Genetic dissection of testis weight in mice: Quantitative trait locus analysis using F 2 intercrosses between strains with extreme testis weight, and association study using Y-consomic strains

Mammalian Genome

Volumn 22, Issue 11-12, 2011, Pages 648-660

  Suto, Jun Ichi ^a  

^a NATIONAL INSTITUTE OF AGROBIOLOGICAL SCIENCES   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ALLELE; ANIMAL TISSUE; ARTICLE; AUTOSOME; CBA MOUSE; CHROMOSOME 1; CHROMOSOME SUBSTITUTION STRAIN; CONTROLLED STUDY; GENE; GENE LOCUS; GENETIC ASSOCIATION; GENETIC VARIABILITY; MALE; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; QUANTITATIVE TRAIT LOCUS; SRY GENE; STRAIN DIFFERENCE; TESTIS WEIGHT; USP9Y GENE; UTY GENE; X CHROMOSOME; Y CHROMOSOME;

ANIMALS; CHROMOSOME MAPPING; CROSSES, GENETIC; FEMALE; MALE; MICE; MICE, INBRED BALB C; MICE, INBRED C3H; MICE, INBRED C57BL; MICE, INBRED CBA; MICE, INBRED DBA; MICROSATELLITE REPEATS; ORGAN SIZE; PHENOTYPE; POLYMORPHISM, SINGLE NUCLEOTIDE; QUANTITATIVE TRAIT LOCI; SPERMATOZOA; TESTIS; X CHROMOSOME; Y CHROMOSOME;

MUS;

EID: 84655161571     PISSN: 09388990     EISSN: 14321777     Source Type: Journal    
DOI: 10.1007/s00335-011-9353-3     Document Type: Article

References (50)

1. H Bolor N Wakasugi WD Zhao A Ishikawa 2006 Detection of quantitative trait loci causing abnormal spermatogenesis and reduced testis weight in the small testis (Smt) mutant mouse Exp Anim 55 97 108 16651692 10.1538/expanim.55. 97 1:CAS:528:DC%2BD28XlsVOjtb0%3D
2. Broman KW, Sen Ś (2009) A guide to QTL mapping with R/qtl. Springer, New York
3. KW Broman H Wu Ś Sen GA Churchill 2003 R/qtl: QTL mapping in experimental crosses Bioinformatics 19 889 890 12724300 10.1093/bioinformatics/ btg112 1:CAS:528:DC%2BD3sXjsVKmtb0%3D (Pubitemid 36582406)
4. C Carlisle H Winking D Weichenhan CM Nagamine 1996 Absence of correlation between Sry polymorphisms and XY sex reversal caused by the M. m. domesticus Y chromosome Genomics 33 32 45 8617507 10.1006/geno.1996.0156 1:CAS:528: DyaK28XisFSms7c%3D (Pubitemid 26119392)
5. AC Cervino G Li S Edwards J Zhu C Laurie G Tokiwa PY Lum S Wang LW Castellani AJ Lusis S Carison AB Sachs EE Schadt 2005 Integrating QTL and high-density SNP analyses in mice to identify Insig2 as a susceptibility gene for plasma cholesterol levels Genomics 86 505 517 16126366 10.1016/j.ygeno.2005. 07.010 1:CAS:528:DC%2BD2MXhtFSitrjF (Pubitemid 41416784)
6. C Chubb 1992 Genes regulating testis size Biol Reprod 47 29 36 1637944 10.1095/biolreprod47.1.29 1:STN:280:DyaK38zksFGjtg%3D%3D
7. Dom sex reversal Nat Genet 6 245 250 8012385 10.1038/ng0394-245 1:CAS:528: DyaK2cXkt1yisbY%3D (Pubitemid 24188620)
8. A Darvasi 2001 In silico mapping of mouse quantitative trait loci Science 294 2423 11865449 10.1126/science.294.5551.2423a 1:STN:280: DC%2BD387is1OrtA%3D%3D
9. K DiPetrillo SW Tsaih S Sheehan C Johns P Kelmenson H Gavras GA Churchill B Paigen 2004 Genetic analysis of blood pressure in C3H/HeJ and SWR/J mice Physiol Genomics 17 215 220 14996992 10.1152/physiolgenomics.00212.2003 1:CAS:528:DC%2BD2cXjs1Olur0%3D (Pubitemid 38924166)
10. EM Eicher 1994 Sex and trinucleotide repeats Nat Genet 6 221 223 8012379 10.1038/ng0394-221 1:STN:280:DyaK2c3ot1Sltw%3D%3D (Pubitemid 24188613)
11. EM Eicher LL Washburn JB Whiteney KE Morrow 1983 Mus poschiavinus Y chromosome in the C57BL/6J murine genome causes sex reversal Science 217 535 537 10.1126/science.7089579 (Pubitemid 12099334)
12. RW Elliott D Poslinski D Tabaczynski C Hohman J Pazik 2004 Loci affecting male fertility in hybrids between Mus macedonicus and C57BL/6 Mamm Genome 15 704 710 15389318 10.1007/s00335-004-2388-y (Pubitemid 39159195)
13. JM Good MD Dean MW Nachman 2008 A complex genetic basis to X-linked hybrid male sterility between two species of house mouse Genetics 179 2213 2228 18689897 10.1534/genetics.107.085340
14. JAM Graves 2010 Sex chromosome evolution and the expression of sex-specific genes in the placenta Placenta 24 S27 S32 10.1016/j.placenta.2009. 12.029 1:CAS:528:DC%2BC3cXit1Gru7w%3D
15. b epitope is encoded by a novel mouse Y chromosome gene Nat Genet 14 474 478 8944031 10.1038/ng1296-474 1:CAS:528:DyaK28XntlGnsL0%3D (Pubitemid 26414595)
16. A Grupe S Germer J Usuka D Aud JK Belknap RF Klein MK Ahluwalia R Higuchi G Peltz 2001 In silico mapping of complex disease-related traits in mice Science 292 1915 1918 11397946 10.1126/science.1058889 1:CAS:528: DC%2BD3MXksVaqurk%3D (Pubitemid 32538367)
17. Y Guo P Lu E Farrell X Zhang P Weller M Monshouwer J Wang G Liao Z Zhang S Hu J Allard S Shafer J Usuka G Peltz 2007 In silico and in vitro pharmacogenetic analysis in mice Proc Natl Acad Sci USA 104 17735 17740 17978195 10.1073/pnas.0700724104 1:CAS:528:DC%2BD2sXht12lsrvP (Pubitemid 350210904)
18. AH Harcourt PH Harvey SG Larson RV Short 1981 Testis weight, body weight and breeding system in primates Nature 293 55 57 7266658 10.1038/293055a0 1:STN:280:DyaL3M3ntVOmtw%3D%3D (Pubitemid 11006040)
19. P Hayward JGM Shire 1974 Y chromosome effect on adult testis size Nature 250 499 500 10.1038/250499a0
20. CS Herrick HG Wolfe 1977 Effect of the Y-chromosome on testis size in the mouse (Mus musculus) Genetics 86 s27
21. SE Hunt U Mittwoch 1987 Y-chromosomal and other factors in the development of testis size in mice Genet Res 50 205 211 3443292 10.1017/S0016672300023715 1:STN:280:DyaL1c7mslyisg%3D%3D
22. C Krausz S Degl'lnnocenti F Nuti A Morelli F Felici A Morelli F Felici M Sansone G Varriale G Forti 2006 Natural transmission of USP9Y gene mutations: a new perspective on the role of AZFa genes in male fertility Hum Mol Genet 15 2673 2681 16893908 10.1093/hmg/ddl198 1:CAS:528:DC%2BD28Xps1Gnur8%3D (Pubitemid 44400394)
23. T Kunieda Y Toyoda 1992 Nucleotide sequence of mouse Sry gene is different between Y chromosome originating from Mus musculus musculus and Mus musculus domesticus Genomics 13 236 237 1349578 10.1016/0888-7543(92)90234-J 1:CAS:528:DyaK38XktVajt7k%3D
24. D L'Hôte C Serres P Laissue A Oulmouden C Rogel-Gaillard X Montagutelli D Vaiman 2007 Centimorgan-range one-step mapping of fertility traits using interspecific recombinant congenic mice Genetics 176 1907 1921 17483418 10.1534/genetics.107.072157 (Pubitemid 47105242)
25. I Le Roy S Tordjman D Migliore-Samour H Degrelle PL Roubertoux 2001 Genetic architecture of testis and seminal vesicle weights in mice Genetics 158 333 340 11333241 (Pubitemid 32428653)
26. N Leader-Williams 1979 Age-related changes in the testicular and antler cycles of reindeer, Rangifer tarandus J Reprod Fertil 57 117 126 512994 10.1530/jrf.0.0570117 1:CAS:528:DyaE1MXlsFGjt7g%3D
27. P Liu Y Wang H Vikis A Maciag D Wang Y Lu Y Liu M You 2006 Candidate lung tumor susceptibility genes identified through whole-genome association analyses in inbred mice Nat Genet 38 888 895 16862160 10.1038/ng1849 1:CAS:528:DC%2BD28XnsVCgsrk%3D (Pubitemid 44141656)
28. A Luddi M Margollicci L Gambera F Serafini M Cioni V De Leo P Balestri P Piomboni 2009 Spermatogenesis in a man with complete deletion of USP9Y New Engl J Med 360 881 885 19246359 10.1056/NEJMoa0806218 1:CAS:528:DC%2BD1MXis1Cnsbk%3D
29. G Marquis S Montplaisir M Pelletier S Mousseau P Auger 1985 Genetic resistance to murine cryptococcosis: Increased susceptibility in the CBA/N XID mutant strain of mice Infect Immun 47 282 287 3880724 1:STN:280: DyaL2M%2FnvVGrtA%3D%3D (Pubitemid 15194624)
30. MP Massett R Fan BC Berk 2009 Quantitative trait loci for exercise training responses in FVB/NJ and C57BL/6J mice Physiol Genomics 40 15 22 19789284 10.1152/physiolgenomics.00116.2009 1:CAS:528:DC%2BC3cXhtlakt7%2FN
31. Y Matsuda T Hirobe VM Chapman 1991 Genetic basis of X-Y chromosome dissociation and male sterility in interspecific hybrids Proc Natl Acad Sci USA 88 4850 4854 2052565 10.1073/pnas.88.11.4850 1:STN:280:DyaK3M3ntFaqsg%3D%3D (Pubitemid 21914640)
32. KE Miller BL Lundrigan PK Tucker 1995 Length variation of CAG repeats in Sry across populations of Mus domesticus Mamm Genome 6 206 208 7749230 10.1007/BF00293015 1:CAS:528:DyaK2MXltlelt70%3D
33. A Oka A Mita N Sakurai-Yamatani H Yamamoto N Takagi T Takano-Shimizu K Toshimori K Moriwaki T Shiroishi 2004 Hybrid breakdown caused by substitution of the X chromosome between two mouse subspecies Genetics 166 913 924 15020476 10.1534/genetics.166.2.913 1:CAS:528:DC%2BD2cXjtlyntLg%3D (Pubitemid 38391750)
34. S Otsuka Y Namiki O Ichii Y Hashimoto N Sasaki D Endoh Y Kon 2010 Analysis of factors decreasing testis weight in MRL mice Mamm Genome 21 153 161 20157820 10.1007/s00335-010-9251-0
35. YG Park R Clifford KH Buetow KW Hunter 2003 Multiple cross and inbred strain haplotype mapping of complex-trait candidate genes Genome Res 13 118 121 12529314 10.1101/gr.786403 1:CAS:528:DC%2BD3sXnvFGlsA%3D%3D
36. DJ Rawlings DC Saffran S Tsukada DA Largaespada JC Grimaldi L Cohen RN Mohr JF Bazan M Howard NG Copeland NA Jenkins ON Witte 1993 Mutation of unique region of Bruton's tyrosine kinase in immunodeficient XID mice Science 261 358 361 8332901 10.1126/science.8332901 1:CAS:528:DyaK3sXmt1Cjs7c%3D (Pubitemid 23281007)
37. I Scher A Ahmed DM Strong AD Steinberg WE Paul 1975 X-linked B-lymphocyte immune defect in CBA/N mice. I. Studies of the function and composition of spleen cells J Exp Med 141 788 803 805203 1:STN:280:DyaE2M7lt1Knsw%3D%3D
38. DM Scott IE Ehrmann PS Ellis CE Bishop AI Agulnik E Simpson MJ Mitchell 1995 Identification of a mouse male-specific transplantation antigen, H-Y Nature 376 695 698 7544442 10.1038/376695a0 1:CAS:528:DyaK2MXnslagtbg%3D
39. JGM Shire A Bartke 1972 Strain differences in testicular weight and spermatogenesis with special reference to C57BL/10J and DBA/2J mice J Endocrinol 55 163 171 4660842 10.1677/joe.0.0550163 1:STN:280:DyaE3s7ns1Chtg%3D%3D
40. R Storchová S Gregorová D Buckiová V Kyselová P Divina J Forejt 2004 Genetic analysis of X-linked hybrid sterility in the house mouse Mamm Genome 15 515 524 15366371 10.1007/s00335-004-2386-0 (Pubitemid 38798842)
41. WL Su SK Sieberts RR Kleinhanz K Lux J Millstein C Molony EE Schadt 2010 Assessing the prospects of genome-wide association studies performed in inbred mice Mamm Genome 21 143 152 20135320 10.1007/s00335-010-9249-7
42. C Sun H Skaletsky B Birren K Devon Z Tang S Silber R Oates DC Page 1999 An azoospermic man with a de novo point mutation in the Y-chromosomal gene USP9Y Nat Genet 23 429 432 10581029 10.1038/70539 1:CAS:528:DyaK1MXnvFOktbs%3D
43. J Suto 2008 Genetic dissection of testis weight in a mouse strain having an extremely large testis: major testis weight determinants are autosomal rather than Y-linked on the basis of comprehensive analyses in Y-chromosome consomic strains Proc Jpn Acad Ser B 84 393 406 10.2183/pjab.84.393
44. y allele at the agouti locus reduces the size and alters the shape of the mandible in mice Proc Jpn Acad Ser B 85 248 257 10.2183/pjab.85.248
45. JD Thomas P Sideras CI Smith I Vorechovsky V Chapman WE Paul 1993 Colocalization of X-linked agammaglobulinemia and X-linked immunodeficiency genes Science 261 355 358 8332900 10.1126/science.8332900 1:CAS:528: DyaK3sXlsFeit7w%3D (Pubitemid 23281006)
46. MHJ Vogt E Goulmy FM Kloosterboer E Blokland RA de Paus R Willemze JH Falkenburg 2000 UTY gene codes for an HLA-B60-restricted human male-specific minor histocompatibility antigen involved in stem cell graft rejection: characterization of the critical polymorphic amino acid residues for T-cell recognition Blood 96 3126 3132 11049993 1:CAS:528:DC%2BD3cXnslGnt7s%3D
47. MHJ Vogt RA de Paus PJ Voogt R Willemze JH Falkenburg 2000 DFFRY codes for a new human male-specific minor transplantation antigen involved in bone marrow graft rejection Blood 95 1100 1105 10648428 1:CAS:528: DC%2BD3cXotV2msA%3D%3D (Pubitemid 30062737)
48. M Vyskočilová Z Pražanová J Piálek 2009 Polymorphism in hybrid male sterility in wild-derived Mus musculus musculus strains on proximal chromosome 17 Mamm Genome 20 83 91 19123034 10.1007/s00335-008-9164-3
49. W Wang LR Meadows JM den Haan NE Sherman Y Chen E Blokland J Shabanowitz AI Agulnik RC Hendrickson CE Bishop 1995 Human H-Y: a male-specific histocompatibility antigen derived from the SMCY protein Science 269 1588 1590 7667640 10.1126/science.7667640 1:CAS:528:DyaK2MXotVOgtrY%3D
50. V Zídek A Musilová P Pintíř M Šimáková M Pravenec 1998 Genetic dissection of testicular weight in the mouse with the BXD recombinant inbred strains Mamm Genome 9 503 505 9657844 10.1007/s003359900808 (Pubitemid 28323757)