
Yamaguchi, T.3
Suzuki, F.4
Miyauchi, S.5
Egashira, T.6
Kumada, H.7
-
25
-
-
23844465454
-
Genetic heterogeneity of the epidermal growth factor receptor in non-small cell lung cancer cell lines revealed by a rapid and sensitive detection system, the peptide nucleic acid-locked nucleic acid PCR clamp
-
DOI 10.1158/0008-5472.CAN-05-0331
-
Nagai Y, Miyazawa H, Huqun, et al. Genetic heterogeneity of the epidermal growth factor receptor in non-small cell lung cancer cell lines revealed by a rapid and sensitive detection system, the peptide nucleic acid-locked nucleic acid PCR clamp. Cancer Res 2005;65:7276-7282. (Pubitemid 41161259)
-
(2005)
Cancer Research
, vol.65
, Issue.16
, pp. 7276-7282
-
-
Nagai, Y.1
Miyazawa, H.2
Huqun3
Tanaka, T.4
Udagawa, K.5
Kato, M.6
Fukuyama, S.7
Yokote, A.8
Kobayashi, K.9
Kanazawa, M.10
Hagiwara, K.11
-
26
-
-
0027394794
-
Association of p53 protein expression with tumor cell proliferation rate and clinical outcome in node-negative breast cancer
-
Allred DC, Clark GM, Elledge R, et al. Association of p53 protein expression with tumor cell proliferation rate and clinical outcome in node-negative breast cancer. J Natl Cancer Inst 1993;85:200-206. (Pubitemid 23046895)
-
(1993)
Journal of the National Cancer Institute
, vol.85
, Issue.3
, pp. 200-206
-
-
Allred, D.C.1
Clark, G.M.2
Elledge, R.3
Fuqua, S.A.W.4
Brown, R.W.5
Chamness, G.C.6
Osborne, C.K.7
McGuire, W.L.8
-
27
-
-
77954526150
-
American Society of Clinical Oncology/College of American Pathologists guideline recommendations of immunohistochemical testing of estrogen and progesterone receptors in breast cancer
-
Hammond ME, Hayes DF, Dowsett M, et al. American Society of Clinical Oncology/College of American Pathologists guideline recommendations of immunohistochemical testing of estrogen and progesterone receptors in breast cancer. J Clin Oncol 2010;28:2784-2795.
-
(2010)
J. Clin. Oncol.
, vol.28
, pp. 2784-2795
-
-
Hammond, M.E.1
Hayes, D.F.2
Dowsett, M.3
-
28
-
-
33947224133
-
Differential constitutive activation of the epidermal growth factor receptor in non-small cell lung cancer cells bearing EGFR gene mutation and amplification
-
DOI 10.1158/0008-5472.CAN-06-3339
-
Okabe T, Okamoto I, Tamura K, et al. Differential constitutive activation of the epidermal growth factor receptor in non-small cell lung cancer cells bearing EGFR gene mutation and amplification. Cancer Res 2007;67:2046-2053. (Pubitemid 46424222)
-
(2007)
Cancer Research
, vol.67
, Issue.5
, pp. 2046-2053
-
-
Okabe, T.1
Okamoto, I.2
Tamura, K.3
Terashima, M.4
Yoshida, T.5
Satoh, T.6
Takada, M.7
Fukuoka, M.8
Nakagawa, K.9
-
29
-
-
57349190180
-
Association of epidermal growth factor receptor EGFR gene mutations with EGFR amplification in advanced non-small cell lung cancer
-
Morinaga R, Okamoto I, Fujita Y, et al. Association of epidermal growth factor receptor (EGFR) gene mutations with EGFR amplification in advanced non-small cell lung cancer. Cancer Sci 2008;99:2455-2460.
-
(2008)
Cancer Sci.
, vol.99
, pp. 2455-2460
-
-
Morinaga, R.1
Okamoto, I.2
Fujita, Y.3
-
30
-
-
0037206022
-
Genetic heterogeneity of single disseminated tumour cells in minimal residual cancer
-
DOI 10.1016/S0140-6736(02)09838-0
-
Klein CA, Blankenstein TJ, Schmidt-Kittler O, et al. Genetic heterogeneity of single disseminated tumour cells in minimal residual cancer. Lancet 2002;360:683-689. (Pubitemid 35232337)
-
(2002)
Lancet
, vol.360
, Issue.9334
, pp. 683-689
-
-
Klein, C.A.1
Blankenstein, T.J.F.2
Schmidt-Kittler, O.3
Petronio, M.4
Polzer, B.5
Stoecklein, N.H.6
Riethmuller, G.7
-
31
-
-
2342544035
-
Comparison of K-ras point mutation distributions in intraductal papillary-mucinous tumors and ductal adenocarcinoma of the pancreas
-
DOI 10.1002/ijc.20084
-
Kitago M, Ueda M, Aiura K, et al. Comparison of K-ras point mutation distributions in intraductal papillary-mucinous tumors and ductal adenocarcinoma of the pancreas. Int J Cancer 2004;110:177-182. (Pubitemid 38580387)
-
(2004)
International Journal of Cancer
, vol.110
, Issue.2
, pp. 177-182
-
-
Kitago, M.1
Ueda, M.2
Aiura, K.3
Suzuki, K.4
Hoshimoto, S.5
Takahashi, S.6
Mukai, M.7
Kitajima, M.8
-
32
-
-
43049132516
-
Tissue heterogeneity of EGFR mutation in lung adenocarcinoma
-
DOI 10.1097/JTO.0b013e318168be93, PII 0124389420080500000013
-
Sakurada A, Lara-Guerra H, Liu N, et al. Tissue heterogeneity of EGFR mutation in lung adenocarcinoma. J Thorac Oncol 2008;3:527-529. (Pubitemid 351630282)
-
(2008)
Journal of Thoracic Oncology
, vol.3
, Issue.5
, pp. 527-529
-
-
Sakurada, A.1
Lara-Guerra, H.2
Liu, N.3
Shepherd, F.A.4
Tsao, M.-S.5
-
33
-
-
13844317894
-
EGFR mutation and resistance of non-small-cell lung cancer to gefitinib
-
DOI 10.1056/NEJMoa044238
-
Kobayashi S, Boqqon TJ, Dayaram T, et al. EGFR mutation and resistance of non-small-cell lung cancer to gefitinib. N Engl J Med 2005;352:786-792. (Pubitemid 40271173)
-
(2005)
New England Journal of Medicine
, vol.352
, Issue.8
, pp. 786-792
-
-
Kobayashi, S.1
Boggon, T.J.2
Dayaram, T.3
Janne, P.A.4
Kocher, O.5
Meyerson, M.6
Johnson, B.E.7
Eck, M.J.8
Tenen, D.G.9
Halmos, B.10
-
34
-
-
79952264325
-
Pretreatment EGFR T790M mutation and BRCA1 mRNA expression in erlotinib-treated advanced non-small-cell lung cancer patients with EGFR mutations
-
Rosell R, Molina MA, Costa C, et al. Pretreatment EGFR T790M mutation and BRCA1 mRNA expression in erlotinib-treated advanced non-small-cell lung cancer patients with EGFR mutations. Clin Cancer Res 2011;17:1160-1168.
-
(2011)
Clin. Cancer Res.
, vol.17
, pp. 1160-1168
-
-
Rosell, R.1
Molina, M.A.2
Costa, C.3
-
35
-
-
79953046542
-
FAS and NF-kB signaling modulate dependence of lung cancers on mutant EGFR
-
Bivona TG, Hieronymus H, Parker J, et al. FAS and NF-kB signaling modulate dependence of lung cancers on mutant EGFR. Nature 2011; 471:523-526
-
(2011)
Nature
, vol.471
, pp. 523-526
-
-
Bivona, T.G.1
Hieronymus, H.2
Parker, J.3
|